公开(公告)号：WO2008021803A3

公开(公告)日：2008-04-17

申请号：PCT/US2007075314

申请日：2007-08-07

Applicant: DADE BEHRING INC ,  MILLER KERRY LYNN ,  ROBB FRANK JAY ,  GEBRIAN PETER LOUIS ,  KOVACS SANDOR LAJOS

Inventor： MILLER KERRY LYNN ,  ROBB FRANK JAY ,  GEBRIAN PETER LOUIS ,  KOVACS SANDOR LAJOS

IPC: G01N33/00

CPC classification number: G01N35/04 ,  G01N2035/0467 ,  Y10T436/11 ,  Y10T436/113332

Abstract: A method for replacing a first sample carried on a moving secondary conveyor onto a moving primary conveyor at a potential interference point while the primary conveyor is tranporting a second sample.

Abstract translation: 一种用于在主输送机运输第二样品的同时将运动的第二输送机上携带的第一样品更换到潜在干扰点处的移动主输送机上的方法。

公开(公告)号：WO2008024758A2

公开(公告)日：2008-02-28

申请号：PCT/US2007076398

申请日：2007-08-21

Applicant: DADE BEHRING INC ,  FARINA EDWARD FRANCIS ,  BUTLER RUSSELL JOHN ,  FERGUSON SAMUEL GARFIELD

Inventor： FARINA EDWARD FRANCIS ,  BUTLER RUSSELL JOHN ,  FERGUSON SAMUEL GARFIELD

IPC: G01N35/00

CPC classification number: G01N35/00 ,  G01N2035/0425 ,  G01N2035/1032 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A system for automatically testing a sample aliquot retained in temporary storage in environmentally controlled conditions on an automated clinical analyzer for a period of time without requiring operator intervention.

Abstract translation: 一种用于在自动化临床分析仪上自动测试在环境控制条件下临时存储的样品等分试样一段时间而不需要操作员干预的系统。

公开(公告)号：WO2007109495A3

公开(公告)日：2007-09-27

申请号：PCT/US2007/064047

申请日：2007-03-15

Applicant: DADE BEHRING INC. ,  HENDERSON, David, G. ,  DUNFEE, William, D. ,  WEITKAMP, Thomas, E

Inventor： HENDERSON, David, G. ,  DUNFEE, William, D. ,  WEITKAMP, Thomas, E

IPC: H01R13/62

Abstract: An improved mounting clamp adapted to simultaneously secure flat ribbon cables and a number of fluid tubes to a surface and having a locking feature to facilitate assembly and release.

公开(公告)号：WO2007062373A2

公开(公告)日：2007-05-31

申请号：PCT/US2006/061155

申请日：2006-11-21

Applicant: DADE BEHRING INC. ,  WALTERS, Jay, Mark ,  CARRIO, Jeannine, Marie ,  THOMPSON, David, Russell ,  LLOYD, Mark, Richard ,  PARMER, Jeffrey, Kenneth ,  WARWICK, Richard, Grear ,  SHIELDS, Thomas, P. ,  HUPPMAN, Lawrence, D.

Inventor： WALTERS, Jay, Mark ,  CARRIO, Jeannine, Marie ,  THOMPSON, David, Russell ,  LLOYD, Mark, Richard ,  PARMER, Jeffrey, Kenneth ,  WARWICK, Richard, Grear ,  SHIELDS, Thomas, P. ,  HUPPMAN, Lawrence, D.

IPC: G01N35/00

CPC classification number: G01N35/00663 ,  B01L3/505 ,  B01L3/52 ,  B01L2200/025 ,  B01L2300/044 ,  G01N1/38 ,  G01N35/025 ,  G01N35/1002 ,  G01N35/1004 ,  G01N2035/0444 ,  Y10T436/11

Abstract: A fluid handling system adapted to provide storage and supply of a number of liquid solutions to an automatic clinical analyzer having three different bottle-like containers, a collapsible plastic-metal-plastic pouch having a mouth-like opening, a fitment to be sealed within mouth-tike opening, a septum within the fitment, and open meal band or cap to seal the septum into the fitment.

