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公开(公告)号：WO2010123534A9
公开(公告)日：2010-12-16
申请号：PCT/US2010000104
申请日：2010-01-15
申请人： RENSSELAER POLYTECH INST , DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU , DANISCO US INC
发明人： DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU
IPC分类号： C12N11/14
CPC分类号： C12N11/14 , A01N59/00 , A01N63/02 , B82Y5/00 , C08K3/041 , C08K3/34 , C08K9/04 , C09D5/025 , C09D5/14 , C09D7/62 , C09D7/67 , C09D7/70 , C11D3/38636 , C12N9/18 , A01N25/10 , A01N25/34 , A01N37/16
摘要： The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.
摘要翻译： 本发明涉及去污复合材料，以及包含该复合材料的方法，组合物和试剂盒。 在一些方面，本发明涉及一种去污复合材料，其包含与碳纳米管缔合的过水解酶，其可用于生产过酸。
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公开(公告)号：WO2007001355A2
公开(公告)日：2007-01-04
申请号：PCT/US2005/031652
申请日：2005-09-07
申请人： RENSSELAER POLYTECHNIC INSTITUTE , DORDICK, Jonathan, S. , KANE, Ravindra, S. , ASURI, Prashanth , KARAJANAGI, Sandeep, S.
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/001 , G01N33/587 , G01N33/588
摘要： This invention is directed to the application of a previously unknown property of nanomaterials - its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions. The enhanced stability is also exploited in the preparation of highly stable and active nanocomposite films that resist nonspecific protein absorption, i.e., inhibit fouling of the films. The protein-nanoparticles conjugates represent a new generation of highly selective, active, and stable catalytic materials. Furthermore, the ability to enhance protein function by interfacing them with nanomaterials has a profound impact on applications ranging from biosensing, diagnostics, vaccines, drug delivery, and biochips, to novel hybrid materials that integrate biotic and abiotic components.
摘要翻译： 本发明涉及以前未知的纳米材料性质的应用 - 其在高温下，在有机溶剂中和在聚合物复合材料中增强蛋白质活性和稳定性的能力。 纳米材料如单壁碳纳米管（SWNT）可以显着增强强力变性环境中的酶功能和稳定性。 实验结果和理论分析表明，稳定性的提高是这些纳米材料的曲率的结果，其抑制不利的蛋白质 - 蛋白质相互作用。 增强的稳定性也被用于制备高度稳定和活性的纳米复合膜，其抵抗非特异性蛋白质吸收，即抑制膜的结垢。 蛋白质 - 纳米颗粒共轭体代表新一代高选择性，活性和稳定的催化材料。 此外，通过与纳米材料接口来增强蛋白质功能的能力对从生物传感，诊断，疫苗，药物递送和生物芯片到包含生物和非生物成分的新型杂交材料的应用具有深远的影响。
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公开(公告)号：WO2011154829A2
公开(公告)日：2011-12-15
申请号：PCT/IB2011/001401
申请日：2011-06-20
申请人： RENSSELAER POLYTECHNIC INSTITUTE , MIYAUCHI, Minoru , MIAO, Jianjun , SIMMONS, Trevor, J. , LEE, Jong-Won , DOHERTY, Thomas, V. , DORDICK, Jonathan, S. , LINHARDT, Robert, J.
发明人： MIYAUCHI, Minoru , MIAO, Jianjun , SIMMONS, Trevor, J. , LEE, Jong-Won , DOHERTY, Thomas, V. , DORDICK, Jonathan, S. , LINHARDT, Robert, J.
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose- sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译： 本发明的实施方案提供一种纤维素包覆的碳纳米管纤维。 本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。 本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。
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4.发明申请BIOCATALYTIC METHODS FOR SYNTHESIZING AND IDENTIFYING BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开用于合成和鉴定生物活性化合物的生物化学方法
公开(公告)号：WO1997010233A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014573
申请日：1996-09-11
IPC分类号： C07D305/00
CPC分类号： C07D493/04 , C07D305/14 , C07H13/06 , C07H13/08 , C07H13/10 , C07H15/18 , C07H15/26 , C07H17/04 , C07H17/08 , C07H19/16
摘要： The invention is in the field of biologically active compounds such as taxol-2'-adipate derivatives, derivatives of bergenin and erythromycin derivatives. Taxol-2'-adipate derivatives have anti-cancer activity analogous to taxol. Bergenin derivatives have angiotensin converting enzyme inhibiting activity, and are therefore useful in the treatment of hypertension. Erythromycin derivatives are useful as antibiotics.
