公开(公告)号：WO2010030251A3

公开(公告)日：2010-06-24

申请号：PCT/SG2009000341

申请日：2009-09-15

Applicant: AGENCY SCIENCE TECH & RES ,  CHEN CARL GANG ,  BHOLA BIPIN SEWAKRAM ,  HO SENG-THIONG

Inventor： CHEN CARL GANG ,  BHOLA BIPIN SEWAKRAM ,  HO SENG-THIONG

IPC: G01N21/41 ,  G01N21/39 ,  G02B6/00

CPC classification number: G01N21/41 ,  G01N21/39 ,  G01N2021/7776 ,  G02B6/12007 ,  G02B6/2932 ,  G02B2006/12107 ,  G02B2006/12138 ,  G02B2006/12164

Abstract: An integrated optical sensor operating in the frequency domain is disclosed together with a system and method for detecting the presence of a sample to be detected with the optical sensor. The optical sensor comprises a substrate for supporting the optical sensor, at least two substantially identical gratings or grating-based resonators, a waveguide directional coupler coupled to the gratings and arranged to receive light from a light source and propagate the light through to the gratings, and a flow cell for housing each of the gratings, each flow cell having a fluidic input and a fluidic output, one flow cell for receiving a reference fluid and another flow cell for receiving a fluid with the sample to be detected; the sample to be detected alters the effective refractive index of the propagating mode inside the grating by binding or being adsorbed by the grating to alter the optical frequency of the light that propagates through the grating. In an embodiment, the grating is surface functionalized with a sensitive layer to enable sample adherence or adsorption.

Abstract translation: 公开了一种在频域中工作的集成光学传感器以及用于利用光学传感器检测待检测样品的存在的系统和方法。 光学传感器包括用于支撑光学传感器的基板，至少两个基本上相同的光栅或基于光栅的谐振器，耦合到光栅并布置成接收来自光源的光并将光传播到光栅的波导定向耦合器， 以及用于容纳每个光栅的流动池，每个流动池具有流体输入和流体输出，用于接收参考流体的一个流动池和用于接收待检测样品的流体的另一流动池; 要检测的样品通过结合或被光栅吸附来改变光栅内的传播模式的有效折射率，以改变通过光栅传播的光的光频率。 在一个实施例中，光栅用敏感层进行表面官能化，以使样品粘附或吸附。

公开(公告)号：WO2014163588A1

公开(公告)日：2014-10-09

申请号：PCT/SG2014/000153

申请日：2014-04-04

Applicant: NITTO DENKO CORPORATION ,  XU, Jianxiong ,  BHOLA, Bipin Sewakram ,  XIE, Hong ,  CHONG, Peini ,  BI, Xinyan

Inventor： XU, Jianxiong ,  BHOLA, Bipin Sewakram ,  XIE, Hong ,  CHONG, Peini ,  BI, Xinyan

IPC: A61B10/00 ,  B01L3/00 ,  G01N1/00 ,  G01N1/02 ,  G01N1/12

CPC classification number: B01L3/0293 ,  A61B10/007 ,  B01L3/5027 ,  B01L2200/0684 ,  B01L2300/069 ,  B01L2300/0864 ,  B01L2300/126 ,  B01L2400/0481

Abstract: A device for collection of a fluid sample, a receptacle for a device for collection of a fluid sample, an assembly for collection of a fluid sample and a method of collecting a fluid sample. The device comprises a carrier; an absorptive material disposed on the carrier; and a compression mechanism disposed on the carrier for compressing the absorptive material under a force applied to the compression mechanism; wherein the compression mechanism comprises a non-absorptive tip portion of the carrier, the tip portion being moveable to compress the absorptive material under the force applied to the tip portion.

