公开(公告)号：WO2012118682A3

公开(公告)日：2014-01-30

申请号：PCT/US2012026223

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  LEE PAUL HUNGCHAUNG ,  LIU RONGHUA ,  SHI XINFENG ,  LIU YUWEN ,  HONG YE ,  CHEN CHARLIE ,  YAO LI ,  BACK ARTHUR ,  FRANCIS CHARLES A

Inventor： LEE PAUL HUNGCHAUNG ,  LIU RONGHUA ,  SHI XINFENG ,  LIU YUWEN ,  HONG YE ,  CHEN CHARLIE ,  YAO LI ,  BACK ARTHUR ,  FRANCIS CHARLES A

IPC: G02C7/04

CPC classification number: B29D11/00038 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L33/10

Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophilic monomer are described. These silicone hydrogel contact lenses have, when fully hydrated, has an equilibrium freezable water content of at least 25% wt/wt as determined by differential scanning calorimetry (DSC). Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了衍生自包含至少一种硅氧烷单体和至少一种亲水单体的可聚合组合物的硅氧烷水凝胶隐形眼镜。 当通过差示扫描量热法（DSC）测定时，这些硅氧水凝胶隐形眼镜在完全水合时具有至少25％wt / wt的平衡可冷冻水含量。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118685A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026230

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Yuwen ,  CHEN, Charie ,  GE, Junhao ,  ZHENG, Ying ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur

Inventor： LIU, Yuwen ,  CHEN, Charie ,  GE, Junhao ,  ZHENG, Ying ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur

IPC: B65B55/02 ,  G02C7/04

CPC classification number: G02B1/043 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group; 1 to 30 unit parts by weight of a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof; and 10 to 39 unit parts by weight of a second siloxane monomer component comprising 3-[tris (trimethylsilyloxy) silyl] propyl methacrylate (TRIS), or MCS-Ml 1, or both; where the polymerizable composition is free of Ν,Ν-dimethylacrylamide (DMA); and a total amount of siloxane monomers present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了硅酮水凝胶隐形眼镜。 透镜衍生自包含30-60单位重量份具有一个N-乙烯基的亲水性单体的可聚合组合物; 1至30单位重量份的包含本文所述的式（1）的硅氧烷单体的第一硅氧烷单体组分或如本文所述的式（2）的硅氧烷单体或本文所述的式（3）的硅氧烷单体或式 其任何组合; 和10至39单位重量份的包含3- [三（甲硅烷基氧基）甲硅烷基]丙基丙烯酸酯（TRIS）或MCS-M111或二者的第二硅氧烷单体组分; 其中可聚合组合物不含α，α-二甲基丙烯酰胺（DMA）; 存在于聚合性组合物中的硅氧烷单体的总量为15〜40单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118681A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026222

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Ronghua ,  SHI, Xinfeng ,  LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur ,  ZHENG, Ying

Inventor： LIU, Ronghua ,  SHI, Xinfeng ,  LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur ,  ZHENG, Ying

IPC: G02C7/04

CPC classification number: G02C7/04 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. The average energy loss of the silicone hydrogel contact lenses is from about 30% to about 45% when the lenses are fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了具有眼睛上可接受的能量损失水平的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自第二硅氧烷单体的单元，其是数均分子量为至少7,000道尔顿的双末端甲基丙烯酸酯封端的聚二甲基硅氧烷。 当透镜完全水合时，硅酮水凝胶隐形眼镜的平均能量损失为约30％至约45％。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118680A1

公开(公告)日：2012-09-07

申请号：PCT/US2012/026220

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Yuwen ,  GE, Junhao ,  CHEN, Charlie ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur ,  FRANCIS, Charles, A.

Inventor： LIU, Yuwen ,  GE, Junhao ,  CHEN, Charlie ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur ,  FRANCIS, Charles, A.

IPC: G02C7/04

CPC classification number: G02B1/043 ,  B29D11/00125 ,  C08L83/12 ,  G02C7/04 ,  G02C7/049 ,  C08L101/14 ,  C08L83/04

Abstract: Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent. The contact lenses have ophthalmically-acceptable ionoflux values and surface wettability, and can be manufactured without the use of volatile organic solvents.

