公开(公告)号：WO2013027196A9

公开(公告)日：2013-02-28

申请号：PCT/IB2012/054305

申请日：2012-08-24

申请人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL ,  MMV MEDICINES FOR MALARIA VENTURE ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  GUY, Rodney Kiplin ,  ZHU, Fangyi ,  CLARK, Julie Anne ,  GUIGUEMDE, Wendyam Armand ,  FLOYD, David ,  KNAPP, Spencer ,  STEIN, Philip ,  CASTRO, Steve

发明人： GUY, Rodney Kiplin ,  ZHU, Fangyi ,  CLARK, Julie Anne ,  GUIGUEMDE, Wendyam Armand ,  FLOYD, David ,  KNAPP, Spencer ,  STEIN, Philip ,  CASTRO, Steve

IPC分类号： C07D217/26 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  A61K31/47 ,  A61P33/06

摘要： In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：WO2013027196A1

公开(公告)日：2013-02-28

申请号：PCT/IB2012054305

申请日：2012-08-24

申请人： ST JUDE CHILDRENS RES HOSPITAL ,  MEDICINES FOR MALARIA VENTURE MMV ,  UNIV RUTGERS ,  GUY RODNEY KIPLIN ,  ZHU FANGYI ,  CLARK JULIE ANNE ,  GUIGUEMDE WENDYAM ARMAND ,  FLOYD DAVID ,  KNAPP SPENCER ,  STEIN PHILIP ,  CASTRO STEVE

发明人： GUY RODNEY KIPLIN ,  ZHU FANGYI ,  CLARK JULIE ANNE ,  GUIGUEMDE WENDYAM ARMAND ,  FLOYD DAVID ,  KNAPP SPENCER ,  STEIN PHILIP ,  CASTRO STEVE

IPC分类号： C07D217/26 ,  A61K31/47 ,  A61P33/06 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

CPC分类号： C07D401/04 ,  A61K31/4725 ,  A61K31/506 ,  A61K45/06 ,  C07D409/04 ,  C07D417/04

摘要： In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

摘要翻译： 一方面，本发明涉及新的取代的2-烷基-1-氧代-N-苯基-3-杂芳基 - ，2,3,4-四氢异喹啉-4-甲酰胺; 用于制备该化合物的合成方法; 包含该化合物的药物组合物 和治疗和/或预防疟疾的方法。 该摘要旨在作为用于在特定领域中进行搜索的目的的扫描工具，并且不旨在限制本发明。