公开(公告)号：WO2004057014A3

公开(公告)日：2005-08-11

申请号：PCT/US0340566

申请日：2003-12-19

Applicant: NOMADICS INC ,  DEANS ROBERT ,  HANCOCK LAWRENCE F ,  MOON JOONG HO

Inventor： DEANS ROBERT ,  HANCOCK LAWRENCE F ,  MOON JOONG HO

IPC: C08G63/48 ,  C09K11/06 ,  C12M1/34 ,  C12Q20060101 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/6845 ,  B01J2219/00497 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00729 ,  C09K11/06 ,  C09K2211/1425 ,  C12Q1/37

Abstract: The present invention involves a series of articles, compositions, methods, and kits. Some aspects of the invention include articles such as particles, sols, blends, dispersions, films, or microarrays that comprise luminescent polymers, as well as methods for making and using such articles. In some cases, the luminescent polymer may be characterized in part by having a delocalized pi-orbital structure, which can allow the polymer to have a high degree of luminosity. The polymers of this invention may also have, in some embodiments, bulky substituents to prevent intermolecular pi-pi interactions that can decrease luminosity. Some articles may include more than one luminescent polymer, for example, a first polymer that absorbs energy and directs the energy to a second polymer that releases the energy. The articles of the invention may be used, in certain embodiments, to detect the presence of other compounds such as single molecules, proteins, or specific nucleic acid sequences, as well as cells, bacteria, and viruses. In one set of embodiments, the luminescent polymers are associated with an entity that can interact with, for example, a nucleic acid or a protein. The association may be direct, or through an energy transfer pathway. The entity can be, for example, a nucleic acid, a charged surface, an intercalating agent, or an entity that releases a quenching agent that interacts with the luminescent polymer.

Abstract translation: 本发明涉及一系列制品，组合物，方法和试剂盒。 本发明的一些方面包括诸如包含发光聚合物的颗粒，溶胶，共混物，分散体，膜或微阵列的制品，以及制备和使用这些制品的方法。 在一些情况下，发光聚合物的特征在于部分通过具有离域π轨道结构，其可以使聚合物具有高度的亮度。 在一些实施方案中，本发明的聚合物还可具有大体积的取代基以防止可降低亮度的分子间pi-π相互作用。 一些制品可以包括多于一种的发光聚合物，例如吸收能量并将能量引导到释放能量的第二聚合物的第一聚合物。 在某些实施方案中，可以使用本发明的制品来检测其它化合物如单分子，蛋白质或特定核酸序列以及细胞，细菌和病毒的存在。 在一组实施方案中，发光聚合物与可与例如核酸或蛋白质相互作用的实体缔合。 该协会可以是直接的，也可以是通过能量转移途径。 该实体可以是例如核酸，带电表面，嵌入剂或释放与发光聚合物相互作用的猝灭剂的实体。

公开(公告)号：WO2004057014A2

公开(公告)日：2004-07-08

申请号：PCT/US2003/040566

申请日：2003-12-19

Applicant: NOMADICS, INC. ,  DEANS, Robert ,  HANCOCK, Lawrence, F. ,  MOON, Joong, Ho

Inventor： DEANS, Robert ,  HANCOCK, Lawrence, F. ,  MOON, Joong, Ho

IPC: C12Q

CPC classification number: G01N33/6845 ,  B01J2219/00497 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00729 ,  C09K11/06 ,  C09K2211/1425 ,  C12Q1/37

Abstract: The present invention involves a series of articles, compositions, methods, and kits. Some aspects of the invention include articles such as particles, sols, blends, dispersions, films, or microarrays that comprise luminescent polymers, as well as methods for making and using such articles. In some cases, the luminescent polymer may be characterized in part by having a delocalized π-orbital structure, which can allow the polymer to have a high degree of luminosity. The polymers of this invention may also have, in some embodiments, bulky substituents to prevent intermolecular π-π interactions that can decrease luminosity. Some articles may include more than one luminescent polymer, for example, a first polymer that absorbs energy and directs the energy to a second polymer that releases the energy. The articles of the invention may be used, in certain embodiments, to detect the presence of other compounds such as single molecules, proteins, or specific nucleic acid sequences, as well as cells, bacteria, and viruses. In one set of embodiments, the luminescent polymers are associated with an entity that can interact with, for example, a nucleic acid or a protein. The association may be direct, or through an energy transfer pathway. The entity can be, for example, a nucleic acid, a charged surface, an intercalating agent, or an entity that releases a quenching agent that interacts with the luminescent polymer.

