公开(公告)号：WO2011120929A3

公开(公告)日：2011-12-15

申请号：PCT/EP2011054743

申请日：2011-03-28

Applicant: UNIV MUENCHEN TECH ,  BAUER JOHANN ,  SCHWAIGER KARIN

Inventor： BAUER JOHANN ,  SCHWAIGER KARIN

IPC: A23K1/00 ,  A23K1/18 ,  A61K9/02 ,  A61K35/74 ,  C12N1/20

CPC classification number: A61K35/741 ,  A23K10/18 ,  A23K50/10 ,  A23K50/60 ,  A23L29/10 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/17 ,  A61K35/74 ,  C12N1/20 ,  A61K2300/00

Abstract: The present invention is directed to a animal feed for calves comprising calf-specific bacteria, optionally lipids, proteins, vitamins and/or mineral materials for conditioning of the intestinal flora in calves, and thus, for prophylaxis and/or treatment of diarrhea in calves.

Abstract translation: 本发明涉及用于犊牛的动物饲料，其包含小牛特异性细菌，任选的脂质，蛋白质，维生素和/或矿物材料，用于调节小牛中的肠道菌群，因此用于预防和/或治疗小牛腹泻 。

公开(公告)号：WO2011120929A2

公开(公告)日：2011-10-06

申请号：PCT/EP2011/054743

申请日：2011-03-28

Applicant: TECHNISCHE UNIVERSITÄT MÜNCHEN ,  BAUER, Johann ,  SCHWAIGER, Karin

Inventor： BAUER, Johann ,  SCHWAIGER, Karin

IPC: A23K1/00

CPC classification number: A61K35/741 ,  A23K10/18 ,  A23K50/10 ,  A23K50/60 ,  A23L29/10 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/17 ,  A61K35/74 ,  C12N1/20 ,  A61K2300/00

Abstract: The present invention is directed to a animal feed for calves comprising calf-specific bacteria, optionally lipids, proteins, vitamins and/or mineral materials for conditioning of the intestinal flora in calves, and thus, for prophylaxis and/or treatment of diarrhea in calves.

Abstract translation: 本发明涉及一种用于小牛的动物饲料，其包含小牛特异性细菌，任选脂质，蛋白质，维生素和/或矿物质材料，用于调理小牛中的肠内菌群，并且因此用于预防 和/或治疗小牛腹泻。

公开(公告)号：WO2004006678A1

公开(公告)日：2004-01-22

申请号：PCT/US2003/022469

申请日：2003-07-17

Applicant: INTRONN, INC. ,  MITCHELL, Lloyd, G. ,  PUTTARAJU, Madaiah ,  DALLINGER, Guenter ,  KLAUSEGGER, Alfred ,  BAUER, Johann

Inventor： MITCHELL, Lloyd, G. ,  PUTTARAJU, Madaiah ,  DALLINGER, Guenter ,  KLAUSEGGER, Alfred ,  BAUER, Johann

IPC: A01N47/40

CPC classification number: C12N15/113 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N2510/00

Abstract: The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated RNA traps-splicing. The compositions of the invention include pre-traps-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a traps-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA). In particular, the PTMs of the present invention can be genetically engineered to interact with a specific target pre­mRNA expressed in cells of the skin so as to result in correction of genetic defects responsible for a variety of different skin disorders to encode a reporter molecule or protein that may have therapeutic value. The compositions of the invention further include recombinant vectors systems capable of expressing the PTMs of the invention and cells expressing said PTMs. The methods of the invention encompass contacting the PTMs of the invention with specific target pre-Mrna expressed within cells of the skin under conditions in which a portion of the PTM is traps-spliced to a portion of the target pre-mRNA to form a chimeric RNA molecule wherein the genetic defect in the specific gene has been corrected. The present invention is based on the successful trans -splicing of the collagen XVII pre-mRNA thereby establishing the usefulness of trans -splicing for correction of skin specific genetic defects. The methods and compositions of the present invention can be used in gene therapy for treatment of specific disorders of the skin, i.e ., genodermatoses, such as epidermal fragility disorders, keratinization disorders, hair disorders and pigmentation disorders as well as cancers of the skin.

