公开(公告)号：WO2007117401A3

公开(公告)日：2008-06-26

申请号：PCT/US2007008218

申请日：2007-03-30

Applicant: JANSSEN PHARMACEUTICA NV ,  EDWARDS JAMES P ,  SAVALL BRAD M ,  SHAH CHANDRAVADAN R

Inventor： EDWARDS JAMES P ,  SAVALL BRAD M ,  SHAH CHANDRAVADAN R

IPC: A61K31/4184 ,  C07D403/02

CPC classification number: C07D403/14 ,  C07D403/06 ,  C07D471/04 ,  C07D487/08

Abstract: Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Abstract translation: 描述了苯并咪唑和吲哚化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。

公开(公告)号：WO2007117401A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/008218

申请日：2007-03-30

Applicant: JANSSEN PHARMACEUTICA N.V. ,  EDWARDS, James, P. ,  SAVALL, Brad, M. ,  SHAH, Chandravadan, R.

Inventor： EDWARDS, James, P. ,  SAVALL, Brad, M. ,  SHAH, Chandravadan, R.

IPC: A61K31/4184 ,  A61K31/405 ,  C07D403/14

CPC classification number: C07D403/14 ,  C07D403/06 ,  C07D471/04 ,  C07D487/08

Abstract: Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Abstract translation: 描述了苯并咪唑和吲哚化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。

公开(公告)号：WO2007117400A3

公开(公告)日：2007-10-18

申请号：PCT/US2007/008217

申请日：2007-03-30

Applicant: JANSSEN PHARMACEUTICA N.V. ,  EDWARDS, James, P. ,  KINDRACHUK, David, E. ,  VENABLE, Jennifer, D.

Inventor： EDWARDS, James, P. ,  KINDRACHUK, David, E. ,  VENABLE, Jennifer, D.

IPC: A61K31/445 ,  C07D401/14

Abstract: Benzoimidazol-2-yl pyridines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.

公开(公告)号：WO2006105304A3

公开(公告)日：2006-10-05

申请号：PCT/US2006/011663

申请日：2006-03-30

Applicant: JANSSEN PHARMACEUTICA N.V. ,  BUTLER, Christopher, R. ,  EDWARDS, James, P. ,  FOURIE, Anne, M. ,  GRICE, Cheryl, A. ,  KARLSSON, Lars ,  SAVALL, Brad, M. ,  TAYS, Kevin, L. ,  WEI, Jianmei

Inventor： BUTLER, Christopher, R. ,  EDWARDS, James, P. ,  FOURIE, Anne, M. ,  GRICE, Cheryl, A. ,  KARLSSON, Lars ,  SAVALL, Brad, M. ,  TAYS, Kevin, L. ,  WEI, Jianmei

IPC: A61K31/445 ,  A61K31/135 ,  C07D211/44 ,  C07D401/04 ,  C07D207/06 ,  C07D223/04 ,  C07D409/12 ,  C07D401/12 ,  C07D241/08 ,  C07D211/58 ,  C07D471/10 ,  C07D401/14 ,  C07D265/30 ,  A61P29/00

Abstract: Leukotrfene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and inflammatory conditions.

公开(公告)号：WO2005092066A2

公开(公告)日：2005-10-06

申请号：PCT/US2005/009715

申请日：2005-03-24

Applicant: JANSSEN PHARMACEUTICA N.V.? ,  BUZARD, Daniel, J. ,  EDWARDS, James, P. ,  KINDRACHUK, David, E. ,  VENABLE, Jennifer, D.

Inventor： BUZARD, Daniel, J. ,  EDWARDS, James, P. ,  KINDRACHUK, David, E. ,  VENABLE, Jennifer, D.

IPC: A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  C07D233/54 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D233/64 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14

Abstract: Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor expression, and in treating conditions such as inflammation, H 4 receptor-mediated conditions, and related conditions.

Abstract translation: 咪唑化合物，组合物和使用它们在白细胞募集抑制中，调节H4受体表达以及治疗诸如炎症，H4受体介导的病症和相关病症的病症的方法。

公开(公告)号：WO2005012296A1

公开(公告)日：2005-02-10

申请号：PCT/US2004/024050

申请日：2004-07-27

Applicant: JANSSEN PHARMACEUTICA N.V. ,  AXE, Frank, U. ,  BEMBENEK, Scott, D. ,  BUTLER, Christopher, R. ,  EDWARDS, James, P. ,  FOURIE, Anne, M. ,  GRICE, Cheryl, A. ,  SAVALL, Brad, M. ,  TAYS, Kevin, L. ,  WEI, Jianmei

Inventor： AXE, Frank, U. ,  BEMBENEK, Scott, D. ,  BUTLER, Christopher, R. ,  EDWARDS, James, P. ,  FOURIE, Anne, M. ,  GRICE, Cheryl, A. ,  SAVALL, Brad, M. ,  TAYS, Kevin, L. ,  WEI, Jianmei

IPC: C07D417/12

CPC classification number: C04B35/632 ,  C07D235/26 ,  C07D263/58 ,  C07D277/68 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D495/10

Abstract: Leukotriene A4 hydrolase (LTA4H) inhibitors of formula I, compositions containing them, and their use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation, wherein X is selected from the group consisting of NR5, O, and S, with R5 being one of the H and CH3; Y is selected from the group consisting of CH2 and O; R4 is selected from the group consisting of H, OCH3, Cl, F, Br, I, OH, NH2, CN, CF3.

