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公开(公告)号：WO2012103444A3
公开(公告)日：2012-09-13
申请号：PCT/US2012022919
申请日：2012-01-27
Inventor： BORCH RICHARD FREDERIC , BOUTSELIS IRENE GEORGE
IPC: A61K39/385 , A61K45/00 , A61K47/00
CPC classification number: A61K47/48084 , A61K38/45 , A61K38/47 , A61K39/39 , A61K39/3955 , A61K47/548 , A61K2039/505 , A61K2039/55505 , A61K2039/60 , A61K2039/627 , C07K16/2896 , C07K2317/76 , C12N9/96 , C12Y204/02036 , C12Y302/01017
Abstract: The invention described herein pertains to compounds and conjugates, to compositions, complexes and formulations comprising the compounds and/or conjugates, and to methods of use of the compounds, conjugates and their compositions, complexes and formulations in vaccines and vaccinations and generating immune responses.
Abstract translation: 本文描述的本发明涉及化合物和缀合物，包含化合物和/或缀合物的组合物，复合物和制剂，以及在疫苗和疫苗接种中产生化合物，缀合物及其组合物，复合物和制剂以及产生免疫应答的方法。
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公开(公告)号：WO2006099313A3
公开(公告)日：2007-06-07
申请号：PCT/US2006008934
申请日：2006-03-13
Applicant: PURDUE RESEARCH FOUNDATION , BORCH RICHARD FREDERIC , GIBBS RICHARD ANTHONY , CLARK MICHELLE MARTIN
Inventor： BORCH RICHARD FREDERIC , GIBBS RICHARD ANTHONY , CLARK MICHELLE MARTIN
CPC classification number: A61K47/548
Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.
Abstract translation: 本文描述了包括一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。
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Patent Agency Ranking
公开(公告)号：WO2006099313A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008934
申请日：2006-03-13
Applicant: PURDUE RESEARCH FOUNDATION , BORCH, Richard, Frederic , GIBBS, Richard, Anthony , CLARK, Michelle, Martin
IPC: A61K47/48
CPC classification number: A61K47/548
Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.
Abstract translation: 本文描述了包含一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。
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公开(公告)号：WO2009029849A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074870
申请日：2008-08-29
Applicant: PURDUE RESEARCH FOUNDATION , BORCH, Richard, Frederic , GIBBS, Richard, Anthony , CLARK, Michelle, Martin , FOUAD, Farid
Inventor： BORCH, Richard, Frederic , GIBBS, Richard, Anthony , CLARK, Michelle, Martin , FOUAD, Farid
IPC: C07D207/00
CPC classification number: C07F9/65515 , C07F9/2412 , C07F9/2458
Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.
Abstract translation: 本文描述了包含一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。
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公开(公告)号：WO2006037090A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034974
申请日：2005-09-28
Inventor： BORCH, Richard, Frederic , BOUTSELIS, Irene, George
IPC: A61K47/48
CPC classification number: A61K47/548
Abstract: Phosphate-substituted therapeutic compounds and analogs thereof that may serve as prodrugs are described. The prodrugs may include phosphorus-containing compounds, drug-phosphate conjugates, and analogs of drug-phosphate conjugates. Also described are analogs of drugs, including phosphorylated drugs, where the linker connecting the phosphate fragment to the drug fragment is other than oxygen, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, oxophosphonates, and the like.
Abstract translation: 描述了可用作前药的磷酸酯取代的治疗化合物及其类似物。 前药可以包括含磷化合物，药物 - 磷酸盐缀合物和药物 - 磷酸盐缀合物的类似物。 还描述了药物的类似物，包括磷酸化药物，其中连接磷酸酯片段与药物片段的连接体不是氧，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，氧膦酸酯等的接头。
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公开(公告)号：WO2012103444A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/022919
申请日：2012-01-27
Inventor： BORCH, Richard, Frederic , BOUTSELIS, Irene, George
IPC: A61K39/00
CPC classification number: A61K47/548 , A61K38/45 , A61K38/47 , A61K39/39 , A61K39/3955 , A61K2039/505 , A61K2039/55505 , A61K2039/60 , A61K2039/627 , C07K16/2896 , C07K2317/76 , C12N9/96 , C12Y204/02036 , C12Y302/01017
Abstract: The invention described herein pertains to compounds and conjugates, to compositions, complexes and formulations comprising the compounds and/or conjugates, and to methods of use of the compounds, conjugates and their compositions, complexes and formulations in vaccines and vaccinations and generating immune responses.
Abstract translation: 本文所述的发明涉及化合物和缀合物，包含所述化合物和/或缀合物的组合物，复合物和制剂，以及所述化合物，缀合物及其组合物，复合物和制剂在 疫苗和疫苗接种并产生免疫应答。
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公开(公告)号：WO2006037090A3
公开(公告)日：2007-05-10
申请号：PCT/US2005034974
申请日：2005-09-28
Inventor： BORCH RICHARD FREDERIC , BOUTSELIS IRENE GEORGE
CPC classification number: A61K47/548
Abstract: Phosphate-substituted therapeutic compounds and analogs thereof that may serve as prodrugs are described. The prodrugs may include phosphorus-containing compounds, drug-phosphate conjugates, and analogs of drug-phosphate conjugates. Also described are analogs of drugs, including phosphorylated drugs, where the linker connecting the phosphate fragment to the drug fragment is other than oxygen, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, oxophosphonates, and the like.
Abstract translation: 描述了可用作前药的磷酸酯取代的治疗化合物及其类似物。 前药可以包括含磷化合物，药物 - 磷酸盐缀合物和药物 - 磷酸盐缀合物的类似物。 还描述了药物的类似物，包括磷酸化药物，其中连接磷酸酯片段与药物片段的连接体不是氧，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，氧膦酸酯等的接头。
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