公开(公告)号：WO2005051422A1

公开(公告)日：2005-06-09

申请号：PCT/GB2004/004850

申请日：2004-11-16

Applicant: CELLTECH R & D LIMITED ,  CHRISTIE, Mark, Ian ,  MEAD, Richard, James ,  ROBINSON, Martyn, Kim ,  RAPECKI, Stephen, Edward

Inventor： CHRISTIE, Mark, Ian ,  MEAD, Richard, James ,  ROBINSON, Martyn, Kim ,  RAPECKI, Stephen, Edward

IPC: A61K39/395

CPC classification number: C07K16/244 ,  A61K47/60 ,  A61K47/6845 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/76

Abstract: The present invention provides a method for the treatment and/or prophylaxis of multiple sclerosis (MS) comprising administering a therapeutically effective amount of an inhibitor of IL-17 activity.

Abstract translation: 本发明提供了治疗和/或预防多发性硬化（MS）的方法，包括给予治疗有效量的IL-17活性抑制剂。

公开(公告)号：WO2008112843A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/056768

申请日：2008-03-13

Applicant: RICARDO, INC. ,  CHRISTIE, Mark ,  STOKES, John

Inventor： CHRISTIE, Mark ,  STOKES, John

IPC: F02P5/00

CPC classification number: F02D41/0025 ,  B60W10/11 ,  B60W10/12 ,  B60W10/16 ,  F02B29/0406 ,  F02D19/0689 ,  F02D19/084 ,  F02D19/087 ,  F02D41/0007 ,  F02D2041/001 ,  F02D2200/0611 ,  Y02T10/36

Abstract: A fuel system and powertrain for a flexible fuel system vehicle utilizes a controller system to control variables in an engine and the final drive optimize operating efficiency of the vehicle while using an alcohol-gasoline blend. The controller system regulates engine operating variables such as fuel pressure, fuel flow, air-fuel flow, air-fuel temperature, and valve timing. The controller system regulates engine operating variables such as transmission gear selection and gear changing as well as differential ratio changes.

Abstract translation: 用于柔性燃料系统车辆的燃料系统和动力系统利用控制器系统来控制发动机中的变量，并且最终驱动器在使用醇 - 汽油混合物时优化车辆的操作效率。 控制器系统调节发动机运行变量，如燃油压力，燃料流量，空气 - 燃料流量，空燃比温度和气门正时。 控制器系统调节发动机运行变量，如变速档位选择和换档以及差速比变化。

公开(公告)号：WO2020188101A1

公开(公告)日：2020-09-24

申请号：PCT/EP2020/057843

申请日：2020-03-20

Applicant: PIKSEL, INC ,  CHRISTIE, Mark

Inventor： CHRISTIE, Mark ,  CHAO, Gerald

IPC: H04N21/233 ,  H04N21/234 ,  H04N21/2343 ,  H04N21/81

Abstract: There is described a method of processing a video file to generate a modified video file, the modified video file including a translated audio content of the video file, the method comprising: receiving the video file; accessing a facial model or a speech model for a specific speaker, wherein the facial model maps speech to facial expressions, and the speech model maps text to speech; receiving a reference content for the originating video file for the specific speaker; generating modified audio content for the specific speaker and/or modified facial expression for the specific speaker; and modifying the video file in accordance with the modified content and/or the modified expression to generate the modified video file.

公开(公告)号：WO2016038199A1

公开(公告)日：2016-03-17

申请号：PCT/EP2015/070859

申请日：2015-09-11

Applicant: PIKSEL, INC ,  CHRISTIE, Mark

Inventor： CHRISTIE, Mark ,  BROWN, Kris ,  MARDLING, Paul ,  TILLMANN, Ralf

IPC: H04N21/239 ,  H04N21/24 ,  H04N21/258

CPC classification number: H04N21/2393 ,  H04L41/5009 ,  H04N21/2405 ,  H04N21/258

Abstract: A network entity for delivering video to a front end in accordance with service level information defining at least one service level requirement for providing a service used in delivering the video, the network entity comprising: an input for receiving a request comprising task information identifying a task to be performed requiring the service for delivery of the video; an interface for communication with processing nodes each configured to provide the service for use in delivering the video; and decision logic coupled to the interface and configured to: receive (i) the request transmitted by the video content provider, (ii) characteristics of the processing nodes, and (iii) the at least one service level requirement for providing the service; select processing node(s) based on the received characteristics and the at least one service level requirement, and communicate via the interface with the processing node(s) selected to perform the task.

