公开(公告)号：WO2007041362A1

公开(公告)日：2007-04-12

申请号：PCT/US2006/038181

申请日：2006-09-28

Applicant: NOVARTIS AG ,  MACHAJEWSKI, Timothy, D. ,  SHAFER, Cynthia, M. ,  MCBRIDE, Christopher ,  ANTONIOS-MCCREA, William ,  DOUGHAN, Brandon, M. ,  LEVINE, Barry, H. ,  XIA, Yi ,  MCKENNA, Maureen ,  WANG, X. Michael ,  MENDENHALL, Kris ,  ZHOU, Yasheen ,  GONG, Baoqing ,  GU, Dan ,  DOLAN, John ,  TULINSKY, John ,  BRINNER, Kristin ,  GAO, Zhenhai

Inventor： MACHAJEWSKI, Timothy, D. ,  SHAFER, Cynthia, M. ,  MCBRIDE, Christopher ,  ANTONIOS-MCCREA, William ,  DOUGHAN, Brandon, M. ,  LEVINE, Barry, H. ,  XIA, Yi ,  MCKENNA, Maureen ,  WANG, X. Michael ,  MENDENHALL, Kris ,  ZHOU, Yasheen ,  GONG, Baoqing ,  GU, Dan ,  DOLAN, John ,  TULINSKY, John ,  BRINNER, Kristin ,  GAO, Zhenhai

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00 ,  C07D211/86

CPC classification number: C07D211/86 ,  C07D471/04

Abstract: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nevous system diseases.

Abstract translation: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物，其立体异构体，互变异构体，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物，单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法，用于预防 或治疗细胞增殖，病毒，自身免疫，心血管和中枢神经系统疾病。

公开(公告)号：WO2006113498A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014194

申请日：2006-04-14

Applicant: CHIRON CORPORATION ,  MACHAJEWSKI, Timothy, D. ,  GAO, Zhenhai ,  LEVINE, Barry, H. ,  ANTONIOS-MCCREA, William ,  BELLAMACINA, Cornelia, R. ,  COSTALES, Abran ,  DOUGHAN, Brandon, M. ,  FONG, Susan ,  HENDRICKSON, Thomas ,  LIN, Xiaodong ,  MCBRIDE, Christopher ,  MCKENNA, Maureen ,  RICO, Alice, C. ,  SHAFER, Cynthia, M. ,  WANG, X., Michael ,  ZHOU, Yasheen ,  XIA, Yi ,  MENDENHALL, Kris, G.

Inventor： MACHAJEWSKI, Timothy, D. ,  GAO, Zhenhai ,  LEVINE, Barry, H. ,  ANTONIOS-MCCREA, William ,  BELLAMACINA, Cornelia, R. ,  COSTALES, Abran ,  DOUGHAN, Brandon, M. ,  FONG, Susan ,  HENDRICKSON, Thomas ,  LIN, Xiaodong ,  MCBRIDE, Christopher ,  MCKENNA, Maureen ,  RICO, Alice, C. ,  SHAFER, Cynthia, M. ,  WANG, X., Michael ,  ZHOU, Yasheen ,  XIA, Yi ,  MENDENHALL, Kris, G.

CPC classification number: C07D401/14 ,  C07D239/84 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.

Abstract translation: 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，药用盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 将2-氨基 - 喹唑啉-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。

公开(公告)号：WO2006113498A3

公开(公告)日：2007-01-11

申请号：PCT/US2006014194

申请日：2006-04-14

Applicant: CHIRON CORP ,  MACHAJEWSKI TIMOTHY D ,  GAO ZHENHAI ,  LEVINE BARRY H ,  ANTONIOS-MCCREA WILLIAM ,  BELLAMACINA CORNELIA R ,  COSTALES ABRAN ,  DOUGHAN BRANDON M ,  FONG SUSAN ,  HENDRICKSON THOMAS ,  LIN XIAODONG ,  MCBRIDE CHRISTOPHER ,  MCKENNA MAUREEN ,  RICO ALICE C ,  SHAFER CYNTHIA M ,  WANG X MICHAEL ,  ZHOU YASHEEN ,  XIA YI ,  MENDENHALL KRIS G

Inventor： MACHAJEWSKI TIMOTHY D ,  GAO ZHENHAI ,  LEVINE BARRY H ,  ANTONIOS-MCCREA WILLIAM ,  BELLAMACINA CORNELIA R ,  COSTALES ABRAN ,  DOUGHAN BRANDON M ,  FONG SUSAN ,  HENDRICKSON THOMAS ,  LIN XIAODONG ,  MCBRIDE CHRISTOPHER ,  MCKENNA MAUREEN ,  RICO ALICE C ,  SHAFER CYNTHIA M ,  WANG X MICHAEL ,  ZHOU YASHEEN ,  XIA YI ,  MENDENHALL KRIS G

IPC: C07D239/84 ,  A61K31/517 ,  A61P35/00 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12

CPC classification number: C07D401/14 ,  C07D239/84 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.

Abstract translation: 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 单独使用2-氨基 - 喹唑啉-5-酮化合物或与至少一种其它治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。