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公开(公告)号：WO2009026348A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/073687
申请日：2008-08-20
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WISCONSIN ALUMNI RESEARCH FOUNDATION , OH, Dong-chan , CLARDY, Jon, C. , SCOTT, Jarrod , CURRIE, Cameron
Inventor： OH, Dong-chan , CLARDY, Jon, C. , SCOTT, Jarrod , CURRIE, Cameron
IPC: C07D317/12
CPC classification number: C07D317/04
Abstract: A Streptomycete bacteria associated with the Southern Pine Beetle (SPB) has been found to synthesize a potent antifungal compound. The spectrum of activity of the isolated antifungal compound is similar to that of amphotericin, and the compound is approximately three-times more potent on a weight basis.
Abstract translation: 已发现与南方松甲虫（SPB）相关的链霉菌属细菌合成有效的抗真菌化合物。 分离的抗真菌化合物的活性谱类似于两性霉素的活性谱，并且该化合物的重量基础上的效力约为三倍。
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公开(公告)号：WO2013002879A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/033571
申请日：2012-04-13
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , SINCLAIR, David, A. , PRICE, Nathan, L. , CHINI, Eduardo , CLARDY, Jon, C. , CAO, Shugeng
Inventor： SINCLAIR, David, A. , PRICE, Nathan, L. , CHINI, Eduardo , CLARDY, Jon, C. , CAO, Shugeng
IPC: C07D403/06 , C07D403/12 , C07D417/04 , C07D311/28
CPC classification number: A61K31/655 , A61K31/122 , A61K31/277 , A61K31/353 , A61K31/427 , A61K31/502 , A61K31/519 , C07D235/16 , C07D277/30 , C07D277/62 , C07D311/28 , C07D495/04
Abstract: The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
Abstract translation: 本发明提供了抑制CD38活性的方法和组合物，以及治疗或预防与CD38活性相关的各种疾病的方法。
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公开(公告)号：WO2009045719A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/076622
申请日：2008-09-17
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CLARDY, Jon, C. , MALONEY, Katherine, N. , SCHROEDER, Frank, C.
Inventor： CLARDY, Jon, C. , MALONEY, Katherine, N. , SCHROEDER, Frank, C.
CPC classification number: C08G63/664 , C07C69/675 , C08G63/06 , C08G73/02 , C08G73/028 , C12P7/625
Abstract: One aspect of the present invention relates to a polymeric material. The invention also relates to a method of making the aforementioned polymer comprising extracting a fungus, wherein the fungus is, for example, an endophytic fungus, such as CR873. The invention further relates to a bioplastic composition comprising the aforementioned polymer.
Abstract translation: 本发明的一个方面涉及聚合物材料。 本发明还涉及制备上述聚合物的方法，其包括提取真菌，其中所述真菌例如是内生真菌，例如CR873。 本发明还涉及包含上述聚合物的生物塑料组合物。
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4.发明申请
公开(公告)号：WO2011053697A8
公开(公告)日：2011-07-14
申请号：PCT/US2010054473
申请日：2010-10-28
Applicant: GENZYME CORP , HARVARD COLLEGE , MASSACHUSETTS INST TECHNOLOGY , MAZITSCHEK RALPH , CLARDY JON C , WIRTH DYANN , WIEGAND ROGER , URGAONKAR SAMEER , BANIECKI MARY LYNN , CORTESE JOSEPH , CELATKA CASSANDRA , XIANG YIBIN , SKERLJ RENATO , BOURQUE ELYSE M J
Inventor： MAZITSCHEK RALPH , CLARDY JON C , WIRTH DYANN , WIEGAND ROGER , URGAONKAR SAMEER , BANIECKI MARY LYNN , CORTESE JOSEPH , CELATKA CASSANDRA , XIANG YIBIN , SKERLJ RENATO , BOURQUE ELYSE M J
CPC classification number: A61K31/40 , A61K31/4439 , C07D209/40 , C07D213/69 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D417/04 , C07D471/04 , C07D491/056
Abstract: The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.
Abstract translation: 本发明涉及用疟疾治疗受试者的方法，包括给予由式（I）表示的2-氨基吲哚化合物。结构式I中变量的值和优选值在本文中定义。
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Patent Agency Ranking
公开(公告)号：WO2011053697A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/054473
申请日：2010-10-28
Applicant: GENZYME CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MAZITSCHEK, Ralph , CLARDY, Jon, C. , WIRTH, Dyann , WIEGAND, Roger , URGAONKAR, Sameer , BANIECKI, Mary, Lynn , CORTESE, Joseph , CELATKA, Cassandra , XIANG, Yibin , SKERLJ, Renato , BOURQUE, Elyse, M.j.
