中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

13 records (took 0.013 seconds)

    COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS
    1.
    发明申请
    COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS 审中-公开
    包含改善神经发育障碍行为的细菌的组合物和方法

    公开(公告)号：WO2016069792A1

    公开(公告)日：2016-05-06

    申请号：PCT/US2015/057888

    申请日：2015-10-28

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： HSIAO, Elaine ,  WU, Wei-Li ,  MAZMANIAN, Sarkis, K.

    IPC: A01N63/00 ,  C12Q1/68 ,  C40B30/04

    CPC classification number: A61K35/741 ,  A61K9/0053 ,  C12Q1/6883

    Abstract: Some embodiments include probiotics for use in treatment of one or more autism spectrum disorder (ASD) or epilepsy in a subject in need thereof. The probiotics can comprise Bacteroides bacteria (e.g., B. fragilis). In some embodiments, the subject is identified in need of treatment ASD or epilepsy based a combination of behavioral symptoms and optional genetic markers. Upon treatment, one or more ASD-related behaviors are improved in the subject.

    Abstract translation: 一些实施方案包括用于治疗有需要的受试者中的一种或多种自闭症谱系障碍（ASD）或癫痫的益生菌。 益生菌可以包括拟杆菌属细菌（例如脆弱杆菌）。 在一些实施方案中，所述对象被鉴定为需要基于行为症状和任选的遗传标记的组合的治疗ASD或癫痫。 在治疗过程中，一个或多个与ASD相关的行为在主题中得到改善。

    PROBIOTIC PREVENTION AND TREATMENT OF COLON CANCER
    2.
    发明申请
    PROBIOTIC PREVENTION AND TREATMENT OF COLON CANCER 审中-公开
    预防和治疗结肠癌的预防和治疗

    公开(公告)号：WO2014182966A1

    公开(公告)日：2014-11-13

    申请号：PCT/US2014/037392

    申请日：2014-05-08

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： MAZMANIAN, Sarkis, K. ,  LEE, Yunkyung

    IPC: A61K39/02 ,  G01N33/00 ,  C07H13/00

    CPC classification number: A61K35/741 ,  A61K31/59 ,  A61K31/715 ,  A61K2300/00

    Abstract: Methods are provided herein for preventing, delaying the onset of or reducing the progression of colorectal tumorigenesis in a subject identified as at risk of colorectal tumorigenesis, comprising adjusting the composition of gut microbiota in the subject via administering to the subject a composition comprising Bacteroides bacteria or administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising zwitterionic polysaccharide (ZPS). In another aspect, methods are provided for treating or ameliorating a colorectal cancer in a subject, comprising adjusting the composition of gut microbiota in the subject having the colorectal cancer. In a further aspect, methods are provided for relieving gastrointestinal (GI) distress of a subject having a colorectal condition, comprising: determining the colorectal condition of the subject; and relieving GI distress in the subject by adjusting the composition of gut microbiota in the subject.

    Abstract translation: 本文提供了用于预防，延迟发现或减少在结肠直肠肿瘤发生风险中的受试者中结肠直肠肿瘤发生进展的发生或减少的方法，其包括通过向受试者施用包含拟杆菌属细菌或组合物的组合物来调节受试者肠道微生物群的组成 向受试者施用治疗有效量的包含两性离子多糖（ZPS）的药物组合物。 在另一方面，提供了用于治疗或改善受试者的结肠直肠癌的方法，包括调整具有结肠直肠癌的受试者中的肠微生物群的组成。 在另一方面，提供了用于减轻具有结肠直肠病症的受试者的胃肠（GI）窘迫的方法，其包括：确定受试者的结肠直肠状况; 并通过调整受试者中肠道微生物群的组成来减轻该受试者的GI痛苦。

    MODULATION OF GUT MICROBIOTA IN HUNTINGTON'S DISEASE AND RETT SYNDROME
    6.
    发明申请
    MODULATION OF GUT MICROBIOTA IN HUNTINGTON'S DISEASE AND RETT SYNDROME 审中-公开

    公开(公告)号：WO2018148220A1

    公开(公告)日：2018-08-16

    申请号：PCT/US2018/017116

    申请日：2018-02-06

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： KHOSHNAN, Ali ,  MAZMANIAN, Sarkis, K.

    IPC: A61P25/22 ,  A61P43/00 ,  C12N1/00 ,  C12N1/20 ,  C12Q1/68

    Abstract: Some embodiments herein related to methods, composition, and/or uses for reducing the likelihood of, delaying the onset of, or ameliorating one or more symptoms associated with Rett syndrome or Huntington's disease. Without being limited by theory, it is contemplated that modulation of gut microbiota can affect symptoms of Rett syndrome and Huntington's disease. Compositions or product combinations comprising, consisting essentially of, or consisting of bacteria and/or antibiotics can be administered to subject in need thereof so as to reduce the likelihood of, delay the onset of, or ameliorate the symptoms.

    COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODECELOPMENTAL DISORDERS
    7.
    发明申请
    COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODECELOPMENTAL DISORDERS 审中-公开
    包含改善神经损伤行为的细菌的组合物和方法

    公开(公告)号：WO2016069801A1

    公开(公告)日：2016-05-06

    申请号：PCT/US2015/057897

    申请日：2015-10-28

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： HSIAO, Elaine ,  MCBRIDE, Sara ,  MAZMANIAN, Sarkis, K.

    IPC: A61P25/18 ,  A61K35/74

    CPC classification number: A61K35/744 ,  A61K35/74 ,  A61K2035/115 ,  Y02A50/473 ,  A61K2300/00

    Abstract: Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiomlaomicron , and/or B. vulgatus ), and/or Enterococcus (e.g., E. faecalis, E.faecium, E. hirae, E. avium, E. durans, E. gallinarum , or E. casseliflavus ). Upon treatment, one or more ASD-related behaviors can be improved in the subject.

    Abstract translation: 一些实施方案包括用于治疗一种或多种自闭症谱系障碍（ASD）的细菌种类和/或有需要的受试者的精神分裂症症状。 细菌物种可以包括拟杆菌属（例如脆弱杆菌，B.thetaiomlaomicron和/或B. vulgatus）和/或肠球菌（例如粪肠球菌，屎肠球菌，E.hirae，禽鸟，E. durans，E. gallinarum或E. casseliflavus）。 治疗后，可以在受试者中改善一种或多种ASD相关行为。

    REGULATE GUT MICROBIOTA TO TREAT NEURODEGENERATIVE DISORDERS
    8.
    发明申请
    REGULATE GUT MICROBIOTA TO TREAT NEURODEGENERATIVE DISORDERS 审中-公开
    调节肠道微生物治疗神经退行性疾病

    公开(公告)号：WO2017205302A1

    公开(公告)日：2017-11-30

    申请号：PCT/US2017/033881

    申请日：2017-05-22

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： MAZMANIAN, Sarkis, K. ,  SAMPSON, Timothy, R.

    IPC: G01N33/569 ,  C12Q1/04 ,  A61K35/741 ,  G01N33/68

    Abstract: Disclosed herein are methods and compositions that can be used to improve motor deficits and neuroinflammation in subjects in need, for example subjects suffering from neurodegenerative disorders (e.g., Parkinson's disease). Also disclosed are methods and compositions that can be used to diagnose neurodegenerative disorders, such as Parkinson's disease.

    Abstract translation: 本文公开了可用于改善有需要的受试者（例如患有神经退行性疾病（例如帕金森病）的受试者）的运动缺陷和神经炎症的方法和组合物。 还公开了可用于诊断神经退行性病症（例如帕金森病）的方法和组合物。

    COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS
    9.
    发明申请
    COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS 审中-公开
    包含细菌的组合物和方法用于改善神经发育障碍中的行为

    公开(公告)号：WO2016069795A2

    公开(公告)日：2016-05-06

    申请号：PCT/US2015/057891

    申请日：2015-10-28

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： BAILEY, Antoinette ,  MAZMANIAN, Sarkis, K.

    IPC: A61K35/741

    CPC classification number: A61K35/741 ,  A61K35/74

    Abstract: Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The subject in need thereof can have a gut micro biota signature characteristic of an adult. The bacterial species can include Bacleroides (e.g., B.fragilis, B. thetaiomtaomicron, and/or B. vulgatus) , and/or Enterococcus ( e.g., E. faecaiis, E. faecium, E. hirae, E. avium, E . durans, E. gallinarum, or E. casseliflavus) . Upon treatment, one or more ASD-related behaviors can be improved in the subject.

    Abstract translation: 一些实施方案包括用于治疗有需要的受试者中的一种或多种自闭症谱系障碍（ASD）和/或精神分裂症症状的细菌物种。 有需要的受试者可具有成人的肠道微生物特征。 细菌种类可以包括Bacleroides（例如，B.fragilis，B.thetaiomtaomicron，和/或B. vulgatus）和/或E.coli， （例如，faecaiis，E.faecium，E.hirae，E.avium，E。durans，E. gallinarum或E.casseliflavus）。 在治疗后，该主题可以改善一项或多项ASD相关行为。

Patent Agency Ranking