公开(公告)号：WO2005003544A1

公开(公告)日：2005-01-13

申请号：PCT/US2004/021290

申请日：2004-07-01

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  PELLIZZARI, Roberto, O.

Inventor： PELLIZZARI, Roberto, O.

IPC: F02G1/043

CPC classification number: F02G1/057 ,  F02G1/055 ,  F28F13/02

Abstract: A heat exchanger for a Stirling cycle machine comprising: an inlet for receiving working fluid; an impingement baffle (215) having a plurality of apertures (265) thereon; and a manifold (235) formed in the space between the interior wall (240) of the Stirling cycle machine and the impingement baffle (215); wherein the working fluid impinges upon the interior wall of the Stirling cycle machine when the working fluid is flowing in a first direction and the working fluid is directed into a chamber of the Stirling cycle machine when the working fluid is flowing in a second direction.

Abstract translation: 一种用于斯特林循环机的热交换器，包括：用于接收工作流体的入口; 其上具有多个孔（265）的冲击挡板（215） 和形成在斯特林循环机的内壁（240）与冲击挡板（215）之间的空间中的歧管（235）; 其中当所述工作流体沿第一方向流动时，所述工作流体冲击所述斯特林循环机的内壁，并且当所述工作流体沿第二方向流动时，所述工作流体被引导到所述斯特林循环机的腔室中。

公开(公告)号：WO2005003543A1

公开(公告)日：2005-01-13

申请号：PCT/US2004/021289

申请日：2004-07-01

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  CHERTOK, Allan

Inventor： CHERTOK, Allan

IPC: F02G1/043

CPC classification number: F02G1/0435 ,  F02G1/043 ,  F02G1/045 ,  F02G2280/10 ,  H02P9/02 ,  H02P25/032

Abstract: A control system for a free piston Stirling engine, the free piston Stirling engine having a power piston, the control system comprising: a) an electromagnetic transducer in mechanical communication with the power piston; and b) a controllable oscillatory power system in electrical communication with the electromagnetic transducer, the system being capable of delivering power to or receiving power from the electromagnetic transducer while enforcing a prescribed amplitude and prescribed frequency of the voltage at the terminais of the electromagnetic transducer.

Abstract translation: 用于自由活塞斯特林发动机的控制系统，具有动力活塞的自由活塞斯特林发动机，该控制系统包括：a）与动力活塞机械连通的电磁换能器; 以及b）与所述电磁换能器电通信的可控振荡电力系统，所述系统能够在电磁换能器的终端处施加电压的规定振幅和规定频率的同时向所述电磁换能器输送功率或从所述电磁换能器接收功率。

公开(公告)号：WO2004071488A1

公开(公告)日：2004-08-26

申请号：PCT/US2003/039561

申请日：2003-12-15

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  PHAM, Stephen

Inventor： PHAM, Stephen

IPC: A61K9/00

CPC classification number: A61K9/008 ,  A61K9/124 ,  A61M11/041 ,  A61M11/044 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0476 ,  A61M2205/3653 ,  A61M2205/502 ,  A61M2205/8206

Abstract: A liquid aerosol generating formulation comprising medicament and at least one liquid perfluorocarbon and/or hydrofluorocarbon. The formulation can include at least one surfactant which stabilizes the medicament. An aerosol of medicament particles can be formed by heating the formulation in a flow passage such that the liquid perfluorocarbon and/or hydrofluorocarbon is vaporized and expands out of an outlet of the flow passage. The flow passage can be a heated capillary sized flow passage in a hand held inhaler. The liquid perfluorocarbon and/or hydrofluorocarbon can deliver drugs having low solubility and/or low potency to a patient as a soft mist aerosol requiring minimal patient coordination.

