公开(公告)号：WO2020141155A1

公开(公告)日：2020-07-09

申请号：PCT/EP2019/087147

申请日：2019-12-30

Applicant: MMV MEDICINES FOR MALARIA VENTURE

Inventor： SCHALKWIJK, Josephus ,  HERMKENS, Pedro Harold Han ,  DECHERING, Koen Jakob ,  BONNERT, Roger Victor

IPC: C07C235/10 ,  A61P33/06 ,  A61P33/02

Abstract: The present invention provides compounds that have antimalarial activity. More in particular, the present invention provides novel compounds that are analogues of pantothenamides. The pantothenamide analogues of this invention have particularly low IC 50 values against the asexual blood stages and gametocytes of malaria parasites. Furthermore, the pantothenamide analogues of this invention are characterized by low hepatic metabolism. Therefore, pantothenamide analogues of the invention are particularly suitable for use in therapeutic and/or prophylactic treatment of protozoan infections in a human or animal subject in need thereof. The invention further provides pharmaceutical formulations comprising the pantothenamide analogues as well as the therapeutic and/or prophylactic uses of the pantothenamide analogues and pharmaceutical formulations comprising them.

公开(公告)号：WO2017009773A1

公开(公告)日：2017-01-19

申请号：PCT/IB2016/054151

申请日：2016-07-12

Applicant: MMV MEDICINES FOR MALARIA VENTURE ,  UNIVERSITY OF CAPE TOWN

Inventor： WATERSON, David ,  WITTY, Michael John ,  CHIBALE, Kelly ,  STREET, Leslie ,  GONZALEZ CABRERA, Diego ,  PAQUET, Tanya

IPC: C07D401/04 ,  A61K31/4965 ,  A61K31/497 ,  C07D241/20 ,  A61P33/06

CPC classification number: C07D241/20 ,  A61K31/4965 ,  A61K31/497 ,  A61K45/06 ,  A61P33/06 ,  C07D401/04 ,  Y02A50/411 ,  A61K2300/00

Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract translation: 本发明涉及氨基吡嗪衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备抑制疟原虫增殖的药物制剂的氨基吡嗪衍生物。

公开(公告)号：WO2013027196A9

公开(公告)日：2013-02-28

申请号：PCT/IB2012/054305

申请日：2012-08-24

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL ,  MMV MEDICINES FOR MALARIA VENTURE ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  GUY, Rodney Kiplin ,  ZHU, Fangyi ,  CLARK, Julie Anne ,  GUIGUEMDE, Wendyam Armand ,  FLOYD, David ,  KNAPP, Spencer ,  STEIN, Philip ,  CASTRO, Steve

Inventor： GUY, Rodney Kiplin ,  ZHU, Fangyi ,  CLARK, Julie Anne ,  GUIGUEMDE, Wendyam Armand ,  FLOYD, David ,  KNAPP, Spencer ,  STEIN, Philip ,  CASTRO, Steve

IPC: C07D217/26 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  A61K31/47 ,  A61P33/06

Abstract: In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：WO2016151521A1

公开(公告)日：2016-09-29

申请号：PCT/IB2016/051670

申请日：2016-03-24

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSITY OF WASHINGTON ,  MMV MEDICINES FOR MALARIA VENTURE

Inventor： PHILLIPS, Margaret ,  CHARMAN, Susan A. ,  RATHOD, Pradipsinh K. ,  MATTHEWS, David ,  WATERSON, David

IPC: C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is related to a use of triazolopyrimidine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to triazolopyrimidine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract translation: 本发明涉及三唑并嘧啶衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备抑制疟原虫增殖的药物制剂的三唑并嘧啶衍生物。

公开(公告)号：WO2021204952A1

公开(公告)日：2021-10-14

申请号：PCT/EP2021/059196

申请日：2021-04-08

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION ,  MMV MEDICINES FOR MALARIA VENTURE

Inventor： GUY, Rodney Kiplin ,  HAMMILL, Jared T. ,  FLOYD, David ,  BURROWS, Jeremy ,  BRAND, Stephen

IPC: C07D401/04 ,  C07D403/04 ,  A61P33/06 ,  A61K31/4725 ,  A61K31/506

Abstract: The present invention is related to new derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to dihydroisoquinoline derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

