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    METHOD OF ENGRAFTING CELLS FROM SOLID TISSUES
    1.
    发明申请
    METHOD OF ENGRAFTING CELLS FROM SOLID TISSUES 审中-公开
    从固体组织中培养细胞的方法

    公开(公告)号：WO2011140428A1

    公开(公告)日：2011-11-10

    申请号：PCT/US2011/035498

    申请日：2011-05-06

    Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  TURNER, Rachael ,  GERBER, David ,  LOZOYA, Oswaldo ,  REID, Lola, M.

    Inventor： TURNER, Rachael ,  GERBER, David ,  LOZOYA, Oswaldo ,  REID, Lola, M.

    IPC: A61M31/00

    CPC classification number: A61K35/407 ,  A61K9/0024 ,  A61K35/39 ,  A61K38/00 ,  A61K47/34 ,  A61K47/36 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/28 ,  C12N5/0672 ,  C12N2533/80 ,  C12N2537/10 ,  Y02A50/411 ,  A61K2300/00

    Abstract: A method of repairing diseased or dysfunctional organs or of establishing a model system of a disease state is provided. For repairing diseased organs, the method involves engraftment of cells from healthy tissue of the diseased or dysfunctional organ admixed with gel-forming biomaterials and nutrient medium, signaling molecules and extracellular matrix components that can be made insoluble rapidly upon transplantation to form a graft. In this way, the graft mimics the complexity of the native microenvironment with a minimum number of components that allow transplantation of cells to successfully engraft, expand and then rebuild part or the entirety of the diseased or dysfunctional organ. In the case of using grafting methods for establishing a disease model, diseased cells may be transplanted in the biomaterials and into experimental hosts.

    Abstract translation: 提供了修复患病或功能失调的器官或建立疾病状态模型系统的方法。 为了修复患病器官，该方法包括从形成生物材料和营养培养基，信号传导分子和细胞外基质组分的混合的患病或功能障碍器官的健康组织中移植细胞，所述分子和细胞外基质组分在移植时可快速溶解以形成移植物。 以这种方式，移植物以最少量的组分模拟天然微环境的复杂性，允许移植细胞以成功移植，扩增，然后重建部分或全部患病或功能失调的器官。 在使用接枝方法建立疾病模型的情况下，可将病变细胞移植到生物材料中并进入实验宿主体内。

    LESS INVASIVE SURGICAL SYSTEM AND METHODS
    4.
    发明申请
    LESS INVASIVE SURGICAL SYSTEM AND METHODS 审中-公开
    无创外科手术系统及方法

    公开(公告)号：WO2006039279A3

    公开(公告)日：2006-07-06

    申请号：PCT/US2005034609

    申请日：2005-09-28

    Applicant: HFSC CO ,  GERBER DAVID ,  HANSON SHAUN ,  HU XIAOPING ,  KEPHART DOUGLAS S ,  KUNTZ KYLE ,  LEE ANDREW M

    Inventor： GERBER DAVID ,  HANSON SHAUN ,  HU XIAOPING ,  KEPHART DOUGLAS S ,  KUNTZ KYLE ,  LEE ANDREW M

    IPC: A61B17/88

    CPC classification number: A61B17/7082 ,  A61B17/7074 ,  A61B17/7076 ,  A61B17/7083 ,  A61B17/7085 ,  A61B17/7089 ,  A61B17/7091

    Abstract: A system for performing a less invasive surgical procedure and, in particular, devices and methods for spinal fixation. The system comprises dilation tool(s), at least one working/insertion cannula, a plurality of screws, at least one fixation rod for connecting the screws, and a rod inserter. The dilation tool(s) may be used to dilate an incision made in a patient to form an opening. Thereafter, a drill may be used to form holes in the vertebrae. An insertion cannula may be attached to a screw and inserted into the opening. The screws may be polyaxial screws and may be inserted into the vertebrae using a screwdriver. An operator may then move the insertion cannula to manipulate a head portions of the screws such that the head portions may be aligned to receive a fixation rod. A rod inserter may be used to insert a fixation rod into the head portions. After the fixation rod is in place, it may be locked to the screws, thereby fixing the system in place on the spine.