Inventor： MAZITSCHEK, Ralph , CLARDY, Jon, C. , WIRTH, Dyann , WIEGAND, Roger , URGAONKAR, Sameer , BANIECKI, Mary, Lynn , CORTESE, Joseph , CELATKA, Cassandra , XIANG, Yibin , SKERLJ, Renato , BOURQUE, Elyse, M.j.
CPC classification number: A61K31/40 , A61K31/4439 , C07D209/40 , C07D213/69 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D417/04 , C07D471/04 , C07D491/056 , Y02A50/411
Abstract: The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.
Abstract translation: 本发明涉及治疗患有疟疾的受试者的方法，所述方法包括施用由式（I）表示的2-氨基吲哚化合物：结构式I中的变量的值和优选值在本文中定义
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6.发明申请SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE 审中-公开双歧杆菌二氢叶酸脱氢酶的小分子抑制剂
公开(公告)号：WO2009137081A2
公开(公告)日：2009-11-12
申请号：PCT/US2009002845
申请日：2009-05-07
Applicant: MASSACHUSETTS INST TECHNOLOGY , HARVARD COLLEGE , GENZYME CORP , BOOKER MICHAEL L , CELATKA CASSANDRA A , CLARDY JON C , PATEL VISHAL P , WIEGAND ROGER C , WIRTH DYANN F
Inventor： BOOKER MICHAEL L , CELATKA CASSANDRA A , CLARDY JON C , PATEL VISHAL P , WIEGAND ROGER C , WIRTH DYANN F
IPC: C07D333/38 , A61K31/4184 , A61P33/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14
CPC classification number: C07D333/38 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14
Abstract: Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.
Abstract translation: 已经鉴定和表征了用于疟原虫酶的二氢乳清酸脱氢酶（DHODH）的抑制剂。 抑制剂具有高特异性，对培养的寄生虫菌株的亚微量功效，表现出药物样性质，并且不显着细胞毒性。
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公开(公告)号：WO2009137081A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/002845
申请日：2009-05-07
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GENZYME CORPORATION , BASTOS, Cecilia , BOOKER, Michael, L. , CELATKA, Cassandra, A. , CLARDY, Jon, C. , CORTESE, Joseph , PATEL, Vishal, P. , SKERLJ, Renato , WIEGAND, Roger, C. , WIRTH, Dyann, F.
Inventor： BASTOS, Cecilia , BOOKER, Michael, L. , CELATKA, Cassandra, A. , CLARDY, Jon, C. , CORTESE, Joseph , PATEL, Vishal, P. , SKERLJ, Renato , WIEGAND, Roger, C. , WIRTH, Dyann, F.
IPC: C07D333/38 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/4184 , A61P33/06
Abstract: Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.
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公开(公告)号：WO2009045719A3
公开(公告)日：2009-06-04
申请号：PCT/US2008076622
申请日：2008-09-17
Applicant: HARVARD COLLEGE , CLARDY JON C , MALONEY KATHERINE N , SCHROEDER FRANK C
Inventor： CLARDY JON C , MALONEY KATHERINE N , SCHROEDER FRANK C
CPC classification number: C08G63/664 , C07C69/675 , C08G63/06 , C08G73/02 , C08G73/028 , C12P7/625
Abstract: One aspect of the present invention relates to a polymeric material. The invention also relates to a method of making the aforementioned polymer comprising extracting a fungus, wherein the fungus is, for example, an endophytic fungus, such as CR873. The invention further relates to a bioplastic composition comprising the aforementioned polymer.
Abstract translation: 本发明的一个方面涉及聚合物材料。 本发明还涉及一种制备上述聚合物的方法，包括提取真菌，其中真菌是例如内生真菌如CR873。 本发明还涉及包含上述聚合物的生物塑料组合物。
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公开(公告)号：WO2009026348A3
公开(公告)日：2009-04-16
申请号：PCT/US2008073687
申请日：2008-08-20
Applicant: HARVARD COLLEGE , WISCONSIN ALUMNI RES FOUND , OH DONG-CHAN , CLARDY JON C , SCOTT JARROD , CURRIE CAMERON
Inventor： OH DONG-CHAN , CLARDY JON C , SCOTT JARROD , CURRIE CAMERON
IPC: C07D317/12 , A61P31/10 , C07D317/04
CPC classification number: C07D317/04
Abstract: A Streptomycete bacteria associated with the Southern Pine Beetle (SPB) has been found to synthesize a potent antifungal compound. The spectrum of activity of the isolated antifungal compound is similar to that of amphotericin, and the compound is approximately three-times more potent on a weight basis.
Abstract translation: 已经发现与南方松甲虫（SPB）相关的链霉菌合成有效的抗真菌化合物。 分离的抗真菌化合物的活性谱类似于两性霉素的活性，并且该化合物在重量基础上是大约三倍的效力。
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