公开(公告)号：WO2015008246A1

公开(公告)日：2015-01-22

申请号：PCT/IB2014/063180

申请日：2014-07-17

Applicant: MMV MEDICINES FOR MALARIA VENTURE ,  DREXEL UNIVERSITY ,  UNIVERSITY OF WASHINGTON

Inventor： BURROWS, Jeremy ,  WYVRATT, Matthew ,  VAIDYA, Akhil ,  KORTAGERE, Sandhya ,  FAN, Erkang ,  CHATTERJEE, Arnab Kumar ,  NAGLE, Advait Suresh ,  KATO, Tomoyo

IPC: C07D403/12 ,  C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/06

CPC classification number: C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61K45/06 ,  C07D403/12

Abstract: The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract translation: 本发明涉及吡唑衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备用于抑制疟疾寄生虫增殖的药物制剂的吡唑衍生物。

公开(公告)号：WO2013121387A1

公开(公告)日：2013-08-22

申请号：PCT/IB2013/051235

申请日：2013-02-15

Applicant: UNIVERSITY OF CAPE TOWN ,  MMV MEDICINES FOR MALARIA VENTURE

Inventor： YOUNIS, Yassir ,  CHIBALE, Kelly ,  WITTY, Michael, John ,  WATERSON, David

IPC: C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10 ,  C07D241/26 ,  A61K31/444 ,  A61K31/497 ,  A61P33/06

CPC classification number: C07D241/20 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  Y02A50/411

Abstract: The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract translation: 本发明涉及氨基吡嗪衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备抑制疟原虫增殖的药物制剂的氨基吡嗪衍生物。

公开(公告)号：WO2021123266A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/087166

申请日：2020-12-18

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  MMV MEDICINES FOR MALARIA VENTURE

Inventor： PHILLIPS, Margaret ,  PALMER, Michael ,  CHARMAN, Susan A. ,  WATTS, Karl, Shawn ,  GERASYUTO, Aleksey I. ,  KRILOV, Goran

IPC: C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  A61K31/4439 ,  A61K31/4196 ,  A61P33/06 ,  C07D207/34 ,  A61K31/357 ,  A61K31/366 ,  A61K31/4162 ,  A61K31/4706

Abstract: The present invention is related to new pyrrole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrrole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

公开(公告)号：WO2018069420A1

公开(公告)日：2018-04-19

申请号：PCT/EP2017/075999

申请日：2017-10-12

Applicant: MMV MEDICINES FOR MALARIA VENTURE

Inventor： VENNERSTROM, Jonathan L. ,  CHARMAN, Susan A.

IPC: C07D405/12 ,  A61K31/4525 ,  A61P33/06

Abstract: The present invention is related to new trioxolane derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to trioxolane derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Abstract translation: 本发明涉及新的三氧杂环戊烷衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体而言，本发明涉及用于制备抑制疟疾寄生虫增殖的药物制剂的三氧杂环戊烷衍生物。

公开(公告)号：WO2015165660A1

公开(公告)日：2015-11-05

申请号：PCT/EP2015/056496

申请日：2015-03-26

Applicant: MMV MEDICINES FOR MALARIA VENTURE

Inventor： HAMEED PEER MOHAMED, Shahul ,  PATIL, Vikas ,  MURUGAN, Kannan ,  VITHALRAO BELLALE, Eknath ,  RAICHURKAR, Anandkumar ,  LANDGE, Sudhir ,  PUTTUR, Jayashree ,  ROY CHOUDHURY, Nilanjana ,  SHANBHAG, Gajanan ,  KOUSHIK, Krishna ,  IYER, Pravin ,  KIRTHIKA SAMBANDAMURTHY, Vasan ,  SOLAPURE, Suresh ,  NARAYANAN, Shridhar

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/506 ,  A61P33/06

CPC classification number: C07D401/14 ,  A61K31/506 ,  A61K45/06 ,  C07D403/14

Abstract: The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and or prevention of malaria caused by plasmodium species, and to their methods of preparation.

Abstract translation: 本发明涉及三氨基嘧啶及其药学上可接受的盐，用于治疗和/或预防疟原虫引起的疟疾及其制备方法。