公开(公告)号：WO2013055489A1

公开(公告)日：2013-04-18

申请号：PCT/US2012/055232

申请日：2012-09-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC. ,  BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  LEACH, Austin, M.

Inventor： BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  LEACH, Austin, M.

IPC: A61L31/02

CPC classification number: A61L31/022 ,  A61L31/14

Abstract: The present disclosure is directed to tantalum-alloy products, implantable medical devices that incorporate tantalum-alloy products such as stents or other implantable medical devices, methods of making and/or processing the tantalum-alloy products and implantable medical devices, and methods of using the implantable medical devices. In an embodiment, a stent includes a stent body having a plurality of struts. At least a portion of the stent body is made from a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % ("wt %") to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof, such as yield strength, ultimate tensile strength, or ductility.

Abstract translation: 本公开涉及钽合金产品，结合钽合金产品例如支架或其他可植入医疗装置的可植入医疗装置，制造和/或加工钽合金产品和可植入医疗装置的方法以及使用方法 可植入医疗器械。 在一个实施例中，支架包括具有多个支柱的支架主体。 支架主体的至少一部分由钽合金制成。 钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量 重量％。 钽合金表现出至少一种通过其热处理改性的机械性能，例如屈服强度，极限拉伸强度或延展性。

公开(公告)号：WO2010009783A1

公开(公告)日：2010-01-28

申请号：PCT/EP2009/003526

申请日：2009-05-18

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED ,  STOCKERT, Gunter ,  BREGULLA, Rainer

Inventor： STOCKERT, Gunter ,  BREGULLA, Rainer

IPC: A61F2/84 ,  A61M25/10

CPC classification number: A61F2/95 ,  A61F2/958 ,  A61F2250/0098 ,  A61M25/10 ,  A61M2025/1061 ,  A61M2025/1079

Abstract: Stent delivery system (1) comprising a catheter (2) having an inner tube (3) and an outer tube (4) surrounding the inner tube (3); a balloon (5) having a proximal end (6) fixed to the outer tube (4) a distal end (7) fixed to the inner tube (3) and an interior (10) including a proximal portion (10A) and distal portion (10B), a stent (8) disposed on said balloon (5) and being expandable from a delivery position to a deployed position by a contrast medium (9) adapted to be supplied to the interior (10) of said balloon (5), and a contrast medium distribution means (11) disposed in the interior (10) of said balloon (5) adapted to equally distribute the contrast medium (9) to both the proximal portion (10A) and the distal portion (10B) of the interior (10) of the balloon (5).

Abstract translation: 支架输送系统（1）包括具有内管（3）的导管（2）和围绕内管（3）的外管（4）; 具有固定到所述外管（4）的近端（6）的气囊（5），固定到所述内管（3）的远端（7）和包括近端部分（10A）和远端部分 （10B），设置在所述球囊（5）上的支架（8）并且可通过适于供应到所述气囊（5）的内部（10）的造影剂（9）从输送位置可展开到展开位置， 以及设置在所述球囊（5）的内部（10）中的造影剂分配装置（11），其适于将造影剂（9）均匀地分配到所述造影剂的近端部分（10A）和远端部分（10B） 球囊（5）的内部（10）。

公开(公告)号：WO2011025743A1

公开(公告)日：2011-03-03

申请号：PCT/US2010/046372

申请日：2010-08-23

Applicant: ABBOTT LABORATORIES ,  LOWE, David ,  BREGULLA, Rainer ,  NEWHAUSER, Richard, R. ,  YRIBARREN, Travis, R.

Inventor： LOWE, David ,  BREGULLA, Rainer ,  NEWHAUSER, Richard, R. ,  YRIBARREN, Travis, R.

IPC: A61F2/90

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/3008 ,  A61F2002/30329 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0036 ,  A61F2250/0039 ,  A61F2250/0042 ,  A61F2250/0067 ,  A61F2250/0098 ,  Y10T29/49826 ,  Y10T29/49888 ,  Y10T29/49906

Abstract: Generally, the present disclosure includes a hybrid segmented endoprosthesis for delivery into a lumen of a body. The hybrid segmented endoprosthesis has different types of segments that are joined together. The segments are typically distinct and distinguishable from each other by each segment having a unique configuration different from at least one other segment. Additionally, the segments can be coupled together by various processes well known for interconnecting the materials of endoprostheses. The segmented endoprosthesis can provide improved deliverability, strength, flexibility, and/or functionality during and after deployment. The use of a segmented endoprosthesis can combine the configurations of multiple small endoprostheses into a standard- or regular-sized endoprosthesis.

