公开(公告)号：WO1989012756A1

公开(公告)日：1989-12-28

申请号：PCT/JP1989000590

申请日：1989-06-13

Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO ,  KUBOMOTO, Wataru ,  DOI, Kazuyuki

Inventor： KABUSHIKI KAISHA KOBE SEIKO SHO

IPC: F15B11/16

CPC classification number: E02F9/2296 ,  E02F9/2239 ,  E02F9/2292 ,  F15B11/17 ,  F15B2211/20553 ,  F15B2211/20576 ,  F15B2211/30595 ,  F15B2211/3116 ,  F15B2211/329 ,  F15B2211/355 ,  F15B2211/36 ,  F15B2211/40515 ,  F15B2211/41554 ,  F15B2211/428 ,  F15B2211/46 ,  F15B2211/67 ,  F15B2211/7142 ,  F15B2211/78

Abstract: This fluid control mechanism has a divergent flow selecting valve means (52) adapted to change pressure fluid admission passages extending from two main pumps (40), (50) to two control valve groups (60), (70), and also confluent selecting valve means (80), (90) adapted to introduce the pressure fluid sent into each control valve group into a working apparatus control valve in the other control valve group. The confluent selecting valve means (80) in a group to which a working apparatus control valve (62), which is required to compensate for an admission rate of the fluid, belongs cancels the confluent function in accordance with an operating signal for the same working apparatus control valve. This mechanism also has a means for limiting the spool stroke of a working apparatus control valve (160) in which a load varies, this means being adapted to introduce a discharged fluid from an actuator into the same actuator again when the load is small. This mechanism further has a sequence valve (170) adapted to operate a spool stroke limiting means (190) in accordance with a primary pilot pressure.

公开(公告)号：WO1994028022A1

公开(公告)日：1994-12-08

申请号：PCT/JP1994000832

申请日：1994-05-25

Applicant: HOECHST JAPAN LIMITED ,  KIMURA, Michio ,  DOI, Kazuyuki

Inventor： HOECHST JAPAN LIMITED

IPC: C07K15/06

CPC classification number: C07K14/475 ,  C07K14/4702 ,  Y10S930/12

Abstract: A protein having a molecular weigth of about 200 kDa as determined by SDS-PAGE conducted under reductive conditions and an amino acid sequence represented by Sequence Listing (1) at the terminal, in particular, a protein originating in an animal brain and having an avidity with heparin-binding growth factors, e.g., OSF-1. The protein is useful as a remedy for disorders of nerve functions or osteogenetic ability, because it combines with OSF-1 (HBGF-8), one of the heparin-binding growth factors having the activities of promoting neuron differentiation and proliferating osteoblasts, to thereby control the action of OSF-1.

Abstract translation: 通过在还原条件下进行的SDS-PAGE测定的分子量约为200kDa的蛋白质和末端由序列表（1）表示的氨基酸序列，特别是源自动物脑并具有亲和力的蛋白质 与肝素结合生长因子，例如OSF-1。 该蛋白质可用作神经功能障碍或成骨能力的障碍，因为它与具有促进神经元分化和增殖成骨细胞活性的肝素结合生长因子之一的OSF-1（HBGF-8）结合，从而 控制OSF-1的动作。

公开(公告)号：WO1997043235A1

公开(公告)日：1997-11-20

申请号：PCT/JP1997001625

申请日：1997-05-14

Applicant: HOECHST PHARMACEUTICALS & CHEMICALS K.K. ,  SAKAI, Kunikazu ,  SATOH, Yusuke ,  DOI, Kazuyuki ,  KITAMURA, Kazuyuki

Inventor： HOECHST PHARMACEUTICALS & CHEMICALS K.K.

IPC: C07C49/713

CPC classification number: C07C49/84 ,  C07C45/00 ,  C07C45/46 ,  C07C45/512 ,  C07C45/62 ,  C07C45/68 ,  C07C45/71 ,  C07C49/713 ,  C07C49/743 ,  C07C49/747 ,  C07C49/825 ,  C07C49/83 ,  C07C49/835

Abstract: Compounds useful as preventive and therapeutic agents for bone and cartilage diseases; and drug compositions containing the same. The compounds are polyhydroxyphenol derivatives of general formula (I) and quinone analogues derived therefrom (wherein R1 is alkyl, optionally substituted benzyl or optionally substituted aryl; R2 is hydrogen, alkyl, alkenyl or optionally substituted benzyl; R3 is hydrogen, alkyl, alkenyl, optionally substituted benzyl, hydroxyl, alkoxy, alkenyloxy or optionally substituted benzyloxy; R4 is hydrogen, alkyl, alkenyl, optionally substituted benzyl or hydroxyl; and R5 and R6 are each independently hydrogen, alkyl, alkenyl or optionally substituted benzyl). The polyhydroxyphenol derivatives and the quinone analogues exhibit a potent inhibitory activity against bone resorption and are useful as preventive and therapeutic agents for bone and cartilage diseases.

Abstract translation: 用作骨和软骨疾病的预防和治疗剂的化合物; 和含有它们的药物组合物。 化合物是通式（I）的多羟基苯酚衍生物和由其衍生的醌类似物（其中R1是烷基，任选取代的苄基或任选取代的芳基; R 2是氢，烷基，烯基或任选取代的苄基; R 3是氢，烷基，烯基， 任选取代的苄基，羟基，烷氧基，烯氧基或任选取代的苄氧基; R 4是氢，烷基，烯基，任选取代的苄基或羟基;且R 5和R 6各自独立地为氢，烷基，烯基或任选取代的苄基。 多羟基苯酚衍生物和醌类似物表现出对骨吸收的有效抑制活性，并且可用作骨和软骨疾病的预防和治疗剂。