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    HISTONE DEACETYLASE INHIBITORS
    1.
    发明申请
    HISTONE DEACETYLASE INHIBITORS 审中-公开
    HISTONE脱乙酰酶抑制剂

    公开(公告)号：WO2008047138A2

    公开(公告)日：2008-04-24

    申请号：PCT/GB2007/004000

    申请日：2007-10-19

    Applicant: UNIVERSITY COLLEGE LONDON ,  BARTS AND THE LONDON NHS TRUST ,  JOEL, Simon, Peter ,  MARSON, Charles, Michael

    Inventor： JOEL, Simon, Peter ,  MARSON, Charles, Michael

    CPC classification number: C07D285/08 ,  C07C233/07 ,  C07C259/06

    Abstract: The present invention provides histone deacetylase inhibitors of general formula (I), a process for the preparation of such compounds and uses of the compounds in medicine, especially in the treatment of cancers: in which R 1 is an optionally substituted aryl, arylalkyl, heteroaryl, heterocycloalkenyl, cycloalkene ring, cycloalkyl, heterocycloalkyl or a combination of such rings to form a linked or fused ring system, R 2 and R 3 is each independently hydrogen, optionally substituted saturated or unsaturated alkyl, optionally substituted aryl or heteroaryl, or a combination thereof to form a linked or fused ring system, alkoxy, thioalkoxy, hydroxyl, hydroxyalkyl, halo, haloalkyl, cyano, nitro, amino, amido, alkylamino, alkylcarbonyloxy, alkoxycarbonyl, alkylcarbonyl, alkylthiocarbonyl, alkylsulfonylamino, aminosulfonyl, alkylsulfinyl, or alkylsulfonyl, or R 3 is absent when Y stands for O or S, or R 2 and R 3 may be linked together and such that, together with the intervening atoms, they form a 5, 6 or 7-membered ring containing one or more heteroatoms, which may be a heteroaryl ring, heterocycloalkenyl ring, or heterocycloalkyl ring, optionally containing up to 4 heteroatoms, e.g. oxygen, nitrogen or sulphur, which ring may be fused to further rings as part of a fused ring system, and which may bear 1, 2 or 3 substituents, which substituents independently have the same meaning as R 2 on any or all of those rings, Q stands for an (alkyl, which may be unsaturated; aryl, arylalkyl, alkylaryl or alkylarylalkyl, all of which may be optionally substituted; and may be optionally interrupted by O, S, NR, CO, C(N=R), where R may be independently hydrogen, alkyl, alkenyl, alkynyl, or alkoxy; V is OH, SH, SR, OR, NH2, NHR, NRR, NROH, NHOR, NROR where R may independently be hydrogen or (C 1 -C 6 ) alkyl, Y is oxygen, or sulphur or N, and Z is O, S, S(=O), S(O)2, NR 4 , -N=, CR 4 R 5 , or -C(R4)=, where R 4 and R 5 independently have the same meaning as R 2 .

    Abstract translation: 本发明提供了通式（I）的组蛋白脱乙酰酶抑制剂，这种化合物的制备方法和该药物在药物中的用途，特别是在治疗癌症中的用途：其中R 1是 任选取代的芳基，芳基烷基，杂芳基，杂环烯基，环烯烃环，环烷基，杂环烷基或这些环的组合以形成连接或稠合的环体系，R 2和R 3， 各自独立地为氢，任选取代的饱和或不饱和烷基，任选取代的芳基或杂芳基，或其组合以形成连接或稠合的环体系，烷氧基，硫代烷氧基，羟基，羟基烷基，卤素，卤代烷基，氰基，硝基，氨基，酰氨基 当Y代表O或S或R 2时，不存在烷基氨基，烷基羰基氧基，烷氧基羰基，烷基羰基，烷硫基羰基，烷基磺酰基氨基，氨基磺酰基，烷基亚磺酰基或烷基磺酰基或R 3， 和R 3可以连接至 并且使得它们与插入的原子一起形成含有一个或多个杂原子的5,6或7元环，杂原子可以是杂芳基环，杂环烯基环或杂环烷基环，任选地含有至多4个杂原子，例如。 氧，氮或硫，该环可以作为稠环系统的一部分与另外的环稠合，并且其可以带有1,2或3个取代基，该取代基独立地具有与R 2相同的含义， 在任何或所有这些环上，Q表示（烷基，其可以是不饱和的;芳基，芳基烷基，烷基芳基或烷基芳基烷基，其全部可以被任选取代;并且可以任选地被O，S，NR，CO， C（N = R），其中R可以独立地是氢，烷基，烯基，炔基或烷氧基; V是OH，SH，SR，OR，NH 2，NHR，NRR，NROH，NHOR，NROR，其中R可以独立地是氢 或（C 1 -C 6）烷基，Y是氧或硫或N，并且Z是O，S，S（= O），S（O） 2，NR 4，-N =，CR 4 R 5或-C（R 4）=，其中R 4， / SUP>和R 5独立地具有与R 2相同的含义。