Abstract translation: 一种用于根据定义用于提供用于传送视频的服务的至少一个服务级别要求的服务级别信息将视频传送到前端的网络实体，所述网络实体包括：用于接收包括识别任务的任务信息的请求的输入 执行要求传送视频的服务; 用于与处理节点通信的接口，每个接口被配置为提供用于传送视频的服务; 以及耦合到所述接口并被配置为：接收（i）由所述视频内容提供商发送的请求，（ii）所述处理节点的特征的决定逻辑，以及（iii）用于提供所述服务的所述至少一个服务级别要求; 基于接收到的特性和至少一个服务级别要求选择处理节点，并且经由与所选择的处理节点的接口进行通信以执行任务。

公开(公告)号：WO2015121438A1

公开(公告)日：2015-08-20

申请号：PCT/EP2015/053144

申请日：2015-02-13

Applicant: PIKSEL, INC ,  CHRISTIE, Mark

Inventor： CHRISTIE, Mark ,  TILLMANN, Ralf Wilhelm

IPC: A61B5/16 ,  H04N5/00 ,  G06F3/01

CPC classification number: H04N21/42201 ,  A61B5/165 ,  A61B5/486 ,  G06F3/011 ,  G06F2203/011 ,  H04N21/41407 ,  H04N21/435 ,  H04N21/44218 ,  H04N21/47202 ,  H04N21/8456

Abstract: Embodiments of a computer implemented method for controlling media content in an environment of a consumer are described, the embodiments having at least one media device for media consumption by the consumer, the method comprising at least one processor configured to provide media content to the media device for consumption by the consumer; receive, from at least one sensor sensed body data of the at least one consumer indicating a state of the consumer; and control the environment or physical state of the consumer in dependence on the sensed body data to modify the indicated state.

Abstract translation: 描述了用于在消费者的环境中控制媒体内容的计算机实现的方法的实施例，所述实施例具有用于消费者消费媒体的至少一个媒体设备，该方法包括被配置为向媒体设备提供媒体内容的至少一个处理器 供消费者消费; 从至少一个传感器接收指示消费者状态的至少一个消费者的身体数据; 并根据检测到的身体数据来控制消费者的环境或身体状态，以修改所指示的状态。

公开(公告)号：WO2015121436A1

公开(公告)日：2015-08-20

申请号：PCT/EP2015/053138

申请日：2015-02-13

Applicant: PIKSEL, INC ,  CHRISTIE, Mark

Inventor： CHRISTIE, Mark

IPC: G06F17/30

CPC classification number: H04N21/44218 ,  G06F17/30032 ,  G06F17/30876 ,  H04N21/435 ,  H04N21/4402 ,  H04N21/4415 ,  H04N21/47202 ,  H04N21/47217 ,  H04N21/858

Abstract: In some embodiments a content delivery system for controlling media content provided by at least one media device for media consumption by at least one consumer is described. In an embodiment the system comprises at least one sensor for sensing body data of the at least one consumer, a receiver for receiving sensed body data from the sensor, a data store storing media content for selection, at least one media device for outputting said selected content to said at least one consumer, and at least one processor configured to query said data store and control the selection of said media content based at least in part on the sensed body data, and control the output of said selected media content to said at least one media device. The sensed body data may indicate the mood or emotional state of the consumer.

