公开(公告)号：WO2015153370A2

公开(公告)日：2015-10-08

申请号：PCT/US2015/023114

申请日：2015-03-27

Applicant: LABIB, Mohamed, E. ,  DUKHIN, Stanislav, S.

Inventor： LABIB, Mohamed, E. ,  DUKHIN, Stanislav, S.

IPC: A61M1/16

CPC classification number: A61M1/34 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/3403 ,  A61M1/341 ,  A61M2205/3331 ,  B01D63/02 ,  B01D63/024 ,  B01D69/084 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/16 ,  B01D2313/20

Abstract: In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.

Abstract translation: 在本发明的实施例中，提供了一种包括中空纤维的透析器或过滤器，其中血液在中空纤维的外部流动，并且透析液或滤液可以在内部流动。 中空纤维的外表面可具有平滑性和血液相容性。 纤维束可具有适当的填充分数并可具有波状纤维。 确定最佳剪切速率和血流速度。 药筒的几何特征，例如与血液的流量分布有关，对于药筒的不同端可能不同。 可能会提供空气流血和栓子陷阱。 延长使用寿命可以通过这些特征的组合来实现，这可以允许额外的治疗和应用或更好的经济性。

公开(公告)号：WO2010039736A3

公开(公告)日：2010-05-27

申请号：PCT/US2009058861

申请日：2009-09-29

Applicant: PRINCETON TRADE & TECHNOLOGY I ,  LABIB MOHAMED EMAM ,  LAI CHING-YUE ,  TABANI YACOOB ,  QIAN ZIYE ,  DUKHIN STANISLAV S ,  MURAWSKI JOSEPH J

Inventor： LABIB MOHAMED EMAM ,  LAI CHING-YUE ,  TABANI YACOOB ,  QIAN ZIYE ,  DUKHIN STANISLAV S ,  MURAWSKI JOSEPH J

IPC: B08B9/032

CPC classification number: B08B9/0326 ,  A61B1/123 ,  A61B1/125 ,  B08B9/0325 ,  B08B9/0328

Abstract: Apparatus and methods are disclosed for cleaning interiors of passageways in endoscopes or other luminal medical devices by flow of liquid and gas therethrough. The liquid flow may include rivulets, droplets or other liquid entities which move on the internal surfaces of the passageways, and may include a three-phase contact interface between liquid and dry solid and gas.

Abstract translation: 公开的装置和方法用于通过液体和气体的流动来清洁内窥镜或其他管腔医疗装置中的通道的内部。 液体流可以包括在通道的内表面上移动的流道，液滴或其它液体实体，并且可以包括液体和干燥固体和气体之间的三相接触界面。

公开(公告)号：WO2017053805A1

公开(公告)日：2017-03-30

申请号：PCT/US2016/053452

申请日：2016-09-23

Applicant: LABIB, Mohamed E. ,  DUKHIN, Stanislav S. ,  ROBERTSON, Jeffrey C.

Inventor： LABIB, Mohamed E. ,  DUKHIN, Stanislav S. ,  ROBERTSON, Jeffrey C.

IPC: B01D63/02

CPC classification number: B01D69/08 ,  A61M1/16 ,  A61M1/34 ,  A61M2205/3334 ,  B01D61/28 ,  B01D63/02 ,  B01D63/022 ,  B01D63/026 ,  B01D2313/10 ,  B01D2313/21 ,  B01D2313/44

Abstract: In embodiments of the invention, there may be provided a cartridge for dialysis or other blood processing therapy. In the cartridge, fibers may be substantially uniformly distributed near a midplane, but near an end, in the inter fiber space, there may be void flow channels, which may cause fluid flow in the inter fiber space to transition within a short region to uniform flow with minimal stagnation zones. Void flow channels may be radially oriented, introducing fluid from the outer circumference, or axially oriented, introducing fluid along the axial direction through passageways through the potting material. In other embodiments, fluid flow in the inter fiber space may be perpendicular to the fibers, or radial with respect to a cartridge longitudinal axis. The cartridge may have blood flow in the inter fiber space, and flow of dialysate or ultrafiltrate in the lumens of the fibers, or the opposite situation.