Abstract translation: 硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成。 隐形眼镜具有眼睛可接受的离子通量值和表面润湿性，并且可以在不使用挥发性有机溶剂的情况下制造。

公开(公告)号：WO2012118677A1

公开(公告)日：2012-09-07

申请号：PCT/US2012/026217

申请日：2012-02-23

Applicant: COOPERVISON INTERNATIONAL HOLDING COMPANY, LP ,  CHEN, Charlie ,  LIU, Yuwen ,  HONG, Ye ,  FRANCIS, Charles, A. ,  ZHENG, Ying ,  YAO, Li ,  BACK, Arthur

Inventor： CHEN, Charlie ,  LIU, Yuwen ,  HONG, Ye ,  FRANCIS, Charles, A. ,  ZHENG, Ying ,  YAO, Li ,  BACK, Arthur

IPC: G02C7/04

CPC classification number: G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

Abstract: Low modulus silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer, or at least one cross-linking agent, or both. The average modulus of the silicone hydrogel contact lenses is from about 0.30 MPa to about 0.90 MPa when the lenses are fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了低模量硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基具有1至4个碳原子的烷基，式（1）的每个R 2独立地为氢原子或甲基; 透镜还包括衍生自第二硅氧烷单体或至少一种交联剂或两者的单元。 当透镜完全水合时，硅酮水凝胶隐形眼镜的平均模量为约0.30MPa至约0.90MPa。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118676A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026216

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur

Inventor： LIU, Yuwen ,  CHEN, Charlie ,  HONG, Ye ,  FRANCIS, Charles, A. ,  YAO, Li ,  BACK, Arthur

IPC: G02C7/04 ,  C08L51/08

CPC classification number: G02B1/043 ,  C08F283/065 ,  C08L51/085 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl- containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了具有高水含量的硅氧烷水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自数均分子量为至少7,000道尔顿的第二硅氧烷单体的单元和至少一种含乙烯基交联剂。 当完全水合时，透镜具有约30重量％至约70重量％的平均水含量。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118675A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026215

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LIU, Yuwen ,  CHEN, Charlie ,  FRANCIS, Charles, A. ,  GE, Junhao ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur ,  ZHENG, Ying

Inventor： LIU, Yuwen ,  CHEN, Charlie ,  FRANCIS, Charles, A. ,  GE, Junhao ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur ,  ZHENG, Ying

IPC: C08F230/08

CPC classification number: G02C7/04 ,  B65B5/04 ,  G02B1/043 ,  C08L83/12 ,  C08L33/08 ,  C08L33/10

Abstract: Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了眼科可接受的可湿性硅氧水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是具有1至4个碳原子的烷基，式（1）的每个R 2独立地为氢原子或甲基，第一硅氧烷单体的数均分子量为400道尔顿 至700道尔顿 和数均分子量大于7,000道尔顿的第二硅氧烷单体; 其中存在于聚合性组合物中的硅氧烷单体的总量为30单位份〜50单位份; 透镜还包括衍生自至少一种具有一个N-乙烯基的亲水性酰胺单体的单元，该单体存在于可聚合组合物中的量为30至60单位份。 当完全水合时，镜片具有眼科可接受的可润湿透镜表面。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2011049562A1

公开(公告)日：2011-04-28

申请号：PCT/US2009/061439

申请日：2009-10-21

Applicant: KCI LICENSING, INC. ,  WILKES, Robert Peyton ,  LONG, Justin Alexander ,  KAZALA, Richard Marvin, Jr. ,  YAO, Li ,  BARTA, Erick, Woodson ,  LOCKE, Christopher, Brian

Inventor： WILKES, Robert Peyton ,  LONG, Justin Alexander ,  KAZALA, Richard Marvin, Jr. ,  YAO, Li ,  BARTA, Erick, Woodson ,  LOCKE, Christopher, Brian

IPC: A61F13/00 ,  A61M1/00

CPC classification number: A61F13/00068 ,  A61F13/00059 ,  A61F13/0276 ,  A61F2013/00174 ,  A61F2013/00536 ,  A61F2013/00795 ,  A61M1/0027 ,  A61M1/0086 ,  A61M1/0088 ,  A61M2205/18 ,  A61M2205/3344 ,  A61M2205/581 ,  A61M2205/583

Abstract: Dressings, systems, and methods are disclosed in some embodiments that involve treating a tissue site with reduced pressure wherein the dressing includes a dressing reduced- pressure indicator that allows one to ascertain that the reduced pressure applied at the dressing is greater than a threshold reduced pressure. The dressing reduced-pressure indicator may include a moving member that is adapted to move under reduced pressure and a visual indicator associated with the moving member. Another embodiment uses an electro-mechanical indicator to provide a powered visual alert or audible alert or another output signal. Other dressings, systems, and methods are disclosed.

