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    METHOD OF DETERMINING LYMPH NODE METASTASIS
    4.
    发明申请
    METHOD OF DETERMINING LYMPH NODE METASTASIS 审中-公开
    确定淋巴结节段转移的方法

    公开(公告)号：WO2008032323A2

    公开(公告)日：2008-03-20

    申请号：PCT/IL2007/001131

    申请日：2007-09-11

    Applicant: SENG ENTERPRISES LTD. ,  ZURGIL, Naomi ,  DEUTSCH, Mordechai

    Inventor： ZURGIL, Naomi ,  DEUTSCH, Mordechai

    IPC: G01N33/50

    CPC classification number: G01N33/57415 ,  G01N2333/70582 ,  G01N2333/96486

    Abstract: A method of determining lymph node metastasis in a subject is disclosed, comprising determining at least one structural or functional parameter of a lymph node cell of a lymph node tissue of the subject, wherein an alteration in the at least one structural or functional parameter with respect to a lymph node cell of a healthy lymph node tissue is indicative of lymph node metastasis. Kits and articles of manufacture are also disclosed for determining lymph node metastasis in a subject as well as methods of diagnosing cancer in general.

    Abstract translation: 公开了确定受试者的淋巴结转移的方法，包括确定受试者的淋巴结组织的淋巴结细胞的至少一个结构或功能参数，其中at 关于健康淋巴结组织的淋巴结细胞的至少一个结构或功能参数指示淋巴结转移。 还公开了用于确定受试者的淋巴结转移的试剂盒和制品以及一般诊断癌症的方法。

    SUBSTANTIALLY INVISIBLE THREE-DIMENSIONAL STRUCTURE FOR THE STUDY OF CELLS
    7.
    发明申请
    SUBSTANTIALLY INVISIBLE THREE-DIMENSIONAL STRUCTURE FOR THE STUDY OF CELLS 审中-公开
    实质研究细胞的三维结构

    公开(公告)号：WO2007074449A3

    公开(公告)日：2007-11-15

    申请号：PCT/IL2006001487

    申请日：2006-12-26

    Applicant: SENG ENTPR LTD ,  DEUTSCH MORDECHAI ,  DEUTSCH ASSAF

    Inventor： DEUTSCH MORDECHAI ,  DEUTSCH ASSAF

    IPC: G01N33/50 ,  B01L3/00 ,  C12M3/00

    CPC classification number: B01L3/5085 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/12 ,  G01N33/5005

    Abstract: A device (10) for the study of cells comprising a structure (18) with an index of refraction similar to that of water having a three-dimensional arrangement of fluid channels is disclosed. Also disclosed is a method for studying cells comprising seeding a structure (18) with an index of refraction similar to that of water having a three-dimensional arrangement of fluid channels with viable cells, immersing the structure (18) in a physiological medium (14), and observing the development of the seeded cells inside the structure.

    Abstract translation: 公开了一种用于研究细胞的装置（10），其包括具有类似于具有流体通道的三维布置的水的折射率的结构（18）。 还公开了一种用于研究细胞的方法，包括将折射率类似于具有活细胞的三维排列流体通道的水的结构（18）接种，将结构（18）浸入生理介质（14） ），观察结构内种子细胞的发育情况。

    DEVICE FOR THE STUDYING INDIVIDUAL CELLS
    8.
    发明申请
    DEVICE FOR THE STUDYING INDIVIDUAL CELLS 审中-公开
    研究个体细胞的装置

    公开(公告)号：WO2006080000A1

    公开(公告)日：2006-08-03

    申请号：PCT/IL2005/000801

    申请日：2005-07-26

    Applicant: SENG ENTERPRISES LTD. ,  DEUTSCH, Mordechai

    Inventor： DEUTSCH, Mordechai

    IPC: B01J19/00

    CPC classification number: B01L3/502715 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00495 ,  B01J2219/00743 ,  B01L3/5027 ,  B01L2200/0668 ,  B01L2300/045 ,  B01L2300/0822 ,  B01L2300/0887 ,  B01L2400/0406

    Abstract: A device for the study individual cells including a picowell array (such as an array of microwells, dimples, depressions, tubes or enclosures) and a fluid reservoir in fluid communication with the picowells through channels is disclosed. Preferably, the device has a movable lid that in one rest location allows loading of cells into the picowell array. Preferably the channels of the device are capillary channels. Also disclosed is a device for the automated study of cells including a picowell-bearing device having a picowell array with a movable lid, a lid-moving component, at least one solution dispensing component and a control system functionally associated with the lid-moving component as well as with the solution dispensing component.

    Abstract translation: 公开了一种用于研究包括皮窝阵列（例如微孔，凹坑，凹陷，管或外壳阵列）的单个电池的装置以及通过通道与皮筒流体连通的流体储存器。 优选地，该装置具有可移动盖，其在一个静止位置允许将细胞装载到皮条阵列中。 优选地，装置的通道是毛细通道。 还公开了一种用于自动研究细胞的装置，包括具有带有可移动盖的皮克阵列的带皮单元装置，盖运动部件，至少一个溶液分配部件和与盖运动部件功能相关的控制系统 以及溶液分配组件。

    MEASUREMENTS OF ENZYMATIC ACTIVITY IN A SINGLE, INDIVIDUAL CELL IN POPULATION
    9.
    发明申请
    MEASUREMENTS OF ENZYMATIC ACTIVITY IN A SINGLE, INDIVIDUAL CELL IN POPULATION 审中-公开
    人口中单个个体细胞的酶活性测定

    公开(公告)号：WO0188176A3

    公开(公告)日：2002-04-11

    申请号：PCT/IL0100443

    申请日：2001-05-17

    Applicant: UNIV BAR ILAN ,  SUNRAY MERAV ,  ZURGIL NAOMI ,  DEUTSCH MORDECHAI

    Inventor： SUNRAY MERAV ,  ZURGIL NAOMI ,  DEUTSCH MORDECHAI

    IPC: G01N21/77 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/37 ,  C12Q1/44 ,  C12Q1/527 ,  G01N21/78 ,  C12Q1/54

    CPC classification number: C12Q1/00

    Abstract: A process for measuring enzymatic activity in an identified, isolated, intact, single, viable cell. Each of the viable cells is placed within individual identified locations on a carrier of a cytometer having means to measure enzymatic activity of a single viable cell placed in an identified location. The identified isolated cell is exposed to a substrate of an enzyme to be measured, and the rate of product formed or released following every exposure of the cell to same or different concentrations of the substrate is measured. The isolated cell may be exposed to a sequence of at least two different concentrations of the substrate, and for each exposure the rate of product formed or released is measured. Figure (1) is a model of intracellular conversion of a substrate to a product.

    Abstract translation: 用于测定鉴定的，分离的，完整的，单一的，活细胞中的酶活性的方法。 将每个活细胞放置在具有测量置于识别位置的单个活细胞的酶活性的方法的细胞计数器载体上的个体识别位置内。 将所鉴定的分离的细胞暴露于要测量的酶的底物，并测量每次细胞暴露于相同或不同浓度的底物后形成或释放的产物的速率。 分离的细胞可以暴露于至少两种不同浓度的底物的序列，并且对于每次暴露，测量形成或释放的产物的速率。 图（1）是将底物转化成产物的模型。

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