公开(公告)号：WO2006099313A3

公开(公告)日：2007-06-07

申请号：PCT/US2006008934

申请日：2006-03-13

Applicant: PURDUE RESEARCH FOUNDATION ,  BORCH RICHARD FREDERIC ,  GIBBS RICHARD ANTHONY ,  CLARK MICHELLE MARTIN

Inventor： BORCH RICHARD FREDERIC ,  GIBBS RICHARD ANTHONY ,  CLARK MICHELLE MARTIN

IPC: A61K47/48 ,  A61P35/00

CPC classification number: A61K47/548

Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.

Abstract translation: 本文描述了包括一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。

公开(公告)号：WO2009029849A1

公开(公告)日：2009-03-05

申请号：PCT/US2008/074870

申请日：2008-08-29

Applicant: PURDUE RESEARCH FOUNDATION ,  BORCH, Richard, Frederic ,  GIBBS, Richard, Anthony ,  CLARK, Michelle, Martin ,  FOUAD, Farid

Inventor： BORCH, Richard, Frederic ,  GIBBS, Richard, Anthony ,  CLARK, Michelle, Martin ,  FOUAD, Farid

IPC: C07D207/00

CPC classification number: C07F9/65515 ,  C07F9/2412 ,  C07F9/2458

Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.

Abstract translation: 本文描述了包含一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。

公开(公告)号：WO2006099313A2

公开(公告)日：2006-09-21

申请号：PCT/US2006/008934

申请日：2006-03-13

Applicant: PURDUE RESEARCH FOUNDATION ,  BORCH, Richard, Frederic ,  GIBBS, Richard, Anthony ,  CLARK, Michelle, Martin

Inventor： BORCH, Richard, Frederic ,  GIBBS, Richard, Anthony ,  CLARK, Michelle, Martin

IPC: A61K47/48

CPC classification number: A61K47/548

Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.

Abstract translation: 本文描述了包含一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。