    Abstract translation: 用于执行侵入性较小的外科手术的系统，特别是用于脊柱固定的装置和方法。 该系统包括扩张工具，至少一个工作/插入插管，多个螺钉，用于连接螺钉的至少一个固定杆和杆插入器。 扩张工具可用于扩张在患者体内形成的切口以形成开口。 此后，可以使用钻头在椎骨中形成孔。 插入插管可以附接到螺钉并插入到开口中。 螺钉可以是多轴螺钉，并且可以使用螺丝刀插入椎骨中。 操作者然后可以移动插入套管以操纵螺钉的头部，使得头部可以对齐以接收固定杆。 杆插入器可用于将固定杆插入头部。 固定杆就位后，可将其锁定在螺钉上，从而将系统固定在脊椎上。

    EGR GENES AS TARGETS FOR THE DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA
    5.
    发明申请
    EGR GENES AS TARGETS FOR THE DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA 审中-公开
    EGR基因作为目标用于诊断和治疗SCHIZOPHRENIA

    公开(公告)号：WO2005004702A3

    公开(公告)日：2006-01-05

    申请号：PCT/US2004021030

    申请日：2004-06-30

    Applicant: MASSACHUSETTS INST TECHNOLOGY ,  UNIV ROCKEFELLER ,  UNIV COLUMBIA ,  GERBER DAVID J ,  GOGOS JOSEPH A ,  HALL DIANA ,  KARAYIORGOU MARIA ,  TONEGAWA SUSUMU

    Inventor： GERBER DAVID J ,  GOGOS JOSEPH A ,  HALL DIANA ,  KARAYIORGOU MARIA ,  TONEGAWA SUSUMU

    IPC: A61B20060101 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in genes encoding an EGR molecule or an EGR interacting molecule, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.

    Abstract translation: 本发明提供用于诊断和治疗精神分裂症及相关病症的靶标，方法和试剂。 本发明通过检测编码EGR分子或EGR相互作用分子的基因的多态性，突变，变化，表达变化等或与这些基因连锁的多态性来提供精神分裂症和精神分裂症易感性的诊断方法。 本发明提供用于检测多态性和变体的寡核苷酸，阵列和抗体。 本发明提供了在这些基因中具有改变的转基因小鼠。 本发明还提供了通过施用靶向这些基因的化合物来治疗精神分裂症的方法。 本发明还提供了用于鉴定通过进行筛选获得的这些化合物和化合物的筛选方法。

    MULTIPLE-BLADE RETRACTOR
    6.
    发明申请
    MULTIPLE-BLADE RETRACTOR 审中-公开
    多叶片放大器

    公开(公告)号：WO2005016131A3

    公开(公告)日：2005-12-29

    申请号：PCT/US2004026750

    申请日：2004-08-16

    Applicant: LEE ANDREW ,  GERBER DAVID

    Inventor： LEE ANDREW ,  GERBER DAVID

    IPC: A61B20060101 ,  A61B1/32 ,  A61B17/02 ,  A61B17/28 ,  G06F17/30

    CPC classification number: A61B17/02 ,  A61B17/0206 ,  A61B17/0293 ,  A61B17/2804 ,  A61B17/2833

    Abstract: A retractor (100) with multiple blade for use in surgery. The retractor may comprise first (110R) and second (110L) elongated portions which are pivotally connected to each other. A first blade (113R) may be connected to the first eleongated portion (110R) and a second blade (113L) may be connected to the second elongated portion (110L). The retractor (100) may also comprise a sliding bar (130) having a third blade (134). The sliding bar (130) may be associated with the first and second elongated portions (110R, 110L) such that movement of the elongated portions relative to each other may result in movement of the sliding bar (130) and, consequently, movement of the third blade (134) relative to the first and second blades (113R, 113L). In one embodiment, the retractor (100) may comprise a tension limiting device (5322) so that the third blade (134) amy remain relatively staionary as the first and second blades (110R, 110L) are moved. The retractor (100) may also comprise a fourth blade (690) operatively connected to the first ands second elongated portions (110R, 110L). The fourth blade (690) may moved independently of the other blades or many move with the other blades.

    Abstract translation: 具有用于手术的多个叶片的牵开器（100）。 牵开器可以包括彼此枢转地连接的第一（110R）和第二（110L）细长部分。 第一叶片（113R）可以连接到第一隆起部分（110R），并且第二叶片（113L）可以连接到第二细长部分（110L）。 牵开器（100）还可以包括具有第三叶片（134）的滑杆（130）。 滑动杆（130）可以与第一和第二细长部分（110R，110L）相关联，使得细长部分相对于彼此的运动可导致滑动杆（130）的运动，并且因此导致 第三叶片（134）相对于第一和第二叶片（113R，113L）。 在一个实施例中，牵开器（100）可以包括张力限制装置（5322），使得当第一和第二叶片（110R，110L）移动时，第三叶片（134）保持相对直立。 牵开器（100）还可以包括可操作地连接到第一和第二细长部分（110R，110L）的第四叶片（690）。 第四刀片（690）可以独立于其他刀片移动，或者与其他刀片多次移动。

