公开(公告)号：WO2022016087A1

公开(公告)日：2022-01-20

申请号：PCT/US2021/042031

申请日：2021-07-16

Applicant: ROBERT BOSCH GMBH ,  JOHNSON, Christopher ,  KAVUSI, Sam ,  FOMINA, Nadezda ,  AHMAD, Habib ,  MARUNIAK, Autumn ,  LANG, Christoph ,  RAGHUNATHAN, Ashwin ,  SHIN, Young Shik ,  DARVISH, Armin ,  PAPAGEORGIOU, Efthymios

Inventor： JOHNSON, Christopher ,  KAVUSI, Sam ,  FOMINA, Nadezda ,  AHMAD, Habib ,  MARUNIAK, Autumn ,  LANG, Christoph ,  RAGHUNATHAN, Ashwin ,  SHIN, Young Shik ,  DARVISH, Armin ,  PAPAGEORGIOU, Efthymios

IPC: C12Q1/00 ,  G01N27/30 ,  G01N27/34

Abstract: Device and methods for controlling pH or ionic gradient comprising a multisite array of feedback electrode sets comprising electrodes and pH sensing elements. The electrodes can include a reference electrode, counter electrode, and a working electrode. The device and methods iteratively select an amount of current and/or voltage to be applied to each working electrode, apply the selected amount of current and/or voltage to each working electrode to change pH of a solution close to the working electrode, and measure the signal output of the sensing element. The multisite array can include feedback and non-feedback electrode sets.

公开(公告)号：WO2014151690A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/026250

申请日：2014-03-13

Applicant: ROBERT BOSCH GMBH ,  FOMINA, Nadezda ,  JOHNSON, Christopher ,  KAVUSI, Sam ,  AHMAD, Habib

Inventor： FOMINA, Nadezda ,  JOHNSON, Christopher ,  KAVUSI, Sam ,  AHMAD, Habib

IPC: G01N27/327 ,  G01N33/543

CPC classification number: G01N33/5438 ,  G01N27/3272

Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.

Abstract translation: 用于生物传感器的装置，其包括测试位点的多位阵列，该装置可用于通过调节电极附近的pH或离子梯度来调节生物学上的（生物分子）探针或检测剂和目标分析物之间的结合相互作用 在这样的生物传感器。 该装置提供了更准确，可靠的生物传感器，其结果更加可重现。 还提供了用于更精确地测量生物样品中感兴趣的分析物的分析方法。

公开(公告)号：WO2011038117A3

公开(公告)日：2011-09-15

申请号：PCT/US2010049996

申请日：2010-09-23

Applicant: UNIV CALIFORNIA ,  ALMUTAIRI ADAH ,  FOMINA NADEZDA ,  SANKARANARAYANAN JAGADIS

Inventor： ALMUTAIRI ADAH ,  FOMINA NADEZDA ,  SANKARANARAYANAN JAGADIS

IPC: A61K47/22

CPC classification number: A61K41/008 ,  A61K9/0009 ,  A61K9/06 ,  A61K9/5138 ,  A61K9/5146 ,  A61K38/43 ,  A61K39/12 ,  A61K39/245 ,  A61K39/385 ,  A61K41/0042 ,  A61K47/34 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/622 ,  C07K16/00 ,  C08G63/06 ,  C08G63/18 ,  C08G63/912 ,  C12N7/00 ,  C12N2710/16634

Abstract: Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.

Abstract translation: 提供了组合物，其中树枝状大分子和/或纳米粒子与多光子响应元件和自毁性寡聚体合成。 该组合物可用于通过照射组合物在组织内选择性地输送有效负荷。 该组合物也可用于放大对照射的敏感性。

公开(公告)号：WO2019014317A1

公开(公告)日：2019-01-17

申请号：PCT/US2018/041591

申请日：2018-07-11

Applicant: ROBERT BOSCH GMBH ,  SHIN, Young, Shik ,  FOMINA, Nadezda ,  JOHNSON, Christopher ,  LANG, Christoph ,  STALEY, Patrick

Inventor： SHIN, Young, Shik ,  FOMINA, Nadezda ,  JOHNSON, Christopher ,  LANG, Christoph ,  STALEY, Patrick

IPC: G01N33/543 ,  G01N33/58 ,  G01N27/327

Abstract: A method for detecting a presence and/or a concentration of a target substance in a reagent solution using enzyme-linked immunosorbent assay (ELIS A) includes binding the target substance directly or indirectly to an electrode, and binding a detection agent directly or indirectly to the bound target substance. The method further includes modulating a pH of only a portion of the reagent solution in which the bound target substance and the bound detection agent are located using the electrode, the modulated pH of the portion of the reagent solution causing the bound detection agent to undergo a change, and detecting the change in the bound detection agent. The detected change corresponds to the presence of the target substance in the reagent solution and/or the concentration of the target substance in the reagent solution.

公开(公告)号：WO2011038117A2

公开(公告)日：2011-03-31

申请号：PCT/US2010/049996

申请日：2010-09-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ALMUTAIRI, Adah ,  FOMINA, Nadezda ,  SANKARANARAYANAN, Jagadis

Inventor： ALMUTAIRI, Adah ,  FOMINA, Nadezda ,  SANKARANARAYANAN, Jagadis

IPC: A61K47/22

CPC classification number: A61K41/008 ,  A61K9/0009 ,  A61K9/06 ,  A61K9/5138 ,  A61K9/5146 ,  A61K38/43 ,  A61K39/12 ,  A61K39/245 ,  A61K39/385 ,  A61K41/0042 ,  A61K47/34 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/622 ,  C07K16/00 ,  C08G63/06 ,  C08G63/18 ,  C08G63/912 ,  C12N7/00 ,  C12N2710/16634

Abstract: Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.

Abstract translation: 提供了组合物，其中用多光子响应元件和自褪色寡聚物合成树枝状大分子和/或纳米颗粒。 组合物可以用于通过照射组合物选择性地递送组织内的有效载荷。 组合物也可用于放大对照射的敏感性。