公开(公告)号：WO2009034514A3

公开(公告)日：2009-10-22

申请号：PCT/IB2008053622

申请日：2008-09-08

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  DE HOOG THOMAS J ,  GILLIES MURRAY F ,  CATTANEO STEFANO ,  MERKLE DENNIS ,  VAN DAM DIRKJAN B ,  SIBILLE JEREMIE

Inventor： DE HOOG THOMAS J ,  GILLIES MURRAY F ,  CATTANEO STEFANO ,  MERKLE DENNIS ,  VAN DAM DIRKJAN B ,  SIBILLE JEREMIE

IPC: B03C5/00 ,  B03C5/02

CPC classification number: B03C5/005 ,  B03C5/026

Abstract: A dielectrophoretic device and method is described for manipulating one or more particles, e.g. living cells. The device comprises a plurality of electrodes in the form of a DEP cage, and a particle movement detection system for detecting movement of the one or more particles within the cage. Particle movement is indicative of passing through the cross-over frequency. The particle movement detection system includes a particle presence sensor and this can be located eccentrically with respect to a trapping point of the DEP cage. The device and method may be used for classification, identification, of quantification of diseased versus healthy cells, for diagnosis, for medical research and development and in therapy. They are particularly useful for investigating living cells whose cell membrane alters in conductivity or permeability.

Abstract translation: 描述了介电泳设备和方法，用于操纵一个或多个颗粒，例如， 活细胞 该装置包括DEP笼形式的多个电极和用于检测笼内的一个或多个颗粒的移动的颗粒运动检测系统。 粒子运动表示穿过交叉频率。 颗粒运动检测系统包括颗粒存在传感器，并且可以相对于DEP笼的捕集点偏心定位。 该装置和方法可用于患病与健康细胞的分类，鉴定，定量诊断，用于医学研究和开发以及治疗。 它们特别适用于调查细胞膜电导率或渗透性变化的活细胞。

公开(公告)号：WO2009066236A1

公开(公告)日：2009-05-28

申请号：PCT/IB2008/054827

申请日：2008-11-18

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  JOHNSON, Mark, T. ,  IMMINK, Albert, H., J. ,  PONJEE, Marc, W., G. ,  GILLIES, Murray, F.

Inventor： JOHNSON, Mark, T. ,  IMMINK, Albert, H., J. ,  PONJEE, Marc, W., G. ,  GILLIES, Murray, F.

IPC: G01N21/55 ,  G01N33/551

CPC classification number: G01N21/552

Abstract: In order to obtain an appropriate coupling in a optical sensing system (100) for sensing particle properties of particles (111) in a sample fluid (117) using frustrated total internal reflection, the cartridge (110) and/or the optical catridge reader (130) is provided with an integrated means (150) that assists in providing an optical coupling. The integrated means (150) may for example be adapted for providing an optical coupling material (152) in the gap between the cartridge (110) and the optical cartridge reader (130), for generating a low pressure or vacuum or for generating a pressure on the cartridge (110) so that a light receiving surface (114) of the cartridge (110) is pressed to an optical component (132) of the reader (130). The latter may allow the use offlat cartridges (110) as the optical component (132) for guiding the light appropriately for having frustrated total internal reflection may be present in the reader (130) rather than being part of the cartridge (110).

Abstract translation: 为了在光学感测系统（100）中获得适当的耦合，用于使用沮丧的全内反射感测样品流体（117）中的颗粒（111）的颗粒性质，盒（110）和/或光学读取器（ 130）设置有协助提供光耦合的集成装置（150）。 集成装置（150）可以例如适于在盒（110）和光盒读取器（130）之间的间隙中提供光耦​​合材料（152），用于产生低压或真空或产生压力 在盒（110）上，使得盒（110）的光接收表面（114）被按压到读取器（130）的光学部件（132）。 后者可以允许使用离子盒（110）作为光学部件（132），用于适当地引导光，以使得沮丧的全内反射可能存在于读取器（130）中，而不是成像盒（110）的一部分。

公开(公告)号：WO2008125927A3

公开(公告)日：2009-01-29

申请号：PCT/IB2007055104

申请日：2007-12-14

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  GILLIES MURRAY F ,  DEN TOONDER JACOB M J ,  PONJEE MARC W G ,  JOHNSON MARK T

