公开(公告)号：WO2007015271A1

公开(公告)日：2007-02-08

申请号：PCT/IT2005/000464

申请日：2005-08-02

Applicant: FIDIA S.P.A. ,  IPPOLITO, Massimo ,  MORFINO, Giuseppe

Inventor： IPPOLITO, Massimo ,  MORFINO, Giuseppe

IPC: G06T7/00 ,  G01B11/00 ,  G01B21/00 ,  G01D5/26 ,  G05D1/02

CPC classification number: G01B11/002

Abstract: A precision measuring system (1) for industrial machines is disclosed, particularly for numerically-controlled machine tools, particularly for measuring the linear displacement transduction of an object (40) comprising at least one optical system (20) equipped with at least one CCD-type optical sensor (10) adapted to acquire images of the object (40) in time; and acquiring, processing and computing means (30) of video signals (80) generated by the CCD-type optical sensor (10) adapted to determine measure signals (90) representing an amount of a displacement of the object (40). A measuring process using the system (1) is further disclosed.

Abstract translation: 公开了一种用于工业机械的精密测量系统（1），特别是用于数控机床，特别是用于测量物体（40）的线性位移转导，包括至少一个装备有至少一个CCD- 适于在时间上获取物体（40）的图像的光学传感器（10）; 以及由CCD型光学传感器（10）产生的适于确定表示物体（40）的位移量的测量信号（90）的视频信号（80）的获取，处理和计算装置（30）。 进一步公开了使用该系统（1）的测量过程。

公开(公告)号：WO1994020516A1

公开(公告)日：1994-09-15

申请号：PCT/US1994001966

申请日：1994-03-04

Applicant: FIDIA S.P.A. ,  ROMEO, Aurelio ,  KIRSCHNER, Gunter ,  CHIZZOLINI, Carlo ,  MANEV, Hari ,  FACCI, Laura

Inventor： FIDIA S.P.A.

IPC: C07H15/10

CPC classification number: C07H15/10

Abstract: Semisynthetic analogues of gangliosides selected from the group consisting of N-sulfo-, N-hydrocarbyl-sulfonyl- and N-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N'-acyl derivatives thereof, N'-sulfo-, N'-hydrocarbylsulfonyl- and N'-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N-acyl derivatives thereof, N,N'-di or polysulfo-N,N'-di- or poly-lyso-gangliosides, N,N'-di- or polyhydrocarbylsulfonyl-N,N'-di- or poly-lyso-gangliosides and N,N'-di- or polyhydrocarbyloxy-N,N'-di- or poly-lyso-gangliosides, and functional derivatives thereof, and salts of these compounds, have protective activity against neurotoxicity induced by excitatory amino acids and are foreseen to be used in therapy in the nervous system and in modulating of the expression of determinants such as CD4 on the surface of human cells in the immune system.

Abstract translation: 神经节苷脂的半合成类似物，其选自N-磺基，N-烃基 - 磺酰基和N-烃氧基 - 磺酰基-N，N'-二甘氨酸神经节苷脂及其N'-酰基衍生物，N'-磺酰基 - ，N'-烃基磺酰基 - 和N'-烃氧基 - 磺酰基-N，N'-二甘氨酸神经节苷脂及其N-酰基衍生物，N，N'-二或多磺基-N，N'-二 - 或多 - 神经节苷脂，N，N'-二 - 或多烃基磺酰基-N，N'-二 - 或多溶血神经节苷脂和N，N'-二 - 或多羟基氧基-N，N'-二 - 或多溶解神经节苷脂 及其功能性衍生物和这些化合物的盐具有针对由兴奋性氨基酸诱导的神经毒性的保护作用，并且预期用于神经系统的治疗和调节人类表面上的诸如CD4的决定簇的表达 免疫系统中的细胞。

公开(公告)号：WO1993021190A1

公开(公告)日：1993-10-28

申请号：PCT/EP1993000915

申请日：1993-04-16

Applicant: FIDIA S.P.A. ,  DI MARTINO, Alessandro ,  CALLEGARO, Lanfranco ,  TOFFANO, Gino

Inventor： FIDIA S.P.A.

