公开(公告)号：WO2012051287A1

公开(公告)日：2012-04-19

申请号：PCT/US2011/055950

申请日：2011-10-12

Applicant: KRAFT FOODS GLOBAL BRANDS LLC ,  CHU, Yi-Fang ,  CHEN, Yumin ,  BROWN, Peter H. ,  LYLE, Barbara J.

Inventor： CHU, Yi-Fang ,  CHEN, Yumin ,  BROWN, Peter H. ,  LYLE, Barbara J.

IPC: A23L1/30 ,  A61K8/97 ,  A61K31/35 ,  A61K36/74

CPC classification number: A61K31/05 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/347 ,  A61K8/4953 ,  A61K8/97 ,  A61K31/35 ,  A61K31/522 ,  A61K45/06 ,  A61K2800/10 ,  A61Q19/00 ,  A61K2300/00 ,  A23V2200/302 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2200/328 ,  A23V2250/2108 ,  A23V2250/2132

Abstract: Embodiments are related to compositions of matter comprising a food, drug, cosmetic, dietary supplement, or biologic product, said product comprised of a phytochemical fraction recovered from a crude caffeine, said phytochemical fraction having a ratio of polyphenols to caffeine of about 20, 10-30 or 40, or greater than 10. In related embodiments, said phytochemical fraction is a retentate of a filtration process of a water suspension of crude caffeine, and wherein said crude caffeine is a product of a green coffee bean decaffeination process. In other related embodiments, said compositions of matter are useful for facilitating neuroprotection, inhibiting COX-2, or stimulating glucose uptake.

Abstract translation: 实施方案涉及包含食品，药物，化妆品，膳食补充剂或生物制品的物质的组合物，所述产物由从粗咖啡因回收的植物化学级分组成，所述植物化学级分的多酚与咖啡因的比例为约20,10 -30或40，或大于10.在相关实施方案中，所述植物化学级分是粗咖啡因的水悬浮液的过滤方法的滞留物，并且其中所述粗咖啡因是生咖啡豆脱咖啡因方法的产物。 在其它相关实施方案中，所述物质组合物可用于促进神经保护作用，抑制COX-2或刺激葡萄糖摄取。

公开(公告)号：WO2011011418A1

公开(公告)日：2011-01-27

申请号：PCT/US2010/042611

申请日：2010-07-20

Applicant: KRAFT FOODS GLOBAL BRANDS LLC ,  CHU, Yi-Fang ,  LOH, Jimbay P. ,  BROWN, Peter H. ,  WILLIAMS, Claire E. ,  LYLE, Barbara J.

Inventor： CHU, Yi-Fang ,  LOH, Jimbay P. ,  BROWN, Peter H. ,  WILLIAMS, Claire E. ,  LYLE, Barbara J.

IPC: A23F5/02 ,  A23F5/20 ,  A23L1/30 ,  A61K8/49 ,  A61K31/522 ,  A61K36/74 ,  A61P1/18

CPC classification number: A61K36/74 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/522 ,  A23V2250/2108 ,  A23V2250/2132 ,  A23V2200/328

Abstract: An improved food product comprising a comestible and a crude caffeine complex as a functional additive is provided. The crude caffeine complex includes a blend of caffeine and coffee-based biologically active compounds. The additive demonstrates an ability to stimulate glucose uptake into cells, provide antioxidant benefits, and anti-inflammatory activities. A method of using the crude caffeine complex and incorporating the crude caffeine complex in comestibles is also provided.

Abstract translation: 提供了包含作为功能性添加剂的食用咖啡因和粗咖啡因复合物的改良食品。 粗咖啡因复合物包括咖啡因和基于咖啡的生物活性化合物的混合物。 添加剂显示了刺激葡萄糖摄入细胞的能力，提供抗氧化益处和抗炎活性。 还提供了使用粗咖啡因复合物并将粗咖啡因复合物掺入食物中的方法。

公开(公告)号：WO2013049523A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/057848

申请日：2012-09-28

Applicant: KRAFT FOODS GROUP BRANDS LLC ,  CHU, Yi-Fang

Inventor： CHU, Yi-Fang

IPC: A61K31/522 ,  A61K36/74 ,  A23L1/00 ,  A61P25/20

CPC classification number: A61K36/74 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/522 ,  A23V2200/322 ,  A23V2250/2108

Abstract: The disclosures relates to methods for suppressing beta-amyloid 1-42 levels in the hippocampus of a subject, methods for reducing and/or preventing the formation of amyloid plaques in the hippocampus of a subject, and methods for improving cognitive function and/or memory retention in a subject. The methods include administering an effective amount of crude caffeine to the subject. The crude caffeine is prepared from a coffee decaffeination process and contains a combination of caffeine and coffee-based biologically active compounds. Crude caffeine is therefore believed to slow down the progression of plaque-associated dementia, including Alzheimer's Disease (AD), through an Aβ-dependent mechanism and can be used a therapeutic agent against plaque-associated dementia.

Abstract translation: 该公开内容涉及用于抑制受试者海马中β-淀粉样蛋白1-42水平的方法，用于减少和/或预防受试者海马中淀粉样蛋白斑的形成的方法，以及用于改善认知功能和/或记忆的方法 保留在一个科目。 所述方法包括向受试者施用有效量的粗咖啡因。 粗咖啡因由咖啡脱咖啡因制备，并含有咖啡因和咖啡基生物活性化合物的组合。 因此，认为粗咖啡因通过Abeta依赖性机制减缓斑块相关性痴呆的发展，包括阿尔茨海默氏病（AD），并可用于治疗斑块相关性痴呆。