Abstract translation: 本发明涉及一系列制品，组合物，方法和试剂盒。 本发明的一些方面包括诸如包含发光聚合物的颗粒，溶胶，共混物，分散体，膜或微阵列的制品，以及制备和使用这些制品的方法。 在一些情况下，发光聚合物的特征在于部分通过具有离域π轨道结构，其可以使聚合物具有高度的亮度。 在一些实施方案中，本发明的聚合物还可具有大体积的取代基以防止可降低亮度的分子间pi-π相互作用。 一些制品可以包括多于一种的发光聚合物，例如吸收能量并将能量引导到释放能量的第二聚合物的第一聚合物。 在某些实施方案中，可以使用本发明的制品来检测其它化合物如单分子，蛋白质或特定核酸序列以及细胞，细菌和病毒的存在。 在一组实施方案中，发光聚合物与可与例如核酸或蛋白质相互作用的实体缔合。 该协会可以是直接的，也可以是通过能量转移途径。 该实体可以是例如核酸，带电表面，嵌入剂或释放与发光聚合物相互作用的猝灭剂的实体。

公开(公告)号：WO2008073173A3

公开(公告)日：2008-12-31

申请号：PCT/US2007019248

申请日：2007-08-31

Applicant: NOMADICS INC ,  DEANS ROBERT ,  ROSE AIMEE ,  BARDON KEVIN M ,  HANCOCK LAWRENCE F ,  SWAGER TIMOTHY M

Inventor： DEANS ROBERT ,  ROSE AIMEE ,  BARDON KEVIN M ,  HANCOCK LAWRENCE F ,  SWAGER TIMOTHY M

IPC: G01N21/77

CPC classification number: G01N21/76 ,  C07D471/14 ,  G01N21/643 ,  G01N21/783 ,  G01N33/0057 ,  G01N2021/7786 ,  G01N2201/0221 ,  Y10T436/10 ,  Y10T436/20 ,  Y10T436/206664

Abstract: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.

Abstract translation: 本发明提供了一系列与爆炸物的测定相关的系统，装置和方法，例如过氧化物或过氧化物前体以及其他物质。 本发明的实施方案可以允许怀疑含有爆炸物（例如，过氧化物）或其它物质的样品与反应物相互作用，其中样品可能反应并引起来自反应物的光发射。 本发明的优点可以包括用于确定基于过氧化物的爆炸物的装置的简化，其中装置是便携式的，并且在一些情况下是一次性的。 其他优点可以包括制造和操作的相对容易。

公开(公告)号：WO2008073173A2

公开(公告)日：2008-06-19

申请号：PCT/US2007/019248

申请日：2007-08-31

Applicant: NOMADICS, INC. ,  DEANS, Robert ,  ROSE, Aimee ,  BARDON, Kevin, M. ,  HANCOCK, Lawrence, F. ,  SWAGER, Timothy, M.

Inventor： DEANS, Robert ,  ROSE, Aimee ,  BARDON, Kevin, M. ,  HANCOCK, Lawrence, F. ,  SWAGER, Timothy, M.

CPC classification number: G01N21/76 ,  C07D471/14 ,  G01N21/643 ,  G01N21/783 ,  G01N33/0057 ,  G01N2021/7786 ,  G01N2201/0221 ,  Y10T436/10 ,  Y10T436/20 ,  Y10T436/206664

Abstract: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.

Abstract translation: 本发明提供了与爆炸物如过氧化物或过氧化物前体以及其它物质的确定有关的一系列系统，装置和方法。 本发明的实施方案可以允许怀疑含有爆炸物（例如，过氧化物）或其它物质的样品与反应物相互作用，其中样品可能反应并引起来自反应物的光发射。 本发明的优点可以包括用于确定基于过氧化物的爆炸物的装置的简化，其中装置是便携式的，并且在一些情况下是一次性的。 其他优点可以包括制造和操作的相对容易。