公开(公告)号：WO2008016648A3

公开(公告)日：2008-02-07

申请号：PCT/US2007/017191

申请日：2007-07-31

Applicant: CYTOKINETICS, INCORPORATED ,  MUCI, Alex ,  FINER, Jeffrey T. ,  MORGAN, Bradley P. ,  RUSSELL, Alan James ,  MORGANS, JR., David J.

Inventor： MUCI, Alex ,  FINER, Jeffrey T. ,  MORGAN, Bradley P. ,  RUSSELL, Alan James ,  MORGANS, JR., David J.

IPC: A01N43/42 ,  A61K31/44 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02

Abstract: Provided are certain chemical entities, and methods of use to modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, neuromuscular disease, and other indications.

公开(公告)号：WO2008016648A2

公开(公告)日：2008-02-07

申请号：PCT/US2007017191

申请日：2007-07-31

Applicant: CYTOKINETICS INC ,  MUCI ALEX ,  FINER JEFFREY T ,  MORGAN BRADLEY P ,  RUSSELL ALAN JAMES ,  MORGANS JR DAVID J

Inventor： MUCI ALEX ,  FINER JEFFREY T ,  MORGAN BRADLEY P ,  RUSSELL ALAN JAMES ,  MORGANS JR DAVID J

IPC: C07D471/02

CPC classification number: C07D471/04

Abstract: Provided are certain chemical entities, and methods of use to modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, neuromuscular disease, and other indications.

Abstract translation: 提供了某些化学实体和调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的用途的方法， 以及用于治疗肥胖，肌肉减少症，消瘦综合征，虚弱，肌肉痉挛，神经肌肉疾病和其他适应症的方法。

公开(公告)号：WO0131335A9

公开(公告)日：2002-08-15

申请号：PCT/US0029570

申请日：2000-10-26

Applicant: CYTOKINETICS INC ,  WOOD KENNETH W ,  FINER JEFFREY T ,  BERAUD CHRISTOPHE ,  MAK JOHN ,  SAKOWICZ ROMAN

Inventor： WOOD KENNETH W ,  FINER JEFFREY T ,  BERAUD CHRISTOPHE ,  MAK JOHN ,  SAKOWICZ ROMAN

IPC: G01N33/50 ,  G01N33/574 ,  A61K39/395

CPC classification number: G01N33/502 ,  G01N33/5011 ,  G01N33/57484 ,  G01N33/57496 ,  G01N2500/04

Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.

Abstract translation: 本文描述了可用于细胞增殖的诊断和预后的方法。 本文还描述了可用于筛选候选生物活性剂以调节细胞增殖能力的方法。 此外，描述了用于癌症治疗性干预的方法和分子靶标（基因及其产物）。

公开(公告)号：WO2001030768A1

公开(公告)日：2001-05-03

申请号：PCT/US2000/029585

申请日：2000-10-26

Applicant: CYTOKINETICS, INC. ,  FINER, Jeffrey, T. ,  BERGNES, Gustave ,  FENG, Bainian ,  SMITH, Whitney, W. ,  CHABALA, John, C.

Inventor： FINER, Jeffrey, T. ,  BERGNES, Gustave ,  FENG, Bainian ,  SMITH, Whitney, W. ,  CHABALA, John, C.

IPC: C07D239/91

CPC classification number: C07D239/91

Abstract: Quinazolinones of formulae (1a), (1b), (1c) and (1d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.

Abstract translation: 公开了式（1a），（1b），（1c）和（1d）的喹唑啉酮。 它们可用于治疗与KSP驱动蛋白活性相关的细胞增殖性疾病和病症。

公开(公告)号：WO2011126790A1

公开(公告)日：2011-10-13

申请号：PCT/US2011/030134

申请日：2011-03-28

Applicant: JOSLIN DIABETES CENTER, INC. ,  KAHN, C., Ronald ,  FINER, Jeffrey, T. ,  LINNEMANN, Thomas ,  WILLIAMS, Lewis, T. ,  KOTHAKOTA, Srinivas ,  MONDON, Carl ,  ZHOU, Aileen ,  LIN, Junyu

Inventor： KAHN, C., Ronald ,  FINER, Jeffrey, T. ,  LINNEMANN, Thomas ,  WILLIAMS, Lewis, T. ,  KOTHAKOTA, Srinivas ,  MONDON, Carl ,  ZHOU, Aileen ,  LIN, Junyu

IPC: A61K38/18 ,  C07K14/50 ,  C12N5/00 ,  C12N5/02

CPC classification number: C07K14/50 ,  A61K38/1825 ,  C12N5/0653 ,  C12N2501/119

Abstract: Methods and materials for inducing brown adipose and for treating obesity using FGF6 and/or FGF9 are provided.