摘要翻译： 本发明涉及生物活性化合物如紫杉醇-2'-己二酸衍生物，白麦烯和红霉素衍生物的衍生物领域。 紫杉醇-2'-己二酸衍生物具有类似于紫杉醇的抗癌活性。 贝格宁衍生物具有血管紧张素转换酶抑制活性，因此可用于治疗高血压。 红霉素衍生物可用作抗生素。
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公开(公告)号：WO2010123534A3
公开(公告)日：2011-02-10
申请号：PCT/US2010000104
申请日：2010-01-15
申请人： RENSSELAER POLYTECH INST , DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU , DANISCO US INC
发明人： DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU
IPC分类号： C12N11/14
CPC分类号： C12N11/14 , A01N59/00 , A01N63/02 , B82Y5/00 , C08K3/041 , C08K3/34 , C08K9/04 , C09D5/025 , C09D5/14 , C09D7/62 , C09D7/67 , C09D7/70 , C11D3/38636 , C12N9/18 , A01N25/10 , A01N25/34 , A01N37/16
摘要： The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.
摘要翻译： 本发明涉及去污复合材料，以及包含其的方法，组合物和试剂盒。 在一些方面，本发明涉及一种去污复合材料，其包含与碳纳米管缔合的过水解酶，其可用于生产过酸。
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公开(公告)号：WO2010123534A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/000104
申请日：2010-01-15
申请人： RENSSELAER POLYTECHNIC INSTITUTE , DINU, Cerasela, Zoica , DORDICK, Jonathan, S. , KANE, Ravindra, S. , SANFORD, Karl , WHITED, Gregory, M. , ZHU, Guangyu , DANISCO US INC.
发明人： DINU, Cerasela, Zoica , DORDICK, Jonathan, S. , KANE, Ravindra, S. , SANFORD, Karl , WHITED, Gregory, M. , ZHU, Guangyu
IPC分类号： C12N11/14
CPC分类号： C12N11/14 , A01N59/00 , A01N63/02 , B82Y5/00 , C08K3/041 , C08K3/34 , C08K9/04 , C09D5/025 , C09D5/14 , C09D7/62 , C09D7/67 , C09D7/70 , C11D3/38636 , C12N9/18 , A01N25/10 , A01N25/34 , A01N37/16
摘要： The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.
摘要翻译： 本发明涉及去污染复合材料，以及包含其的方法，组合物和试剂盒。 在一些方面，本发明涉及一种净化复合物，其包含与碳纳米管结合的过水解酶，其可用于生产过酸。
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7.发明申请
公开(公告)号：WO2007053561A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/042345
申请日：2006-10-31
申请人： RENSSELAER POLYTECHNIC INSTITUTE , LEE, Moo-Yeal , KUMAR, R., Anand , CLARK, Douglas, S. , DORDICK, Jonathan, S.
CPC分类号： G01N33/5014 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/0065 , B01J2219/00659 , B01J2219/00664 , B01J2219/00743 , C12N2503/00 , C12N2533/54
摘要： The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate.
摘要翻译： 本发明涉及采用小型化三维细胞芯片用于测试和引导化合物，前药，药物和P-450产生的药物代谢物的高通量毒理学筛选的筛选平台。 为此，三维细胞芯片采用封装在矩阵（例如，胶原或藻酸胶体）中的人体细胞，其体积小于排列在官能化底物（例如，玻璃显微镜载玻片）上的10nL，用于空间可寻址筛选 多种试验化合物。 利用目前的平台，可以发现超过3,000个细胞基质岛可以同时筛选多个剂量的多种化合物和高度复制。
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公开(公告)号：WO2011154829A3
公开(公告)日：2012-06-07
申请号：PCT/IB2011001401
申请日：2011-06-20
申请人： RENSSELAER POLYTECH INST , MIYAUCHI MINORU , MIAO JIANJUN , SIMMONS TREVOR J , LEE JONG-WON , DOHERTY THOMAS V , DORDICK JONATHAN S , LINHARDT ROBERT J
发明人： MIYAUCHI MINORU , MIAO JIANJUN , SIMMONS TREVOR J , LEE JONG-WON , DOHERTY THOMAS V , DORDICK JONATHAN S , LINHARDT ROBERT J
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose- sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译： 本发明的实施方案提供一种纤维素包覆的碳纳米管纤维。 本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。 本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。
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公开(公告)号：WO2011028668A4
公开(公告)日：2011-09-09
申请号：PCT/US2010047183
申请日：2010-08-30
CPC分类号： C08B37/0063 , C08B37/0003 , C12P19/26
摘要： A method for the production of heparosan from fermentation culture of E. coli K5 suitable for industrial production, exhibiting superior yield and purity, smaller culture volumes, faster growth, and lower costs.
摘要翻译： 一种适用于工业生产的大肠杆菌K5发酵培养生产肝素的方法，具有优异的产量和纯度，较小的培养体积，更快的生长和更低的成本。
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公开(公告)号：WO2011028668A3
公开(公告)日：2011-03-10
申请号：PCT/US2010/047183
申请日：2010-08-30
摘要： A method for the production of heparosan from fermentation culture of E. coli K5 suitable for industrial production, exhibiting superior yield and purity, smaller culture volumes, faster growth, and lower costs.
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