Abstract translation: 用于收集流体样品的装置，用于收集流体样品的装置的容器，用于收集流体样品的组件和收集流体样品的方法。 该装置包括载体; 设置在载体上的吸收材料; 以及设置在所述载体上的压缩机构，用于在施加到所述压缩机构的力下压缩所述吸收材料; 其中所述压缩机构包括所述载体的非吸收性顶端部分，所述尖端部分可移动以在施加到所述尖端部分的力下压缩所述吸收材料。

公开(公告)号：WO2013077808A1

公开(公告)日：2013-05-30

申请号：PCT/SG2012/000413

申请日：2012-11-01

Applicant: NITTO DENKO CORPORATION ,  BHOLA, Bipin Sewakram ,  CHUA, Pei Zhi Gary ,  THAVEEPRUNGSRIPORN, Visit

Inventor： BHOLA, Bipin Sewakram ,  CHUA, Pei Zhi Gary ,  THAVEEPRUNGSRIPORN, Visit

IPC: A61B5/00 ,  G01N21/27

CPC classification number: A61B5/14551 ,  A61B5/1495 ,  A61B2560/0233 ,  G01N21/274 ,  G01N21/276

Abstract: There is provided a method of obtaining a correction factor to compensate for wavelength shifts of a light source, the method comprising (i) detecting by a light detector, a first optical characteristic of substaintially unfiltered light emitted by the light source; (ii) detecting by the light detector, a second optical characteristic of filtered light from the light source; and (ii) comparing the first optical characteristic, the second characteristic and a predetermined set of values to obtain the correction factor. A calibration device and physiological parameter measurement device capable of facilitating performance or performing the method are also disclosed.

Abstract translation: 提供了一种获得补偿光源的波长偏移的校正因子的方法，该方法包括：（i）通过光检测器检测由光源发射的原始未过滤的光的第一光学特性; （ii）由光检测器检测来自光源的滤光的第二光学特性; 和（ii）比较第一光学特性，第二特性和预定值的值以获得校正因子。 还公开了能够促进性能或执行该方法的校准装置和生理参数测量装置。

公开(公告)号：WO2012033466A1

公开(公告)日：2012-03-15

申请号：PCT/SG2011/000305

申请日：2011-09-08

Applicant: NITTO DENKO CORPORATION ,  TAKAYAMA, Kazuya ,  MD KASSIM, Md Irwan ,  BHOLA, Bipin Sewakram ,  THET, Khine Cho ,  SAMSUDIN, Sulhede

Inventor： TAKAYAMA, Kazuya ,  MD KASSIM, Md Irwan ,  BHOLA, Bipin Sewakram ,  THET, Khine Cho ,  SAMSUDIN, Sulhede

IPC: G01N21/31 ,  G01N21/55

CPC classification number: G01N21/553 ,  G01N21/31 ,  G01N21/7703 ,  G01N2021/7783 ,  G01N2201/0245 ,  G01N2201/086

Abstract: A holder for a sensor waveguide structure for an optical biosensor, a biosensor comprising a holder, a method of assembling an optical biosensor, and a method of biosensing. The holder comprises means for aligning the sensor waveguide structure with an input waveguide structure and an output waveguide structure of the biosensor, for guiding a light signal from the input waveguide structure through the sensor waveguide structure and to the output waveguide structure.

Abstract translation: 用于光学生物传感器的传感器波导结构的保持器，包括保持器的生物传感器，组装光学生物传感器的方法和生物传感方法。 保持器包括用于将传感器波导结构与生物传感器的输入波导结构和输出波导结构对准的装置，用于引导来自输入波导结构的光信号通过传感器波导结构和输出波导结构。

公开(公告)号：WO2013172781A1

公开(公告)日：2013-11-21

申请号：PCT/SG2012/000170

申请日：2012-05-17

Applicant: NITTO DENKO CORPORATION ,  TAKAYAMA, Kazuya ,  BHOLA, Bipin Sewakram

Inventor： TAKAYAMA, Kazuya ,  BHOLA, Bipin Sewakram

IPC: G02B6/26 ,  G02B6/10 ,  G02B6/00

CPC classification number: G02B6/1221 ,  G02B6/138

Abstract: A light coupling device is proposed, as well as a method for fabricating the device. The light coupling device has a coupling spot 4 formed over a transparent substrate 13 with a cladding layer 2 in between. One or more waveguide cores 1 contact the coupling spot, and extend in its plane. Light traverses the transparent substrate 13 and the cladding layer 2, and enters the coupling spot 4, where it is scattered by scattering elements. At least a portion of the light enters the waveguide core(s) 1. A first reflection mirror 5 is formed on the surface of the coupling spot 4 facing the transparent substrate 13, with an aperture for the light to pass through. A back reflection mirror 6 is provided on the surface of the coupling spot 4 opposite the transparent substrate 13. A second reflection mirror 7 may be formed between the cladding layer 2 and the transparent substrate 13.

