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公开(公告)号：WO2011060196A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056420
申请日：2010-11-11
Applicant: ANACOR PHARMACEUTICALS, INC. , HERNANDEZ, Vincent, S. , LI, Xianfeng , ZHANG, Suoming , AKAMA, Tsutomu , ZHANG, Yanchen , LIU, Yang , PLATTNER, Jacob, J. , ALLEY, Michael, Kevin Richard , ZHOU, Yasheen , NEIMAN, James, A.
Inventor： HERNANDEZ, Vincent, S. , LI, Xianfeng , ZHANG, Suoming , AKAMA, Tsutomu , ZHANG, Yanchen , LIU, Yang , PLATTNER, Jacob, J. , ALLEY, Michael, Kevin Richard , ZHOU, Yasheen , NEIMAN, James, A.
CPC classification number: C07F5/025
Abstract: This invention relates to 6-substituted benzoxaborole compounds of the following formula and their use for treating bacterial infections.
Abstract translation: 本发明涉及下式的6-取代苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：WO2008079988A2
公开(公告)日：2008-07-03
申请号：PCT/US2007088392
申请日：2007-12-20
Applicant: NOVARTIS VACCINES & DIAGNOSTIC , RAMURTHY SAVITHRI , LIN XIAODONG , SUBRAMANIAN SHARADA , RICO ALICE C , WANG XIAOJING M , JAIN RAMA , MURRAY JEREMY M , BASHAM STEVEN E , WARNE ROBERT L , SHU WEI , ZHOU YASHEEN , DOVE JEFFREY , AIKAWA MINA , AMIRI PAYMAN
Inventor： RAMURTHY SAVITHRI , LIN XIAODONG , SUBRAMANIAN SHARADA , RICO ALICE C , WANG XIAOJING M , JAIN RAMA , MURRAY JEREMY M , BASHAM STEVEN E , WARNE ROBERT L , SHU WEI , ZHOU YASHEEN , DOVE JEFFREY , AIKAWA MINA , AMIRI PAYMAN
CPC classification number: C07D239/84 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D411/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
Abstract translation: 本发明提供了作为PDK1抑制剂的新化合物。 还提供了包含所述化合物的药物组合物，以及用所述化合物或组合物治疗增殖性疾病如癌症的方法。
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公开(公告)号：WO2006113498A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014194
申请日：2006-04-14
Applicant: CHIRON CORPORATION , MACHAJEWSKI, Timothy, D. , GAO, Zhenhai , LEVINE, Barry, H. , ANTONIOS-MCCREA, William , BELLAMACINA, Cornelia, R. , COSTALES, Abran , DOUGHAN, Brandon, M. , FONG, Susan , HENDRICKSON, Thomas , LIN, Xiaodong , MCBRIDE, Christopher , MCKENNA, Maureen , RICO, Alice, C. , SHAFER, Cynthia, M. , WANG, X., Michael , ZHOU, Yasheen , XIA, Yi , MENDENHALL, Kris, G.
Inventor： MACHAJEWSKI, Timothy, D. , GAO, Zhenhai , LEVINE, Barry, H. , ANTONIOS-MCCREA, William , BELLAMACINA, Cornelia, R. , COSTALES, Abran , DOUGHAN, Brandon, M. , FONG, Susan , HENDRICKSON, Thomas , LIN, Xiaodong , MCBRIDE, Christopher , MCKENNA, Maureen , RICO, Alice, C. , SHAFER, Cynthia, M. , WANG, X., Michael , ZHOU, Yasheen , XIA, Yi , MENDENHALL, Kris, G.
CPC classification number: C07D401/14 , C07D239/84 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/12 , C07D417/14
Abstract: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.
