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公开(公告)号：WO2012134436A1
公开(公告)日：2012-10-04
申请号：PCT/US2011/030152
申请日：2011-03-28
Applicant: FLIR SYSTEMS, INC. , DEANS, Robert , ROSE, Aimee , MCDANIEL, William , THOMPSON, Aaron , SHAULL, Steven
Inventor： DEANS, Robert , ROSE, Aimee , MCDANIEL, William , THOMPSON, Aaron , SHAULL, Steven
IPC: G01N33/58
CPC classification number: G01N21/6428 , G01N21/7703 , G01N33/52 , G01N33/94 , G01N2021/7786
Abstract: Embodiments described herein provide materials, devices, and methods relating to the determination of analytes such as drugs, toxins, explosives, other controlled substances and contraband materials, and the like. In some embodiments, the analyte may be detected in vapor phase. Some embodiments may allow for highly sensitive and essentially instantaneous detection of analytes including drugs.
Abstract translation: 本文所述的实施方案提供了与分析物如药物，毒素，爆炸物，其它受控物质和违禁物质等的测定相关的材料，装置和方法。 在一些实施方案中，可以在气相中检测分析物。 一些实施方案可以允许对包括药物在内的分析物进行高度灵敏和基本上即时的检测。
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公开(公告)号：WO2007087292A3
公开(公告)日：2007-08-02
申请号：PCT/US2007/001746
申请日：2007-01-23
Applicant: ATHERSYS, INC. , MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , MAYS, Robert W. , DEANS, Robert J. , HESS, David C. , CARROLL, James E. , BORLONGAN, Cesar V.
Inventor： MAYS, Robert W. , DEANS, Robert J. , HESS, David C. , CARROLL, James E. , BORLONGAN, Cesar V.
Abstract: The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MAPCs, in children for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.
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公开(公告)号：WO2008073173A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/019248
申请日：2007-08-31
Applicant: NOMADICS, INC. , DEANS, Robert , ROSE, Aimee , BARDON, Kevin, M. , HANCOCK, Lawrence, F. , SWAGER, Timothy, M.
Inventor： DEANS, Robert , ROSE, Aimee , BARDON, Kevin, M. , HANCOCK, Lawrence, F. , SWAGER, Timothy, M.
CPC classification number: G01N21/76 , C07D471/14 , G01N21/643 , G01N21/783 , G01N33/0057 , G01N2021/7786 , G01N2201/0221 , Y10T436/10 , Y10T436/20 , Y10T436/206664
Abstract: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.
Abstract translation: 本发明提供了与爆炸物如过氧化物或过氧化物前体以及其它物质的确定有关的一系列系统，装置和方法。 本发明的实施方案可以允许怀疑含有爆炸物（例如，过氧化物）或其它物质的样品与反应物相互作用，其中样品可能反应并引起来自反应物的光发射。 本发明的优点可以包括用于确定基于过氧化物的爆炸物的装置的简化，其中装置是便携式的，并且在一些情况下是一次性的。 其他优点可以包括制造和操作的相对容易。
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公开(公告)号：WO2007087293A3
公开(公告)日：2007-11-22
申请号：PCT/US2007001747
申请日：2007-01-23
Applicant: ATHERSYS INC , MAYS ROBERT W , DEANS ROBERT J
Inventor： MAYS ROBERT W , DEANS ROBERT J
CPC classification number: A61K35/545 , A61K38/13 , A61K45/06 , C12N5/0607 , A61K2300/00
Abstract: The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like with MAPCs, without the need for adjunctive immunosuppressive treatment.
Abstract translation: 本发明涉及用MAPCs治疗各种损伤，病症，功能障碍，疾病等，而不需要辅助免疫抑制治疗。
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公开(公告)号：WO2007087292A2
公开(公告)日：2007-08-02
申请号：PCT/US2007001746
申请日：2007-01-23
Applicant: ATHERSYS INC , MED COLLEGE GEORGIA RES INST , MAYS ROBERT W , DEANS ROBERT J , HESS DAVID C , CARROLL JAMES E , BORLONGAN CESAR V
Inventor： MAYS ROBERT W , DEANS ROBERT J , HESS DAVID C , CARROLL JAMES E , BORLONGAN CESAR V
CPC classification number: A61K35/545 , A61K38/13 , A61K45/06 , C12N5/0607 , A61K2300/00
Abstract: The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MAPCs, in children for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.