IPC: C07F09/10

CPC classification number: A61K31/685 ,  A61K35/30 ,  C07F9/103

Abstract: A phospholipid mixture in which the biological and pharmacological properties are maintained but from which unconventional viruses causing e.g. bovine spongiform encephalopathy are selectively eliminated may be prepared by extraction of phospholipids from bovine brain by a mixture of organic solvents of which one is a chlorinated hydrocarbon or by silica gel chromatography with elution with a succession of eluents consisting of chloroform, lower alcohols and water, or by a combination of extraction and silica gel chromatography. Purified phospholipids can be used in pharmaceutical compositions.

Abstract translation: 一种磷脂混合物，其中保持生物和药理学性质，但是由非常规病毒引起，例如， 选择性地消除牛海绵状脑病可以通过其中一种是氯代烃的有机溶剂的混合物或通过硅胶色谱法从牛脑中提取磷脂来制备，用一系列由氯仿，低级醇和水组成的洗脱液洗脱， 或通过萃取和硅胶色谱法的组合。 纯化的磷脂可用于药物组合物中。

公开(公告)号：WO1993020824A1

公开(公告)日：1993-10-28

申请号：PCT/EP1993000894

申请日：1993-04-13

Applicant: FIDIA S.P.A. ,  ROMEO, Aurelio ,  TOFFANO, Gino

Inventor： FIDIA S.P.A.

IPC: A61K31/70

CPC classification number: A61K31/70

Abstract: Pharmaceutical compositions containing monosialoganglioside derivatives suitable for the treatment of spinal cord injury caused by hypoxic-ischaemic or traumatic events, in which said derivatives are selected from the group consisting of the inner ester (AGF2) and the methyl ester (AGF4) of the monosialoganglioside (GM1).

Abstract translation: 含有适用于治疗由缺氧缺血性或创伤性事件引起的脊髓损伤的单唾液酸神经节苷脂衍生物的药物组合物，其中所述衍生物选自单唾液酸神经节苷脂的内酯（AGF2）和甲酯（AGF4） GM1）。

公开(公告)号：WO1991007417A1

公开(公告)日：1991-05-30

申请号：PCT/EP1990001960

申请日：1990-11-16

Applicant: FIDIA S.P.A. ,  DELLA VALLE, Francesco ,  CALLEGARO, Lanfranco ,  LORENZI, Silvana

Inventor： FIDIA S.P.A.

IPC: C07H15/10

CPC classification number: C07H15/10 ,  C07H1/08

Abstract: The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.

Abstract translation: 本发明的方法涉及制备神经节苷脂混合物的方法，所述神经节苷脂混合物没有与非传统的危及生命的病毒相关的污染物，而不改变中枢和周围神经系统上混合物的生物学和药理学特征。

公开(公告)号：WO1989010941A1

公开(公告)日：1989-11-16

申请号：PCT/EP1989000519

申请日：1989-05-12

Applicant: FIDIA S.P.A.

Inventor： FIDIA S.P.A. ,  DELLA VALLE, Francesco ,  ROMEO, Aurelio

IPC: C08B15/00

CPC classification number: A61K9/0014 ,  A61K8/0208 ,  A61K8/73 ,  A61K8/731 ,  A61K8/733 ,  A61K8/735 ,  A61K8/736 ,  A61K47/36 ,  A61K47/38 ,  A61K2800/57 ,  A61L15/28 ,  A61L15/425 ,  A61L17/10 ,  A61L27/20 ,  A61L27/58 ,  A61L31/042 ,  A61Q19/00 ,  C08B11/20 ,  C08B15/005 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0084 ,  C08L5/00

Abstract: Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inner cross-linked esters of polysaccharide acids are useful in the field of biodegradable plastic materials, to manufacture sanitary and surgical articles, in the cosmetic and pharmaceutical fields, in the food industry and in many other industrial fields.