Abstract translation: 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，药用盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 将2-氨基 - 喹唑啉-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。
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公开(公告)号：WO2017151492A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/019658
申请日：2017-02-27
Applicant: ANACOR PHARMACEUTICALS, INC. , BILL AND MELINDA GATES FOUNDATION , LI, Xianfeng , LUNDE, Christopher, S. , JACOBS, Robert, T. , ZHOU, Yasheen
Inventor： LI, Xianfeng , LUNDE, Christopher, S. , JACOBS, Robert, T. , ZHOU, Yasheen
Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
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公开(公告)号：WO2007117607A9
公开(公告)日：2008-03-06
申请号：PCT/US2007008592
申请日：2007-04-05
Applicant: NOVARTIS VACCINES & DIAGNOSTIC , RAMURTHY SAVITHRI , LIN XIADONG , SUBRAMANIAN SHARADA , RICO ALICE C , WANG XIAJONG M , JAIN RAMA , MURRAY JEREMY M , BASMAN STEVEN E , WARNE ROBERT L , SHU WEI , ZHOU YASHEEN , DOVE JEFFREY , AIKAWA MINA , AMIRI PAYMAN , WANG WEIBO , JANSEN JOHANNA M , WAGMAN ALLAN S , PFISTER KEITH B , NG SIMON C
Inventor： RAMURTHY SAVITHRI , LIN XIADONG , SUBRAMANIAN SHARADA , RICO ALICE C , WANG XIAJONG M , JAIN RAMA , MURRAY JEREMY M , BASMAN STEVEN E , WARNE ROBERT L , SHU WEI , ZHOU YASHEEN , DOVE JEFFREY , AIKAWA MINA , AMIRI PAYMAN , WANG WEIBO , JANSEN JOHANNA M , WAGMAN ALLAN S , PFISTER KEITH B , NG SIMON C
IPC: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12
CPC classification number: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
Abstract: The invention provides quinazoline compounds that are inhibitors of PDKl. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
Abstract translation: 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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Patent Agency Ranking
公开(公告)号：WO2007117607A3
公开(公告)日：2007-10-18
申请号：PCT/US2007/008592
申请日：2007-04-05
Applicant: NOVARTIS VACCINES & DIAGNOSTICS, INC. , RAMURTHY, Savithri , LIN, Xiadong , SUBRAMANIAN, Sharada , RICO, Alice, C. , WANG, Xiajong, M. , JAIN, Rama , MURRAY, Jeremy, M. , BASMAN, Steven, E. , WARNE, Robert, L. , SHU, Wei , ZHOU, Yasheen , DOVE, Jeffrey , AIKAWA, Mina , AMIRI, Payman , WANG, Weibo , JANSEN, Johanna, M. , WAGMAN, Allan, S. , PFISTER, Keith, B. , NG, Simon, C.
Inventor： RAMURTHY, Savithri , LIN, Xiadong , SUBRAMANIAN, Sharada , RICO, Alice, C. , WANG, Xiajong, M. , JAIN, Rama , MURRAY, Jeremy, M. , BASMAN, Steven, E. , WARNE, Robert, L. , SHU, Wei , ZHOU, Yasheen , DOVE, Jeffrey , AIKAWA, Mina , AMIRI, Payman , WANG, Weibo , JANSEN, Johanna, M. , WAGMAN, Allan, S. , PFISTER, Keith, B. , NG, Simon, C.
IPC: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12
Abstract: The invention provides quinazoline compounds that are inhibitors of PDKl. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
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公开(公告)号：WO2007001406A3
公开(公告)日：2007-07-19
申请号：PCT/US2005035853
申请日：2005-10-05
Applicant: CHIRON CORP , BURGER MATTHEW T , BUSSIERE DIRKSEN , MURRAY JEREMY , NG SIMON , NI ZHI-JIE , PFISTER KEITH B , WAGMAN ALLAN S , ZHOU YASHEEN
Inventor： BURGER MATTHEW T , BUSSIERE DIRKSEN , MURRAY JEREMY , NG SIMON , NI ZHI-JIE , PFISTER KEITH B , WAGMAN ALLAN S , ZHOU YASHEEN
CPC classification number: C07D487/04 , A61K47/542
Abstract: The present invention discloses novel compounds, compositions containing the compounds and methods for the treatment of viral infection, particularly hepatitis C and SARS. In particular the invention provides aryl-containing macrocyclic compounds useful for the inhibition of HCV and SARS viral replication.