Abstract translation: 本发明涉及用MAPCs治疗各种各样的损伤，疾病，功能障碍，疾病等，特别是在某些方面，治疗由缺氧导致的缺氧症，包括由全身缺氧引起的，以及由 血液供应不足 在一些进一步的细节中，本发明涉及例如在儿童中用MAPC治疗缺氧缺血性脑损伤，以及例如在成人中用MAPC治疗皮层梗死和中风。
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Patent Agency Ranking
公开(公告)号：WO2018102740A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064299
申请日：2017-12-01
Applicant: RUBIUS THERAPEUTICS, INC. , DEANS, Robert, J. , ELLOUL, Sivan , DOWDEN, Nathan
Inventor： DEANS, Robert, J. , ELLOUL, Sivan , DOWDEN, Nathan , KAHVEJIAN, Avak , MATA-FINK, Jordi
Abstract: The present disclosure provides, e.g., compositions and method for treating cancers, e.g., solid tumors. In embodiments, the compositions comprise an erythroid cell expressing an exogenous polypeptide, e.g., a polypeptide that promotes penetration of the erythroid cell into the solid tumor.
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公开(公告)号：WO2017127123A1
公开(公告)日：2017-07-27
申请号：PCT/US2016/017848
申请日：2016-02-12
Applicant: ABT HOLDING COMPANY , KATHOLIEKE UNIVERSITEIT LEUVEN , LUTTON, Aernout , DEANS, Robert, J.
Inventor： LUTTON, Aernout , DEANS, Robert, J.
IPC: C12N5/07
CPC classification number: A61K35/28 , A01K2207/12 , A61K9/0014 , A61K9/0019 , A61K35/12 , C12N5/0607
Abstract: The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.
Abstract translation: 本发明提供了通过应用如本申请所述的细胞来治疗伤口的方法。 在一个方面，该方法提供了对皮肤伤口的治疗。 在一般的实施方案中，细胞被递送到伤口而不被附着到递送载体中的功能化基底。
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公开(公告)号：WO2014169277A1
公开(公告)日：2014-10-16
申请号：PCT/US2014/034015
申请日：2014-04-14
Applicant: LAFRANCESCA, Saverio , TING, Anthony P. , DEANS, Robert J.
Inventor： LAFRANCESCA, Saverio , TING, Anthony P. , DEANS, Robert J.
IPC: A61K35/12
CPC classification number: A61K35/12
Abstract: The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo , the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.
Abstract translation: 本发明提供了改善器官移植成功的方法和组合物。 所述方法和组合物旨在将移植前，期间和/或之后所需器官暴露于干细胞。 在一个实施方案中，干细胞减少缺血对指定要收获的用于移植或已经收获用于移植的器官的有害作用。 在体外灌注指定用于移植的器官的另一个实施方案中，该方法涉及通过用含有干细胞的培养基灌注器官来减少缺血再灌注损伤。
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公开(公告)号：WO2008073173A3
公开(公告)日：2008-12-31
申请号：PCT/US2007019248
申请日：2007-08-31
Applicant: NOMADICS INC , DEANS ROBERT , ROSE AIMEE , BARDON KEVIN M , HANCOCK LAWRENCE F , SWAGER TIMOTHY M
Inventor： DEANS ROBERT , ROSE AIMEE , BARDON KEVIN M , HANCOCK LAWRENCE F , SWAGER TIMOTHY M
IPC: G01N21/77
CPC classification number: G01N21/76 , C07D471/14 , G01N21/643 , G01N21/783 , G01N33/0057 , G01N2021/7786 , G01N2201/0221 , Y10T436/10 , Y10T436/20 , Y10T436/206664
Abstract: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.
Abstract translation: 本发明提供了一系列与爆炸物的测定相关的系统，装置和方法，例如过氧化物或过氧化物前体以及其他物质。 本发明的实施方案可以允许怀疑含有爆炸物（例如，过氧化物）或其它物质的样品与反应物相互作用，其中样品可能反应并引起来自反应物的光发射。 本发明的优点可以包括用于确定基于过氧化物的爆炸物的装置的简化，其中装置是便携式的，并且在一些情况下是一次性的。 其他优点可以包括制造和操作的相对容易。
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公开(公告)号：WO2008121124A1
公开(公告)日：2008-10-09
申请号：PCT/US2007/018722
申请日：2007-08-24
Applicant: NOMADICS, INC. , DEANS, Robert , ROSE, Aimee , O'DELL, Brian, Dwyane , LA GRONE, Marcus, J.
Inventor： DEANS, Robert , ROSE, Aimee , O'DELL, Brian, Dwyane , LA GRONE, Marcus, J.
CPC classification number: G01N21/766 , G01N33/0057 , G01N2201/0221
Abstract: The current invention provides a detector and method suitable for sensing vapor- phase hydrogen peroxide. The detector utilizes a chemiluminescent material comprising a peroxide reactive compound, a dye and a solvent. Upon reaction with hydrogen peroxide, the chemiluminescent material will generate detectible light.
Abstract translation: 本发明提供了一种适用于检测气相过氧化氢的检测器和方法。 检测器使用包含过氧化物反应性化合物，染料和溶剂的化学发光材料。 当与过氧化氢反应时，化学发光材料将产生可检测的光。
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