公开(公告)号：WO2022087428A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/056275

申请日：2021-10-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CARNEGIE MELLON UNIVERSITY

Inventor： OGRAS, Umit ,  MARCULESCU, Radu ,  AKOGLU, Ali ,  CHAKRABARTI, Chaitali ,  BLISS, Daniel ,  ARDA, Samet Egemen ,  SARTOR, Anderson ,  KUMBHARE, Nirmal ,  KRISHNAKUMAR, Anish ,  MACK, Joshua ,  GOKSOY, Ahmet ,  MANDAL, Sumit

IPC: G06F1/32

Abstract: Hierarchical and lightweight imitation learning (IL) for power management of embedded systems-on-chip (SoCs), also referred to herein as HiLITE, is provided. Modern SoCs use dynamic power management (DPM) techniques to improve energy efficiency. However, existing techniques are unable to efficiently adapt the runtime decisions considering multiple objectives (e.g., energy and real-time requirements) simultaneously on heterogeneous platforms. To address this need, embodiments described herein propose HiLITE, a hierarchical IL framework that maximizes energy efficiency while satisfying soft real-time constraints on embedded SoCs. This approach first trains DPM policies using IL; then, it applies a regression policy at runtime to minimize deadline misses. HiLITE improves the energy-delay product by 40% on average, and reduces deadline misses by up to 76%, compared to state-of-the-art approaches. In addition, the trained policies not only achieve high accuracy, but also have negligible prediction time overhead and small memory footprint.

公开(公告)号：WO2022087415A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/056258

申请日：2021-10-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CARNEGIE MELLON UNIVERSITY

Inventor： OGRAS, Umit ,  MARCULESCU, Radu ,  AKOGLU, Ali ,  CHAKRABARTI, Chaitali ,  BLISS, Daniel ,  ARDA, Samet Egemen ,  SARTOR, Anderson ,  KUMBHARE, Nirmal ,  KRISHNAKUMAR, Anish ,  MACK, Joshua ,  GOKSOY, Ahmet ,  MANDAL, Sumit

IPC: G06F9/46 ,  G06F15/16 ,  G06F15/173 ,  G06N7/00 ,  H04L12/911

Abstract: Runtime task scheduling using imitation learning (IL) for heterogenous many-core systems is provided. Domain-specific systems-on-chip (DSSoCs) are recognized as a key approach to narrow down the performance and energy-efficiency gap between custom hardware accelerators and programmable processors. Reaching the full potential of these architectures depends critically on optimally scheduling the applications to available resources at runtime. Existing optimization-based techniques cannot achieve this objective at runtime due to the combinatorial nature of the task scheduling problem. In an exemplary aspect described herein, scheduling is posed as a classification problem, and embodiments propose a hierarchical IL-based scheduler that learns from an Oracle to maximize the performance of multiple domain-specific applications. Extensive evaluations show that the proposed IL-based scheduler approximates an offline Oracle policy with more than 99% accuracy for performance- and energy-based optimization objectives. Furthermore, it achieves almost identical performance to the Oracle with a low runtime overhead and high adaptivity.

公开(公告)号：WO2022087442A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/056290

申请日：2021-10-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CARNEGIE MELLON UNIVERSITY

Inventor： OGRAS, Umit ,  MARCULESCU, Radu ,  AKOGLU, Ali ,  CHAKRABARTI, Chaitali ,  BLISS, Daniel ,  ARDA, Samet Egemen ,  SARTOR, Anderson ,  KUMBHARE, Nirmal ,  KRISHNAKUMAR, Anish ,  MACK, Joshua ,  GOKSOY, Ahmet ,  MANDAL, Sumit

IPC: G06F8/20 ,  G06F8/30 ,  G06F9/4401 ,  G06F9/50 ,  G06F13/10

Abstract: A user-space emulation framework for heterogeneous system-on-chip (SoC) design is provided. Embodiments described herein propose a portable, Linux-based emulation framework to provide an ecosystem for hardware-software co-design of heterogeneous SoCs (e.g., domain-specific SoCs (DSSoCs)) and enable their rapid evaluation during the pre-silicon design phase. This framework holistically targets three key challenges of heterogeneous SoC design: accelerator integration, resource management, and application development. These challenges are addressed via a flexible and lightweight user-space runtime environment that enables easy integration of new accelerators, scheduling heuristics, and user applications, and the utility of each is illustrated through various case studies. A prototype compilation toolchain is introduced that enables automatic mapping of unlabeled C code to heterogeneous SoC platforms. Taken together, this environment offers a unique ecosystem to rapidly perform functional verification and obtain performance and utilization estimates that help accelerate convergence towards a final heterogeneous SoC design.