Abstract translation: 公开了酸多糖的间和/或分子内交联的酯，其中部分或全部羧基用同一分子的羟基和/或酸多糖的不同分子酯化。 这些多糖酸的内部交联酯可用于可生物降解的塑料材料领域，在食品工业和许多其他工业领域的化妆品和制药领域中制造卫生和外科用品。

公开(公告)号：WO2022029678A1

公开(公告)日：2022-02-10

申请号：PCT/IB2021/057200

申请日：2021-08-05

Applicant: FIDIA S.P.A.

Inventor： BENE, Giacomo ,  MORFINO, Giuseppe

IPC: B23Q1/01 ,  B23Q1/62 ,  B23Q5/38 ,  B23Q5/56 ,  B23Q1/012 ,  B23Q1/017 ,  B23Q1/621 ,  B23Q5/385

Abstract: A machine tool has a substantially straight guide element (2) extending along a first axis (A1); two carriages (3, 4), which are arranged at a fixed distance (D) from one another along the guide element (2) and are capable of sliding together along the guide element (2); a slide (5), which is interposed between the two carriages (3, 4), is carried by the two carriages (3, 4) and can slide relative to them along a second axis (A2) perpendicular to the first axis (A1); and a milling head (6), which is carried by the slide (5) and is configured to carry a milling tool.

公开(公告)号：WO2012153316A1

公开(公告)日：2012-11-15

申请号：PCT/IB2012/052390

申请日：2012-05-14

Applicant: FIDIA S.P.A. ,  REPOSSINI, Claudio Ugo Protaso ,  MORFINO, Giuseppe

Inventor： REPOSSINI, Claudio Ugo Protaso ,  MORFINO, Giuseppe

IPC: B23Q1/48 ,  B23Q1/54 ,  B23Q5/56

CPC classification number: B23Q1/488 ,  B23Q1/5406 ,  B23Q1/5412 ,  B23Q5/56

Abstract: The tool carrying head (1) comprises a first fork-shaped carrying structure (2), having two branches or prongs (2a, 2b) facing each other; a second carrying structure (3), mounted rotatably between the branches (2a, 2b) of the fork-shaped structure (2) about a first axis (A-A) which is essentially orthogonal to the branches or prongs (2a, 2b), and defining an internal through opening (4); a third carrying structure (5) mounted rotatably in the through opening (4) of the second structure (3), about a second axis (B-B) which is orthogonal to the first axis (A-A); and a tool carrying spindle (6) mounted rotatably in the third carrying structure (5) about a third axis (C-C) which is orthogonal to the first and second axes (A-A, B-B).

Abstract translation: 工具承载头（1）包括具有彼此面对的两个分支或分支（2a，2b）的第一叉形承载结构（2） 第二承载结构（3），其围绕基本上与分支或分支（2a，2b）正交的第一轴线（AA）可旋转地安装在叉形结构（2）的分支（2a，2b）之间;以及 限定内部通孔（4）; 围绕与第一轴线（A-A）正交的第二轴线（B-B）可旋转地安装在第二结构（3）的通孔（4）中的第三承载结构（5） 以及与第一和第二轴线（A-A，B-B）正交的第三轴线（C-C）可旋转地安装在第三承载结构（5）中的工具承载主轴（6）。

公开(公告)号：WO2012017419A1

公开(公告)日：2012-02-09

申请号：PCT/IB2011/053512

申请日：2011-08-05

Applicant: FIDIA S.p.A. ,  MORFINO, Giuseppe ,  FRANCESE, Carla ,  VESCO, Mario ,  GHEZZO, Edoardo

Inventor： MORFINO, Giuseppe ,  FRANCESE, Carla ,  VESCO, Mario ,  GHEZZO, Edoardo

IPC: G05B19/4069

CPC classification number: G05B19/4069 ,  G05B2219/32351 ,  G05B2219/35304 ,  G05B2219/35306 ,  G05B2219/35311 ,  Y02P90/26