Abstract translation: 在本发明的实施例中，可以提供用于透析或其它血液处理治疗的药筒。 在墨盒中，纤维可以在中平面附近基本上均匀分布，但在纤维间隙附近接近一端，可能存在空隙流动通道，这可能导致纤维间隙中的流体流动在短区域内过渡到均匀 流动与最小停滞区。 空隙流动通道可以是径向定向的，从外周引入流体或轴向定向，沿轴向引入流体通过通过灌封材料的通道。 在其它实施例中，纤维间隙中的流体流动可以垂直于纤维，或者相对于药筒纵向轴线是径向的。 药筒可能在纤维间隙中具有血液流动，并且纤维内腔中的透析液或超滤液的流动或相反的情况。

公开(公告)号：WO2017048224A1

公开(公告)日：2017-03-23

申请号：PCT/US2015/050004

申请日：2015-09-14

Applicant: LABIB, Mohamed, E. ,  DUKHIN, Stanislav, S. ,  KELLY, Thomas ,  MATERNA, Peter

Inventor： LABIB, Mohamed, E. ,  DUKHIN, Stanislav, S. ,  KELLY, Thomas ,  MATERNA, Peter

IPC: B01D61/28 ,  B01D63/02 ,  A61M1/16

CPC classification number: A61M1/1625 ,  B01D61/28 ,  B01D63/02 ,  B01D2313/08

Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

Abstract translation: 本发明的实施例涉及用于进行血液透析和相关的体外血液处理模式和疗法的药筒，系统和方法，其中血液在纤维间隙中流动并且透析液在中空纤维内腔中流动。 可以提供适当的连接器和配合方向。 可以提供轨道分配器，纤维的扇形和特征，以促进纤维束中的纤维间隔的均匀性。 轨道分配器可以包含轮廓表面，流动重定向器，非均匀电导流动元件，通孔分配器和其他特征。 可以将纤维束分成两组纤维，每组具有单独的控制流体。 可以为各种疗法提供适当的系统。 通过纤维的流动可以是平行的，横向的或其它构型。 这些各种特征可以使得能够长期应用于所有透析和超滤相关疗法，以及其它疗法以及包括植入物，便携式和可穿戴物在内的应用。

公开(公告)号：WO2010039730A2

公开(公告)日：2010-04-08

申请号：PCT/US2009/058838

申请日：2009-09-29

Applicant: PRINCETON TRADE & TECHNOLOGY, INC. ,  LABIB, Mohamed, Emam ,  DUKHIN, Stanislav, S. ,  MURAWSKI, Joseph, J. ,  TABANI, Yacoob ,  LAI, Ching-Yue

Inventor： LABIB, Mohamed, Emam ,  DUKHIN, Stanislav, S. ,  MURAWSKI, Joseph, J. ,  TABANI, Yacoob ,  LAI, Ching-Yue

IPC: B08B9/032

CPC classification number: B08B9/032 ,  B08B9/0325 ,  B08B9/0326

Abstract: A method, composition and apparatus for cleaning an internal surface of a narrow diameter channel. The method includes: i) flowing a liquid cleaning medium and a gas through the internal channel under one or more flow regimes that creates surface flow entities in contact with and sliding along the surface of the channel, said surface flow entities having three-phase contact lines and associated menisci, said surface flow entities detaching contaminants with which they come in contact from the internal surface of the channel; ii) rinsing the internal surface of the channel to remove residual liquid cleaning medium and detached contaminants from the channel; wherein during step i): the detachment of contaminants from the internal surface of the channel is produced by a sweeping of the internal surface of the internal channel with the three-phase contact lines of the surface flow entities, the cleaning medium is not predispersed in the gas before entering the channel, and less that 10% of the surface of the channel is covered by a contiguous annular film.

Abstract translation: 用于清洁窄直径通道的内表面的方法，组合物和设备。 该方法包括：i）使液体清洁介质和气体在一个或多个流动状态下流过内部通道，以产生与通道的表面接触并沿其滑动的表面流动实体，所述表面流动实体具有三相接触 线和相关的半月板，所述表面流动实体分离与通道的内表面接触的污染物; ii）冲洗通道的内表面以除去残留的液体清洁介质并从通道中分离污染物; 其中在步骤i）期间：通过利用表面流动实体的三相接触线清扫内部通道的内表面来产生污染物从通道内表面的分离，清洁介质未预先分散 进入通道前的气体以及少于通道表面的10％被连续的环形膜覆盖。