Abstract translation: 包含药物和至少一种液体全氟化碳和/或氢氟烃的液体气溶胶产生剂。 制剂可以包括使药物稳定的至少一种表面活性剂。 可以通过在流动通道中加热制剂使得液体全氟化碳和/或氢氟烃被蒸发并从流动通道的出口膨胀而形成药物颗粒的气溶胶。 流动通道可以是手持式吸入器中的加热毛细管尺寸的流动通道。 液体全氟化碳和/或氢氟碳化合物可以将药物具有低溶解度和/或低效力，作为需要最少患者协调的软雾气雾剂给病人。

公开(公告)号：WO2004068593A2

公开(公告)日：2004-08-12

申请号：PCT/US2003/039327

申请日：2003-12-10

Applicant: CHRYSALIS TECHNOLOGIES, INCORPORATED

Inventor： PELLIZZARI, Roberto, O.

IPC: H01L31/058

CPC classification number: F23D3/00 ,  F23K5/18 ,  F23K5/20 ,  F23L15/04 ,  Y02E20/348 ,  Y02T10/16 ,  Y02T10/166

Abstract: A hybrid system for generating electrical power. The hybrid system includes a photovoltaic array for collecting and converting solar radiation into electrical power, an apparatus for producing power from a source of liquid fuel, the apparatus including at least one capillary flow passage, the at least one capillary flow passage having an inlet end and an outlet end, the inlet end in fluid communication with the source of liquid fuel, a heat source arranged along the at least one capillary flow passage, the heat source operable to heat the liquid fuel in the at least one capillary flow passage to a level sufficient to change at least a portion thereof from a liquid state to a vapor state and deliver a stream of substantially vaporized fuel from the outlet end of the at least one capillary flow passage, a combustion chamber in communication with the outlet end of the at least one capillary flow passage and a conversion device operable to convert heat released by combustion in the combustion chamber into electrical power, and a storage device electrically connected to the photovoltaic array and the conversion device for storing the electrical power produced by the photovoltaic array and the conversion device.

Abstract translation: 一种用于产生电力的混合系统。 混合系统包括用于收集和将太阳辐射转换成电力的光伏阵列，用于从液体燃料源产生动力的装置，该装置包括至少一个毛细管流动通道，该至少一个毛细管流动通道具有入口端 以及出口端，所述入口端与液体燃料源流体连通，沿着所述至少一个毛细管流动通道布置的热源，所述热源可操作以将所述至少一个毛细管流动通道中的液体燃料加热到 足以将其至少一部分从液态改变为蒸汽状态，并从所述至少一个毛细管流动通道的出口端输送基本上蒸发的燃料流，所述燃烧室与所述至少一个毛细管流动通道的出口端相连通 至少一个毛细管流动通道和可操作以将在燃烧室中燃烧释放的热量转换为电力的转换装置和存储器 电连接到光伏阵列的装置和用于存储由光伏阵列和转换装置产生的电力的转换装置。

公开(公告)号：WO2003049785A3

公开(公告)日：2003-06-19

申请号：PCT/US2002/038690

申请日：2002-12-04

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED

Inventor： SPRINKEL, Jr., F., Murphy ,  FOURNIER, Jay, A.

IPC: A61M15/00

Abstract: A fluid vaporizing device (100) such as an aerosol generator having a tubular heater in the form of thin film of resistance heating material lining a fluid passage (130) and method for forming the tubular heater within the fluid passage (130). The tubular heater can be heated to volatilize a fluid within the passage. The fluid vaporizing device (100) can be used for the generation of aerosols containing medicated material.

公开(公告)号：WO2001031071A1

公开(公告)日：2001-05-03

申请号：PCT/US2000/029028

申请日：2000-10-20

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED

Inventor： DEEVI, Seetharama, C. ,  PRASAD, Y., V., R., K. ,  SASTRY, D., H.

IPC: C21D1/02

CPC classification number: C22C1/0491 ,  B22F3/16 ,  B22F2998/00 ,  B22F2998/10 ,  C21D6/00 ,  C21D7/13 ,  C22C38/06 ,  C22C38/12 ,  C22C38/14 ,  C22F1/183 ,  B22F9/082 ,  B22F3/18 ,  B22F3/14 ,  B22F3/17

Abstract: An innovative combination of powder metallurgy and hot working steps have allowed for optimization of the processing route for extruded powder metallurgical iron aluminide that is produced from both water atomization and gas atomized powders. Utilizing strain and strain rates sufficient to achieve dynamic recrystallization or superplastic deformation of the intermetallic alloy under hot working conditions, manufacturing methods have been developed which take advantage of the inherent properties of these two regimes to optimize the processing of iron aluminide alloys.

