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公开(公告)号：WO2017041102A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/050415
申请日：2016-09-06
CPC分类号： A61M1/3678 , A61M1/3692 , A61M2202/0427 , A61M2202/0429 , A61M2202/0456 , A61M2202/08 , A61M2205/0244 , B06B1/0674
摘要： Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
摘要翻译： 公开了声学设备。 这些装置包括流动室，超声换能器，反射器，入口，滤液出口，浓缩物出口和任选的脂质收集阱。 超声波换能器和反射器在流动室中产生多维声驻波，其将红细胞和/或血液从血液中捕获和分离。 可以通过浓缩物出口回收浓缩的红细胞，通过脂质收集阱可以回收脂质，剩余的血液可以通过滤液出口回收。 还公开了从血液中分离血液成分（例如红细胞，脂质，血小板，白细胞）的方法。 红细胞可以用溶剂洗涤以除去不想要的混合物。 可以从血液中加入或除去冷冻保护剂。
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公开(公告)号：WO2016201385A3
公开(公告)日：2016-12-15
申请号：PCT/US2016/037104
申请日：2016-06-11
发明人： GILMANSHIN, Rudolf , LIPKENS, Bart
摘要： The devices for inspecting, detecting, isolating, monitoring, characterizing, or separating pathogens in blood containing blood cells include a flow chamber (100) having a solvent inlet (112), at least one host-fluid inlet (114), a particulate outlet (116), at least one residual outlet (118), and a transducer (120) and a reflector (130). The methods include trapping the pathogens in the acoustic standing wave, introducing a solvent into the flow chamber, and removing the pathogens from the device. The devices for inspecting, detecting, isolating, monitoring, characterizing, or separating specialized circulating cells in blood containing blood cells include a flow chamber having at least one inlet and at least one outlet, and a microscope objective and a cover glass. The methods include driving the transducer to create an acoustic standing wave in the flow chamber and microbubbles in the blood.
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公开(公告)号：WO2016201385A2
公开(公告)日：2016-12-15
申请号：PCT/US2016/037104
申请日：2016-06-11
发明人： GILMANSHIN, Rudolf , LIPKENS, Bart
CPC分类号： G01N33/491 , A61M1/362 , A61M1/3678 , B01D21/283 , B01D43/00 , B01L3/502715 , B01L3/502761 , B01L2200/025 , B01L2200/0647 , B01L2300/0867 , B01L2300/0877 , B01L2400/0436 , B06B1/0622 , C12Q1/24 , G01N15/1404 , G01N15/1436 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N33/574 , G01N2015/1006 , G01N2015/149
摘要： Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating pathogens in blood containing blood cells are disclosed. The devices include a flow chamber having a solvent inlet, at least one host-fluid inlet, a particulate outlet, at least one residual outlet, and a reflector. The methods include trapping the pathogens in the acoustic standing wave, introducing a solvent into the flow chamber, and removing the pathogens from the device. Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating specialized circulating cells in blood containing blood cells are also disclosed. The devices include a flow chamber having at least one inlet and at least one outlet, and a microscope objective and a cover glass. The methods include driving the transducer to create an acoustic standing wave in the flow chamber and microbubbles in the blood.
摘要翻译： 公开了用于检测，检测，分离，监测，表征或分离血液中血液中病原体的装置和方法。 这些装置包括具有溶剂入口，至少一个主流体入口，微粒出口，至少一个剩余出口和反射器的流动室。 所述方法包括将声波驻波中的病原体捕获，将溶剂引入流动室中，并从装置中除去病原体。 还公开了用于检查，检测，分离，监测，表征或分离含血液血细胞中的专用循环细胞的装置和方法。 这些装置包括具有至少一个入口和至少一个出口以及显微镜物镜和盖玻璃的流动室。 这些方法包括驱动换能器以在流动室中产生声驻波并在血液中产生微泡。
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公开(公告)号：WO2016176663A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/030315
申请日：2016-04-29
CPC分类号： C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
摘要： Devices for separating materials from a host fluid are disclosed. The devices 100 include a flow chamber, an ultrasonic transducer 120, and a reflector 130. The ultrasonic transducer 120 and reflector 130 create an angled acoustic standing wave oriented at an angle A relative to the direction of mean flow 116 through the flow chamber. The angled acoustic standing wave 122 results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
摘要翻译： 公开了用于从主体流体分离材料的装置。 装置100包括流动室，超声波换能器120和反射器130.超声波换能器120和反射器130产生相对于通过流动室的平均流动方向116以角度A定向的倾斜声驻波。 倾斜的声驻波122导致具有使材料偏转的轴向力分量的声辐射力，从而可以分离材料和主流体。 倾斜的声驻波可以相对于通过流动室的平均流动的方向以大约20°至大约70°的角度定向，从而偏离，收集，分离或分流材料与流过流过装置的流体 速率约400mL / min，高达约700mL / min。
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5.发明申请METHODS AND APPARATUS FOR PARTICLE AGGREGATION USING ACOUSTIC STANDING WAVES 审中-公开使用声学波形的粒子聚集的方法和装置
公开(公告)号：WO2016154475A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/024082
申请日：2016-03-24
IPC分类号： B01D21/28
CPC分类号： B01D21/283 , C02F1/36 , C12M47/02
摘要： Devices for separating materials from a host fluid are disclosed. The devices include an acoustic chamber, the figure indicates the view perpendicular to an ultrasonic transducer (130), having an inlet at the bottom and an outlet at the top. The ultrasonic transducer (130) and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps the materials and permits a continuous separation of the materials from the host fluid (vertical flow direction 120). The materials and the host fluid can thus be separately collected. Multiple sets of trapping lines (132) are generated by the acoustic standing wave, and the transducer (130) is oriented or has a shape to minimize cross-sectional area for straight vertical channels between the trapping lines.