    SYSTEM, METHOD, COMPUTER PROGRAM PRODUCT AND APPARATUS FOR PRODUCING DENTAL RESTORATIONS
    7.
    发明申请
    SYSTEM, METHOD, COMPUTER PROGRAM PRODUCT AND APPARATUS FOR PRODUCING DENTAL RESTORATIONS 审中-公开
    系统，方法，计算机程序产品和用于生产牙齿恢复的装置

    公开(公告)号：WO2005072227A2

    公开(公告)日：2005-08-11

    申请号：PCT/US2005/001795

    申请日：2005-01-18

    Applicant: GERBER SCIENTIFIC PRODUCTS, INC. ,  STROBEL, Wolfgang, M. ,  GERBER, David, J.

    Inventor： STROBEL, Wolfgang, M. ,  GERBER, David, J.

    IPC: A61C13/00 ,  A61C13/08

    CPC classification number: A61C13/0004 ,  A61C13/0019 ,  A61C13/082

    Abstract: Systems, methods and computer program products for producing dental restorations that can include the use of a computer integrated manufacturing system. Using this system, physical properties of a tooth are collected, for the automated manufacturing of a dental restoration. The invention, in one embodiment, includes creating a color map comprising at least one color value, a computer program product for producing a dental restoration layer, as well as a method for producing a dental restoration using a computerized system.

    Abstract translation: 用于生产牙科修复体的系统，方法和计算机程序产品，其可以包括使用计算机集成制造系统。 使用该系统，收集牙齿的物理性质，用于牙科修复体的自动化制造。 在一个实施例中，本发明包括创建包括至少一个颜色值的颜色映射图，用于产生牙齿修复层的计算机程序产品，以及使用计算机化系统生产牙齿修复体的方法。

    LESS INVASIVE SURGICAL SYSTEM AND METHODS
    10.
    发明申请
    LESS INVASIVE SURGICAL SYSTEM AND METHODS 审中-公开
    更少的外科手术系统和方法

    公开(公告)号：WO2006039279A2

    公开(公告)日：2006-04-13

    申请号：PCT/US2005/034609

    申请日：2005-09-28

    Applicant: HFSC COMPANY ,  GERBER, David ,  HANSON, Shaun ,  HU, Xiaoping ,  KEPHART, Douglas, S. ,  KUNTZ, Kyle ,  LEE, Andrew, M.

    Inventor： GERBER, David ,  HANSON, Shaun ,  HU, Xiaoping ,  KEPHART, Douglas, S. ,  KUNTZ, Kyle ,  LEE, Andrew, M.

    IPC: A61B17/88

    CPC classification number: A61B17/7082 ,  A61B17/7074 ,  A61B17/7076 ,  A61B17/7083 ,  A61B17/7085 ,  A61B17/7089 ,  A61B17/7091

    Abstract: A system for performing a less invasive surgical procedure and, in particular, devices and methods for spinal fixation. The system comprises dilation tool(s), at least one working/insertion cannula, a plurality of screws, at least one fixation rod for connecting the screws, and a rod inserter. The dilation tool(s) may be used to dilate an incision made in a patient to form an opening. Thereafter, a drill may be used to form holes in the vertebrae. An insertion cannula may be attached to a screw and inserted into the opening. The screws may be polyaxial screws and may be inserted into the vertebrae using a screwdriver. An operator may then move the insertion cannula to manipulate a head portions of the screws such that the head portions may be aligned to receive a fixation rod. A rod inserter may be used to insert a fixation rod into the head portions. After the fixation rod is in place, it may be locked to the screws, thereby fixing the system in place on the spine.

    Abstract translation: 用于执行微创手术过程的系统，特别是用于脊柱固定的装置和方法。 该系统包括扩张工具，至少一个工作/插入套管，多个螺钉，至少一个用于连接螺钉的固定杆和杆插入器。 （一个或多个）扩张工具可用于扩张在患者中形成的切口以形成开口。 此后，可以使用钻头在椎骨上形成孔。 插入套管可以连接到螺钉并插入开口中。 螺钉可以是多轴螺钉并且可以使用螺丝刀插入椎骨中。 操作者然后可以移动插入套管以操纵螺钉的头部部分，使得头部部分可以对齐以接收固定杆。 杆插入器可用于将固定杆插入头部。 固定杆就位后，可将其锁定在螺钉上，从而将系统固定在脊柱上。

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