Abstract translation: 本发明公开了新化合物，含有该化合物的组合物和治疗病毒感染，特别是丙型肝炎和SARS的方法。 具体地说，本发明提供了可用于抑制HCV和SARS病毒复制的含芳基的大环化合物。
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公开(公告)号：WO2010028005A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055677
申请日：2009-09-02
Applicant: ANACOR PHARMACEUTICALS, INC. , ZHOU, Yasheen , ZHANG, Yong-kang , AKAMA, Tsutomu , JARNAGIN, Kurt
Inventor： ZHOU, Yasheen , ZHANG, Yong-kang , AKAMA, Tsutomu , JARNAGIN, Kurt
IPC: A01N55/08
CPC classification number: A61K31/69 , A61K45/06 , C07F5/025 , Y02A50/411 , A61K2300/00
Abstract: This invention provides, among other things, novel compounds useful for treating inflammatory conditions, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
Abstract translation: 除其他之外，本发明提供了用于治疗炎性病症的新型化合物，含有这些化合物的药物组合物以及这些化合物与至少一种另外的治疗有效药剂的组合。
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公开(公告)号：WO2009140309A2
公开(公告)日：2009-11-19
申请号：PCT/US2009043672
申请日：2009-05-12
Applicant: ANACOR PHARMACEUTICALS INC , GLAXOSMITHKLINE , XIA YI , ALLEY MICHAEL RICHARD KEVIN , ZHOU YASHEEN , HERNANDEZ VINCENT S , PLATTNER JACOB J , DING CHARLES Z , CAO KATHY , ZHANG YONG-KANG , AKAMA TSUTOMU , SLIGAR JESSICA , BENOWITZ ANDREW , JIA GUOFENG , OU LIGONG , SARASWAT NEERJA , RAMACHANDRAN SREEKANTH , DIAPER CHRIS , ZHANG YANCHEN , BANDA GOVERDHAN REDDY , NIEMAN JAMES , KERAMANE MEDHI , MOHAMMAD RAHIM , SUBEDI RAJENDRA , LIANG HONG , SINGH RAJESHWAR
Inventor： XIA YI , ALLEY MICHAEL RICHARD KEVIN , ZHOU YASHEEN , HERNANDEZ VINCENT S , PLATTNER JACOB J , DING CHARLES Z , CAO KATHY , ZHANG YONG-KANG , AKAMA TSUTOMU , SLIGAR JESSICA , BENOWITZ ANDREW , JIA GUOFENG , OU LIGONG , SARASWAT NEERJA , RAMACHANDRAN SREEKANTH , DIAPER CHRIS , ZHANG YANCHEN , BANDA GOVERDHAN REDDY , NIEMAN JAMES , KERAMANE MEDHI , MOHAMMAD RAHIM , SUBEDI RAJENDRA , LIANG HONG , SINGH RAJESHWAR
IPC: A62D3/36 , A62D101/22
CPC classification number: A61K31/33 , A61K31/43 , A61K45/06 , C07F5/025 , A61K2300/00
Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
Abstract translation: 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：WO2007117607A2
公开(公告)日：2007-10-18
申请号：PCT/US2007008592
申请日：2007-04-05
Applicant: NOVARTIS VACCINES & DIAGNOSTIC , RAMURTHY SAVITHRI , LIN XIADONG , SUBRAMANIAN SHARADA , RICO ALICE C , WANG XIAJONG M , JAIN RAMA , MURRAY JEREMY M , BASHMAN STEVEN E , WARNE ROBERT L , SHU WEI , ZHOU YASHEEN , DOVE JEFFREY , AIKAWA MINA , AMIRI PAYMAN , WANG WEIBO , JENSEN JOHANNA M , WAGMAN ALLAN S , PFISTER KEITH B , NG SIMON C
Inventor： RAMURTHY SAVITHRI , LIN XIADONG , SUBRAMANIAN SHARADA , RICO ALICE C , WANG XIAJONG M , JAIN RAMA , MURRAY JEREMY M , BASHMAN STEVEN E , WARNE ROBERT L , SHU WEI , ZHOU YASHEEN , DOVE JEFFREY , AIKAWA MINA , AMIRI PAYMAN , WANG WEIBO , JENSEN JOHANNA M , WAGMAN ALLAN S , PFISTER KEITH B , NG SIMON C
IPC: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04
CPC classification number: C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
Abstract: The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
Abstract translation: 本发明提供了作为PDK1抑制剂的新型喹唑啉化合物。 还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。
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