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    WIRE ATTACHMENT
    1.
    发明申请
    WIRE ATTACHMENT 审中-公开

    公开(公告)号：WO2021061197A1

    公开(公告)日：2021-04-01

    申请号：PCT/US2020/025753

    申请日：2020-03-30

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP ,  MITCHELL, Robert A. ,  GIRARDOT, James D.

    Inventor： MITCHELL, Robert A. ,  GIRARDOT, James D.

    IPC: F16G11/02 ,  F16C1/14

    Abstract: A swaged fitting can be fixed to a wire rope while simultaneously providing a desired shape and size, thereby avoiding the need for subsequent material removal. In one application, the swaged fitting is fixed to the wire rope by a forging operation such that the fitting is securely fixed provides a straight-sided construct once fixed to the wire rope. After the forging operation and without further material removal, the straight sides of the finished fitting are generally parallel to the longitudinal axis of the wire rope, while the end surfaces of the fitting are generally perpendicular to this longitudinal axis. This arrangement provides a strong and effective force-transfer interface for, e.g., end-effectors in medical devices.

    NI-FREE BETA TI ALLOYS WITH SHARE MEMORY AND SUPER-ELASTIC PROPERTIES
    4.
    发明申请
    NI-FREE BETA TI ALLOYS WITH SHARE MEMORY AND SUPER-ELASTIC PROPERTIES 审中-公开
    NI-FREE BETA TI合金具有共享存储器和超弹性特性

    公开(公告)号：WO2018089028A1

    公开(公告)日：2018-05-17

    申请号：PCT/US2016/061843

    申请日：2016-11-14

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP

    Inventor： CAI, Song ,  SHAFFER, Jeremy, E. ,  GRIEBEL, Adam, J.

    IPC: C22C14/00 ,  C22F1/18 ,  A61L27/06 ,  A61L27/50

    Abstract: A group of substantially nickel-free beta-titanium alloys have shape memory and super-elastic properties suitable for, e.g., medical device applications. In particular, the present disclosure provides a titanium-based group of alloys including 16-20 at.% of hafnium, zirconium or a mixture thereof, 8-17 at.% niobium, and 0.25-6 at.% tin. This alloy group exhibits recoverable strains of at least 3.5% after axial, bending or torsional deformation. In some instances, the alloys have a capability to recover of more than 5% deformation strain. Niobium and tin are provided in the alloy to control beta phase stability, which enhances the ability of the materials to exhibit shape memory or super-elastic properties at a desired application temperature (e.g., body temperature). Hafnium and/or zirconium may be interchangeably added to increase the radiopacity of the material, and also contribute to the superelasticity of the material.

    Abstract translation: 一组基本上不含镍的β-钛合金具有适合于例如医疗器械应用的形状记忆和超弹性特性。 具体而言，本公开提供了包含16-20原子％的铪，锆或其混合物，8-17原子％铌和0.25-6原子％锡的钛基合金组。 该合金组在轴向，弯曲或扭转变形后表现出至少3.5％的可恢复应变。 在某些情况下，合金具有恢复5％以上变形应变的能力。 在合金中提供铌和锡以控制β相稳定性，这增强了材料在期望的应用温度（例如体温）下展现形状记忆或超弹性性能的能力。 铪和/或锆可以互换地添加以增加材料的射线不透性，并且还有助于材料的超弹性。

    BIODEGRADABLE WIRE FOR MEDICAL DEVICES
    5.
    发明申请
    BIODEGRADABLE WIRE FOR MEDICAL DEVICES 审中-公开
    生物可治疗的医疗器械线

    公开(公告)号：WO2014197781A2

    公开(公告)日：2014-12-11

    申请号：PCT/US2014/041267

    申请日：2014-06-06

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP.

    Inventor： SCHAFFER, Jeremy, E. ,  GRIEBEL, Adam, J.

