公开(公告)号：WO2012118685A3

公开(公告)日：2014-04-24

申请号：PCT/US2012026230

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  LIU YUWEN ,  CHEN CHARLIE ,  GE JUNHAO ,  ZHENG YING ,  XU YUAN ,  YAO LI ,  BACK ARTHUR

Inventor： LIU YUWEN ,  CHEN CHARLIE ,  GE JUNHAO ,  ZHENG YING ,  XU YUAN ,  YAO LI ,  BACK ARTHUR

IPC: G02C7/04

CPC classification number: G02B1/043 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group; 1 to 30 unit parts by weight of a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof; and 10 to 39 unit parts by weight of a second siloxane monomer component comprising 3-[tris (trimethylsilyloxy) silyl] propyl methacrylate (TRIS), or MCS-M11, or both; where the polymerizable composition is free of &Ngr;,&Ngr;-dimethylacrylamide (DMA); and a total amount of siloxane monomers present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了硅酮水凝胶隐形眼镜。 透镜衍生自包含30-60单位重量份具有一个N-乙烯基的亲水性单体的可聚合组合物; 1至30单位重量份的包含本文所述的式（1）的硅氧烷单体的第一硅氧烷单体组分或如本文所述的式（2）的硅氧烷单体或本文所述的式（3）的硅氧烷单体或式 其任何组合; 和10至39单位重量份的包含3- [三（甲硅烷基氧基）甲硅烷基]丙基丙烯酸酯（TRIS）或MCS-M11的第二硅氧烷单体组分或两者; 其中可聚合组合物不含N，N-二甲基丙烯酰胺（DMA）; 存在于聚合性组合物中的硅氧烷单体的总量为15〜40单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118673A3

公开(公告)日：2014-03-13

申请号：PCT/US2012026213

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  FRANCIS CHARLES A ,  ZHENG YING ,  XU YUAN ,  YAO LI ,  BACK ARTHUR ,  HONG YE ,  CHEN CHARLIE

Inventor： FRANCIS CHARLES A ,  ZHENG YING ,  XU YUAN ,  YAO LI ,  BACK ARTHUR ,  HONG YE ,  CHEN CHARLIE

IPC: C08G77/04 ,  B29C39/00 ,  G02C7/04

CPC classification number: C08F230/08 ,  C08F222/1006

Abstract: Dimensionally stable silicone hydrogel contact lenses and manufacturing processes are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1), wherein R1, R2, m and n are as defined herein; the lenses also include units derived from a second siloxane monomer represented by formula (2), wherein R1, R2, m, n, a and b are as defined herein; the second siloxane monomer having a number average molecular weight of at least 3,000 daltons that is present in the polymerizable composition in an amount such that ratio of the first siloxane monomer to the second siloxane monomer is at least 2:1 based on unit parts by weight.

Abstract translation: 描述了尺寸稳定的硅酮水凝胶隐形眼镜和制造工艺。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物，其中R 1，R 2，m和n如本文所定义; 透镜还包括衍生自由式（2）表示的第二硅氧烷单体的单元，其中R 1，R 2，m，n，a和b如本文所定义; 所述第二硅氧烷单体的数均分子量为至少3,000道尔顿，其存在于所述可聚合组合物中，其量使得所述第一硅氧烷单体与所述第二硅氧烷单体的比例基于单位重量份计至少为2:1 。

公开(公告)号：WO2012118681A3

公开(公告)日：2013-12-12

申请号：PCT/US2012026222

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  LIU RONGHUA ,  SHI XINFENG ,  LIU YUWEN ,  CHEN CHARLIE ,  HONG YE ,  FRANCIS CHARLES A ,  YAO LI ,  BACK ARTHUR ,  ZHENG YING

Inventor： LIU RONGHUA ,  SHI XINFENG ,  LIU YUWEN ,  CHEN CHARLIE ,  HONG YE ,  FRANCIS CHARLES A ,  YAO LI ,  BACK ARTHUR ,  ZHENG YING

IPC: G02C7/04

CPC classification number: G02C7/04 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. The average energy loss of the silicone hydrogel contact lenses is from about 30% to about 45% when the lenses are fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了具有眼睛上可接受的能量损失水平的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自第二硅氧烷单体的单元，其是数均分子量为至少7,000道尔顿的双末端甲基丙烯酸酯封端的聚二甲基硅氧烷。 当透镜完全水合时，硅酮水凝胶隐形眼镜的平均能量损失为约30％至约45％。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012154268A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/026225

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  ZHENG, Ying ,  XU, Yuan ,  GE, Junhao ,  FRANCIS, Charles, A. ,  SUN, Yuan ,  LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  QIU, Hongjin ,  YAO, Li ,  BACK, Arthur

Inventor： ZHENG, Ying ,  XU, Yuan ,  GE, Junhao ,  FRANCIS, Charles, A. ,  SUN, Yuan ,  LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  QIU, Hongjin ,  YAO, Li ,  BACK, Arthur

IPC: C08F290/06

CPC classification number: B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ethercontaining monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weighs are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当在聚合性组合物中存在至少一种含亲水性乙烯基醚单体时 ，以1〜20个单位重量的量存在。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118684A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026228

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Yuwen ,  HONG, Ye ,  GE, Junhao ,  XU, Yuan ,  CHEN, Charlie ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur

Inventor： LIU, Yuwen ,  HONG, Ye ,  GE, Junhao ,  XU, Yuan ,  CHEN, Charlie ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur

IPC: G02C7/04 ,  C08L51/08

CPC classification number: G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

Abstract translation: 衍生自包含由式（3）表示的第一硅氧烷单体的聚合性组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118678A1

公开(公告)日：2012-09-07

申请号：PCT/US2012/026218

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  HONG, Ye ,  YAO, Li ,  LIU, Yuwen ,  CHEN, Charlie ,  BACK, Arthur

Inventor： HONG, Ye ,  YAO, Li ,  LIU, Yuwen ,  CHEN, Charlie ,  BACK, Arthur

IPC: G02C7/04

CPC classification number: G02C7/049 ,  C08L83/12 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

Abstract: Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively. The silicone hydrogel contact lenses have good manufacturing processability, can be manufactured without the use of alcohol solvents, and have excellent surface wettability.

Abstract translation: 硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成，其中可聚合组合物具有 亲水性含乙烯基单体的总量与含丙烯酸酯的硅氧烷单体的总量的摩尔比分别为5:1至30:1。 硅酮水凝胶隐形眼镜具有良好的制造加工性，可以在不使用醇溶剂的情况下制造，并且具有优异的表面润湿性。

公开(公告)号：WO2012118670A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026210

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur

Inventor： LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur

IPC: B65B55/02 ,  G02C7/04

CPC classification number: G02B1/043 ,  B65B55/02 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

Abstract: Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.

Abstract translation: 制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。 如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。 水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

公开(公告)号：WO2008131268A4

公开(公告)日：2009-02-19

申请号：PCT/US2008060886

申请日：2008-04-18

Applicant: COOPERVISION INT HOLDING CO LP ,  WARREN TIM ,  DAULTON JAY SCOTT ,  CHEN CHARLIE

Inventor： WARREN TIM ,  DAULTON JAY SCOTT ,  CHEN CHARLIE

IPC: B29D11/00 ,  C08F290/06 ,  G02C7/02

CPC classification number: B29D11/00067 ,  B29C33/60 ,  B29C37/0067 ,  B29D11/0025 ,  Y10S425/808

Abstract: Methods of producing silicone hydrogel ophthalmic lenses include contacting one or more delensed silicone hydrogel ophthalmic lens with a liquid composition that contains alcohol, water, and a surfactant. The methods can be steps of an extraction/hydration procedure used in the production of silicone hydrogel contact lenses. In some examples, contacting silicone hydrogel ophthalmic lens products with a liquid composition that contains alcohol, water, and a surfactant can significantly reduce or prevent surface distortion of the ophthalmic lens resulting from the extraction procedure. Some methods include subsequently contacting the silicone hydrogel ophthalmic lens with a liquid composition consisting essentially of water and a surfactant.

Abstract translation: 生产硅酮水凝胶眼科镜片的方法包括将一种或多种疏水性硅氧水凝胶眼用透镜与含有醇，水和表面活性剂的液体组合物接触。 该方法可以是用于生产硅酮水凝胶隐形眼镜的提取/水合程序的步骤。 在一些实例中，将硅酮水凝胶眼用透镜产品与含有醇，水和表面活性剂的液体组合物接触可显着降低或防止由提取程序引起的眼科镜片的表面变形。 一些方法包括随后使硅氧水凝胶眼用透镜与基本上由水和表面活性剂组成的液体组合物接触。

公开(公告)号：WO2007146300A3

公开(公告)日：2008-10-02

申请号：PCT/US2007013809

申请日：2007-06-12

Applicant: COOPERVISION INT HOLDING CO LP ,  CHEN CHARLIE ,  HONG YE ,  MANESIS NICK

Inventor： CHEN CHARLIE ,  HONG YE ,  MANESIS NICK

IPC: G02C7/04 ,  C08F290/06 ,  C08G77/04 ,  G02B1/04

CPC classification number: C08L83/14 ,  C08F283/12 ,  C08F290/068 ,  C08L51/085 ,  G02B1/043 ,  C08L2666/02

Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products produced from a polymerizable composition comprising a combination of particular components. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

Abstract translation: 具有眼睛可接受的表面润湿性的硅酮水凝胶隐形眼镜是由包含特定组分的组合的可聚合组合物制备的预提取聚合的硅氧水凝胶隐形眼镜产品获得的。 硅酮水凝胶隐形眼镜可以从非极性树脂基隐形眼镜模具获得，而不用表面处理或聚合润湿剂的互穿聚合物网络获得。 还描述了相关的透镜产品，可聚合组合物和方法。

公开(公告)号：WO2005060661A3

公开(公告)日：2005-08-04

申请号：PCT/US2004042221

申请日：2004-12-16

Applicant: UNIV CALIFORNIA ,  SAWYERS CHARLES L ,  CHEN CHARLIE D ,  WELSBIE DEREK

Inventor： SAWYERS CHARLES L ,  CHEN CHARLIE D ,  WELSBIE DEREK

IPC: A01N43/04 ,  A61K31/70 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574

CPC classification number: G01N33/57434 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N2333/723 ,  G01N2500/04

Abstract: Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest (2-5 fold) increase in androgen receptor (AR) mRNA was the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides insight toward the design of novel antiandrogens.

Abstract translation: 使用基于芯片的同基因前列腺癌异种移植模型，我们发现雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。 增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。 本发明提供了用于检查新的治疗方式的基于细胞的测定，并提供了对新型抗雄激素的设计的洞察。