Abstract translation: 提供了诱导褐色脂肪和使用FGF6和/或FGF9治疗肥胖症的方法和材料。

公开(公告)号：WO2008016676A3

公开(公告)日：2009-04-09

申请号：PCT/US2007017246

申请日：2007-08-01

Applicant: CYTOKINETICS INC ,  QIAN XIANGPING ,  FINER JEFFREY T ,  LU PU-PING ,  CHUANG CHIHYUAN GRACE ,  MORGAN BRADLEY P ,  MORGANS DAVID J JR

Inventor： QIAN XIANGPING ,  FINER JEFFREY T ,  LU PU-PING ,  CHUANG CHIHYUAN GRACE ,  MORGAN BRADLEY P ,  MORGANS DAVID J JR

IPC: A61K31/42 ,  C07D257/04

CPC classification number: C07D309/28 ,  C07D207/14 ,  C07D211/32 ,  C07D211/62 ,  C07D215/38 ,  C07D257/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D417/12

Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

Abstract translation: 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。

公开(公告)号：WO2008016666A2

公开(公告)日：2008-02-07

申请号：PCT/US2007/017231

申请日：2007-08-01

Applicant: CYTOKINETICS, INCORPORATED ,  QIAN, Xiangping ,  FINER, Jeffrey T. ,  LU, Pu-Ping ,  CHUANG, Chihyuan (Grace) ,  MORGAN, Bradley P. ,  MORGANS, JR., David J.

Inventor： QIAN, Xiangping ,  FINER, Jeffrey T. ,  LU, Pu-Ping ,  CHUANG, Chihyuan (Grace) ,  MORGAN, Bradley P. ,  MORGANS, JR., David J.

IPC: A61K31/427

CPC classification number: C07D401/12 ,  C07D239/88

Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

公开(公告)号：WO2008016666A3

公开(公告)日：2008-07-24

申请号：PCT/US2007017231

申请日：2007-08-01

Applicant: CYTOKINETICS INC ,  QIAN XIANGPING ,  FINER JEFFREY T ,  LU PU-PING ,  CHUANG CHIHYUAN GRACE ,  MORGAN BRADLEY P ,  MORGANS DAVID J JR

Inventor： QIAN XIANGPING ,  FINER JEFFREY T ,  LU PU-PING ,  CHUANG CHIHYUAN GRACE ,  MORGAN BRADLEY P ,  MORGANS DAVID J JR

IPC: C07D211/32 ,  A61K31/428 ,  A61K31/454 ,  C07D277/82

CPC classification number: C07D401/12 ,  C07D239/88

Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

Abstract translation: 描述调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，药物组合物和治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的方法。

公开(公告)号：WO2008016676A2

公开(公告)日：2008-02-07

申请号：PCT/US2007/017246

申请日：2007-08-01

Applicant: CYTOKINETICS, INCORPORATED ,  QIAN, Xiangping ,  FINER, Jeffrey, T. ,  LU, Pu-Ping ,  CHUANG, Chihyuan (Grace) ,  MORGAN, Bradley, P. ,  MORGANS, David, J., JR.

Inventor： QIAN, Xiangping ,  FINER, Jeffrey, T. ,  LU, Pu-Ping ,  CHUANG, Chihyuan (Grace) ,  MORGAN, Bradley, P. ,  MORGANS, David, J., JR.

IPC: C07D401/02

CPC classification number: C07D309/28 ,  C07D207/14 ,  C07D211/32 ,  C07D211/62 ,  C07D215/38 ,  C07D257/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D417/12

Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

Abstract translation: 描述了调节平滑肌肌球蛋白和/或非肌肉肌球蛋白的化学实体，治疗与平滑肌肌球蛋白和/或非肌肉肌球蛋白相关的疾病和病症的药物组合物和方法。

公开(公告)号：WO2008016669A2

公开(公告)日：2008-02-07

申请号：PCT/US2007/017235

申请日：2007-08-01

Applicant: CYTOKINETICS, INCORPORATED ,  MUCI, Alex ,  FINER, Jeffrey T. ,  LU, Pu-Ping ,  RUSSELL, Alan James ,  MORGAN, Bradley P. ,  MORGANS, David J. Jr.

Inventor： MUCI, Alex ,  FINER, Jeffrey T. ,  LU, Pu-Ping ,  RUSSELL, Alan James ,  MORGAN, Bradley P. ,  MORGANS, David J. Jr.

IPC: C07D487/02

CPC classification number: C07D487/04

Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.

Abstract translation: 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的用途， 以及用于治疗肥胖，肌营养不良，消瘦综合征，虚弱，恶病质，肌肉痉挛，手术后和创伤后肌肉无力，神经肌肉疾病等指征的治疗方法。