利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

206 条记录 (耗时 0.02 秒)

    TUBULIN ISOTYPE SCREENING IN CANCER THERAPY USING HALICHONDRIN B ANALOGS
    2.
    发明申请
    TUBULIN ISOTYPE SCREENING IN CANCER THERAPY USING HALICHONDRIN B ANALOGS 审中-公开
    使用HALICHONDRIN B模拟物的癌症治疗中的TUBULIN同位素筛选

    公开(公告)号：WO2006076100A3

    公开(公告)日：2009-04-02

    申请号：PCT/US2005044421

    申请日：2005-12-07

    申请人： EISAI CO LTD ,  AGOULNIK SERGEI ,  KUZNETSOV GALINA ,  LITTLEFIELD BRUCE A

    发明人： AGOULNIK SERGEI ,  KUZNETSOV GALINA ,  LITTLEFIELD BRUCE A

    IPC分类号： G01N33/574

    CPC分类号： A61K31/353 ,  G01N33/5091 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57496 ,  G01N2500/00 ,  Y10T436/143333

    摘要： Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include halichondrin B analogs. It has been shown that the susceptibility of certain cancers to analogs of halichondrin B correlates with the expression of particular tubulin isotypes or other microtubule-associated proteins such as MAP-4 and stathmin. Correlations such as these may be used in identifying patients suitable for treatment using a particular chemotherapeutic agent. Such a system avoids treating patients with cytotoxic compounds where there is a minimal or no effect on the cancer. The invention also provides a system of establishing these correlations for different compounds and cancer types. The system will be particularly useful in establishing correlations between anti-microtubule agents and cancers such as lung, breast, and ovarian cancer. Kits and reagents useful in practicing the invention are also provided.

    摘要翻译： 影响细胞中微管组装或分解的化学治疗剂是细胞复制的有效抑制剂。 这些试剂的实例包括软骨素B类似物。 已经显示某些癌症对软骨素B类似物的敏感性与特定的微管蛋白同种型或其它微管相关蛋白如MAP-4和stathmin的表达相关。 诸如这些的相关性可以用于鉴定适合于使用特定化学治疗剂的治疗的患者。 这样的系统避免了治疗患有细胞毒性化合物的患者，其中对癌症最小或没有影响。 本发明还提供了一种为不同化合物和癌症类型建立这些相关性的系统。 该系统将特别有用于建立抗微管剂和肺癌，乳腺癌和卵巢癌等癌症之间的相关性。 还提供了可用于实践本发明的试剂盒和试剂。

    RECOVERY SYSTEM
    6.
    发明申请
    RECOVERY SYSTEM 审中-公开
    恢复系统

    公开(公告)号：WO2007008593A3

    公开(公告)日：2007-04-05

    申请号：PCT/US2006026340

    申请日：2006-07-07

    申请人： EISAI CO LTD ,  MANN BRAD ,  BALLANCE EDDIE ,  GROBIN ALLEN

    发明人： MANN BRAD ,  BALLANCE EDDIE ,  GROBIN ALLEN

    IPC分类号： A61J1/00

    CPC分类号： B09B3/0058

    摘要： A system allows for the safe, rapid, efficient recovery of a drug solution from sealed vials. The system is closed so that highly potent compounds can later be recovered and reworked without large investment in further engineering controls. The system includes three main components: a recovery device that holds sealed vials containing a solution, and provides means to access the contents of the vials; a peristaltic pump that pumps solution out of the vials; and a recovery tank that receives the pumped solution.

    摘要翻译： 系统允许从密封的小瓶中安全，快速，有效地回收药物溶液。 系统关闭，因此高效的化合物可以随后回收和重新加工，而无需大量投资进一步的工程控制。 该系统包括三个主要组成部分：一个收容装置，用于容纳含有溶液的密封小瓶，并提供进入小瓶内容物的装置; 将溶液从小瓶中抽出的蠕动泵; 以及接收泵送的溶液的回收罐。