公开(公告)号：WO2020081441A9

公开(公告)日：2020-04-23

申请号：PCT/US2019/056091

申请日：2019-10-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： FERRY, David ,  WHITESIDE, Vincent ,  SELLERS, Ian, R.

IPC: H01L31/02 ,  H01L31/0352 ,  H01L31/036 ,  H01L31/068 ,  H01L31/0687 ,  H01L31/072 ,  H01L31/0725 ,  H01L31/09 ,  H01L31/101

Abstract: A photovoltaic device configured to substantially avoid radiative recombination of photo-generated carriers, reduce loss of energy of the photo-generated carriers through the phonon emission, extract photo-generated carriers substantially exclusively from the multi-frequency satellite valley(s) of the bandstructure of the used semiconductor material as opposed to the single predetermined extremum of the bandstructure. Methodologies of fabrication and operation of such a device.

公开(公告)号：WO2018213759A1

公开(公告)日：2018-11-22

申请号：PCT/US2018/033481

申请日：2018-05-18

Applicant: ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF NORTHERN ARIZONA UNIVERSITY ,  BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO

Inventor： KEIM, Paul S. ,  AUCOIN, David P. ,  SETTLES, Erik W. ,  YI, Jinhee

IPC: C12Q1/04 ,  G01N33/50 ,  G01N33/53 ,  G01N33/534 ,  G01N33/569

CPC classification number: G01N33/56911 ,  G01N33/54313 ,  G01N33/54386 ,  G01N2469/20

Abstract: Implementations of diagnostic systems for detecting a bacterial infection in a subject may include: a device for receiving a sample of a bodily fluid from a subject, a chemical composition configured to react with one or more antibodies in the bodily fluid, and an indicator configured to indicate or respond to a product of the reaction of the chemical composition with one or more antibodies in a bodily fluid received into the device. The antibodies may be produced in response to one or more conserved antigens from one or more bacteria identified as potentially associated with at least one disease associated with the subject. The device may be coated with the chemical composition. The indicator may be configured to communicate to a user of the system a presence or an absence of the one or more antibodies in the bodily fluid.

公开(公告)号：WO2015069790A1

公开(公告)日：2015-05-14

申请号：PCT/US2014/064161

申请日：2014-11-05

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  BRITISH COLUMBIA CANCER AGENCY BRANCH ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNVIERSITY OF ARIZONA ,  UNIVERSITAT DE BARCELONA ,  HOSPITAL CLINIC DE BARCELONA ,  CLEVELAND CLINIC ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  OREGON HEALTH & SCIENCE UNIVERSITY ,  JULIUS-MAXIMILIANS-UNIVERSITY OF WUERZBURG ,  OSLO UNIVERSITY HOSPITAL HF

Inventor： STAUDT, Louis M. ,  WRIGHT, George W. ,  SCOTT, David William ,  CONNORS, Joseph M. ,  GASCOYNE, Randy D. ,  RIMSZA, Lisa ,  CAMPO GUERRI, Elias ,  GREINER, Timothy C. ,  COOK, James Robert ,  FU, Kai ,  WILLIAMS, Paul Michael ,  LIH, Chih-Jian ,  JAFFE, Elaine S. ,  BRAZIEL, Rita M. ,  ROSENWALD, Andreas ,  SMELAND, Erlend B. ,  CHAN, Wing C. ,  OTT, German ,  DELABIE, Jan ,  WEISENBURGER, Dennis

IPC: C12Q1/68

CPC classification number: G06F19/20 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/166 ,  G06F19/12

Abstract: The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

Abstract translation: 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样弥漫性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活组织检查样品。

公开(公告)号：WO2018014019A3

公开(公告)日：2018-01-18

申请号：PCT/US2017/042367

申请日：2017-07-17

Applicant: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY OFFICE OF INTELECTUAL PROPERTY MANAGEMENT TECHNOLOGY, DEVELOPMENT CENTER ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： PIAO, Daqing ,  PATEL, Sanjay