Abstract translation: 通常，本公开包括用于输送到身体的内腔中的混合分段内用假体。 混合分段内假体具有连接在一起的不同类型的段。 通过每个段具有不同于至少一个其它段的独特构造，段通常是不同的和可区分的。 另外，通过众所周知的用于互连内裤的材料的各种方法，片段可以联结在一起。 分段内假体可以在部署期间和之后提供改进的可交付性，强度，灵活性和/或功能。 使用分段内假体可以将多个小型内假体的构型组合成标准尺寸或正常大小的内置假体。

公开(公告)号：WO2009080327A2

公开(公告)日：2009-07-02

申请号：PCT/EP2008010953

申请日：2008-12-19

Applicant: ABBOTT LAB VASCULAR ENTPR LTD ,  BREGULLA RAINER ,  OSMAN KARIM ,  NEWHAUSER RICHARD

Inventor： BREGULLA RAINER ,  OSMAN KARIM ,  NEWHAUSER RICHARD

IPC: A61F2/91 ,  A61F2/915

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91558 ,  A61F2210/0004

Abstract: The present invention relates to an endoprosthesis that is expandable from a contracted configuration to an expanded configuration and that includes a plurality of longitudinally adjacent web rings. Each of the web rings is defined by web elements disposed circumferentially around a longitudinal axis, which are adjoined one to the other at junction bends. A first junction bend in a first web ring is coupled to a second junction bend in a second web ring by a connector which includes three or more struts of essentially equal length that extend circumferentially in essentially parallel directions. The struts of the connector are adjoined in sequence by coupling segments that, in one embodiment of the invention, are arcuate in shape. In another configuration, the connector is a flexible connector that is structured to absorb at least some of the axial and torsional stresses applied to the endoprosthesis.

Abstract translation: 本发明涉及一种可从收缩构型扩展到扩张构造并且包括多个纵向相邻的腹板环的内用假体。 每个网环由围绕纵向轴线周向设置的腹板元件限定，纵向轴线在连接弯曲处彼此相邻。 第一腹板环中的第一接合弯曲部通过连接器耦合到第二腹板环中的第二接合弯曲部，所述连接器包括基本上相等长度的三个或更多个基本上相等的长度的支撑件，其基本上沿平行方向周向延伸。 连接器的支柱依次连接在一起，在本发明的一个实施例中，弓形的形状是联接的。 在另一种构造中，连接器是柔性连接器，其被构造成吸收施加到内假体的至少一些轴向和扭转应力。

公开(公告)号：WO2013055490A1

公开(公告)日：2013-04-18

申请号：PCT/US2012/055234

申请日：2012-09-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC ,  BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  LEACH, Austin, M.

Inventor： BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  LEACH, Austin, M.

IPC: A61L31/02 ,  A61L31/10

CPC classification number: A61L31/088 ,  A61L31/022 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

Abstract: The present disclosure is directed to a drug-eluting implantable medical devices that includes a tantalum-alloy body having a drug-eluting coating thereon for delivering a drug to treat, for example, restenosis. In an embodiment, an implantable medical device includes a body sized and configured to be implanted in a living subject. At least a portion of the body may comprise a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % ("wt %") to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof. The body has a drug-eluting coating thereon.

Abstract translation: 本公开涉及药物洗脱可植入医疗装置，其包括其上具有药物洗脱涂层的钽合金体，用于递送药物以治疗例如再狭窄。 在一个实施例中，可植入医疗装置包括尺寸和构造成植入生物体内的体。 身体的至少一部分可以包括钽合金。 钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量 重量％。 钽合金具有通过其热处理而改性的至少一种机械性能。 身体上有药物洗脱涂层。

公开(公告)号：WO2012084202A3

公开(公告)日：2012-06-28

申请号：PCT/EP2011/006440

申请日：2011-12-20

Applicant: BENTLEY SURGICAL GMBH ,  OBRADOVIĆ, Milisav ,  BREGULLA, Rainer

Inventor： OBRADOVIĆ, Milisav ,  BREGULLA, Rainer

IPC: A61F2/06 ,  A61F2/90

Abstract: Stent-Graft aus einem Stent (1) mit einer Mehrzahl von nebeneinander angeordneten und miteinander verbundenen Ringsegmenten (3) und wenigstens einer Membran (2) mit wenigstens einem randständigen Ringsegment (4) mit mäandrierendem Stegverlauf, bei dem einwärts- oder auswärts weisende Stegschlingen (5) eingeschnitten sind, dergestalt, dass Federzungen (6) entstehen, die formschlüssig in den Stegschlingen (5) angeordnet sind und gegen den Stegverlauf federnd beweglich sind, wobei die Membran (2) zwischen Federzungen (6) und Steg eingeklemmt ist.

公开(公告)号：WO2010069562A1

公开(公告)日：2010-06-24

申请号：PCT/EP2009/009049

申请日：2009-12-16

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED ,  BREGULLA, Rainer

Inventor： BREGULLA, Rainer

IPC: A61F2/01

CPC classification number: A61F2/01 ,  A61F2/848 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2230/0023

Abstract: As described herein, a body lumen filter (100) is provided that includes a body configured to move between a pre-deployed state and a deployed state. In the deployed state, the body has filtering openings (150) defined therein. The body lumen filter also includes at least one anchor (140) coupled to the body, the anchor including a base and a bulbed (170) portion, having a major cross-sectional dimension that is larger than a major cross-sectional dimension of the base.