摘要翻译： 公开了用于从主体流体分离材料的装置。 这些装置包括声学室，该图表示垂直于超声换能器（130）的视图，其具有底部的入口和顶部的出口。 超声波换能器（130）和反射器在声学室中产生多维声驻波，其捕获材料并允许材料与主体流体（垂直流动方向120）的连续分离。 因此，可以分别收集材料和主体流体。 通过声驻波产生多组捕获线（132），并且换能器（130）被定向或具有使捕集线之间的直立垂直通道的横截面积最小化的形状。
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公开(公告)号：WO2016100923A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066884
申请日：2015-12-18
发明人： LIPKENS, Bart , MILLER, Erik , ROSS-JOHNSRUD, Benjamin , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid medium are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid medium is being drawn.
摘要翻译： 公开了用于将流体介质中的生物细胞与其它材料分离的声学灌注装置。 这些装置包括连接到声学室的入口端口，出口端口和收集端口。 超声波换能器在声学室中产生声驻波，允许流体通过收集口连续流动，同时将声室内的生物细胞保持回流到生物反应器，流体介质从该反应器被拉出。
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公开(公告)号：WO2016004398A3
公开(公告)日：2016-03-17
申请号：PCT/US2015039125
申请日：2015-07-02
申请人： FLODESIGN SONICS INC
发明人： LIPKENS BART , MCCARTHY BRIAN , BARNES JASON , MEALEY DANE , ROSS-JOHNSRUD BEN , PRESZ JR WALTER M , CHITALE KEDAR
IPC分类号： C12N13/00
CPC分类号： B01D21/283 , B01D21/0045
摘要： An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles / secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
摘要翻译： 公开了一种消声装置，其包括流体混合物的基本垂直的流动路径，以便改进颗粒/次要流体与初级流体的分离。 垂直流动路径降低了由重力引起的声室中的速度非均匀性。 该装置包括其中产生多维声驻波的声室。 流体可以使用排放扩散器引入到声室中，其中多个入口进入声室的底部附近，使得流动对称性减少重力驱动的流动不均匀性，以及入口混合物流之间的任何流动干扰效应 进入声室并连续重力驱动的颗粒群落出。
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公开(公告)号：WO2015069739A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064088
申请日：2014-11-05
发明人： LIPKENS, Bart , BARNES, Jason , MEALEY, Dane , PRESZ, Walter M. Jr , KOWALSKI, Stanley, III , MASI, Louis , KENNEDY, Thomas J., III , MCCARTHY, Brian , ROSS-JOHNSRUD, Ben
CPC分类号： C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
摘要： An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
摘要翻译： 公开了一种由模块化部件组成的消声器。 本文公开了多个模块，包括超声换能器模块，输入/输出模块，收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒（例如生物细胞）的适当流体动力学的不同系统。
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公开(公告)号：WO2014176559A1
公开(公告)日：2014-10-30
申请号：PCT/US2014/035557
申请日：2014-04-25
发明人： LIPKENS, Bart , MERCADO, Ari , MARTIN, Arthur , MASI, Louis , DIONNE, Jason
IPC分类号： B01D11/00
CPC分类号： B01D21/00 , B01D11/0223 , B01D11/0265 , B01D21/283 , B01D2221/10 , G01N33/15
摘要： Active pharmaceutical ingredients can be separated from their excipients by dissolving a pharmaceutical product (e.g. tablet, pill) into a solvent, then running the solution through an acoustophoretic device. Standing waves are used to separate the excipient from the active ingredient dissolved in the solvent.
摘要翻译： 活性药物成分可以通过将药物产品（例如片剂，丸剂）溶解到溶剂中，然后将溶液通过声学渗透装置来从其赋形剂中分离出来。 使用驻波将赋形剂与溶解在溶剂中的活性成分分离。
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公开(公告)号：WO2014055219A3
公开(公告)日：2014-04-10
申请号：PCT/US2013/059640
申请日：2013-09-13
IPC分类号： G01F1/66
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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