IPC: A61B1/07 ,  A61B1/313

Abstract: Taught herein is a new contact-based optical imaging technology, en-face differential optical topography ( en-face DOT), which performs real-time visualization of subsurface tissue heterogeneity within a depth up to 3mm and over a 9.5mm diameter FOV with a modest mm-level lateral resolution. An embodiment of the probe fits in a 12mm port and houses at its maximum 128 copper-coated 750μηι fibers that form radially alternating illumination (70 fibers) and detection (58 fibers) channels. By simultaneously illuminating the 70 source channels of the laparoscopic probe that is in contact with a scattering medium and concurrently measuring the light diffusely propagated to the 58 detector channels, the presence of near-surface optical heterogeneities can be resolved in an en-face 9.5mm field-of-view in real-time. Visualization of subsurface margin of strong attenuation contrast at a depth up to 3 mm is demonstrated at one wavelength at a frame rate of 1.3 Hz.

公开(公告)号：WO2016054642A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/054027

申请日：2015-10-05

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： MEUILLET, Emmanuelle, J. ,  ZHANG, Shuxing ,  CHEN, Lu

IPC: A01N41/10 ,  A61K31/00 ,  A61K31/10

CPC classification number: A01N41/10 ,  A61K31/00 ,  A61K31/10 ,  C07D213/83 ,  C07D233/84 ,  C07D285/135 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04

Abstract: Identification and evaluation of a set of first-in-class potent inhibitors targeting a new cancer target, Grb2-associated binder~1 (GAB1 ), which integrates signals from different signaling pathways and is frequently over-expressed in cancer ceils. Intensive computational modeling is utilized to understand the structure of the GAB1 pleckstrin homology (PH) domain and screened five million compounds. Upon biological evaluation, several inhibitors were found that induced large conformational changes of the target structure exhibited strong selective binding to GAB1 PH domain. Particularly, these inhibitors demonstrated potent and tumor-specific cytotoxicity in breast cancer cells. This targeting GAB1 signaling may be used for cancer therapy, especially for triple negative breast cancer patients.

Abstract translation: 鉴定和评估一组针对新的癌症靶点的一级有效抑制剂，Grb2相关的结合物〜1（GAB1），其整合来自不同信号传导途径的信号，并且在癌细胞中经常被过表达。 利用强大的计算建模来了解GAB1 pleckstrin同源性（PH）结构域并筛选了500万种化合物。 在生物学评估中，发现几种抑制剂诱导靶组织的大的构象变化表现出对GAB1PH结构域的强选择性结合。 特别地，这些抑制剂在乳腺癌细胞中表现出有效的和肿瘤特异性的细胞毒性。 这种靶向GAB1信号传导可用于癌症治疗，特别是三阴性乳腺癌患者。

公开(公告)号：WO2015168614A2

公开(公告)日：2015-11-05

申请号：PCT/US2015/028877

申请日：2015-05-01

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： OUPICKY, David ,  STEFAN, Mihaela, C. ,  BIEWER, Michael, C.

IPC: A61K9/51

CPC classification number: A61K47/6935 ,  A61K47/593 ,  A61K47/60

Abstract: Compositions and methods for the delivery of a histone deacetylase inhibitor provided.

Abstract translation: 用于递送组蛋白脱乙酰酶抑制剂的组合物和方法。

公开(公告)号：WO2012145607A2

公开(公告)日：2012-10-26

申请号：PCT/US2012/034421

申请日：2012-04-20

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ARIZONA BOARD OF REGENTS ON BEHALF OF UNIVERSITY OF ARIZONA ,  THOMPSON, Patricia ,  BONDY, Melissa ,  MILLS, Gordon ,  ZHANG, Li ,  VACHIDIS, Spyros

Inventor： THOMPSON, Patricia ,  BONDY, Melissa ,  MILLS, Gordon ,  ZHANG, Li ,  VACHIDIS, Spyros

IPC: G01N33/574 ,  C12Q1/68 ,  C12N15/11

CPC classification number: C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/156 ,  G01N33/57415 ,  G01N2800/52 ,  C12Q2537/16

Abstract: Methods and compositions for the prognosis and classification of cancer, especially breast cancer, are provided. For example, in certain aspects methods for cancer prognosis using copy number analysis of selected biomarkers are described. In further aspects, copy number information may be used to predict metastasis risk and help treatment decision-making.

Abstract translation: 提供了用于癌症，特别是乳腺癌的预后和分类的方法和组合物。 例如，在某些方面，描述了使用所选生物标志物的拷贝数分析的癌症预后的方法。 在进一步的方面，可以使用拷贝数信息来预测转移风险并帮助治疗决策。