公开(公告)号：WO2006119301A3

公开(公告)日：2007-01-11

申请号：PCT/US2006016858

申请日：2006-05-02

Applicant: NEW JERSEY TECH INST ,  PFEFFER ROBERT ,  DAVE RAJESH ,  DUKHIN STANISLAV ,  QUEVEDO JOSE A

Inventor： PFEFFER ROBERT ,  DAVE RAJESH ,  DUKHIN STANISLAV ,  QUEVEDO JOSE A

IPC: B01D39/02 ,  B01D46/30

CPC classification number: B01D46/30 ,  B01D39/04 ,  B01D46/003 ,  B01D2239/0258 ,  B01D2279/51 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/776 ,  Y10S977/777 ,  Y10S977/778

Abstract: Systems and methods for achieving filtration are provided that utilize agglomerates or granules of nanoparticles. The agglomerates or granules of nanoparticles may be used as and/or incorporated into a HEPA filtration system to remove solid or liquid submicron-sized particles, e.g., MPPS, in an efficient and efficacious manner. The filtration systems and methods are provided that utilize agglomerates or granules in a size range of about 100- 500 microns. The agglomerates or granules of nanoparticles exhibit a hierarchical fractal structure. In the case of agglomerates of nanoparticles, porosities of 0.9 or greater are generally employed, and for granules of nanoparticles, porosities that are smaller than 0.9 may be employed. Filter media formed from the agglomerates or granules may be formed from materials such as carbon black and fumed silica, and may be employed in baffled or non-baffled filtration apparatus.

Abstract translation: 提供用于实现过滤的系统和方法，其利用纳米颗粒的附聚物或颗粒。 纳米颗粒的附聚物或颗粒可以用作和/或并入HEPA过滤系统中以有效和有效的方式除去固体或液体亚微米尺寸的颗粒，例如MPPS。 提供了使用约100-500微米尺寸范围内的附聚物或颗粒的过滤系统和方法。 纳米颗粒的团聚体或颗粒呈现分层结构。 在纳米颗粒附聚物的情况下，通常使用0.9或更大的孔隙率，并且对于纳米颗粒的颗粒，可以使用小于0.9的孔隙率。 由附聚物或颗粒形成的过滤介质可以由诸如炭黑和煅制二氧化硅的材料形成，并且可以用于挡板或非挡板过滤装置中。

公开(公告)号：WO2015168642A1

公开(公告)日：2015-11-05

申请号：PCT/US2015/028925

申请日：2015-05-01

Applicant: LABIB, Mohamed, E. ,  DUKHIN, Stanislav, S.

Inventor： LABIB, Mohamed, E. ,  DUKHIN, Stanislav, S.

IPC: A61F11/00

CPC classification number: A61F11/002 ,  A61F2/0077 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/04 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/21 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/602 ,  A61L2430/14 ,  A61M31/002

Abstract: A tympanostomy tube containing a polymeric material and a drug is described. The polymeric material may comprise a non-resorbable polymer and a water-soluble polymer. The drug may be released when the device is contacted by an aqueous liquid such as middle ear exudate during otitis media. The implant may contain sufficient drug to treat multiple episodes of otitis media or to catch subsequent episodes in their early stages as a prophylactic. The device may be hydrophilic and further may contain a surfactant. The implant may be porous. The implant may have enhanced surface area at places exposed to middle ear liquid and may have enlarged mass so as to contain an increased total amount of drug. Intentional reorientation of the patient's head may aid in moving drug-containing liquid around the middle ear cavity. Similar implants can be used in other mucosal cavities.

Abstract translation: 描述了含有聚合物材料和药物的鼓膜造口管。 聚合物材料可以包含不可再吸收的聚合物和水溶性聚合物。 当器械在中耳炎期间由诸如中耳渗出物的水性液体接触时，药物可能被释放。 植入物可以含有足够的药物以治疗多发性中耳炎或在其早期阶段将随后的发作作为预防措施。 该装置可以是亲水性的并且还可以含有表面活性剂。 植入物可以是多孔的。 植入物可能在暴露于中耳液体的地方具有增强的表面积，并且可能具有增大的质量，以便含有增加的药物总量。 患者头部的故意重新定向可能有助于将含药液体移动到中耳腔周围。 类似的植入物可用于其他粘膜腔。