Abstract translation: 式I的白三烯A4水解酶（LTA4H）抑制剂，含有它们的组合物及其用于抑制LTA4H酶活性以及治疗，预防或抑制与炎症有关的炎症和/或病症的用途，其中X选自 的NR 5，O和S，其中R 5是H和CH 3之一; Y选自CH 2和O; R 4选自H，OCH 3，Cl，F，Br，I，OH，NH 2，CN，CF 3。

公开(公告)号：WO2004022061A1

公开(公告)日：2004-03-18

申请号：PCT/US2003/027990

申请日：2003-09-05

Applicant: JANSSEN PHARMACEUTICA, N.V. ,  DUNFORD, Paul, J., ,  EDWARDS, James, P., ,  KARLSSON, Lars, ,  LEUNG, Wai-Ping, ,  THURMOND, Robin, L., ,  WEI, Jianmei,

Inventor： DUNFORD, Paul, J., ,  EDWARDS, James, P., ,  KARLSSON, Lars, ,  LEUNG, Wai-Ping, ,  THURMOND, Robin, L., ,  WEI, Jianmei,

IPC: A61K31/496

CPC classification number: A61K31/496 ,  C07D209/42

Abstract: A method to treat allergic rhinitis is disclosed in which patients are administered certain indolyl compounds.

Abstract translation: 公开了一种治疗过敏性鼻炎的方法，其中给予某些吲哚基化合物。

公开(公告)号：WO2004022060A2

公开(公告)日：2004-03-18

申请号：PCT/US2003/027461

申请日：2003-09-04

Applicant: JANSSEN PHARMACEUTICA, N.V. ,  CARRUTHERS, Nicholas, I., ,  DVORAK, Curt, A. ,  EDWARDS, James, P. ,  GRICE, Cheryl, A. ,  JABLONOWSKI, Jill, A. ,  LY, Kiev, S. ,  PIO, Barbara, A. ,  SHAH, Chandravadan, R. ,  VENABLE, Jennifer, D.

Inventor： CARRUTHERS, Nicholas, I., ,  DVORAK, Curt, A. ,  EDWARDS, James, P. ,  GRICE, Cheryl, A. ,  JABLONOWSKI, Jill, A. ,  LY, Kiev, S. ,  PIO, Barbara, A. ,  SHAH, Chandravadan, R. ,  VENABLE, Jennifer, D.

IPC: A61K31/496

CPC classification number: C07D235/24 ,  C07D263/58 ,  C07D277/68 ,  C07D403/06 ,  C07D451/04 ,  C07D471/04

Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H 4 receptor, including allergic rhinitis.

Abstract translation: 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症，包括过敏性鼻炎。

公开(公告)号：WO2002068427A1

公开(公告)日：2002-09-06

申请号：PCT/IB2002/000538

申请日：2002-02-23

Applicant: LIGAND PHARMACEUTICALS INCORPORATED ,  HIGUCHI, Robert, I. ,  ZHI, Lin ,  KARANEWSKY, Donald, S. ,  THOMPSON, Anthony, W. ,  CAFERRO, Thomas, R. ,  MANI, Neelakandha, S. ,  CHEN, Jyun-Hung ,  CUMMINGS, Marquis, L. ,  EDWARDS, James, P. ,  ADAMS, Mark, E. ,  DECKHUT, Charlotte, L., F.

Inventor： HIGUCHI, Robert, I. ,  ZHI, Lin ,  KARANEWSKY, Donald, S. ,  THOMPSON, Anthony, W. ,  CAFERRO, Thomas, R. ,  MANI, Neelakandha, S. ,  CHEN, Jyun-Hung ,  CUMMINGS, Marquis, L. ,  EDWARDS, James, P. ,  ADAMS, Mark, E. ,  DECKHUT, Charlotte, L., F.

IPC: C07D498/04

CPC classification number: C07D498/04 ,  C07D498/14 ,  Y02P20/582

Abstract: Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.

Abstract translation: 描述了新型非甾体三环喹啉酮和三环喹啉化合物以及作为雄激素受体（AR）的激动剂，部分激动剂和/或拮抗剂及其用途的组合物及其用途。

公开(公告)号：WO2014151380A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/025609

申请日：2014-03-13

Applicant: JANSSEN PHARMACEUTICA NV ,  CHAI, Wenying ,  DVORAK, Curt A. ,  ECCLES, Wendy ,  EDWARDS, James P. ,  GOLDBERG, Steven D, ,  KRAWCZUK, Paul J. ,  LEBSACK, Alec D. ,  LIU, Jing ,  PIPPEL, Daniel J. ,  SALES, Zachary S. ,  TANIS, Virginia M. ,  TICHENOR, Mark S. ,  WIENER, John J. M.

Inventor： CHAI, Wenying ,  DVORAK, Curt A. ,  ECCLES, Wendy ,  EDWARDS, James P. ,  GOLDBERG, Steven D, ,  KRAWCZUK, Paul J. ,  LEBSACK, Alec D. ,  LIU, Jing ,  PIPPEL, Daniel J. ,  SALES, Zachary S. ,  TANIS, Virginia M. ,  TICHENOR, Mark S. ,  WIENER, John J. M.

IPC: C07D401/12 ,  C07D403/12 ,  A61K31/4184 ,  A61K31/4439 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07D401/12 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X 1 , X 1' , X 1'' , R 1 , R 2 and R 3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

Abstract translation: 本发明涉及式（I）化合物及其溶剂合物，水合物及其药学上可接受的盐，其中X1，X1'，X1“，R1，R2和R3如本文所定义，可用作FLAP调节剂。 本发明还涉及包含式（I）化合物的药物组合物。 制备和使用式（I）化合物的方法也在本发明的范围内。