公开(公告)号：WO2007032016A1

公开(公告)日：2007-03-22

申请号：PCT/IN2005/000397

申请日：2005-12-02

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ,  PULI, Narendra ,  BANDA, Gangadasu ,  UPPALANCHI, Srinivas ,  METTU, Ravinder ,  KUMAR, Sriramoju Bharat ,  CHILUKURI, Ramesh ,  RAO, Vaidya Jayathirtha ,  RAO, Janaswamy Madhusudhan

Inventor： PULI, Narendra ,  BANDA, Gangadasu ,  UPPALANCHI, Srinivas ,  METTU, Ravinder ,  KUMAR, Sriramoju Bharat ,  CHILUKURI, Ramesh ,  RAO, Vaidya Jayathirtha ,  RAO, Janaswamy Madhusudhan

IPC: C07D213/61 ,  C07D213/79 ,  C07D213/80 ,  A61K31/44 ,  A61P33/06

CPC classification number: C07D213/80 ,  C07D213/61 ,  C07D213/79

Abstract: The present invention is directed towards the synthesis of novel and new chloropyridine skeleton based compounds and these are Bayllis Hillman adducts having a remarkable in vitro anti-malarial activity. These compounds have been found to possess anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum . The anti-malarial compounds of the present invention inhibit the mature schizonts in vitro.

Abstract translation: 本发明涉及新的和新的基于氯吡啶骨架的化合物的合成，并且这些是具有显着体外抗疟疾活性的Bayllis Hillman加合物。 已经发现这些化合物具有针对氯喹敏感性和氯喹抗性恶性疟原虫的抗疟疾活性。 本发明的抗疟疾化合物在体外抑制成熟的裂殖体。

公开(公告)号：WO2010141406A3

公开(公告)日：2010-12-09

申请号：PCT/US2010/036808

申请日：2010-06-01

Applicant: OSI PHARMACEUTICALS, INC. ,  APPARI, Rama, Devi ,  CHEN, Xin ,  CHILUKURI, Ramesh ,  CREW, Andrew, P. ,  DONG, Hanqing ,  FERRARO, Caterina ,  FOREMAN, Kenneth ,  GUPTA, Ramesh, C. ,  LI, An-hu ,  SHERMAN, Dan ,  STOLZ, Kathryn, M. ,  VOLK, Brian ,  ZAHLER, Robert

Inventor： APPARI, Rama, Devi ,  CHEN, Xin ,  CHILUKURI, Ramesh ,  CREW, Andrew, P. ,  DONG, Hanqing ,  FERRARO, Caterina ,  FOREMAN, Kenneth ,  GUPTA, Ramesh, C. ,  LI, An-hu ,  SHERMAN, Dan ,  STOLZ, Kathryn, M. ,  VOLK, Brian ,  ZAHLER, Robert

IPC: C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  A61P35/00 ,  A61K31/497

Abstract: Compounds of Formula (1), as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

公开(公告)号：WO2010141406A2

公开(公告)日：2010-12-09

申请号：PCT/US2010036808

申请日：2010-06-01

Applicant: OSI PHARM INC ,  APPARI RAMA DEVI ,  CHEN XIN ,  CHILUKURI RAMESH ,  CREW ANDREW P ,  DONG HANQING ,  FERRARO CATERINA ,  FOREMAN KENNETH ,  GUPTA RAMESH C ,  LI AN-HU ,  SHERMAN DAN ,  STOLZ KATHRYN M ,  VOLK BRIAN ,  ZAHLER ROBERT

Inventor： APPARI RAMA DEVI ,  CHEN XIN ,  CHILUKURI RAMESH ,  CREW ANDREW P ,  DONG HANQING ,  FERRARO CATERINA ,  FOREMAN KENNETH ,  GUPTA RAMESH C ,  LI AN-HU ,  SHERMAN DAN ,  STOLZ KATHRYN M ,  VOLK BRIAN ,  ZAHLER ROBERT

IPC: C07D401/12 ,  A61K31/497 ,  A61P35/00 ,  C07D403/12 ,  C07D403/14

CPC classification number: C07F9/65583 ,  A61K31/497 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07F9/65122 ,  C07F9/6544

Abstract: Compounds of Formula (1), as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

Abstract translation: 式（1）的化合物，如下文所定义：和其药学上可接受的盐，合成，中间体，制剂及其治疗方法，包括至少部分由FAK介导的癌症。