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8 条记录 (耗时 0.01 秒)

    SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION CONTAINING PRAMIPEXOLE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF WITH IMPROVED STABILITY
    2.
    发明申请
    SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION CONTAINING PRAMIPEXOLE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF WITH IMPROVED STABILITY 审中-公开
    缓释型药物组合物，含有普拉克珠或药物可接受的盐，具有改善的稳定性

    公开(公告)号：WO2012002644A2

    公开(公告)日：2012-01-05

    申请号：PCT/KR2011/003515

    申请日：2011-05-12

    申请人： HYUNDAI PHARM CO., LTD. ,  BIO PHARMARTIS CO., LTD. ,  LEE, Sang-Joon ,  CHANG, Kwan-Young ,  AHN, Jae-Soon ,  CHO, Jae-Min ,  KAM, Sung-Hoon

    发明人： LEE, Sang-Joon ,  CHANG, Kwan-Young ,  AHN, Jae-Soon ,  CHO, Jae-Min ,  KAM, Sung-Hoon

    IPC分类号： A61K31/425 ,  A61K9/22 ,  A61K9/20 ,  A61K47/38

    CPC分类号： A61K31/425 ,  A61K9/2027 ,  A61K9/2054

    摘要： Disclosed is a sustained-release pharmaceutical composition containing pramipexole or a pharmaceutically acceptable salt thereof and, more particularly, a pharmaceutical composition that uses a stabilizer for inhibiting production of related substances caused by additives and greatly enhances stability. The pharmaceutical composition shows an effectively controlled dissolution profile, realizing its usefulness in the manufacture of pramipexole-containing sustained-release preparations in various dosage forms easy for drug release control; includes a stabilizer to minimize impurity production of the drug-containing products during drug storage, remarkably improving chemical stability; and thereby eliminates a need for separate studies on the physical chemical structure analysis and/or on the toxicological effects of the corresponding impurities.

    摘要翻译： 公开了含有普拉克索或其药学上可接受的盐的缓释药物组合物，并且更具体地，公开了使用稳定剂抑制由添加剂引起的相关物质的产生并大大增强稳定性的药物组合物。 该药物组合物表现出有效控制的溶出曲线，实现了其在制备容易控制药物释放的各种剂型的含普拉克索缓释制剂中的用途; 包括稳定剂以使药物储存期间含药产品的杂质产生最小化，显着改善化学稳定性; 从而消除了对物理化学结构分析和/或相应杂质的毒理学效应的单独研究的需要。

    SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION CONTAINING PRAMIPEXOLE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF WITH IMPROVED STABILITY
    5.
    发明申请
    SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION CONTAINING PRAMIPEXOLE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF WITH IMPROVED STABILITY 审中-公开
    含有PRAMIPEXOLE或其药学上可接受的盐的持续释放的药物组合物具有改善的稳定性

    公开(公告)号：WO2012002644A3

    公开(公告)日：2012-04-12

    申请号：PCT/KR2011003515

    申请日：2011-05-12

    申请人： HYUNDAI PHARM CO LTD ,  BIO PHARMARTIS CO LTD ,  LEE SANG-JOON ,  CHANG KWAN-YOUNG ,  AHN JAE-SOON ,  CHO JAE-MIN ,  KAM SUNG-HOON

    发明人： LEE SANG-JOON ,  CHANG KWAN-YOUNG ,  AHN JAE-SOON ,  CHO JAE-MIN ,  KAM SUNG-HOON

    IPC分类号： A61K31/425 ,  A61K9/20 ,  A61K9/22 ,  A61K47/38

    CPC分类号： A61K31/425 ,  A61K9/2027 ,  A61K9/2054

    摘要： Disclosed is a sustained-release pharmaceutical composition containing pramipexole or a pharmaceutically acceptable salt thereof and, more particularly, a pharmaceutical composition that uses a stabilizer for inhibiting production of related substances caused by additives and greatly enhances stability. The pharmaceutical composition shows an effectively controlled dissolution profile, realizing its usefulness in the manufacture of pramipexole-containing sustained-release preparations in various dosage forms easy for drug release control; includes a stabilizer to minimize impurity production of the drug-containing products during drug storage, remarkably improving chemical stability; and thereby eliminates a need for separate studies on the physical chemical structure analysis and/or on the toxicological effects of the corresponding impurities.

    摘要翻译： 公开了含有普拉克索或其药学上可接受的盐的缓释药物组合物，更具体地，使用稳定剂抑制由添加剂引起的相关物质的生成的药物组合物，并且极大地提高了稳定性。 药物组合物显示有效控制的溶出曲线，实现其在制备容易用于药物释放控制的各种剂型中的含普拉克考的缓释制剂的有用性; 包括稳定剂，以使药物储存期间药物含量产物的杂质产生最小化，显着提高化学稳定性; 从而消除了对物理化学结构分析和/或相应杂质的毒理作用的单独研究的需要。