Abstract translation: 粉末冶金和热加工步骤的创新组合允许优化由水雾化和气体雾化粉末生产的挤出粉末冶金铁铝化物的加工路线。 处理图在750℃-1150℃的温度范围和0.001-100s-1的应变速率下开发。 气体雾化材料的加工图表明，动态重结晶发生在宽范围的温度和应变速率下，其最佳值为1075℃和0.1s -1。 该域内的晶粒尺寸变化与齐纳霍洛蒙参数相关。 与气体雾化材料不同，水雾化材料加工图中的特征随应变而变化。 该材料在变形的初始阶段呈现动态再结晶，产生稳定的细晶粒结构。 在温度> 1000℃的随后的变形过程中，该微观结构负责在低于0.1s -1的应变速率下发生超塑性变形，应变速率> 10s -1时动态再结晶。 气体雾化材料易于流动不稳定，如应变速率高于10 s -1的流动定位，而水雾化材料在较高的应变和应变速率下表现出稳定的流动。 利用足以在热加工条件下实现金属间合金的动态再结晶或超塑性变形的应变和应变速率，已经开发了利用这两种方式的固有性质来优化铁铝化合物的加工的制造方法。

公开(公告)号：WO2006028843A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/030955

申请日：2005-08-31

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  MAHARAJH, Niranjan ,  TUCKER, Chris ,  KEELER, David

Inventor： MAHARAJH, Niranjan ,  TUCKER, Chris ,  KEELER, David

IPC: F22B35/18 ,  F22B1/28 ,  F22B37/38

CPC classification number: F22B37/38 ,  F22B1/28 ,  F22B35/18

Abstract: A programmable vapor generator forms a volatilized liquid by supplying a material in liquid form to a flow passage and heating the flow passage, such that the material volatilizes and expands out of an outlet of the channel. The volatilized material, if desired, mixes with ambient air such that volatilized material condenses to form the aerosol. An apparatus and method for generating such a volatilized liquid, as well as the control and methods of heating, are disclosed as an analytical tool useful for experimental use, a tool useful for production of commercial products or an inhaler device.

Abstract translation: 可编程蒸汽发生器通过将液体形式的材料供应到流动通道并加热流动通道，使得材料从通道的出口挥发和膨胀而形成挥发液体。 如果需要，挥发的物质与环境空气混合，使得挥发的物质冷凝形成气溶胶。 公开了用于产生这种挥发性液体的装置和方法以及加热控制和方法，作为可用于实验用途的分析工具，用于生产商业产品或吸入器装置的工具。

公开(公告)号：WO2004112799A1

公开(公告)日：2004-12-29

申请号：PCT/US2004/018887

申请日：2004-06-14

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  NGUYEN, Tung, T. ,  BROWN, Nina ,  LIN, Jui, C. ,  PHAM, Stephen ,  COX, Kenneth, A. ,  MCRAE, Douglas, D. ,  NICHOLS, Walter, A.

Inventor： NGUYEN, Tung, T. ,  BROWN, Nina ,  LIN, Jui, C. ,  PHAM, Stephen ,  COX, Kenneth, A. ,  MCRAE, Douglas, D. ,  NICHOLS, Walter, A.

IPC: A61K31/573

CPC classification number: A61K31/137 ,  A61K9/0073 ,  A61K31/573 ,  A61K47/08 ,  A61K47/10 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0025 ,  A61M15/025 ,  A61M2016/0021 ,  A61M2205/8206 ,  A61M2205/8237

Abstract: Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precursor material through a flow passage heated to convert the carrier into a vapor and the second component into nanoscale particles. The nanoscale particles preferably consist essentially of the second component and can consist essentially of dry, solid particles. The particle generator can be incorporated in a hand be produced by flowing a solution of medicament, control release agent and carrier liquid through a capillary heater.