Abstract translation: 提出了一种光耦合装置，以及一种制造该装置的方法。 光耦合装置具有在透明基板13之间形成有耦合点4，其间具有包层2。 一个或多个波导芯1接触耦合点，并在其平面上延伸。 光穿过透明基板13和包覆层2，并进入耦合光点4，在该耦合光点被散射元件散射。 光的至少一部分进入波导芯1.在耦合光点4的面向透明基板13的表面上形成第一反射镜5，具有光通过的孔。 背面反射镜6设置在与透明基板13相对的耦合光斑4的表面上。可以在包层2和透明基板13之间形成第二反射镜7。

公开(公告)号：WO2013039452A1

公开(公告)日：2013-03-21

申请号：PCT/SG2011/000317

申请日：2011-09-15

Applicant: NITTO DENKO CORPORATION ,  TAKAYAMA, Kazuya ,  BHOLA, Bipin Sewakram

Inventor： TAKAYAMA, Kazuya ,  BHOLA, Bipin Sewakram

IPC: G02B6/00 ,  G02B6/26 ,  G02B6/28 ,  G02B6/34 ,  G02B6/42

CPC classification number: G02B6/26 ,  G02B6/001 ,  G02B6/004 ,  G02B6/2848 ,  G02B6/2852 ,  G02B6/34 ,  G02B6/4201

Abstract: A method and structure for coupling light into a waveguide (501, 502). The method comprises the steps of providing nano- sized or sub-micron scattering elements in a coupling spot (503) disposed in a plane of a waveguide core (501) of the waveguide; directing the light (504) into the coupling spot; and subjecting the light to scattering at the scattering elements such that at least a portion of the scattered light is coupled into the waveguide core (501).

Abstract translation: 一种用于将光耦合到波导（501,502）中的方法和结构。 该方法包括以下步骤：在布置在波导的波导芯（501）的平面中的耦合点（503）中提供纳米尺寸或亚微米散射元件; 将光（504）引导到耦合点中; 并且使光在散射元件处散射，使得至少一部分散射光耦合到波导芯（501）中。

公开(公告)号：WO2010030251A2

公开(公告)日：2010-03-18

申请号：PCT/SG2009/000341

申请日：2009-09-15

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  CHEN, Carl, Gang ,  BHOLA, Bipin, Sewakram ,  HO, Seng-Thiong

Inventor： CHEN, Carl, Gang ,  BHOLA, Bipin, Sewakram ,  HO, Seng-Thiong

IPC: G01N21/41 ,  G01N21/39 ,  G02B6/00

CPC classification number: G01N21/41 ,  G01N21/39 ,  G01N2021/7776 ,  G02B6/12007 ,  G02B6/2932 ,  G02B2006/12107 ,  G02B2006/12138 ,  G02B2006/12164

Abstract: An integrated optical sensor operating in the frequency domain is disclosed together with a system and method for detecting the presence of a sample to be detected with the optical sensor. The optical sensor comprises a substrate for supporting the optical sensor, at least two substantially identical gratings or grating-based resonators, a waveguide directional coupler coupled to the gratings and arranged to receive light from a light source and propagate the light through to the gratings, and a flow cell for housing each of the gratings, each flow cell having a fluidic input and a fluidic output, one flow cell for receiving a reference fluid and another flow cell for receiving a fluid with the sample to be detected; the sample to be detected alters the effective refractive index of the propagating mode inside the grating by binding or being adsorbed by the grating to alter the optical frequency of the light that propagates through the grating. In an embodiment, the grating is surface functionalized with a sensitive layer to enable sample adherence or adsorption.

Abstract translation: 在频域中操作的集成光学传感器与用于检测待利用光学传感器检测的样本的存在的系统和方法一起被公开。 光学传感器包括用于支撑光学传感器的基板，至少两个基本相同的光栅或基于光栅的谐振器，波导定向耦合器，耦合到光栅并布置成接收来自光源的光并将光传播到光栅， 以及用于容纳每个光栅的流动池，每个流动池具有流体输入和流体输出，一个流动池用于接收参考流体，另一个流动池用于接收待检测样品的流体; 待检测的样品通过结合或被光栅吸收来改变光栅内传播模式的有效折射率，以改变传播通过光栅的光的光学频率。 在一个实施例中，光栅用敏感层表面官能化以使样品粘附或吸附。