公开(公告)号：WO2021163613A1

公开(公告)日：2021-08-19

申请号：PCT/US2021/018023

申请日：2021-02-12

Applicant: COGNITION THERAPEUTICS, INC.

Inventor： CATALANO, Susan ,  IZZO, Nicholas

IPC: C07K16/18 ,  C12P21/08 ,  G01N33/68

Abstract: The present disclosure relates to methods of decreasing amyloid β monomers and methods of treating cognitive decline in a subject, wherein the treatment results in an increase in amyloid β oligomers and a reduction in cognitive decline. The present disclosure relates to treating cognitive decline, wherein target engagement can be measured in the clinic after treating.

公开(公告)号：WO2019089988A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058789

申请日：2018-11-01

Applicant: COGNITION THERAPEUTICS, INC.

Inventor： CATALANO, Susan M. ,  IZZO, Nicholas J.

IPC: C07D209/44 ,  A61K31/4035 ,  A61P25/28

Abstract: The present invention is directed to methods of treating Alzheimer's disease. Also disclosed are methods of identifying novel compounds that may be useful in the treatment and prevention of Alzheimer's disease as well as methods of determing the Alzheimer's disease status of a subject.

公开(公告)号：WO2013029057A4

公开(公告)日：2013-08-01

申请号：PCT/US2012052572

申请日：2012-08-27

Applicant: COGNITION THERAPEUTICS INC ,  CATALANO SUSAN M ,  RISHTON GILBERT ,  IZZO NICHOLAS J

Inventor： CATALANO SUSAN M ,  RISHTON GILBERT ,  IZZO NICHOLAS J

IPC: A61K31/135

CPC classification number: C07D491/107 ,  C07B2200/07 ,  C07C211/28 ,  C07C211/29 ,  C07C215/54 ,  C07C217/58 ,  C07C217/62 ,  C07C235/60 ,  C07C317/32 ,  C07C2601/10 ,  C07C2602/10 ,  C07D209/44 ,  C07D211/14 ,  C07D211/22 ,  C07D295/08 ,  C07D295/096 ,  C07D319/18 ,  C07D491/10

Abstract: This invention relates to novel diarylamino compounds that bind to the sigma-2 receptor, to pharmaceutical compositions comprising such compounds, and to methods for inhibiting or restoring synapse loss in neuronal cells, modulating a membrane trafficking change in neuronal cells, and treating cognitive decline and neurodegenerative diseases and disorders therewith.

Abstract translation: 本发明涉及与σ-2受体结合的新型二芳基氨基化合物，包含此类化合物的药物组合物，以及抑制或恢复神经元细胞中突触丧失，调节神经元细胞膜运输变化和治疗认知衰退的方法，以及 神经退行性疾病和病症。

公开(公告)号：WO2010118055A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/030130

申请日：2010-04-06

Applicant: COGNITION THERAPEUTICS, INC.

Inventor： RISHTON, Gilbert M. ,  CATALANO, Susan

IPC: A61K36/906 ,  A61K31/40 ,  C07D207/04

CPC classification number: C07C217/62 ,  C07C211/27 ,  C07D207/08 ,  C07D211/22

Abstract: Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.

Abstract translation: 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。

公开(公告)号：WO2015116923A1

公开(公告)日：2015-08-06

申请号：PCT/US2015/013754

申请日：2015-01-30

Applicant: COGNITION THERAPEUTICS, INC.

Inventor： RISHTON, Gilbert ,  CATALANO, Susan, M. ,  LOOK, Gary, C.

IPC: A61K31/404 ,  A61K31/405 ,  A61P25/28 ,  A61P25/00

CPC classification number: C07D209/44 ,  C07D209/62 ,  C07D403/06 ,  C07D491/048 ,  C07D491/056

Abstract: Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta- associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.