Abstract translation: 一种流体处理系统，适于向具有三个不同瓶状容器的自动临床分析仪提供多种液体溶液的储存和供应，具有口状开口的可折叠的塑料金属塑料袋，待密封的配件 口袋开口，配件内的隔膜，以及开放的餐巾带或帽子将隔垫密封成配件。

公开(公告)号：WO2007058654A1

公开(公告)日：2007-05-24

申请号：PCT/US2005/041593

申请日：2005-11-17

Applicant: DADE BEHRING INC. ,  TENG, Zhu ,  MOORE, Jeffrey. L. ,  CRAIG, Alan, R. ,  HICKEY, Gary ,  SCHELP, Carsten ,  WEI, Tie, Quan

Inventor： TENG, Zhu ,  MOORE, Jeffrey. L. ,  CRAIG, Alan, R. ,  HICKEY, Gary ,  SCHELP, Carsten ,  WEI, Tie, Quan

IPC: G01N33/544 ,  G01N33/548 ,  G01N33/549 ,  G01N33/53 ,  C07K1/10

CPC classification number: C07K9/00 ,  A61K38/00 ,  G01N33/54393 ,  G01N33/548 ,  G01N33/549

Abstract: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.

Abstract translation: 公开了用于在用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的试剂之一包含含有多糖的固体支持物。 该方法包括在用于进行结合测定的测定培养基中包含可与多糖连接的蛋白质的可溶性化合物。 还公开了用于确定疑似含有分析物的样品中分析物的存在和/或量的方法和组合物。 所述方法包括作为试剂的固体支持物，其包含多糖和包含与多糖连接的蛋白质的可溶性化合物。

公开(公告)号：WO2006108079A8

公开(公告)日：2007-04-19

申请号：PCT/US2006012758

申请日：2006-04-05

Applicant: DADE BEHRING INC ,  CLARK DOUGLAS PAUL ,  WALTERS JAY MARK

Inventor： CLARK DOUGLAS PAUL ,  WALTERS JAY MARK

IPC: A61M37/00 ,  B65D39/00 ,  B65D41/00 ,  B65D43/00 ,  B65D47/00 ,  B65D57/00

CPC classification number: B65D51/002 ,  A61B10/0096 ,  B01L3/50825 ,  B01L2200/142 ,  B01L2200/148 ,  B01L2300/044 ,  G01N2035/00287

Abstract: A re-sealing puncturable closure for use with vials having calibration or control solutions chemicals therein adapted for use in a manner that advantageously minimizes evaporation from a solution vial prior to and subsequent to aspiration of solution therefrom.

Abstract translation: 用于具有校准或对照溶液化学品的小瓶的再密封可穿刺闭合件，其适于以有利地最小化溶液小瓶在从其中抽出溶液之前和之后的蒸发的方式使用。

公开(公告)号：WO2006009670A1

公开(公告)日：2006-01-26

申请号：PCT/US2005/020830

申请日：2005-06-09

Applicant: DADE BEHRING INC. ,  PANKRATZ, Thomas, John, Robert ,  DEVLIN, William, Jackson, Sr. ,  THOMPSON, David, Russell ,  HESSLER, William, Kirk

Inventor： PANKRATZ, Thomas, John, Robert ,  DEVLIN, William, Jackson, Sr. ,  THOMPSON, David, Russell ,  HESSLER, William, Kirk

IPC: G01N1/00

CPC classification number: G01N35/1016 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A liquid aspiration method which includes aspirating partial aliquots of liquid at a number of different depths of penetration of a pipette tip (20) into a liquid (14). The different depths (dashed lines 1-8) are selected so that partial aliquot segments are obtained throughout the entire depth of sample, optionally excluding the extreme top and bottom levels.

Abstract translation: 一种液体抽吸方法，其包括将吸液管尖端（20）穿入多个不同深度的液体的部分等分试样吸入液体（14）中。 选择不同的深度（虚线1-8），使得在样品的整个深度获得部分等分试样片段，可选地排除极限顶部和底部水平。

公开(公告)号：WO2005061482A1

公开(公告)日：2005-07-07

申请号：PCT/US2004/041691

申请日：2004-12-13

Applicant: DADE BEHRING INC. ,  ZHENG, Yi, Feng ,  YANG, Yali

Inventor： ZHENG, Yi, Feng ,  YANG, Yali

IPC: C07D317/48

CPC classification number: C07D405/12 ,  C07D317/60 ,  C07D317/64 ,  C07D403/12 ,  C07K16/44 ,  G01N33/946 ,  Y10S435/961 ,  Y10S435/975

Abstract: Methods, compositions and kits are disclosed. Enzyme conjugates of Formula (I) are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I are employed to prepare antibodies for an methylenedioxyamphetamine, a methylenedioxyethamphetamine, and/or for a methylene- dioxymethamphetamine for use in assays for the determination of an methylenedioxyamphetamine, a methyl enedioxyethamphetamine, and/or a methylene-dioxymethamphetamine. The enzyme conjugates may also be employed to screen antibodies for use in such methods.