Abstract translation: 本发明提供了通过靶向剪接体介导的RNA捕获 - 剪接产生新的核酸分子的方法和组合物。 本发明的组合物包括设计成与靶前体信使RNA分子（靶前体mRNA）相互作用的诱捕前剪接分子（PTM），并介导产生新型嵌合RNA分子的陷阱剪接反应（嵌合 RNA）。 特别地，本发明的PTM可以进行遗传工程改造以与皮肤细胞中表达的特异性靶基因前体RNA相互作用，从而导致对多种不同皮肤病症负责编码报告分子或蛋白质的遗传缺陷的校正 这可能有治疗价值。 本发明的组合物还包括能够表达本发明的PTM和表达所述PTM的细胞的重组载体系统。 本发明的方法包括使本发明的PTM与在皮肤细胞内表​​达的特异性靶前Mrna接触，其中一部分PTM被剪接到目标前mRNA的一部分以形成嵌合体 其中特异性基因的遗传缺陷已被校正的RNA分子。 本发明基于胶原XVII前体mRNA的成功的转拼，从而确定了用于修复皮肤特异性遗传缺陷的转拼的有用性。 本发明的方法和组合物可用于治疗皮肤特异性病症的基因疗法，即皮肤病，如表皮脆性障碍，角质化病症，毛发病症和色素沉着病以及皮肤癌。

公开(公告)号：WO1996018151A1

公开(公告)日：1996-06-13

申请号：PCT/DE1995001602

申请日：1995-11-17

Applicant: FRIEDRICH MERK TELEFONBAU GMBH ,  NEUMEYER, Karl ,  BAUER, Johann

Inventor： FRIEDRICH MERK TELEFONBAU GMBH

IPC: G06F12/06

CPC classification number: G05B19/042 ,  G05B2219/21059 ,  G05B2219/23306 ,  G05B2219/23338 ,  G05B2219/25257 ,  G05B2219/25265 ,  G05B2219/25302 ,  G05B2219/25303 ,  G05B2219/25304 ,  G06F12/0623

Abstract: A control device has a first microprocessor system and a first linearly addressable storage for program codes and system data and a second storage for additional program codes and other system data that may be driven with the same addresses. The first storage is driven by a first additional address line and the second storage is driven by a second additional address line of the logic circuitry. The logic circuitry forms the address lines from the status bit of the microprocessor device automatically generated on the basis of the instructions to be processed. Additional registers and an enlarged address decoding logic in the logic circuitry attribute storage blocks to another address area and allow storage blocks in the same address area to be selectively operated. The address volume of a microprocessor system is thus increased in a simple manner and a process is obtained for reading and writing into storage areas that allows system control units to be advantageously serviced at a distance.

Abstract translation: 本发明涉及一种具有微处理器系统和用于程序代码和系统数据，并用相同的地址存储附加的程序代码和其它系统数据的第二可寻址的第一线性寻址存储器的控制装置，其中，所述第一存储器的由第一附加地址线控制和所述控制 第二存储器被逻辑电路的第二附加地址线进行的，该逻辑电路形成从自动生成由于命令的地址线将被处理的微处理器装置的状态位。 附加的寄存器，并在逻辑电路中的扩展地址解码逻辑具有存储器块到另一个地址范围，并允许在同一范围内的存储块的选择操作。 特此微处理器系统实现Adressiervolumes的简单延伸，并用于读取和存储区域允许该写入的方法允许远程维护系统控制是有利的。

公开(公告)号：WO2010127757A3

公开(公告)日：2011-01-27

申请号：PCT/EP2010002243

申请日：2010-04-12

Applicant: MERCK PATENT GMBH ,  DIETZ JOHAN ,  HOLSCHUH KARL ,  BAUER JOHANN ,  KLEIN SYLKE

Inventor： DIETZ JOHAN ,  HOLSCHUH KARL ,  BAUER JOHANN ,  KLEIN SYLKE

IPC: G06K19/06 ,  B42D15/00 ,  G07D7/00

CPC classification number: G06K19/06196 ,  G07D7/04

Abstract: The invention relates to a method for encoding products, wherein a magnetic composition containing magnetic nanoparticles is applied to at least one pre-determined surface unit of the surface of a product, and is dried and/or hardened. In the magnetic composition, monodispersed isotropic magnetic nanoparticles having at least one pre-determined nominal particle size are distributed homogeneously in a pre-determined concentration. A code is formed from the nominal particle size and/or from the concentration of the magnetic nanoparticles in the magnetic composition. The invention also relates a product encoded in such a way, and to a magnetic composition.

