-
1.发明申请METHODS AND COMPOSITIONS FOR LIMITING VIABILITY OF A MODIFIED HOST CELL OUTSIDE OF DESIGNATED PROCESS CONDITIONS 审中-公开用于限制指定过程条件外修改的主机单元的可行性的方法和组合
公开(公告)号：WO2012040361A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052606
申请日：2011-09-21
Applicant: JOULE UNLIMITED TECHNOLOGIES, INC. , CHURCH, George , SKRALY, Frank, Anthony , GREEN, Brian, D. , HARRISON, Jacob, Carter
Inventor： CHURCH, George , SKRALY, Frank, Anthony , GREEN, Brian, D. , HARRISON, Jacob, Carter
CPC classification number: C12N15/63 , C07K14/435 , C12N13/00
Abstract: The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
Abstract translation: 本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。 公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。
-
公开(公告)号：WO2007120208A3
公开(公告)日：2008-08-28
申请号：PCT/US2006044209
申请日：2006-11-14
Applicant: HARVARD COLLEGE , CHURCH GEORGE M , PORRECA GREGORY J , SHENDURE JAY , ROSENBAUM ABRAHAM
Inventor： CHURCH GEORGE M , PORRECA GREGORY J , SHENDURE JAY , ROSENBAUM ABRAHAM
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q2565/513 , C12Q2563/155 , C12Q2531/125
Abstract: The present invention relates to methods for sequencing a polynucleotide immobilized on an array having a plurality of specific regions each having a defined diameter size, including synthesizing a concatemer of a polynucleotide by rolling circle amplification, wherein the concatemer has a cross-sectional diameter greater than the diameter of a specific region, immobilizing the concatemer to the specific region to make an immobilized concatemer, and sequencing the immobilized concatemer.
Abstract translation: 本发明涉及用于对固定在阵列上的多核苷酸进行测序的方法，所述阵列具有多个具有限定直径尺寸的特定区域，包括通过滚圆扩增来合成多核苷酸的连接体，其中所述并联体的横截面直径大于 特定区域的直径，将连接体固定到特定区域以制备固定化的连接体，并测序固定化的连接体。
-
公开(公告)号：WO2007136835A3
公开(公告)日：2007-11-29
申请号：PCT/US2007/012077
申请日：2007-05-19
Applicant: CODON DEVICES, INC , CHURCH, George , BAYNES, Brian, M.
Inventor： CHURCH, George , BAYNES, Brian, M.
IPC: C12N15/09
Abstract: The invention provides methods and compositions relating to cells having altered functions, and the nucleic acids that impart those functions. Altered cellular function arises from in vivo directed recombination of genetic elements to yield a recombined nucleic acid. These methods and compositions may utilize altered host cells having altered recombination enzyme profiles and/or altered recombination sites. The invention involves in some aspects methods for assembling nucleic acid molecules, such as genomic DNA. Aspects of the invention also provide kits, compositions, devices, and systems for generating novel recombined nucleic acids and cells having altered cell function.
-
4.发明申请
公开(公告)号：WO2007075438A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/047949
申请日：2006-12-15
Applicant: CODON DEVICES, INC. , CHURCH, George , LIU, David
Inventor： CHURCH, George , LIU, David
Abstract: Certain aspects of the present invention provide artificial polypeptides containing ; one or more unnatural amino acids and methods for producing and using the artificial polypeptides.
-
5.发明申请POLYPEPTIDES COMPRISING UNNATURAL AMINO ACIDS, METHODS FOR THEIR PRODUCTION AND USES THEREFOR 审中-公开包含非天然氨基酸的多肽及其制备方法和用途
公开(公告)号：WO2007075438A2
公开(公告)日：2007-07-05
申请号：PCT/US2006047949
申请日：2006-12-15
Applicant: CODON DEVICES INC , CHURCH GEORGE , LIU DAVID
Inventor： CHURCH GEORGE , LIU DAVID
Abstract: Certain aspects of the present invention provide artificial polypeptides containing ; one or more unnatural amino acids and methods for producing and using the artificial polypeptides.
