公开(公告)号：WO1996039026A1

公开(公告)日：1996-12-12

申请号：PCT/US1996009005

申请日：1996-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BITENSKY, Mark, W. ,  YOSHIDA, Tatsuro

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

IPC: A01N01/02

CPC classification number: A01N1/0226 ,  A01N1/02

Abstract: A cost-effective, 4 DEG C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 DEG C for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

Abstract translation: 描述了保持红细胞质量并延长输血后体内存活的成本有效的4℃储存程序。 通过在储存时从其中除去氧气，可以保持三磷酸腺苷水平，并在4℃保存长时间的红细胞的溶血和膜囊泡生成减少。 通过加入磷酸铵，一些样品中储存的红细胞的腺苷三磷酸水平升高。

公开(公告)号：WO2006031385A3

公开(公告)日：2007-01-18

申请号：PCT/US2005029832

申请日：2005-08-24

Applicant: GEN HOSPITAL CORP ,  SHEVKOPLYAS SERGEY S ,  MUNN LANCE ,  BITENSKY MARK W ,  YOSHIDA TATSURO ,  SUN CHENGHAI

Inventor： SHEVKOPLYAS SERGEY S ,  MUNN LANCE ,  BITENSKY MARK W ,  YOSHIDA TATSURO ,  SUN CHENGHAI

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: G01N33/491 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0418 ,  B01L2400/0487 ,  G01N15/042 ,  G01N15/05 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1486 ,  G01N2015/149

Abstract: Devices, systems and methods for separating particles are disclosed.

Abstract translation: 公开了用于分离颗粒的装置，系统和方法。

公开(公告)号：WO2006031385A2

公开(公告)日：2006-03-23

申请号：PCT/US2005/029832

申请日：2005-08-24

Applicant: THE GENERAL HOSPITAL CORPORATION ,  SHEVKOPLYAS, Sergey, S. ,  MUNN, Lance ,  BITENSKY, Mark, W. ,  YOSHIDA, Tatsuro ,  SUN, Chenghai

Inventor： SHEVKOPLYAS, Sergey, S. ,  MUNN, Lance ,  BITENSKY, Mark, W. ,  YOSHIDA, Tatsuro ,  SUN, Chenghai

IPC: B01D49/00

CPC classification number: G01N33/491 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0418 ,  B01L2400/0487 ,  G01N15/042 ,  G01N15/05 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1486 ,  G01N2015/149

Abstract: Devices, systems and methods for separating particles are disclosed.

Abstract translation: 公开了用于分离颗粒的装置，系统和方法。

公开(公告)号：WO0226114A3

公开(公告)日：2002-06-20

申请号：PCT/US0142338

申请日：2001-09-27

Applicant: BITENSKY MARK W ,  YOSHIDA TATSURO ,  FRANK MICHAEL G ,  DERGANC JURE ,  GABEL CHRISTOPHER

Inventor： BITENSKY MARK W ,  YOSHIDA TATSURO ,  FRANK MICHAEL G ,  DERGANC JURE ,  GABEL CHRISTOPHER

IPC: B81B1/00 ,  C12M1/34 ,  G01N15/00 ,  G01N15/14 ,  G01N33/00 ,  B01D57/02 ,  B01L11/00 ,  C12Q1/00

CPC classification number: C12M41/46 ,  B01J2219/00596 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/0074 ,  C12M23/16 ,  G01N15/1463 ,  G01N33/54366 ,  G01N2015/0076 ,  G01N2015/1486 ,  G01N2015/1495 ,  G01N2015/1497

Abstract: A cellular diagnostic array (20) has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse , including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, a gradient array (20) having rectangular shaped channels (32) is used to capture cells and readily show the ratio of volume to surface area for the captured cell. The second silicone rubber array (20) provided by the present invention employs an array of wedge-shaped pipettes, each of which captures an individual cell. The position of the cell within a wedge is enough to determine the cell's actual surface area and volume. A third type of cellular diagnostic array according to the present invention employs an array of channel designed to deform a cell to show how the cell responds to repeated deformations.

Abstract translation: 已经开发了一种细胞诊断阵列（20），其提供了准确和可重复的测量各个细胞的物理参数，包括细胞膜表面积，细胞体积和过量的膜。 采用三种不同的模式。 在第一设计中，使用具有矩形通道（32）的梯度阵列（20）来捕获单元并且容易地显示所捕获的单元的体积与表面积的比率。 由本发明提供的第二硅橡胶阵列（20）采用楔形移液管阵列，其中每个捕获单个细胞。 楔形件内的电池的位置足以确定电池的实际表面积和体积。 根据本发明的第三种类型的细胞诊断阵列采用设计成使细胞变形以显示细胞如何响应于重复变形的通道阵列。