Abstract translation: 异二氢吲哚sigma-2受体拮抗剂化合物，包含这些化合物的药物组合物，以及抑制神经元细胞中Abet相关突触丢失或突触功能障碍的方法，调节神经元细胞中Abeta相关膜运输变化，以及治疗与Abeta病理学相关的认知衰退 被提供。

公开(公告)号：WO2013029057A3

公开(公告)日：2013-02-28

申请号：PCT/US2012/052572

申请日：2012-08-27

Applicant: COGNITION THERAPEUTICS, INC. ,  CATALANO, Susan, M. ,  RISHTON, Gilbert ,  IZZO, Nicholas, J.

Inventor： CATALANO, Susan, M. ,  RISHTON, Gilbert ,  IZZO, Nicholas, J.

IPC: A61K31/135

Abstract: This invention relates to novel diarylamino compounds that bind to the sigma-2 receptor, to pharmaceutical compositions comprising such compounds, and to methods for inhibiting or restoring synapse loss in neuronal cells, modulating a membrane trafficking change in neuronal cells, and treating cognitive decline and neurodegenerative diseases and disorders therewith.

公开(公告)号：WO2012106426A1

公开(公告)日：2012-08-09

申请号：PCT/US2012/023483

申请日：2012-02-01

Applicant: COGNITION THERAPEUTICS, INC. ,  RISHTON, Gilbert M. ,  CATALANO, Susan

Inventor： RISHTON, Gilbert M. ,  CATALANO, Susan

IPC: A61K31/137

CPC classification number: C07C33/20 ,  C07B2200/07 ,  C07C33/14 ,  C07C33/26 ,  C07C33/30 ,  C07C211/27 ,  C07C215/26 ,  C07C215/28 ,  C07C2601/16

Abstract: Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.

Abstract translation: 提供了用于治疗认知衰退的中枢神经系统药物候选物，特别是阿尔茨海默氏病的化合物。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。

公开(公告)号：WO2011106785A3

公开(公告)日：2011-09-01

申请号：PCT/US2011/026530

申请日：2011-02-28

Applicant: COGNITION THERAPEUTICS, INC. ,  CATALANO, Susan

Inventor： CATALANO, Susan

IPC: G01N33/48

Abstract: Embodiments described herein are directed to methods of identifying agents effective to treat cognitive decline and diseases associated therewith. Embodiments described herein are also directed to kits for performing methods described herein. Embodiments described are also directed to methods of diagnosis and uses of the same.

Abstract translation: 本文描述的实施方案涉及鉴定有效治疗认知衰退的药剂和与其相关疾病的方法。 这里描述的实施例还涉及用于执行本文描述的方法的套件。 所描述的实施例也涉及诊断和使用它们的方法。

公开(公告)号：WO2011014880A1

公开(公告)日：2011-02-03

申请号：PCT/US2010/044136

申请日：2010-08-02

Applicant: COGNITION THERAPEUTICS, INC. ,  RISHTON, Gilbert, M. ,  CATALANO, Susan

Inventor： RISHTON, Gilbert, M. ,  CATALANO, Susan

IPC: A01N31/00 ,  A61K31/045

CPC classification number: C07C211/27 ,  A61K31/015 ,  C07B2200/07 ,  C07C33/14 ,  C07C33/30 ,  C07C211/25 ,  C07C403/08 ,  C07C403/18 ,  C07C2601/16

Abstract: Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.

Abstract translation: 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。

公开(公告)号：WO2022197885A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020687

申请日：2022-03-17

Applicant: COGNITION THERAPEUTICS, INC.

Inventor： CAGGIANO, Anthony ,  CATALANO, Susan M. ,  HAMBY, Mary ,  IZZO, Nicholas ,  LOOK, Gary C. ,  RISHTON, Gilbert M. ,  RICCIARDI, Lisa

IPC: C07D471/18 ,  C07D487/10 ,  G01N33/50

Abstract: The present disclosure relates to methods of treating neurological diseases, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound or pharmaceutical composition according to any embodiment described herein. The present disclosure relates to the methods of treating Parkinson's disease and Dementia with Lew Bodies, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound or pharmaceutical composition according to any embodiment described herein.