Abstract: The system performs control and virtual display (1) for a machine tool (M) which comprises a tool-holder (2) for a tool (T), a carrier (3) for a workpiece (W) to be machined by means of the tool (T), and a plurality of actuator devices (Al,..., AN) which can be controlled by means of associated drivers (D1,..., DN) in order to bring about controlled relative displacements between the tool (T) and the workpiece (W) along respective axes. The control system (1) comprises: a numerical controller (NC) which is connected to the drivers (D1,..., DN) and is suitable for implementing a machining program that is predetermined according to the features of the workpiece (W) to be produced and the features of the tool (T); the numerical controller (NC) is suitable for calculating, on the basis of the machining program, target coordinates defining positions of the tool (T) along the axes, which positions are to be reached by the activation of the associated actuator devices (Al, AN); image display means (ID); and a processing system (P) which is incorporated in and/or connected to the numerical controller (NC) in order to receive the calculated target coordinate values, and which is arranged to generate, on the basis of the target coordinates and of stored mathematical models of the machine (M), of the workpiece and of the tool, image data suitable for producing on the image display means (ID) a predictive, virtual, two-dimensional representation of the positions adopted by the workpiece (W) and by the tool (T) up to a preselected future moment.

Abstract translation: 该系统对机床（M）执行控制和虚拟显示（1），该机床包括用于工具（T）的工具架（2），用于待加工的工件（W）的载体（3） 工具（T）以及可以通过相关联的驱动器（D1，...，DN）控制的多个致动器装置（A1，...，AN），以便在工具 （T）和工件（W）。 控制系统（1）包括：数字控制器（NC），其连接到驱动器（D1，...，DN）并且适于实现根据工件（W）的特征预定的加工程序， （T）的特征; 数值控制器（NC）适于基于加工程序计算定义工具（T）沿着轴的位置的目标坐标，通过激活相关联的致动器装置（A1， 一个）; 图像显示装置（ID）; 以及处理系统（P），其被并入和/或连接到数字控制器（NC），以便接收所计算的目标坐标值，并且被配置为基于目标坐标和存储的数学 机器（M）的工件和工具的模型，适于在图像显示装置（ID）上生成由工件（W）采用的位置的预测，虚拟，二维表示的图像数据，以及通过 工具（T）直到预选的未来时刻。

公开(公告)号：WO1994001435A1

公开(公告)日：1994-01-20

申请号：PCT/EP1993001743

申请日：1993-07-06

Applicant: FIDIA S.P.A. ,  BARTOLINI, Alessandro ,  GHELARDINI, Carla ,  GIOTTI, Alberto ,  GUALTIERI, Fulvio ,  SCAPECCHI, Serena ,  TOFFANO, Gino

Inventor： FIDIA S.P.A.

IPC: C07D451/10

CPC classification number: C07D451/04 ,  C07D451/10

Abstract: Compounds of general formula (I), where Ar = phenyl or beta-naphtyl, R1 = one or more substituents of the phenyl or beta-naphtyl nucleus, preferably in para position, and selected out of the group consisting of H, CH3, C(CH3)3, CH2-CH-(CH3)2, O-CH3, C1, F, Br, CF3, NH2, S-CH3, SO-CH3, CN, NO2; R2 = H, CH3, C2H5, CH(CH3)2, CH2OH, C6H5; R3 = (a); where R4 = H, CH3, C2H5, CH(CH3)2, CH2-C6H5; R5 = H, CH3; X = none O, S, NH, NCH3; Y = O, NH, both in the racemic form and in the isomeric enantiomeric forms, which produce a nootropic effect, i.e. memory enhancement and learning facilitation, as well as an analgesic effect.

Abstract translation: 通式（I）的化合物，其中Ar =苯基或β-萘基，R1 =苯基或β-萘基核的一个或多个取代基，优选在对位，并选自H，CH 3，C （CH 3）3，CH 2 -CH-（CH 3）2，O-CH 3，C 1，F，Br，CF 3，NH 2，S-CH 3，SO-CH 3，CN，NO 2; R2 = H，CH3，C2H5，CH（CH3）2，CH2OH，C6H5; R3 =（a）; 其中R 4 = H，CH 3，C 2 H 5，CH（CH 3）2，CH 2 -C 6 H 5; R5 = H，CH3; X =不是O，S，NH，NCH 3; Y = O，NH，均以外消旋形式和异构对映异构体形式产生，其产生向异性作用，即记忆增强和学习促进作用以及止痛作用。