Abstract translation: 本发明的某些方面提供了人造多肽，其含有; 一种或多种非天然氨基酸以及生产和使用人造多肽的方法。
-
Patent Agency Ranking
公开(公告)号：WO2006055836A3
公开(公告)日：2007-03-22
申请号：PCT/US2005041953
申请日：2005-11-16
Applicant: HARVARD COLLEGE , CHURCH GEORGE M , REPPAS NIKOS
Inventor： CHURCH GEORGE M , REPPAS NIKOS
IPC: C12N15/74
CPC classification number: C12N15/90 , A01K2217/05 , A01K2217/075 , C12N15/902
Abstract: The present invention relates to methods, cells and compositions for performing in vivo recombination without the need for clonal selection. These methods, cells and compositions are useful for the automation of recombination. The present invention provides methods for performing sequential steps in genome engineering, as well as for achieving parallel and multiplex genome engineering.
Abstract translation: 本发明涉及用于进行体内重组而不需要克隆选择的方法，细胞和组合物。 这些方法，细胞和组合物可用于重组的自动化。 本发明提供了用于在基因组工程中执行顺序步骤以及实现并行和多重基因组工程的方法。
-
公开(公告)号：WO2006076679A1
公开(公告)日：2006-07-20
申请号：PCT/US2006/001425
申请日：2006-01-13
Applicant: CODON DEVICES, INC. , CHURCH, George , BAYNES, Brian
Inventor： CHURCH, George , BAYNES, Brian
CPC classification number: C12N15/1089 , C12N15/1031 , C12N15/66 , C40B30/02 , G06F19/16 , G06F19/22
Abstract: In certain aspects the present invention provides methods and compositions related to rational protein design.
Abstract translation: 在某些方面，本发明提供了与合理蛋白质设计有关的方法和组合物。
-
公开(公告)号：WO2006073504A3
公开(公告)日：2006-07-13
申请号：PCT/US2005/027695
申请日：2005-08-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHURCH, George , PORRECA, Gregory , SHENDURE, Jay
Inventor： CHURCH, George , PORRECA, Gregory , SHENDURE, Jay
IPC: G01N33/50 , G01N33/532 , G01N21/76
Abstract: Novel methods and compositions for DNA sequencing are provided. The methods described herein are useful for sequencing homopolymeric regions of DNA. The methods also prevent the accumulation of mistakes and inefficiencies in the sequencing reaction.
-
公开(公告)号：WO2005082098A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/006425
申请日：2005-02-28
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHURCH, George, M. , SHENDURE, Jay , PORRECA, Gregory, J. , ZHU, Jun
Inventor： CHURCH, George, M. , SHENDURE, Jay , PORRECA, Gregory, J. , ZHU, Jun
CPC classification number: C12Q1/6834 , C12N15/1093 , C12Q1/6874 , C12Q2565/537 , C12Q2563/149 , C12Q2537/143 , C12Q2565/601
Abstract: Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.
Abstract translation: 提供小型化，高密度，基于微珠的阵列。 还提供了生产和使用克隆珠子的方法以及生产和使用小型化，高密度，基于珠子的阵列的方法。
-
10.发明申请METHODS AND COMPOSITIONS FOR LIMITING VIABILITY OF A MODIFIED HOST CELL OUTSIDE OF DESIGNATED PROCESS CONDITIONS 审中-公开用于限制指定过程条件外修改的主机单元的可行性的方法和组合
公开(公告)号：WO2012040361A3
公开(公告)日：2014-03-27
申请号：PCT/US2011052606
申请日：2011-09-21
Applicant: JOULE UNLTD TECHNOLOGIES INC , CHURCH GEORGE , SKRALY FRANK ANTHONY , GREEN BRIAN D , HARRISON JACOB CARTER
Inventor： CHURCH GEORGE , SKRALY FRANK ANTHONY , GREEN BRIAN D , HARRISON JACOB CARTER
CPC classification number: C12N15/63 , C07K14/435 , C12N13/00
Abstract: The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
Abstract translation: 本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。 公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。
-
-
-
-
-
-
-
-
-
Search Results
67
records
(took 0.024 seconds)