Abstract translation: 公开了方法，组合物和试剂盒。 式（I）的酶缀合物用于测定亚甲二氧基苯丙胺，亚甲基二氧代苯丙胺和/或亚甲二氧基甲基安非他明的测定中。 式I的免疫原性缀合物用于制备用于亚甲二氧基苯丙胺，亚甲基二氧代安非他明和/或亚甲基二氧代甲基安非他明的抗体，用于测定亚甲二氧基苯丙胺，甲基烯二氧基苯乙醚和/或亚甲基二氧化甲基安非他明。 酶缀合物也可用于筛选用于这些方法的抗体。

公开(公告)号：WO2005058865A2

公开(公告)日：2005-06-30

申请号：PCT/US2004041622

申请日：2004-12-13

Applicant: DADE BEHRING INC ,  ZHENG YI FENG ,  LIU HSHIOU-TING ,  YANG YALI

Inventor： ZHENG YI FENG ,  LIU HSHIOU-TING ,  YANG YALI

IPC: A61K39/385 ,  C07D207/40 ,  C07D317/48 ,  C07D317/58 ,  C07D405/12 ,  C07K14/47 ,  C07K16/18 ,  C07K16/44 ,  C07K17/06 ,  G01N33/53 ,  G01N33/531 ,  G01N33/532 ,  G01N33/533 ,  G01N33/535 ,  G01N33/537 ,  G01N33/543 ,  G01N33/94

CPC classification number: C07D317/48 ,  C07D317/58 ,  C07D405/12 ,  C07K16/44 ,  G01N33/532 ,  G01N33/946

Abstract: Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA) and 4-hydroxy-3-methoxy-methamphetamine (HMMA). The method comprises providing in combination in a medium (i) a sample suspected of containing the compound and (ii) an antibody raised against a compound of Formula I that comprises a protein. The medium is examined for the presence a complex comprising the compound and the antibody where the presence of such as complex indicates the presence of the compound in the sample. In one aspect of the above embodiment, the combination further comprises a label conjugate of the compound Formula I.

Abstract translation: 披露了方法，组合物和试剂盒。 该方法涉及确定例如3,4-亚甲基二氧苯丙胺（MDA），3,4-亚甲二氧基 - 甲基苯丙胺（MDMA），3,4-亚甲二氧基 - 乙基安非他明（MDEA）和4- 羟基-3-甲氧基甲基苯丙胺（HMMA）。 该方法包括在介质中组合提供（i）怀疑含有化合物的样品和（ii）针对包含蛋白质的式I化合物产生的抗体。 检查培养基中是否存在包含化合物和抗体的复合物，其中诸如复合物的存在表明样品中化合物的存在。 在上述实施方案的一个方面，所述组合还包含化合物式I的标记物缀合物。

公开(公告)号：WO2005058864A1

公开(公告)日：2005-06-30

申请号：PCT/US2004/041618

申请日：2004-12-13

Applicant: DADE BEHRING INC. ,  ZHENG, Yi, Feng ,  LIU, Hshiou-ting

Inventor： ZHENG, Yi, Feng ,  LIU, Hshiou-ting

IPC: C07D317/48

CPC classification number: C07D405/12 ,  C07D317/58 ,  C07K16/44 ,  G01N33/946 ,  Y10S435/961 ,  Y10S435/975

Abstract: Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4­methylenedioxyamphetamine (MDA)3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA) and 4-hydroxy-3-methoxy­methamphetamine (HMMA). The method comprises providing in combination in a medium (i) a sample suspected of containing the compound and (ii) an antibody raised against a compound of Formula I that comprises a protein. The medium is examined for the presence a complex comprising the compound and the antibody where the presence of such as complex indicates the presence of the compound in the sample. In one aspect of the above embodiment, the combination further comprises a label conjugate of the compound Formula I.

Abstract translation: 公开了方法，组合物和试剂盒。 这些方法涉及确定存在的主要成分分析物，例如3,4-亚甲二氧基苯丙胺（MDA）3,4-亚甲二氧基 - 甲基苯丙胺（MDMA），3,4-亚甲二氧基 - 乙基苯丙胺（MDEA）和4-羟基 - 3-甲氧基甲基苯丙胺（HMMA）。 该方法包括在介质中提供（i）怀疑含有该化合物的样品和（ii）针对包含蛋白质的式I化合物产生的抗体。 检查介质是否存在包含化合物和抗体的复合物，其中诸如复合物的存在表明样品中存在化合物。 在上述实施方案的一个方面，组合还包含化合物式I的标记缀合物。