Abstract translation: 在一些实施方案中公开了敷料，系统和方法，其包括以减压处理组织部位，其中所述敷料包括敷料减压指示器，其允许人们确定在敷料处施加的减压大于阈值减压 。 敷料减压指示器可以包括适于在减压下移动的移动构件和与移动构件相关联的视觉指示器。 另一实施例使用机电指示器来提供动力视觉警报或听觉警报或另一输出信号。 公开了其他敷料，系统和方法。

公开(公告)号：WO2008036607A3

公开(公告)日：2008-05-22

申请号：PCT/US2007078659

申请日：2007-09-17

Applicant: COOPERVISION INT HOLDING CO LP ,  YAO LI ,  NIU XUXIAN

Inventor： YAO LI ,  NIU XUXIAN

IPC: B29D11/00

CPC classification number: B29D11/00038 ,  B29D11/0048 ,  G02C7/04 ,  Y10S425/808

Abstract: Contact lens molds and methods of producing soft cast-molded contact lens products are provided. The methods include placing a soft hydrophilic contact lens-forming composition in a cavity formed between a first mold member and a second mold member, subjecting the composition in the cavity to conditions effective to form a contact lens product from the composition, and repeating the placing and subjecting steps a plurality of times, thereby producing a plurality of soft contact lens products. At least the first mold members, and advantageously all of the first and second mold members, are injection-molded with a nucleated thermoplastic polyolefin resin having a melt flow rate in a range of 10 g/10 min to about 40 g/10 min.

Abstract translation: 提供隐形眼镜模具以及生产软质模制隐形眼镜产品的方法。 所述方法包括将柔性亲水性隐形眼镜形成组合物置于形成于第一模具构件和第二模具构件之间的空腔中，使空腔中的组合物经受有效地从组合物形成隐形眼镜产品的条件，并重复放置 并对其进行多次处理，从而产生多个软性隐形眼镜产品。 至少第一模具构件以及有利地所有的第一和第二模具构件都用具有10克/ 10分钟至约40克/ 10分钟范围内的熔体流动速率的成核热塑性聚烯烃树脂注模。

公开(公告)号：WO2008036607A2

公开(公告)日：2008-03-27

申请号：PCT/US2007/078659

申请日：2007-09-17

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  YAO, Li ,  NIU, Xuxian

Inventor： YAO, Li ,  NIU, Xuxian

IPC: B29D11/00

CPC classification number: B29D11/00038 ,  B29D11/0048 ,  G02C7/04 ,  Y10S425/808

Abstract: Contact lens molds and methods of producing soft cast-molded contact lens products are provided. The methods include placing a soft hydrophilic contact lens-forming composition in a cavity formed between a first mold member and a second mold member, subjecting the composition in the cavity to conditions effective to form a contact lens product from the composition, and repeating the placing and subjecting steps a plurality of times, thereby producing a plurality of soft contact lens products. At least the first mold members, and advantageously all of the first and second mold members, are injection-molded with a nucleated thermoplastic polyolefin resin having a melt flow rate in a range of 10 g/10 min to about 40 g/10 min.

Abstract translation: 提供隐形眼镜模具和生产软铸塑隐形眼镜产品的方法。 所述方法包括将软质亲水性形成隐形眼镜的组合物置于第一模具构件和第二模具构件之间形成的空腔中，使空腔中的组合物经受有效形成来自组合物的隐形眼镜产物的条件，并且重复该配置 并且多次进行步骤，由此生产多个软性隐形眼镜产品。 至少第一模具构件以及有利地全部的第一和第二模具构件用具有10g / 10min至约40g / 10min范围内的熔体流动速率的成核热塑性聚烯烃树脂注射成型。