公开(公告)号：WO2023091934A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/079942

申请日：2022-11-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： GRADINARU, Viviana ,  CHEN, Xinhong

IPC: A01N63/00 ,  C12Q1/70 ,  C12N15/86 ,  C07K14/00 ,  C07H21/04

Abstract: Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased transduction enrichment in the heart and/or skeletal muscle and, in some cases, reduced transduction in the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Gene therapy using the rAAVs is described. Also described are methods of treating diseases and conditions of the heart and/or skeletal muscle.

公开(公告)号：WO2023060095A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077555

申请日：2022-10-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： JIN, Zhiyang ,  SHAPIRO, Mikhail G. ,  LAKSHMANAN, Anupama ,  TRAN, Teresa

IPC: C07K14/195 ,  A61K49/22 ,  A61B8/08 ,  C07K14/005 ,  C07K14/215 ,  C07K2319/00 ,  C12N15/625 ,  C12N15/85 ,  C12N2503/00 ,  C12N2800/107 ,  C12N5/0686 ,  C12Q1/6897

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in calcium imaging. There are provided, in some embodiments, Ca2+-sensing GvpC proteins. Disclosed herein include Ca2+-sensing gas vesicles (GVs) comprising Ca2+-sensing GvpC proteins. In some embodiments, the Ca2+-sensing GvpC protein is capable of undergoing a first allosteric conformational change upon the Ca2+-binding domain binding Ca2+ that causes the Ca2+-sensing GV to change from a GV stiff state to a GV soft state. One or more of the mechanical, acoustic, surface, and magnetic properties of a Ca2+-sensing GV can differ between the GV soft state and the GV stiff state.

公开(公告)号：WO2022266637A1

公开(公告)日：2022-12-22

申请号：PCT/US2022/072958

申请日：2022-06-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： FIKES, Austin, C. ,  MIZRAHI, Oren ,  WIESEMULLER, Fabian ,  GDOUTOS, Eleftherios ,  TRUONG, Alan ,  PELLEGRINO, Sergio ,  HAJIMIRI, Seyed, Ali

IPC: H01Q1/38 ,  H01Q9/28 ,  H01Q19/30

Abstract: A self-deployable antenna and/or antenna array that is made up of one or more antenna elements. Each of the antenna elements has a structural base that supports portions of the antenna and can be positioned between a stored configuration for compaction and a deployed configuration for transmitting. The antenna elements and structural base can be part of a base substrate that provides a base support for the antenna and/or antenna array to be compacted and deployed.

公开(公告)号：WO2022251711A8

公开(公告)日：2022-12-01

申请号：PCT/US2022/031458

申请日：2022-05-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CAI, Long ,  ENG, Chee, Huat (Linus)

IPC: C12Q1/6806

Abstract: Disclosed herein are methods for generating a massive number of chemically ligateable probes for multiplexed Fluorescence In Situ Hybridization (FISH) using a hybrid- primer. Also, the disclosure sets forth methods, in addition to using the same, and other solutions to problems in the relevant field.

公开(公告)号：WO2022183058A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/018009

申请日：2022-02-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： FU, Donglong ,  DAVIS, Mark, E.

IPC: B01J20/18 ,  B01J20/30 ,  B01D53/62

Abstract: The present disclosure is directed to metal ion-containing zeolitic compositions, preferably transition metal ion-containing, more preferably zinc ion containing zeolitic compositions, that are useful for scavenging CO2 from low-CO2-content feed streams, including air, and method of making and using the same. In some embodiments, the compositions comprise zinc-ion-doped zeolites having AEI, AFX, or CHA topologies.

公开(公告)号：WO2022182903A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017757

申请日：2022-02-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  DAR, Daniel ,  NEWMAN, Dianne K. ,  FREDIA, Kirsten ,  LONG, Cai

Inventor： DAR, Daniel ,  NEWMAN, Dianne K. ,  FREDIA, Kirsten ,  LONG, Cai

IPC: C12Q1/6816 ,  C12Q1/6841

Abstract: Method for detecting and barcoding the molecular changes occurring in two or more samples upon exposure to different stimuli. This disclosure herein sets for methods that allow a targeted transcriptome-imaging approach that records both gene-expression and spatial context within microscale assemblies at a single-cell and molecule resolution on biological samples. This disclosure herein sets for methods that allows the application to a variety of biological samples for the study of cellular processes, growth, and interactions between biological samples.

公开(公告)号：WO2022159951A1

公开(公告)日：2022-07-28

申请号：PCT/US2022/070255

申请日：2022-01-19

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  TOOFON, INC.

Inventor： OL, Michael, V. ,  GHARIB, Morteza ,  EMADI, Amir

IPC: B64C39/02 ,  B64C27/02

Abstract: A system and method for controlling a multi-rotor aircraft that implements the unconventional use of different sized rotors. The different sized rotors than the main rotors tend to generate an unbalanced torque and pitch on the aircraft that effectively decouples the pitch and yaw control from the main rotors. The atypical design tends to lend itself to improved control capabilities and simplified control systems. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.

公开(公告)号：WO2022132662A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/063143

申请日：2021-12-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： YIN, Lifeng ,  GU, Alan Yalun ,  HOFFMANN, Michael R

IPC: C02F1/461 ,  C02F1/467 ,  C02F1/72

Abstract: The systems and methods for wastewater treatment comprise a porous substrate with photocatalytic material(s), and optionally electrocatalytic material(s), for generation of hydroxyl radicals that decompose contaminants in wastewater. The systems and methods intentionally facilitate the photocatalytic and/or electrocatalytic generation of oxygen bubbles, which facilitate an increase in concentration of hydroxyl radicals and shrink the liquid layer of wastewater at photocatalytic and/or electrocatalytic surfaces where hydroxyl radicals are generated in order to decrease quenching of hydroxyl radicals and simultaneously increase utilization or efficiency of the hydroxyl radicals for decomposition of contaminants. In embodiments, the systems and methods prolong hydroxyl radical lifetime and enhance water treatment performance for residential, commercial, municipal, medical, and/or industrial applications. In embodiments, oxygen bubbles generated on surfaces are compressed into pores or microchannels where they store generated hydroxyl radicals to prolong their lifetime in the gas phase and exchange hydroxyl radicals with the adjacent liquid layer.

公开(公告)号：WO2022055871A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/049270

申请日：2021-09-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： MOISEYENKO, Anastasiya, O. ,  SAMPSON, Timothy, R. ,  MAZMANIAN, Sarkis, K.

IPC: A23L2/02 ,  A61K36/21 ,  A61K36/23

Abstract: Some embodiments herein relate generally to compositions comprising microbial organisms and/or components thereof for improving a neurological disorder, or symptoms associated with a neurological disorder, such as Parkinson's disease, and methods of using the same.

公开(公告)号：WO2021248060A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035990

申请日：2021-06-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  BASF SE

Inventor： LISZKA, Michael ,  WU, Zachary ,  YANG, Kevin

IPC: C12N15/62 ,  G06N3/02 ,  G06N3/08

Abstract: The disclosure provides systems and methods for generating a signal peptide amino acid sequence using deep learning, where a signal peptide is generated for input protein sequences, amino acids of the protein sequences are tokenized and mapped to a sequence of continuous representations to decode an output signal peptide sequence based on the input protein sequence.