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公开(公告)号：WO2006099313A3
公开(公告)日：2007-06-07
申请号：PCT/US2006008934
申请日：2006-03-13
Applicant: PURDUE RESEARCH FOUNDATION , BORCH RICHARD FREDERIC , GIBBS RICHARD ANTHONY , CLARK MICHELLE MARTIN
Inventor： BORCH RICHARD FREDERIC , GIBBS RICHARD ANTHONY , CLARK MICHELLE MARTIN
CPC classification number: A61K47/548
Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.
Abstract translation: 本文描述了包括一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。
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公开(公告)号：WO2009029849A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074870
申请日：2008-08-29
Applicant: PURDUE RESEARCH FOUNDATION , BORCH, Richard, Frederic , GIBBS, Richard, Anthony , CLARK, Michelle, Martin , FOUAD, Farid
Inventor： BORCH, Richard, Frederic , GIBBS, Richard, Anthony , CLARK, Michelle, Martin , FOUAD, Farid
IPC: C07D207/00
CPC classification number: C07F9/65515 , C07F9/2412 , C07F9/2458
Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.
Abstract translation: 本文描述了包含一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。
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3.发明申请LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS 审中-公开长链羧甲基纤维素和用作抗炎剂的模拟物
公开(公告)号：WO2010033687A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057293
申请日：2009-09-17
Applicant: PURDUE RESEARCH FOUNDATION , GIBBS, Richard, Anthony , JIANG, Qing , LILL, Markus, A.
Inventor： GIBBS, Richard, Anthony , JIANG, Qing , LILL, Markus, A.
IPC: A01N43/78
CPC classification number: A61K31/352 , A61K31/36 , A61K2300/00
Abstract: Provided are long-chain carboxychromanol compounds useful for treating conditions associated with the need to inhibit cyclooxygenase-1, cyclooxygenase-2, and/or 5- lipoxygenase, and pharmaceutical formulations containing the compounds.
Abstract translation: 提供了可用于治疗与需要抑制环加氧酶-1，环加氧酶-2和/或5-脂氧合酶相关的病症的长链羧基二氢吲哚化合物，以及含有该化合物的药物制剂。
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公开(公告)号：WO2006099313A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008934
申请日：2006-03-13
Applicant: PURDUE RESEARCH FOUNDATION , BORCH, Richard, Frederic , GIBBS, Richard, Anthony , CLARK, Michelle, Martin
IPC: A61K47/48
CPC classification number: A61K47/548
Abstract: Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like.
Abstract translation: 本文描述了包含一种或多种磷酸酯片段或磷酸酯片段的类似物的法呢基转移酶的含磷抑制剂的中性前体药物。 磷酸酯片段的类似物包括将磷酸酯片段与药物的剩余部分连接的除氧以外的各种接头，例如但不限于形成氨基磷酸酯，膦酸酯，二氟磷酸酯，磷酸酯等的接头。
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