    IPC: A61K9/00 ,  C22C23/00

    CPC classification number: C22F1/06 ,  A61L31/022 ,  A61L31/148 ,  B32B15/01 ,  B32B15/013 ,  C21D9/525 ,  C22C23/00 ,  C22C23/02 ,  C22C23/04 ,  C22C23/06 ,  C22C38/02

    Abstract: A bioabsorbable material composition includes magnesium (Mg), lithium (Li) and calcium (Ca). Lithium is provided in a sufficient amount to enhance material ductility, while also being provided in a sufficiently low amount to maintain corrosion resistance at suitable levels. Calcium is provided in a sufficient amount to enhance mechanical strength and/or further influence the rate of corrosion, while also being provided in a sufficiently low amount to preserve material ductility. The resultant ductile base material may be cold-worked to enhance strength, such as for medical applications. In one application, the material may be drawn into a fine wire, which may be used to create resorbable structures for use in vivo such as stents.

    Abstract translation: 生物可吸收材料组合物包括镁（Mg），锂（Li）和钙（Ca）。 提供足够量的锂以提高材料延展性，同时还提供足够低的量以将耐腐蚀性保持在合适的水平。 提供足够量的钙以提高机械强度和/或进一步影响腐蚀速率，同时还以足够低的量提供钙以保持材料延展性。 所得的延性基材可以被冷加工以增强强度，例如用于医疗应用。 在一个应用中，材料可以被拉成细丝，其可以用于产生用于体内的可再吸收结构，例如支架。

    TITANIUM-NIOBIUM-HAFNIUM ALLOY SHAPE MEMORY WIRE
    6.
    发明申请
    TITANIUM-NIOBIUM-HAFNIUM ALLOY SHAPE MEMORY WIRE 审中-公开
    钛 - 铌 - 铌合金形状记忆线

    公开(公告)号：WO2014182691A2

    公开(公告)日：2014-11-13

    申请号：PCT/US2014/036961

    申请日：2014-05-06

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP.

    Inventor： SCHAFFER, Jeremy, E.

    IPC: C22C14/00

    CPC classification number: A61M25/09 ,  A61F2/86 ,  A61F2210/0014 ,  A61L31/022 ,  A61L31/14 ,  A61L2400/16 ,  A61M2025/09141 ,  C21D1/26 ,  C21D8/06 ,  C21D9/525 ,  C21D2201/01 ,  C22C14/00 ,  C22C30/00 ,  C22F1/006 ,  C22F1/183

    Abstract: Ti-Nb-Hf/Zr-(Cr) alloy shape-memory wires are provided which are suitable for use in medical devices and actuators, and methods for manufacturing such wires are provided. The present shape-memory Ti-Nb-Hf/Zr-(Cr) alloy is a superelastic wire material particularly suited for in vivo applications. For example, the present Ti-Nb-Hf/Zr-(Cr) alloy wire is radiopaque, thereby enabling surgical use of a monolithic, shape-memory alloy wire while preserving the ability to monitor the in vivo location of the wire through X-ray or other radiation-based imaging systems. In addition, the present Ti-Nb-Hf/Zr-(Cr) alloy can be manufactured to exhibit shape-memory alloy material properties without the use of nickel as an alloy constituent, thereby accommodating nickel-sensitive patients. The present Ti-Nb-Hf/Zr-(Cr) alloy can also be processed to exhibit a martensite/austenite transformation temperature near body-temperature, i.e., 37 °C, so that shape-memory effects can be utilized to accomplish work in vivo .

    Abstract translation: 提供适用于医疗器械和致动器的Ti-Nb-Hf / Zr-（Cr）合金形状记忆线，以及制造这种线的方法。 本形状记忆Ti-Nb-Hf / Zr-（Cr）合金是特别适用于体内应用的超弹性线材。 例如，本发明的Ti-Nb-Hf / Zr-（Cr）合金线是不透射线的，从而能够外部使用整体式的形状记忆合金丝，同时保持通过X射线监测线的体内位置的能力， 射线或其他基于辐射的成像系统。 此外，本发明的Ti-Nb-Hf / Zr-（Cr）合金可以制造成具有形状记忆合金材料性质而不使用镍作为合金成分，从而适应镍敏感的患者。 目前的Ti-Nb-Hf / Zr-（Cr）合金也可以加工成在体温附近呈现出马氏体/奥氏体转变温度，即37℃，从而可以利用形状记忆效应来完成工作 体内。

    MAGNESIUM-BASED ABSORBABLE ALLOYS
    7.
    发明申请
    MAGNESIUM-BASED ABSORBABLE ALLOYS 审中-公开

    公开(公告)号：WO2020247383A1

    公开(公告)日：2020-12-10

    申请号：PCT/US2020/035731

    申请日：2020-06-02

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP

    Inventor： SCHAFFER, Jeremy E. ,  GRIEBEL, Adam J.

