公开(公告)号：WO1998015570A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018222

申请日：1997-10-09

Applicant: SYNAPTIC PHARMACEUTICAL CORPORATION ,  BARD, Jonathan, A. ,  BOROWSKY, Beth ,  SMITH, Kelli, E. ,  BRANCHEK, Theresa, A. ,  GERALD, Christophe, P., G. ,  JONES, Kenneth, A.

Inventor： SYNAPTIC PHARMACEUTICAL CORPORATION

IPC: C07K01/14

CPC classification number: C07K16/2869 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/72 ,  G01N2500/10

Abstract: This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

Abstract translation: 本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针 编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法 受体。

公开(公告)号：WO1995017906A1

公开(公告)日：1995-07-06

申请号：PCT/US1994014436

申请日：1994-12-28

Applicant: SYNAPTIC PHARMACEUTICAL CORPORATION ,  BARD, Jonathan, A. ,  WALKER, Mary, W. ,  BRANCHEK, Theresa ,  WEINSHANK, Richard, L.

Inventor： SYNAPTIC PHARMACEUTICAL CORPORATION

IPC: A61K38/17

CPC classification number: C07K14/70571 ,  A01K2217/05 ,  A61K38/00

Abstract: This invention provides an isolated nucleic acid molecule encoding a human Y4 receptor, an isolated protein which is a human Y4 receptor, vectors comprising an isolated nucleic acid molecule encoding a human Y4 receptor, mammalian cells comprising such vectors, antibodies directed to the human Y4 receptor, nucleic acid probes useful for detecting nucleic acid encoding human Y4 receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human Y4 receptor, pharmaceutical compounds related to human Y4 receptors, and nonhuman transgenic animals which express DNA encoding a normal or a mutant human Y4 receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human Y4 receptor.

Abstract translation: 本发明提供了编码人Y4受体的分离的核酸分子，作为人Y4受体的分离蛋白质，包含编码人Y4受体的分离的核酸分子的载体，包含该载体的哺乳动物细胞，针对人Y4受体的抗体 可用于检测编码人Y4受体的核酸的核酸探针，与编码人Y4受体的核酸分子的任何序列互补的反义寡核苷酸，与人Y4受体相关的药物化合物和表达正常的DNA的非人转基因动物 或突变型人Y4受体。 本发明还提供了确定配体结合，检测表达，药物筛选和涉及人Y4受体的治疗的方法。

公开(公告)号：WO1994008040A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009187

申请日：1993-09-24

Applicant: SYNAPTIC PHARMACEUTICAL CORPORATION ,  BARD, Jonathan, A. ,  FORRAY, Carlos ,  WEINSHANK, Richard, L.

Inventor： SYNAPTIC PHARMACEUTICAL CORPORATION

IPC: C12Q01/00

CPC classification number: C12Q1/6876 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/70571 ,  C12N15/8509 ,  C12Q2600/158 ,  G01N2500/10

Abstract: This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention also provides a protein, antibody directed to the protein and pharmaceutical compounds related to alpha 1a, alpha 1b and alpha 1c adrenergic receptors. This invention provides nucleic acid probe, antisense oligonucleotide complementary to alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human alpha 1a, alpha 1b and alpha 1c adrenergic receptors.

Abstract translation: 本发明提供编码和表达正常或突变的α1a，α1b和α1c肾上腺素能受体基因的分离的核酸，载体，转化的哺乳动物细胞和非人转基因动物。 本发明还提供了一种针对蛋白质的蛋白质抗体和与α1a，α1b和α1c肾上腺素能受体相关的药物化合物。 本发明提供核酸探针，与α1a，α1b和α1c肾上腺素能受体基因互补的反义寡核苷酸。 本发明还提供了确定配体结合，检测表达，药物筛选和治疗以减轻与人α1a，α1b和α1c肾上腺素能受体相关的异常的方法。

公开(公告)号：WO1994009828A1

公开(公告)日：1994-05-11

申请号：PCT/US1993010553

申请日：1993-10-29

Applicant: SYNAPTIC PHARMACEUTICAL CORPORATION ,  BARD, Jonathan, A. ,  BRANCHEK, Theresa ,  WEINSHANK, Richard, L.

Inventor： SYNAPTIC PHARMACEUTICAL CORPORATION

IPC: A61K48/00

CPC classification number: C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0356 ,  A01K2267/0375 ,  A61K38/00 ,  C07K14/70571

Abstract: This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4B receptor, pharmaceutical compounds related to the human 5-HT4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4B receptor.

Abstract translation: 本发明提供编码哺乳动物5-HT4B受体的分离的核酸分子和编码人5-HT4B受体的分离的核酸分子，其是哺乳动物5-HT4B受体的分离的蛋白质，载体包含编码哺乳动物的分离的核酸分子 5-HT4B受体的载体，包含编码人5-HT4B受体的分离的核酸分子的载体，包含这种载体的哺乳动物细胞，针对5-HT4B受体的抗体，用于检测编码哺乳动物或人5- HT4B受体，与编码哺乳动物或人类5-HT4B受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT4B受体相关的药物化合物。 本发明还提供了用于确定配体结合，检测表达，药物筛选和用于减轻与人5-HT4B受体相关的异常的治疗的方法。