Inventor： GILLIES MURRAY F ,  DEN TOONDER JACOB M J ,  PONJEE MARC W G ,  JOHNSON MARK T

IPC: F04B19/00 ,  B01L3/00

CPC classification number: B01F13/0059 ,  B01F13/0091 ,  B01L3/50273 ,  B01L3/502792 ,  B01L7/52 ,  B01L7/54 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1872 ,  B01L2400/0484 ,  B01L2400/0633 ,  B01L2400/0688 ,  F04B19/006 ,  F04B19/24 ,  F04D33/00

Abstract: The invention relates to microfluidic system (100), particularly a biosensor, for manipulating a sample in a sample chamber (1). The device comprises at least one actuator (10) that reversibly changes its spatial configuration if it is heated and/or cooled. The actuator (10) may particularly be arranged adjacent to an associated heating element (20) of a 5 heating array that is used to establish a predetermined spatial and/or temporal temperature profile in the sample chamber (1). The configuration change of the actuator (10) can be used to move the sample fluid or to control its passage through fluid channels. A plurality of actuators (10) may optionally be provided that undergo their configuration changes at different temperatures, particularly temperatures within a range that is passed during a 10 reaction like PCR.

Abstract translation: 本发明涉及用于操纵样品室（1）中的样品的微流体系统（100），特别是生物传感器。 该装置包括至少一个致动器（10），其如果被加热和/或冷却则可逆地改变其空间构造。 致动器（10）可以特别地布置成与用于在样品室（1）中建立预定空间和/或时间温度分布的5个加热阵列的相关联的加热元件（20）相邻。 致动器（10）的配置变化可用于移动样品流体或控制其通过流体通道。 可以任选地提供多个致动器（10），其在不同温度，特别是在10反应期间通过的范围内的温度（如PCR）中进行其配置变化。

公开(公告)号：WO2008120135A3

公开(公告)日：2008-10-09

申请号：PCT/IB2008/051102

申请日：2008-03-25

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  GILLIES, Murray, F. ,  PONJEE, Marc, W., G. ,  JOHNSON, Mark, T.

Inventor： GILLIES, Murray, F. ,  PONJEE, Marc, W., G. ,  JOHNSON, Mark, T.

IPC: B01L3/00 ,  G01P5/10 ,  G01P5/18 ,  G01F1/684 ,  G01F1/696 ,  G01F1/708

Abstract: A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component individually. The components comprise at least one heater element (13). The active matrix includes a two-dimensional array of electronic components (12) realized in thin film technology. The active matrix provides a high versatility of the device. The thin film technology ensures a very cost efficient manufacturing also of large devices. In the micro-fluidic device the fluid flow can be detected.

公开(公告)号：WO2008020374A3

公开(公告)日：2008-04-24

申请号：PCT/IB2007053176

申请日：2007-08-10

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  JOHNSON MARK T ,  DEN TOONDER JACOB M J ,  GILLIES MURRAY F ,  FRENCH IAN ,  PONJEE MARC W G

Inventor： JOHNSON MARK T ,  DEN TOONDER JACOB M J ,  GILLIES MURRAY F ,  FRENCH IAN ,  PONJEE MARC W G

IPC: F04B19/00 ,  F04D33/00

CPC classification number: F04D33/00 ,  B01F13/0059 ,  B01F13/0091 ,  F04B19/006

Abstract: The invention relates to an electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems. An electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems, wherein an 2-dimensional matrix array of poly MEMS actuators (PMA) (1) is arranged in a 2-dimenional system in which each single actuator is electrically/electronically steered independently from each other, in order to be able to generate a pattern of activation in the matrix.

Abstract translation: 本发明涉及使用有源矩阵原理的电基微流体装置，用于医疗和健康以及健康产品，特别是生物芯片或生物系统。 一种使用有源矩阵原理的基于电的微流体装置，用于医疗和健康以及健康产品，特别是生物芯片或生物系统，其中多MEMS致动器（PMA）（1）的二维矩阵阵列被布置 在其中每个单个致动器彼此独立地电/电控制的二维系统中，以便能够在矩阵中产生激活模式。

公开(公告)号：WO2008020355A3

公开(公告)日：2008-04-17

申请号：PCT/IB2007053005

申请日：2007-07-30

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  JOHNSON MARK T ,  BUDZELAAR FRANCISCUS P M ,  GILLIES MURRAY F

Inventor： JOHNSON MARK T ,  BUDZELAAR FRANCISCUS P M ,  GILLIES MURRAY F

IPC: G02F1/167 ,  G09G3/34

CPC classification number: G02F1/167 ,  G02F1/134363 ,  G09G3/3446 ,  G09G2300/0434 ,  G09G2320/0252

Abstract: A display device and a method for driving the display device is disclosed. The display device comprises drive circuitry (35) and a plurality of pixels (PIXl, PIX2, PIX3, PIX4, PIX5, PIX6) having movable charged particles (116). The drive circuitry is configured to apply control signals to the pixels to move the charged particles between first (110) and second (112) regions of each pixel in order to alter the optical appearance of each pixel. The method for each pixel comprises a pre-addressing stage (PRA) of moving the charged particles towards the boundary (114) between the first and second regions, and then an addressing stage (ADD) of moving the particles to one side or the other side of the boundary, in dependence on the desired optical appearance of the pixel.