公开(公告)号：WO2011152857A1

公开(公告)日：2011-12-08

申请号：PCT/US2011/000970

申请日：2011-05-27

Applicant: LABIB, Mohamed, E. ,  DAVIDSON, Theodore ,  DUKHIN, Stanislav, S. ,  EHRLICH, Garth ,  POST, James, C. ,  STOODLEY, Paul

Inventor： LABIB, Mohamed, E. ,  DAVIDSON, Theodore ,  DUKHIN, Stanislav, S. ,  EHRLICH, Garth ,  POST, James, C. ,  STOODLEY, Paul

IPC: A61K47/30

CPC classification number: A61K31/496 ,  A61K9/0024 ,  A61K9/2027 ,  A61K31/785 ,  Y02A50/478 ,  Y02A50/481

Abstract: Polymeric articles capable of releasing drugs at therapeutic levels over extended periods of time, and methods for producing the extended release articles.

Abstract translation: 能够在长时间内以治疗水平释放药物的聚合制品以及用于制备延长释放制品的方法。

公开(公告)号：WO2010039730A3

公开(公告)日：2010-05-27

申请号：PCT/US2009058838

申请日：2009-09-29

Applicant: PRINCETON TRADE & TECHNOLOGY I ,  LABIB MOHAMED EMAM ,  DUKHIN STANISLAV S ,  MURAWSKI JOSEPH J ,  TABANI YACOOB ,  LAI CHING-YUE

Inventor： LABIB MOHAMED EMAM ,  DUKHIN STANISLAV S ,  MURAWSKI JOSEPH J ,  TABANI YACOOB ,  LAI CHING-YUE

IPC: B08B9/032

CPC classification number: B08B9/032 ,  B08B9/0325 ,  B08B9/0326

Abstract: A method, composition and apparatus for cleaning an internal surface of a narrow diameter channel. The method includes: i) flowing a liquid cleaning medium and a gas through the internal channel under one or more flow regimes that creates surface flow entities in contact with and sliding along the surface of the channel, said surface flow entities having three-phase contact lines and associated menisci, said surface flow entities detaching contaminants with which they come in contact from the internal surface of the channel; ii) rinsing the internal surface of the channel to remove residual liquid cleaning medium and detached contaminants from the channel; wherein during step i): the detachment of contaminants from the internal surface of the channel is produced by a sweeping of the internal surface of the internal channel with the three-phase contact lines of the surface flow entities, the cleaning medium is not predispersed in the gas before entering the channel, and less that 10% of the surface of the channel is covered by a contiguous annular film.

Abstract translation: 一种用于清洁窄径通道内表面的方法，组合物和设备。 该方法包括：i）在一个或多个流动状态下使液体清洁介质和气体流过内部通道，该流动状态产生与通道表面接触和滑动的表面流动实体，所述表面流动实体具有三相接触 线和相关的半月板，所述表面流动实体分离它们与沟道的内表面接触的污染物; ii）冲洗通道的内表面以除去残余的液体清洁介质并从通道中分离污染物; 其中在步骤i）期间：污染物从通道的内表面的分离是通过用表面流动实体的三相接触线清扫内部通道的内表面来产生的，清洁介质不预先分散在 在进入通道之前的气体和较少的通道表面的10％被邻接的环形膜覆盖。

公开(公告)号：WO2015153370A3

公开(公告)日：2015-11-19

申请号：PCT/US2015023114

申请日：2015-03-27

Applicant: LABIB MOHAMED E ,  DUKHIN STANISLAV S

Inventor： LABIB MOHAMED E ,  DUKHIN STANISLAV S

IPC: B01D63/02 ,  A61M1/16 ,  B01D69/08

CPC classification number: A61M1/34 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/3403 ,  A61M1/341 ,  A61M2205/3331 ,  B01D63/02 ,  B01D63/024 ,  B01D69/084 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/16 ,  B01D2313/20

Abstract: In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.

Abstract translation: 在本发明的实施方案中，提供了包含中空纤维的透析器或过滤器，其中血液在中空纤维的外部流动，并且透析液或滤液可能在内部流动。 中空纤维的外表面可具有平滑性和血液相容性的特性。 纤维束可以具有适当的填充分数，并且可以具有波状纤维。 确定最佳剪切速率和血速。 墨盒的几何特征，例如关于血液的流动分布，对于墨盒的不同端部可能是不同的。 可以提供排气和栓塞。 可以通过这些特征的组合来实现延长的使用寿命，这可以允许额外的治疗和应用或更好的经济性。