Abstract translation: 用于产生纳米尺寸颗粒的液体纳米级颗粒前体材料包括至少一种高挥发性载体和第二组分。 纳米级粒子产生装置通过使液体纳米级粒子前体材料通过加热的流动通道将载体转化为蒸气并将第二组分转变为纳米级颗粒而产生纳米级颗粒。 纳米尺度颗粒优选基本上由第二组分组成，并且可以基本上由干燥的固体颗粒组成。 颗粒发生器可以通过流过药物，控制释放剂和载液的溶液通过毛细管加热器而被并入手中。

公开(公告)号：WO2004071491A1

公开(公告)日：2004-08-26

申请号：PCT/US2003/039819

申请日：2003-12-15

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  BLONDINO, Frank, E. ,  POKLIS, Justin ,  BAKER, Matthew

Inventor： BLONDINO, Frank, E. ,  POKLIS, Justin ,  BAKER, Matthew

IPC: A61K9/12

CPC classification number: A61K9/0078 ,  A61K31/485 ,  A61K31/496 ,  Y10S514/958

Abstract: A liquid aerosol formulation comprising at least one thermally stable active ingredient selected from the group consisting of buspirone, buprenorphine, triazolam, cyclobenzaprine, zolpidem, pharmaceutically acceptable salts and esters thereof and derivatives thereof. The liquid formulation can include an organic solvent such as propylene glycol and one or more optional excipients. The active ingredient can be present in an amount of 0.01 to 5 wt. % and the formulation can be heated to provide a vapor which forms an aerosol having a mass median acrodynamic diameter of less than 3 um.

Abstract translation: 一种液体气溶胶制剂，其包含至少一种选自丁螺环酮，丁丙诺啡，三唑仑，环苯扎林，唑吡旦，其药学上可接受的盐和酯及其衍生物的热稳定活性成分。 液体制剂可以包括有机溶剂如丙二醇和一种或多种任选的赋形剂。 活性成分的存在量可以为0.01〜5wt。 ％，并且可以加热制剂以提供形成具有小于3um的质量中值动力学直径的气溶胶的蒸气。

公开(公告)号：WO2004022242A1

公开(公告)日：2004-03-18

申请号：PCT/US2003/027729

申请日：2003-09-05

Applicant: CHRYSALIS TECHNOLOGIES INCORPORATED ,  NGUYEN, Tung, T. ,  MCREA, Douglas, D. ,  COX, Kenneth, A. ,  NICHOLS, Walter, A. ,  SMITH, Ulysses ,  GROLLIMUND, Gary, E. ,  BROOKMAN, Donald, L.

Inventor： NGUYEN, Tung, T. ,  MCREA, Douglas, D. ,  COX, Kenneth, A. ,  NICHOLS, Walter, A. ,  SMITH, Ulysses ,  GROLLIMUND, Gary, E. ,  BROOKMAN, Donald, L.

IPC: B05B1/24

CPC classification number: B05B17/04 ,  A61M11/001 ,  A61M11/041 ,  A61M11/042 ,  A61M15/008 ,  A61M15/025 ,  A61M2205/50 ,  A61M2205/8206 ,  B05B1/24

Abstract: An aerosol generating device generates an aerosol having a desired particle size by passing a liquid through a flow passage heated to convert the liquid into a vapor. The flow passage includes an outlet section that controls the exit velocity of the vapor and produces an aerosol with a desired particle size. The aerosol generator can be incorporated in a hand held inhaler, and the liquid can include a medicament, which is delivered to a targeted portion of the lung using the inhaler.

Abstract translation: 气溶胶发生装置通过使液体通过加热的流动通道以将液体转化为蒸气而产生具有期望的粒度的气雾剂。 流动通道包括出口部分，其控制蒸汽的出口速度并产生具有期望粒度的气溶胶。 气溶胶发生器可以装在手持式吸入器中，液体可以包括药物，使用吸入器将药物输送到肺部的目标部位。