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公开(公告)号：WO2023087012A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/079848
申请日：2022-11-15
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： THATCHER, Gregory R. , RANA, Ajay , XIONG, Rui , PRINCIPE, Daniel , LI, Yangfeng
IPC分类号： A61K31/437 , A61K31/444 , C07D471/04 , A61P35/00
摘要： In accordance with the purpose(s) of the present disclosure, described herein are methods for treating cancer associated with a Ras mutation in a subject in need of treatment comprising administering to the subject an effective amount of a compound of formula I as described herein or a pharmaceutically acceptable salt thereof. The compounds described herein have improved efficacy compared to the benchmark BET inhibitor JQ-1 and comparable efficacy to high dose JQ-1 with respect to the treatment of PDAC. In one aspect, the compounds are administered in combination with an effective amount of an immune checkpoint inhibitor such as, for example, PD-1/PD-L1 inhibitor, a CTLA-4 inhibitor, or a combination thereof.
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公开(公告)号：WO2023039353A2
公开(公告)日：2023-03-16
申请号：PCT/US2022/075864
申请日：2022-09-01
发明人： SONG, Pengfei , CHEN, Xi , LOWERISON, Matthew, R.
摘要： Described here are systems and methods for super-resolution ultrasound microvessel imaging and velocimetry. The systems and methods utilize deep learning and parallel computing to realize real-time super-resolution microvascular imaging and quantitative analysis and display.
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公开(公告)号：WO2023018607A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/039520
申请日：2022-08-05
发明人： VASISHT, Deepak , SINGH, Gagandeep , LIU, Zikun
IPC分类号： G06N3/08 , H04B7/0413 , H04W24/08 , G06N20/00 , H04L5/14
摘要： An example embodiment may involve receiving, at a node of a radio access network, input signals on a plurality of wireless channels, wherein uplink channels in the plurality of wireless channels are respectively associated with downlink channels in the plurality of wireless channels; determining uplink characteristics for the uplink channels; providing, to a trained neural network, the uplink characteristics, wherein the trained neural network was iteratively trained, with a training data set of recorded uplink characteristics and recorded downlink characteristics, to form predictions of the recorded downlink characteristics from the recorded uplink characteristics, wherein the trained neural network includes an encoder that maps the recorded uplink characteristics to latent vector representations, and a decoder that maps the latent vector representations to the predictions; receiving, from the trained neural network, a prediction of downlink characteristics for the downlink channels; and transmitting, on the downlink channels, output signals based on the prediction.
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4.发明申请
公开(公告)号：WO2022261199A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032663
申请日：2022-06-08
申请人： THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： SAMPEN, Hee-jeong, Im , LIU, Ying
IPC分类号： A61K31/33 , A61K31/495 , A61K31/505 , A61K31/00
摘要： Disclosed herein are nanoparticles comprising Pazopanib or a derivative thereof encapsulated by the copolymer poly(lactic-co-gly colic acid) (PLGA). Also disclosed herein are methods for treating osteoarthritis, inhibiting or preventing cartilage degeneration, and reducing or inhibiting pain-associated depression in subjects with joint pain with nanoparticles comprising Pazopanib or a derivative thereof.
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公开(公告)号：WO2022256736A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/032355
申请日：2022-06-06
摘要： The disclosure provides example devices and methods for virus and bacterium detection and identification. The example device includes (a) a housing having an air inlet and an air outlet, (b) a substrate disposed within the housing, where the at least one substrate has a through-slot, where the substrate has a plurality of wells, (c) an air-handling and precipitation chamber, a reagent and reaction chamber, and a detection chamber arranged in series and each coupled to the top surface of the substrate, (d) a first actuator coupled to the substrate and configured to rotate the substrate, (e) a second actuator coupled to and configured to rotate the air-handling and precipitation chamber, the reagent and reaction chamber, and the detection chamber, and (f) at least one processor electrically coupled to the air-handling and precipitation chamber, the reagent and reaction chamber, the detection chamber, the first actuator, and the second actuator.
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公开(公告)号：WO2022216734A1
公开(公告)日：2022-10-13
申请号：PCT/US2022/023521
申请日：2022-04-05
发明人： ZHANG, Weiping
摘要： Compositions and methods for eliciting an immune response in a subject against Vibrio cholerae are provided. The compositions include fusion proteins with one or more epitopes from Vibrio cholerae, nucleic acids and vectors encoding the fusion proteins, pharmaceutical compositions, immunogenic compositions, and vaccines. In examples, the methods include administering a disclosed composition to a subject, such as a human.
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公开(公告)号：WO2022159491A1
公开(公告)日：2022-07-28
申请号：PCT/US2022/012980
申请日：2022-01-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE PENN STATE RESEARCH FOUNDATION
发明人： GARCIA, George , SHOWALTER, Hollis , RAJESWARAN, Walajapet , LEE, Pil , FRANZBLAU, Scott , MURAKAMI, Katsuhiko
IPC分类号： A61K31/5386 , A61P31/06 , C07D498/18
摘要： Provided herein are compounds that are potent inhibitors of the Mycobacterium tuberculosis (MTB) RNA polymerase (RNAP), which exhibit significantly reduced activation of the human pregnane X receptor (hPXR), resulting in dramatically reduced induction of hepatic cytochromes P450 2C9 and 3A4 (CYP2C9, CYP3A4), as well as a number of Phase II metabolism enzymes. Also provided herein are pharmaceutical compositions comprising the compounds, and methods of treating tuberculosis using the compounds.
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公开(公告)号：WO2022150633A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011680
申请日：2022-01-07
IPC分类号： A61K31/138 , A61K31/282 , A61K31/337 , A61K31/495
摘要： Compounds, compositions, and methods for the induction of cell death, for example, pancreatic cancer cell death in a subject having pancreatic cancer. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can be synergistic and can have lower toxicity effects than other compounds and combinations of compounds.
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公开(公告)号：WO2022125437A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/062006
申请日：2021-12-06
发明人： MOORE, Jeffrey, S. , GEUBELLE, Philippe, H. , SOTTOS, Nancy, R. , FEINBERG, Adam, M. , LLOYD, Evan, M.
摘要： A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction. The spontaneous heating of the monomer solution downstream of the polymerization front and the initiation of another polymerization reaction occurs cyclically, producing multiple new polymerization fronts and spatial variations in reaction temperature across the monomer solution. Once polymerization is complete, a spontaneously patterned polymer is formed.
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公开(公告)号：WO2022108781A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/058513
申请日：2021-11-09
摘要： A robotic surgical station (1), comprising: ■ a wheeled base (100) configured to be rested on the ground; ■ a partial-ring shaped structure (210) slidably coupled to the based (210) to be rotatable relative to the base (100) about a horizontal roll axis (R) passing through a center (C) of the ring shape; ■ a patient's bed (600) restrained to a first arcuate segment (211) of the partial-ring shaped structure (210) at a first mount (220); * a plurality of robotic arms (900) restrained to a second arcuate segment (212) of the partial-ring shaped structure (210) at a second mount (250); and ■ a remote control unit (801) that may be used by a surgeon to command one or more of said plurality of robotic arms (900), wherein the second arcuate segment (212) is rotatable sideways with respect to the first arcuate segment (211) in such a way to allow full access to the patient's bed (600) by a surgeon.
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