    HOMOGENEOUS LIGAND BINDING ASSAY
    3.
    发明申请
    HOMOGENEOUS LIGAND BINDING ASSAY 审中-公开
    均质配体结合测定

    公开(公告)号：WO2003031975A1

    公开(公告)日：2003-04-17

    申请号：PCT/GB2002/004539

    申请日：2002-10-07

    Applicant: BARTS AND THE LONDON NHS TRUST ,  QUEEN MARY (UNIVERSITY OF LONDON) ,  PRICE, Christopher ,  HOLOWNIA, Peter

    Inventor： PRICE, Christopher ,  HOLOWNIA, Peter

    IPC: G01N33/543

    CPC classification number: G01N33/54326

    Abstract: A process for detecting an analyte which is a first component of a complementary ligand-receptor pair (for example an antigen), wherein the process employs colloidal magnetic particles which have bound to their surface the first component or a second component (for example an antibody) of the complementary ligand receptor pair. The process comprises: causing the analyte to take part in a specific binding reaction with the said second component of the complementary ligand-receptor pair, in the presence of the magnetic particles, under conditions such that the magnetic particles are caused to aggregate and thereby their apparent particle size is increased. The amount of increase in apparent particle size is dependent upon the amount of analyte present. The analyte is detected by detecting the apparent increase in particle size. At least 90% of the colloidal magnetic paricles have a particle size of from 6 to 16nm excluding the said bound component of the complementary ligand-receptor pair.

    Abstract translation: 用于检测作为互补配体 - 受体对（例如抗原）的第一组分的分析物的方法，其中该方法使用与其表面结合第一组分或第二组分的胶体磁性颗粒（例如抗体 ）互补配体受体对。 该方法包括：使得分析物在磁性颗粒的存在下与互补配体 - 受体对的所述第二组分参与特异性结合反应，使得使磁性颗粒聚集，从而使它们 表观粒径增加。 表观粒度的增加量取决于存在的分析物的量。 通过检测颗粒大小的明显增加来检测分析物。 除了互补配体 - 受体对的所述结合成分之外，至少90％的胶体磁性颗粒具有6至16nm的粒度。

    CATHETER APPARATUS
    4.
    发明申请
    CATHETER APPARATUS 审中-公开
    导管装置

    公开(公告)号：WO2009050478A1

    公开(公告)日：2009-04-23

    申请号：PCT/GB2008/003522

    申请日：2008-10-17

    Applicant: BARTS AND THE LONDON NHS TRUST ,  JAIN, Ajay Kumar

    Inventor： JAIN, Ajay Kumar

    IPC: A61M25/00

    CPC classification number: A61M25/0074 ,  A61M25/0082 ,  A61M2025/0036

    Abstract: A catheter apparatus is provided with lumens for accommodating guidewires. The apparatus comprises an actuator controllable to move the distal ends of the lumens relative to each other. Accordingly, the separation of the guidewires can be controlled, enabling probing by the guidewires of different area of an occlusion in a blood vessel, such as a chronic total occlusion.

    Abstract translation: 导管装置设置有用于容纳导丝的腔。 该装置包括可控制的致动器，用于相对于彼此移动腔的远端。 因此，可以控制导线的分离，使得能够通过诸如慢性完全闭塞的血管中闭塞的不同区域的导丝来探测。

    DEVICE FOR AMELIORATING SYMPTOMS OF GAIT-IMPAIRED PATIENT
    5.
    发明申请
    DEVICE FOR AMELIORATING SYMPTOMS OF GAIT-IMPAIRED PATIENT 审中-公开
    改善患者症状的装置

