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    SAMPLING DEVICE
    1.
    发明申请
    SAMPLING DEVICE 审中-公开
    采样设备

    公开(公告)号：WO2011120004A3

    公开(公告)日：2012-03-08

    申请号：PCT/US2011030073

    申请日：2011-03-25

    Applicant: STOKES BIO LTD ,  DAVIES MARK ,  DALTON TARA ,  SAYERS MICHAEL ,  CHAWKE BRIAN

    Inventor： DAVIES MARK ,  DALTON TARA ,  SAYERS MICHAEL ,  CHAWKE BRIAN

    IPC: G01N1/10 ,  B01L3/00 ,  G01N35/10

    CPC classification number: B01L3/021 ,  B01L3/0293 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0673 ,  Y10T436/25 ,  Y10T436/25625

    Abstract: The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfludic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including an outer sheath; a plurality of tubes within the sheath, in which at least one of the tubes acquires a sample, and at least one tubes expels a fluid that is immiscible with the sample, in which the at least one tube that acquires the sample is extendable beyond a distal end of the sheath and retractable to within the sheath; and a valve connected to a distal portion of the sheath, in which the valve opens when the tube extends beyond the distal end and closes when the tube retracts to within the sheath.

    Abstract translation: 本发明一般涉及用于获取和/或分配样品而不将气体引入微流体系统（如液桥系统）中的装置，系统和方法。 示例性实施例提供了一种包括外护套的取样装置; 护套内的多个管，其中至少一个管获取样品，并且至少一个管排出与样品不混溶的流体，其中获取样品的至少一个管可以延伸超过 护套的远端并伸缩到护套内; 以及连接到所述护套的远端部分的阀，当所述管延伸超过所述远端时所述阀打开，并且当所述管缩回到所述护套内时所述阀闭合。

    DEVICES, SYSTEMS, AND METHODS FOR AMPLIFYING NUCLEIC ACIDS
    3.
    发明申请
    DEVICES, SYSTEMS, AND METHODS FOR AMPLIFYING NUCLEIC ACIDS 审中-公开
    用于放大核酸的装置，系统和方法

    公开(公告)号：WO2011119994A2

    公开(公告)日：2011-09-29

    申请号：PCT/US2011/030047

    申请日：2011-03-25

    Applicant: STOKES BIO LIMITED ,  DAVIES, Mark ,  DALTON, Tara

    Inventor： DAVIES, Mark ,  DALTON, Tara

    IPC: C12M1/38 ,  C12Q1/68

    CPC classification number: B01L7/525 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2400/0457 ,  B01L2400/0487 ,  C12Q1/6851 ,  C12Q2565/629 ,  C12Q2561/113

    Abstract: The present invention generally relates to a devices, systems, and methods for amplifying nucleic acids in flowing droplets. In certain embodiments, the invention provides a device for amplifying nucleic acids including at least one channel through which sample droplets including nucleic acids flow, in which the nucleic acids in the droplets are optically detectable while the droplets are flowing through the channel, and a plurality of temperature zones in thermal contact with the channel, in which the zones are located at different locations along the channel and the zones are separated from each other.

    Abstract translation: 本发明一般涉及用于扩散流动液滴中的核酸的装置，系统和方法。 在某些实施方案中，本发明提供了用于扩增核酸的装置，所述装置包括至少一个通道，通过该通道，包含核酸的样品液滴流过，其中液滴中的核酸在液滴流过通道时是可光学检测的， 的温度区与通道热接触，其中区域沿着通道位于不同的位置，并且区域彼此分离。

    A MICROFLUIDIC DROPLET QUEUING NETWORK
    5.
    发明申请
    A MICROFLUIDIC DROPLET QUEUING NETWORK 审中-公开
    一个微型流氓排球网络

    公开(公告)号：WO2007091229A1

    公开(公告)日：2007-08-16

    申请号：PCT/IE2007/000014

    申请日：2007-02-07

    Applicant: STOKES BIO LIMITED ,  DAVIES, Mark ,  DALTON, Tara ,  GARVEY, Julie ,  CURRAN, Kieran ,  CURTIN, Damian

    Inventor： DAVIES, Mark ,  DALTON, Tara ,  GARVEY, Julie ,  CURRAN, Kieran ,  CURTIN, Damian

    IPC: B01F13/00 ,  B01L3/00 ,  G01N35/08

    CPC classification number: B01J19/0046 ,  B01F13/0071 ,  B01F15/0201 ,  B01F15/0232 ,  B01J2219/00313 ,  B01J2219/00353 ,  B01J2219/00479 ,  B01J2219/00587 ,  B01J2219/00608 ,  B01L3/5025 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2400/0487 ,  Y10T436/25

    Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) ("aqueous phase") flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.

    Abstract translation: 多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。 室（3）连接四个端口，在使用时永久充满油（11）。 油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。 油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。 桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。 这些阶段是密度匹配的，以创造引力几乎可忽略的环境。 这导致当从毛细管尖端悬浮时，液滴（10）采用球形。 此外，质量流量的相等性等于体积流量的相等。 入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

    SAMPLING DEVICE
    9.
    发明申请
    SAMPLING DEVICE 审中-公开
    采样设备

    公开(公告)号：WO2010133965A3

    公开(公告)日：2011-05-26

    申请号：PCT/IB2010001333

    申请日：2010-05-10

    Applicant: STOKES BIO LTD ,  DAVIES MARK ,  DALTON TARA ,  SAYERS MICHAEL ,  CHAWKE BRIAN

    Inventor： DAVIES MARK ,  DALTON TARA ,  SAYERS MICHAEL ,  CHAWKE BRIAN

    IPC: B01L99/00 ,  G01N35/10

    CPC classification number: B01L3/0293 ,  B01L3/021 ,  B01L7/52 ,  B01L2200/0642

    Abstract: The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including: a sampling member (101) for acquiring or dispensing a sample; and a supply (106) of a fluid that is immiscible with the sample; in which the device is configured to provide a continuous flow of immiscible fluid enveloping the sampling member (101).

    Abstract translation: 本发明总体上涉及用于获取和/或分配样品而不将气体引入微流体系统如液桥系统的装置，系统和方法。 示例性实施例提供一种采样装置，包括：用于采集或分配样本的采样部件（101） 和与样品不混溶的流体供应源（106）; 其中所述装置被配置为提供包围所述采样构件（101）的不混溶流体的连续流。

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