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1.发明申请
公开(公告)号：WO2022155477A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012533
申请日：2022-01-14
摘要： The present disclosure relates to novel expression vectors, host cells and methods useful to produce cells comprising one or more sequences of interest.
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2.发明申请
公开(公告)号：WO2019217822A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031729
申请日：2019-05-10
IPC分类号： A61K31/4439 , A61K31/426 , A61K31/454 , A61K31/433 , A61K31/519 , A61K31/437 , A61P29/00 , A61P7/10
摘要： Provided herein are compounds and methods of using compounds for preventing or treating inflammatory diseases in a subject in need of such prevention or treatment. In particular, provided herein are compounds and methods of using compounds for the treatment of inflammatory conditions induced by or associated with autoimmune, metabolic, or cardiovascular diseases and with inflammatory conditions induced by or associated with surgery and trauma. More particularly, provided herein are compounds for use as anti-inflammatory agents, such as the compounds of Formula I or compounds of Formula I':
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公开(公告)号：WO2019140253A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/013289
申请日：2019-01-11
发明人： HAYDEN, Stuart , LOY, Ryan , SAWCHUK, Dennis , WOLFF, Melissa , ZHANG, Wa
摘要： Provided herein are compounds for use as salty taste modifying or enhancing agents, and for use in modifying or enhancing the flavor of reduced sodium products and increasing palatability of products that may have reduced sodium content. Also provided herein are methods for modulating the perceived saltiness of a product by adding compounds as disclosed herein to the product.
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公开(公告)号：WO2018013739A3
公开(公告)日：2018-01-18
申请号：PCT/US2017/041795
申请日：2017-07-12
发明人： SAWCHUK, Dennis , SCHMID, Lori
摘要： The present disclosure provides edible compositions comprising a flavor-grade sweet taste modulator or a combination of flavor-grade sweet taste modulators or a flavor-grade bitter taste blocker or a combination of flavor-grade bitter taste blockers of the present disclosure, food products comprising such edible compositions and methods of preparing such food products. The present disclosure also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.
摘要翻译： 本公开提供了包含风味级甜味调节剂或风味级甜味调节剂或风味级苦味阻断剂或风味级苦味阻断剂的组合的可食用组合物 包含此类可食用组合物的食物产品以及制备此类食物产品的方法。 本公开还提供了减少食品中糖含量的方法，减少饮食中卡路里摄入量的方法，以及增强食品甜味或阻止苦味的方法。
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公开(公告)号：WO2016115278A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/013296
申请日：2016-01-13
发明人： JIANG, Deshou , ZHOU, Hao , HAYDEN, Stuart
IPC分类号： C07D311/20 , A23L2/60 , A61K47/22 , A61K8/49 , A23L27/30
CPC分类号： C07D311/20 , A23L27/30 , A23L27/86 , A23L27/88 , A23L33/125 , A23V2002/00 , A61K8/498 , A61K47/22 , A61Q11/00 , A61Q19/00 , C07D311/42
摘要： The present disclosure provides edible compositions comprising a flavor- grade sweet taste modulator or a combination of flavor-grade sweet taste modulators or a flavor-grade bitter taste blocker or a combination of flavor-grade bitter taste blockers of the present disclosure, food products comprising such edible compositions and methods of preparing such food products. The present disclosure also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.
摘要翻译： 本公开提供了包含风味级甜味调节剂或风味级甜味调节剂或风味级苦味抑制剂或本公开的风味级苦味阻滞剂的组合的食用组合物，其包含 这种食用组合物和制备这种食品的方法。 本公开还提供了减少食品中糖的量的方法，减少饮食中的热量摄入的方法，以及增加甜味或阻止食品中苦味的方法。
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公开(公告)号：WO2014153000A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/028605
申请日：2014-03-14
发明人： LUO, Robert, Zhiyong , CURRAN, Kevin, Joseph , HAYDEN, Stuart , YANG, Gengcheng , JIANG, Deshou , KRAL, Vincent
IPC分类号： C07D311/22 , A23L1/236
CPC分类号： A23L1/236 , A23L2/60 , A23L5/00 , A23L27/30 , A23L27/88 , A23L29/30 , A23L29/37 , A23L33/125 , A23V2002/00 , C07D311/32
摘要： The present invention provides edible compositions comprising a sweet taste modulator of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste in a food product.
摘要翻译： 本发明提供了包含本发明的甜味调节剂，包含这种可食用组合物的食品和制备这种食品的方法的食用组合物。 本发明还提供减少食品中糖的量的方法，减少饮食中的热量摄入的方法，以及增加食品中甜味的方法。
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公开(公告)号：WO2013058758A3
公开(公告)日：2013-04-25
申请号：PCT/US2011/057146
申请日：2011-10-20
申请人： CHROMOCELL CORPORATION , KRAFT FOODS GROUP BRANDS LLC , BRENNAN, Francis Xavier , JONES, William P. , LELAND, Jane V. , HAYASHI, David
IPC分类号： A61K31/045 , A61K47/00
摘要： The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
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8.发明申请COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTER TASTE 审中-公开化合物，组合物和减少或消除叮咬的方法
公开(公告)号：WO2011130705A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032780
申请日：2011-04-15
申请人： CHROMOCELL CORPORATION , KRAFT FOODS GLOBAL BRANDS LLC , SHEKDAR, Kambiz , LAVERY, Daniel , GUNNET, Joseph , LANGER, Jessica , LELAND, Jane V. , HAYASHI, David , BROWN, Peter H. , SLADE, Louise , JONES, William P.
发明人： SHEKDAR, Kambiz , LAVERY, Daniel , GUNNET, Joseph , LANGER, Jessica , LELAND, Jane V. , HAYASHI, David , BROWN, Peter H. , SLADE, Louise , JONES, William P.
CPC分类号： A23L27/86 , A23L27/16 , A23L27/2024 , A23L27/203 , A23L27/204 , A23L27/2052 , A23V2002/00 , A61K47/02 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/44 , C07C63/06 , C07C69/78 , C07D311/20 , C07D311/22 , C07D311/72
摘要： The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaC1 in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
摘要翻译： 本发明提供了包含本发明化合物，包含这种可食用组合物的食品和制备这种食品的方法的食用组合物。 本发明还提供减少食品中NaCl的量的方法，减少饮食中的钠摄取量的方法以及降低食品中苦味的方法。
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9.发明申请
公开(公告)号：WO2019200369A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/027424
申请日：2019-04-15
IPC分类号： A61K31/4439 , A61K31/426 , A61K31/433 , A61K31/454 , A61P25/00
摘要： Provided herein are compounds and methods of using compounds for preventing or treating peripheral nerve damage in a subject in need of such prevention or treatment. In particular, provided herein are compounds and methods of using compounds for the prevention of peripheral nerve damage from chemotherapy, metabolic dysfunction, surgery/trauma, and other causes (PND). More particularly, provided herein are compounds and methods of using compounds as neuroprotective agents which are compounds that inhibit sodium channels that allow peripheral nociceptive neurons to signal to the central nervous system, such as the compounds of Formula (I) or compounds of Formula (I').
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公开(公告)号：WO2019113443A3
公开(公告)日：2019-06-13
申请号：PCT/US2018/064473
申请日：2018-12-07
发明人： JIANG, Deshou , SHAH, Purvi , SAWCHUK, Dennis
IPC分类号： A23L27/30 , C07D209/20
摘要： The present disclosure provides compounds of Formula (I) and edible compositions comprising compounds of Formula (I) which are suitable for use as sweeteners, for example, by incorporation into edible compositions. Also provided herein are methods of preparing comestible compositions comprising compounds of Formula (I).
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