Abstract translation: 在一些实施例中，描述了用于控制由至少一个媒体设备提供以供至少一个消费者消费媒体的媒体内容的内容传送系统。 在一个实施例中，系统包括用于感测至少一个消费者的身体数据的至少一个传感器，用于从传感器接收感测身体数据的接收器，存储用于选择的媒体内容的数据存储器，至少一个媒体设备，用于输出所选择的 至少一个消费者的内容，以及至少一个处理器，被配置为至少部分地基于感测到的身体数据来查询所述数据存储并控制对所述媒体内容的选择，并且控制所选择的媒体内容的输出到所述至少一个消费者 至少一个媒体设备。 检测到的身体数据可以指示消费者的情绪或情绪状态。

公开(公告)号：WO2016038103A1

公开(公告)日：2016-03-17

申请号：PCT/EP2015/070640

申请日：2015-09-09

Applicant: PIKSEL, INC ,  CHRISTIE, Mark

Inventor： CHRISTIE, Mark

IPC: H04H60/48 ,  H04H60/59 ,  H04H60/58 ,  H04H60/06 ,  H04H60/04 ,  H04H60/66

CPC classification number: H04N21/44008 ,  H04H60/04 ,  H04H60/07 ,  H04H60/48 ,  H04H60/58 ,  H04H60/59 ,  H04N21/44222 ,  H04N21/454 ,  H04N21/4627 ,  H04N21/47202 ,  H04N21/4882

Abstract: There is disclosed a computer system for analysing content, comprising: a detection module connected to receive at least one piece of digital content, the detection module being operable to access a set of compliance rules and compare the received at least one piece of digital content with the set of compliance rules, the detection module further being configured to generate an alert if the result of the analysis indicates a breach of at least one of the rules; a moderator module connected to receive the alert, the moderator module configured to enable output to a moderator based only on the piece of digital content which caused the alert to be generated, whereby the moderator can assess a modification to be made to the piece of content which caused the alert to be generated.

Abstract translation: 公开了一种用于分析内容的计算机系统，包括：被连接以接收至少一个数字内容的检测模块，所述检测模块可操作以访问一组遵从性规则，并将所接收的至少一个数字内容与 所述一致性规则，所述检测模块还被配置为：如果所述分析的结果指示违反所述规则中的至少一个规则，则生成警报; 连接以接收警报的主持人模块，所述主持人模块被配置为仅基于引起所述警报的所述数字内容的输出到主持人，由此所述主持人可以评估对所述内容的修改 这引起了警报的产生。

公开(公告)号：WO2003070242A1

公开(公告)日：2003-08-28

申请号：PCT/GB2003/000720

申请日：2003-02-19

Applicant: CELLTECH R & D LIMITED ,  WATSON, Robert, John ,  MEISSNER, Johannes, Wilhelm, Georg ,  CHRISTIE, Mark, Ian ,  OWEN, David, Alan

Inventor： WATSON, Robert, John ,  MEISSNER, Johannes, Wilhelm, Georg ,  CHRISTIE, Mark, Ian ,  OWEN, David, Alan

IPC: A61K31/4468

CPC classification number: C07D401/12 ,  C07D211/58 ,  C07D405/12 ,  C07D409/12

Abstract: Cyclic amino derivatives of formula (1) are described: (1) wherein: m and n, which may be the same or different, is each zero or the integer 1 or 2; AIk 3 is a covalent bond or a straight or branched C 1-6 alkylene chain; R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a straight or branched C 1-6 alkyl group; D is an optionally substituted aromatic or heteroaromatic group; E is an optionally substituted C 7-10 cycloalkyl, C 7-10 cycloalkenyl or C 7-10 polycycloaliphatic group; and the salts, solvates, hydrates, tautomers or N-oxides thereof. The compounds are potent and selective modulators of the interaction between CXCR3 and its chemokine ligands and are thus of use in medicine, for example in the prevention or treatment of conditions involving inappropriate T-cell trafficking such as certain inflammatory, autoimmune and immunoregulatory disorders as described hereinafter.

Abstract translation: 描述式（1）的环状氨基衍生物：（1）其中：m和n可以相同或不同，分别为零或整数1或2; Alk3是共价键或直链或支链C 1-6亚烷基链; R 1和R 2可以相同或不同，分别为氢原子或直链或支链C 1-6烷基; D是任选取代的芳族或杂芳族基团; E是任选取代的C7-10环烷基，C7-10环烯基或C7-10多环脂族基团; 及其盐，溶剂化物，水合物，互变异构体或N-氧化物。 这些化合物是CXCR3与其趋化因子配体之间相互作用的有效和选择性调节剂，因此可用于医学中，例如用于预防或治疗涉及不适当的T细胞运输的病症，例如所述的某些炎症，自身免疫和免疫调节性疾病 以下。