Abstract translation: 本发明涉及一种用于产品的编码的方法，其中施加包含磁性纳米颗粒以至少一个产品的表面的预定单位区域中的磁性组合物，并进行干燥和/或固化，由此单分散在磁性组合物各向同性磁 纳米颗粒，其具有至少一个预定的标称粒度存在于以均匀分布的预定的浓度，并且其中从所述标称颗粒尺寸和/或从磁纳米粒子的浓度的代码被形成在磁性组合物的相应的编码产物和磁 组成。

公开(公告)号：WO2012010251A1

公开(公告)日：2012-01-26

申请号：PCT/EP2011/003242

申请日：2011-06-30

Applicant: MERCK PATENT GMBH ,  HENZLER, Tanja ,  HOLSCHUH, Karl ,  BAUER, Johann ,  HERGET, Thomas ,  HARTMANN, Michael ,  POETZ, Oliver ,  JOOS, Thomas

Inventor： HENZLER, Tanja ,  HOLSCHUH, Karl ,  BAUER, Johann ,  HERGET, Thomas ,  HARTMANN, Michael ,  POETZ, Oliver ,  JOOS, Thomas

IPC: G01N33/543

CPC classification number: G01N21/6428 ,  B82Y15/00 ,  G01N33/54346 ,  G01N33/588

Abstract: The present invention relates to a method and kit for performing assays like immunoassays. The assays are performed by using two different types of magnetic beads.

Abstract translation: 本发明涉及用于进行如免疫测定法的测定的方法和试剂盒。 通过使用两种不同类型的磁珠来进行测定。

公开(公告)号：WO2010130447A1

公开(公告)日：2010-11-18

申请号：PCT/EP2010/002941

申请日：2010-05-12

Applicant: BREITENBACH-KOLLER, Hannelore ,  HINTNER, Helmut ,  BAUER, Johann ,  HAUBENREISSER, Olaf

Inventor： BREITENBACH-KOLLER, Hannelore ,  HINTNER, Helmut ,  BAUER, Johann ,  HAUBENREISSER, Olaf

IPC: C12Q1/68

CPC classification number: C12Q1/6897 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions. Also, kits are provided which comprise the identified compounds and/or proteins in addition to suitable means for performing the methods of the invention

Abstract translation: 本发明涉及用于筛选真核细胞中化合物和/或突变核糖体蛋白的系统和方法，其增加或减少靶基因的翻译，从而改善或恢复靶基因的有缺陷和/或不需要的翻译。 公开了本发明的方法和系统，其药物和化妆品组合物，其用于制备药物的用途，治疗疾病或病症的方法或与基因的缺陷翻译有关的美容条件的化合物和蛋白质 ，例如遗传性疾病如大疱性表皮松解症，以及用于临床评估这些疾病或病症的诊断措施。 此外，提供了包含鉴定的化合物和/或蛋白质的试剂盒，以及用于进行本发明的方法的合适的方法

公开(公告)号：WO1997025730A1

公开(公告)日：1997-07-17

申请号：PCT/DE1996002461

申请日：1996-12-19

Applicant: SIEMENS AKTIENGESELLSCHAFT ,  DREXLER, Johann ,  BRANDL, Wolfgang ,  ADLFINGER, Peter ,  KOPPMANN, Bardo ,  BAUER, Johann

Inventor： SIEMENS AKTIENGESELLSCHAFT

IPC: H01H11/00

CPC classification number: H01H89/06 ,  H01H11/0031 ,  H01H71/082

Abstract: The invention concerns a wiring component (11) with which a power switch (1) can be interconnected both with an alternating current contactor (2) as well as with a direct current contactor (3), even when the connecting strips (5, 8) of the contactors (2, 3) are placed differently with respect to the connecting strips (4) of the power switch (1). This is effected by matching the bend and the material thickness m of the two Z-shaped stamped bent parts (12) used in the wiring component (11).

