公开(公告)号：WO2009105782A1

公开(公告)日：2009-08-27

申请号：PCT/US2009/034926

申请日：2009-02-23

Applicant: SEQUOIA PHARMACEUTICALS, INC. ,  EISSENSTAT, Michael ,  DUAN, Dehui ,  ERICKSON, John, W.

Inventor： EISSENSTAT, Michael ,  DUAN, Dehui ,  ERICKSON, John, W.

IPC: A01N43/08 ,  A61K31/34

CPC classification number: A61K45/06 ,  A61K31/34 ,  A61K2300/00

Abstract: Compositions and methods of treating viral infections are provided. More particularly, compositions including a combination of protease inhibitors and cytochrome p450 enzyme inhibitors are provided. Methods of using the compositions for treatment of diseases or disorders caused by a virus such as HIV infections are also provided.

Abstract translation: 提供了治疗病毒感染的组合物和方法。 更具体地，提供包含蛋白酶抑制剂和细胞色素p450酶抑制剂的组合的组合物。 还提供了使用组合物治疗由病毒如HIV感染引起的疾病或病症的方法。

公开(公告)号：WO2009105781A1

公开(公告)日：2009-08-27

申请号：PCT/US2009/034924

申请日：2009-02-23

Applicant: SEQUOIA PHARMACEUTICALS, INC. ,  EISSENSTAT, Michael ,  DUAN, Dehui ,  ERICKSON, John, W. ,  GULNIK, Sergei

Inventor： EISSENSTAT, Michael ,  DUAN, Dehui ,  ERICKSON, John, W. ,  GULNIK, Sergei

IPC: A01N37/12 ,  A61K31/16 ,  A61K31/195

CPC classification number: C07D307/79 ,  A61K31/343 ,  A61K45/06

Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Abstract translation: 提供抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。

公开(公告)号：WO2009105774A2

公开(公告)日：2009-08-27

申请号：PCT/US2009/034915

申请日：2009-02-23

Applicant: SEQUOIA PHARMACEUTICALS, INC. ,  EISSENSTAT, Michael ,  DUAN, Dehui

Inventor： EISSENSTAT, Michael ,  DUAN, Dehui

IPC: C07D405/02

CPC classification number: C07D307/79 ,  C07D307/82 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Abstract translation: 提供抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。

公开(公告)号：WO2009070744A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084992

申请日：2008-11-26

Applicant: SEQUOIA PHARMACEUTICALS, INC. ,  EISSENSTAT, Michael ,  DUAN, Dehui ,  KANG, Ji-hye

Inventor： EISSENSTAT, Michael ,  DUAN, Dehui ,  KANG, Ji-hye

IPC: A61K31/405

CPC classification number: C07D307/79 ,  A61K31/343 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/443 ,  A61K31/444 ,  A61K31/485 ,  A61K31/497 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D471/04 ,  C12N9/0077 ,  C12Y114/14001

Abstract: Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 2D6 enzymes.

Abstract translation: 提供了抑制细胞色素P450 2D6酶的方法，可用于通过细胞色素P450 2D6阻止药物或其他分子的降解来改善疾病的治疗。 提供的药物组合物可用作增强剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450 2D6酶体内降解的药物的治疗效果。

公开(公告)号：WO2009105774A3

公开(公告)日：2009-12-10

申请号：PCT/US2009034915

申请日：2009-02-23

Applicant: SEQUOIA PHARMACEUTICALS INC ,  EISSENSTAT MICHAEL ,  DUAN DEHUI ,  KANG JIHYE

Inventor： EISSENSTAT MICHAEL ,  DUAN DEHUI ,  KANG JIHYE

IPC: A01N37/12 ,  A61K31/16 ,  A61K31/195

CPC classification number: C07D307/79 ,  C07D307/82 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Abstract translation: 提供了抑制细胞色素P450酶的方法，其可以用于通过阻止细胞色素P450对药物或其他分子的降解来改善疾病的治疗。 提供了可用作增强剂的药物组合物，以改善药代动力学，提高生物利用度并增强经细胞色素P450酶进行体内降解的药物的治疗效果。

公开(公告)号：WO2009105776A1

公开(公告)日：2009-08-27

申请号：PCT/US2009/034917

申请日：2009-02-23

Applicant: SEQUOIA PHARMACEUTICALS, INC. ,  EISSENSTAT, Michael ,  DUAN, Dehui

Inventor： EISSENSTAT, Michael ,  DUAN, Dehui

IPC: A01N37/34 ,  A61K31/275

CPC classification number: C07D405/14 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/443 ,  A61K45/06 ,  C07D231/12 ,  C07D307/79 ,  C07D307/81 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  Y10T436/14

Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Abstract translation: 提供了抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。

公开(公告)号：WO2008022345A3

公开(公告)日：2008-09-18

申请号：PCT/US2007076296

申请日：2007-08-20

Applicant: SEQUOIA PHARMACEUTICALS INC ,  EISSENSTAT MICHAEL ,  DUAN DEHUI

Inventor： EISSENSTAT MICHAEL ,  DUAN DEHUI

IPC: A61K31/33

CPC classification number: A61K31/343 ,  A61K31/33 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  C07D307/79 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/048 ,  A61K2300/00

Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Abstract translation: 提供抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。

公开(公告)号：WO2008022345A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/076296

申请日：2007-08-20

Applicant: SEQUOIA PHARMACEUTICALS, INC. ,  EISSENSTAT, Michael ,  DUAN, Dehui

Inventor： EISSENSTAT, Michael ,  DUAN, Dehui

IPC: A61K9/14

CPC classification number: A61K31/343 ,  A61K31/33 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  C07D307/79 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/048 ,  A61K2300/00

Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

Abstract translation: 提供了可用于改善细胞色素P450酶的方法