Abstract translation: 如本文所述，提供体腔过滤器（100），其包括构造成在预部署状态和展开状态之间移动的主体。 在展开状态下，主体具有限定在其中的过滤开口（150）。 所述体腔过滤器还包括联接到所述主体的至少一个锚固件（140），所述锚固件包括基部和突出部（170），所述锚固体具有大的横截面尺寸，所述主横截面尺寸大于所述主体的主横截面尺寸 基础。

公开(公告)号：WO2013055491A1

公开(公告)日：2013-04-18

申请号：PCT/US2012/055237

申请日：2012-09-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC. ,  BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  FRICK, Carl, P. ,  LEACH, Austin, M.

Inventor： BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  FRICK, Carl, P. ,  LEACH, Austin, M.

IPC: C22C19/07 ,  C22C27/02 ,  C22C27/04 ,  C22C38/18 ,  C22F1/18 ,  A61F2/02 ,  A61F2/06 ,  A61F2/82

CPC classification number: C22C27/04 ,  A61F2/91 ,  A61F2/915 ,  A61L31/022 ,  C22C19/07 ,  C22C27/02 ,  C22C38/18 ,  C22F1/18

Abstract: A stent and method for manufacturing a stent that achieves both strength as well as ductility. In the manufacturing process, the material used to form the stent is only partially annealed to lower the grain size across the thickness of the stent. The material is partially annealed either prior to or after the cutting a stent pattern into a tube.

Abstract translation: 用于制造实现强度和延展性的支架的支架和方法。 在制造过程中，用于形成支架的材料仅部分退火，以降低穿过支架厚度的晶粒尺寸。 在将支架图案切割成管之前或之后，该材料部分退火。

公开(公告)号：WO2012084202A2

公开(公告)日：2012-06-28

申请号：PCT/EP2011006440

申请日：2011-12-20

Applicant: BENTLEY SURGICAL GMBH ,  OBRADOVIC MILISAV ,  BREGULLA RAINER

Inventor： OBRADOVIC MILISAV ,  BREGULLA RAINER

IPC: A61F2/07 ,  A61F2/91 ,  A61F2/915

CPC classification number: A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/91525 ,  A61F2002/91583 ,  A61F2220/0008 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054

Abstract: The invention relates to a stent graft comprising a stent (1) having a plurality of ring segments (3) disposed adjacent to one another and connected to one another and at least one membrane (2) having at least one marginal ring segment (4) having a meandering web configuration, wherein web loops (5) which point inwards or outwards are cut in such a way as to produce spring tabs (6) which are disposed so that they engage positively in the web loops (5) and are resiliently movable against the web configuration, wherein the membrane (2) is gripped between the spring tabs (6) and the web.

Abstract translation: 支架的支架移植物（1）配置有多个并列并相互连接的环段（3）和至少一个膜（2）具有至少一个边缘环段（4）具有蜿蜒幅当然，在向内或向外的网环（ 5）被切割，使得所述弹簧舌（6）形成，该形状配合（在web环5）被布置和被弹性抵靠网络历史记录可动，其中，所述膜（2）6）和纸幅夹（弹簧指之间。

公开(公告)号：WO2010077973A3

公开(公告)日：2010-08-26

申请号：PCT/US2009068301

申请日：2009-12-16

Applicant: SHRIVASTAVA SANJAY ,  OBRADOVIC MILISAV ,  TANG NIE ,  BREGULLA RAINER ,  GREEN MICHAEL

Inventor： SHRIVASTAVA SANJAY ,  OBRADOVIC MILISAV ,  TANG NIE ,  BREGULLA RAINER ,  GREEN MICHAEL

IPC: A61F2/01

CPC classification number: A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2002/8486 ,  A61F2230/0006 ,  A61F2230/008 ,  A61F2250/0067

Abstract: An implantable lumen filter (200) is described. The implantable lumen filter includes a body (202) having a proximal end (202a), a distal end (202b), and a generally tapered outer surface (204). The outer surface is formed by a plurality of struts (206a, 206b). The plurality of struts forms a plurality of apertures (210). The apertures are dimensioned to inhibit and/or to lyse particulates of a selected size from passing through the apertures. The body (202) is transitionable from a collapsed state toward a deployed state. The implantable lumen filter includes an engaging portion (220) having a proximal end (220a) and a distal end (220b). The proximal end of the engaging portion is connected to a distal end of the body. The engaging portion has a generally annular shape and is configured to engage an inner surface of a body lumen.

Abstract translation: 描述可植入管腔过滤器（200）。 可植入管腔过滤器包括具有近端（202a），远端（202b）和大致锥形的外表面（204）的主体（202）。 外表面由多个支柱（206a，206b）形成。 多个支柱形成多个孔（210）。 孔的尺寸被设计成抑制和/或裂解选定尺寸的颗粒通过孔。 主体（202）可以从折叠状态向展开状态转换。 可植入管腔过滤器包括具有近端（220a）和远端（220b）的接合部分（220）。 接合部分的近端连接到主体的远端。 接合部分具有大致环形的形状并且构造成接合体腔的内表面。