Abstract translation: 本发明的布线模块（11）可以是功率开关互连（1）既与交流接触器（2），并用一个直流接触器（3），即使在连接轨道（5,8）的接触器（2,3 ）位于不同的相（向断路器（1）的连接杆4）。 这是通过调节偏转，并用于在布线的块的材料厚度米实现（11）的Z形冲压和弯曲部分（12）。

公开(公告)号：WO2013014247A1

公开(公告)日：2013-01-31

申请号：PCT/EP2012/064728

申请日：2012-07-26

Applicant: BAUER, Johann ,  ETTINGER, Monika ,  GRATZ, Iris ,  PECKL-SCHMID, Doris

Inventor： BAUER, Johann ,  ETTINGER, Monika ,  GRATZ, Iris ,  PECKL-SCHMID, Doris

IPC: A61K39/00

CPC classification number: A61K48/005 ,  A61K38/39 ,  A61K39/0008 ,  A61K48/0075 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54

Abstract: The present invention relates to a composition for use in the prevention of the rejection of skin tissue, comprising an effective amount of a peptide comprising an epitope of an antigen selected from the group of the polypeptides type XVII collagen, VII collagen, integrin alpha 6, integrin beta 4, chains of laminin, chains of laminin 322, type IV collagen, plectin, plakoglobin, bullous pemphigoid antigen 1, periplakin, envoplakin, desmoglein 1, desmoglein 3, a desmocollin and human bullous pemphigoid antigen 2 (hBPAG2) wherein said epitope induces immunological tolerance against its underlying polypeptide, and/or a nucleic acid for expressing a peptide comprising an epitope of said antigen as well as a gene therapy based on the composition, in the context of autoimmune blistering diseases, such as bullous pemphigoid or genetic skin diseases such as epidermolysisbullosa.

Abstract translation: 本发明涉及一种用于预防皮肤组织排斥的组合物，其包含有效量的包含抗原表位的肽，所述抗原选自XVII型胶原多肽，VII胶原，整联蛋白α6， 整联蛋白β4，层粘连蛋白链，层粘连蛋白322链，IV型胶原，plectin，血红蛋白，大疱性类天疱疮抗原1，periplakin，envoplakin，脱骨髓蛋白1，脱骨髓蛋白3，脱纤毛蛋白和人大疱性类天疱疮抗原2（hBPAG2），其中所述表位 在自身免疫性起泡疾病如大疱性类天疱疮或遗传性皮肤的情况下，诱导针对其潜在多肽的免疫耐受性和/或用于表达包含所述抗原表位的肽的核酸以及基于该组合物的基因治疗 疾病如表皮松解症。

公开(公告)号：WO2010012472A1

公开(公告)日：2010-02-04

申请号：PCT/EP2009/005538

申请日：2009-07-30

Applicant: BAUER, Johann ,  MITCHELL, Lloyd, G.

Inventor： BAUER, Johann ,  MITCHELL, Lloyd, G.

IPC: A61K48/00

CPC classification number: C12N15/85 ,  A61K48/005 ,  C07K14/78 ,  C12N2740/13043 ,  C12N2840/445

Abstract: The present invention relates to specific and markedly improved pre-mRNA trans -splicing molecule (RTM) molecules which are designed to correct specific genes expressed within cells to be targeted, and which are associated with epidermolysis bullosa, cystic fibrosis, pachyonychia congenital, and psoriasis or neurodermitis, as well as cancers of the skin. In particular, the RTMs of the present invention are genetically engineered to interact with a specific target pre-mRNA expressed in cells to be targeted so as to result in correction of genetic defects or reprogramming of gene expression responsible for a variety of different skin disorders.

Abstract translation: 本发明涉及特异性和显着改进的mRNA前转录分子（RTM），其被设计用于校正在靶细胞内表达的特异性基因，并且其与大疱性表皮松解，囊性纤维化，先天性先天性和牛皮癣相关 或神经性皮炎，以及皮肤癌。 特别地，本发明的RTM被遗传工程改造以与待靶向的细胞中表达的特异性靶mRNA前体相互作用，从而导致基因缺陷的校正或负责各种不同皮肤病症的基因表达的重新编程。