    IPC: A61F2/86 ,  A61F2/06 ,  A61L27/04

    Abstract: A magnesium alloy contains a small amount of lithium, zinc, calcium, and manganese. For example, the magnesium alloy may include between 1-5 wt.% lithium, between 0.2-2.0 wt.% zinc, between 0.1-0.5 wt.% calcium, and between 0.1-0.8 wt.% manganese. These alloying elements are all nutrient elements, such that the present alloy can be safely broken down in vivo, then absorbed and/or expelled from the body. Li, Zn, Ca and Mn each contribute to solid-solution strengthening of the alloy. Ca also acts as a grain refiner, while Zn and Ca both form strengthening and corrosion-controlling intermetallic compounds. Optionally, the alloy may also include a small amount of yttrium for added strength and corrosion resistance.

    APPARATUS AND METHOD FOR METAL-MEDIATED CATALYSIS
    8.
    发明申请
    APPARATUS AND METHOD FOR METAL-MEDIATED CATALYSIS 审中-公开

    公开(公告)号：WO2019217350A1

    公开(公告)日：2019-11-14

    申请号：PCT/US2019/031010

    申请日：2019-05-07

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP ,  MEER, Marja Ter ,  ZELIKIN, Alexander N.

    Inventor： MEER, Marja Ter ,  ZELIKIN, Alexander N. ,  SCHAFFER, Jeremy E. ,  DILLION, Ross

    IPC: A61F2/86 ,  A61L31/02 ,  A61L31/08

    Abstract: Metallic implants having an ability to mimic enzyme catalysis in the absence of an enzyme, and methods for use of the same in conjunction with catalysis targets are disclosed. For example, metallic wires may be used as a biocatalytic implantable biomaterial to mimic enzyme activation of prodrugs. In use, prodrugs may be provided in conjunction with such metallic wires to provide localized therapy at the site of wire implantation. In an antibacterial application, for example, the catalytic activity enabled by the wire material mimics the activity of an enzyme such that it is able to cleave one or more of the chemical bonds of a promoiety of a prodrug, releasing an active agent -in this instance an antimicrobial agent- locally in the vicinity of the wire material, thereby resulting in a significant zone of inhibition of bacterial proliferation around the metallic wires in vivo .

    NI-FREE BETA TI ALLOYS WITH SHAPE MEMORY AND SUPER-ELASTIC PROPERTIES
    9.
    发明申请
    NI-FREE BETA TI ALLOYS WITH SHAPE MEMORY AND SUPER-ELASTIC PROPERTIES 审中-公开

    公开(公告)号：WO2018089028A8

    公开(公告)日：2018-05-17

    申请号：PCT/US2016/061843

    申请日：2016-11-14

    Applicant: FORT WAYNE METALS RESEARCH PRODUCTS CORP

    Inventor： CAI, Song ,  SHAFFER, Jeremy, E. ,  GRIEBEL, Adam, J.

    IPC: C22C14/00 ,  C22F1/18 ,  A61L27/06 ,  A61L27/50

    Abstract: A group of substantially nickel-free beta-titanium alloys have shape memory and super-elastic properties suitable for, e.g., medical device applications. In particular, the present disclosure provides a titanium-based group of alloys including 16-20 at.% of hafnium, zirconium or a mixture thereof, 8-17 at.% niobium, and 0.25-6 at.% tin. This alloy group exhibits recoverable strains of at least 3.5% after axial, bending or torsional deformation. In some instances, the alloys have a capability to recover of more than 5% deformation strain. Niobium and tin are provided in the alloy to control beta phase stability, which enhances the ability of the materials to exhibit shape memory or super-elastic properties at a desired application temperature (e.g., body temperature). Hafnium and/or zirconium may be interchangeably added to increase the radiopacity of the material, and also contribute to the superelasticity of the material.

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