    公开(公告)号：WO2006111735A2

    公开(公告)日：2006-10-26

    申请号：PCT/GB2006/001415

    申请日：2006-04-19

    Applicant: BARTS AND THE LONDON NHS TRUST ,  CURTIS, Clive, Ronald

    Inventor： CURTIS, Clive, Ronald

    IPC: A61H5/00

    CPC classification number: A61H5/00 ,  A61H3/00 ,  A61N2005/0648

    Abstract: A device for improving the gait of a gait-impaired patient, for example, a patient suffering from Parkinson's Disease, comprises a support frame (101) carried on the head of the patient, first and second cue means (120), such as LEDs or LCDs, mounted on the device, for projecting first and second visual cues at fixed points into the field of vision of the left eye and the right eye respectively of the patient, and circuitry for causing alternate actuation of the first and second cue means, to activate the said first and second visual cues alternately. The device may also include an additional LED (21) adapted to provide a stimulus to the peripheral vision of the patient. The device may be incorporated into a pair of spectacles or goggles, or may be a clip-on attachment for an existing a pair of spectacles or goggles.

    Abstract translation: 用于改善步态障碍患者（例如患有帕金森病的患者）的步态的装置包括：承载在患者头部的支撑框架（101），第一和第二提示装置（120），例如LED 或LCD，用于将固定点处的第一和第二视觉提示分别投射到患者的左眼和右眼的视野中，以及用于引起第一和第二提示装置的替代致动的电路， 以交替地激活所述第一和第二视觉提示。 该装置还可以包括适于向患者的周边视觉提供刺激的附加LED（21）。 该装置可以并入一对眼镜或护目镜中，或者可以是用于现有的一副眼镜或护目镜的夹子附件。

    STEERABLE ELEMENT FOR USE IN SURGERY
    6.
    发明申请
    STEERABLE ELEMENT FOR USE IN SURGERY 审中-公开
    在手术中使用的可移植元件

    公开(公告)号：WO2012123737A1

    公开(公告)日：2012-09-20

    申请号：PCT/GB2012/050555

    申请日：2012-03-14

    Applicant: BARTS AND THE LONDON NHS TRUST ,  JAIN, Ajay Kumar ,  MCCULLOCH, Andrew Douglas

    Inventor： JAIN, Ajay Kumar ,  MCCULLOCH, Andrew Douglas

    IPC: A61M25/01

    CPC classification number: A61M25/0155 ,  A61M25/0138

    Abstract: A steerable element for use in surgery, comprising: an inflatable member; and an elongate frame azimuthally surrounding said inflatable member, wherein: said inflatable member is configured to press against said elongate frame on inflation so as to cause a change in the curvature of said elongate frame. A catheter, an insertion system, a medical implant comprising the steerable element, a delivery system comprising the steerable element, and a method of configuring the steerable element for use.

    Abstract translation: 一种用于手术的可操纵元件，包括：可充气构件; 以及围绕所述可膨胀构件的细长框架，其中：所述可膨胀构件构造成在膨胀时压靠所述细长框架，从而引起所述细长框架的曲率的变化。 导管，插入系统，包括可转向元件的医疗植入物，包括可转向元件的输送系统以及配置可转向元件以供使用的方法。

    FRACTURE REDUCTION APPARATUS
    7.
    发明申请
    FRACTURE REDUCTION APPARATUS 审中-公开
    骨折减少装置

    公开(公告)号：WO2005027749A2

    公开(公告)日：2005-03-31

    申请号：PCT/GB2004/003885

    申请日：2004-09-10

    Applicant: BARTS AND THE LONDON NHS TRUST ,  PERSAD, Ramkumair

    Inventor： PERSAD, Ramkumair

    IPC: A61B17/00

    CPC classification number: A61F5/04

    Abstract: An apparatus for reducing a fracture in the lower arm of a patient, comprising securing means for restraining the upper arm of the patient, means for supporting the lower arm generally at right angles to the upper arm, and generally horizontal, means for applying a traction force of from 40N to 110N to the lower arm to reduce the fracture, wherein the means for applying a traction force includes attachment means capable of being secured to the hand to transmit the traction force to the lower arm.

    Abstract translation: 一种用于减少患者的下臂中的骨折的装置，包括用于限制患者的上臂的固定装置（10,20），用于大体上与上臂成直角地支撑下臂的装置（15），以及 大体上水平的装置（30,35,40,50,65）用于施加40N至110N的牵引力到下臂以减少断裂，其中用于施加牵引力的装置包括附接装置（80,82， 84），其能够固定到手上以将牵引力传递到下臂。

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