Abstract translation: 公开了一种用于驱动显示装置的显示装置和方法。 显示装置包括具有可移动带电粒子（116）的驱动电路（35）和多个像素（PIX1，PIX2，PIX3，PIX4，PIX5，PIX6）。 驱动电路被配置为向像素施加控制信号以将带电粒子移动到每个像素的第一（110）和第二（112）区域之间，以改变每个像素的光学外观。 每个像素的方法包括将带电粒子移动到第一和第二区域之间的边界（114）的预寻址级（PRA），然后将粒子移动到一侧或另一侧的寻址级（ADD） 边界，这取决于像素的期望的光学外观。

公开(公告)号：WO2008035293A2

公开(公告)日：2008-03-27

申请号：PCT/IB2007/053792

申请日：2007-09-19

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PONJEE, Marc, W., G. ,  DEN TOONDER, Jacob, M., J. ,  GILLIES, Murray, F. ,  JOHNSON, Mark, T.

Inventor： PONJEE, Marc, W., G. ,  DEN TOONDER, Jacob, M., J. ,  GILLIES, Murray, F. ,  JOHNSON, Mark, T.

CPC classification number: F04D33/00 ,  B01L3/50273 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2400/0484 ,  Y10T29/494

Abstract: The Invention concerns to a micro-fluidic device for the use in biochip or bio- system, wherein an 2 dimensional matrix array of temperature sensitive po Iy-MEM actuators (1) is arranged in a 2 dimensional thermal processing array, in which each single temperature control element (6) or thermal element can be steered independently from each other, in order to be able to activate each single poly-MEM actuator (1).

Abstract translation: 本发明涉及用于生物芯片或生物系统的微流体装置，其中将温度敏感的pIy-MEM致动器（1）的二维矩阵阵列布置在二维热处理阵列中，其中每个单个 温度控制元件（6）或热元件可以彼此独立地转向，以便能够激活每个单个多MEM执行元件（1）。

公开(公告)号：WO2008020374A2

公开(公告)日：2008-02-21

申请号：PCT/IB2007/053176

申请日：2007-08-10

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  JOHNSON, Mark, T. ,  DEN TOONDER, Jacob, M., J. ,  GILLIES, Murray, F. ,  FRENCH, Ian ,  PONJEE, Marc, W., G.

Inventor： JOHNSON, Mark, T. ,  DEN TOONDER, Jacob, M., J. ,  GILLIES, Murray, F. ,  FRENCH, Ian ,  PONJEE, Marc, W., G.

IPC: F04D33/00

CPC classification number: F04D33/00 ,  B01F13/0059 ,  B01F13/0091 ,  F04B19/006

Abstract: The invention relates to an electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems. An electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems, wherein an 2-dimensional matrix array of poly MEMS actuators (PMA) (1) is arranged in a 2-dimenional system in which each single actuator is electrically/electronically steered independently from each other, in order to be able to generate a pattern of activation in the matrix.

Abstract translation: 本发明涉及一种使用有源矩阵原理的电动微流体装置，用于医疗和健康和保健产品，特别是生物芯片或生物系统。 一种使用有源矩阵原理的电动微流体装置，用于医疗和健康和保健产品，特别是生物芯片或生物系统，其中布置了多MEMS致动器（PMA）（2）的二维矩阵阵列 在其中每个单个致动器彼此独立地电/电子导向的二维系统中，以便能够在矩阵中产生激活模式。

公开(公告)号：WO2005078517A9

公开(公告)日：2006-10-26

申请号：PCT/IB2005050499

申请日：2005-02-08

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS CORP ,  SALTERS BART A ,  GILLIES MURRAY F

Inventor： SALTERS BART A ,  GILLIES MURRAY F

IPC: G02F1/133 ,  G02F1/167

CPC classification number: G02F1/167 ,  G02F1/132

Abstract: An electronic paint for an electrophoretic display includes a lower conductive layer, a thermal addressing layer disposed on the lower conductive layer, a layer of electrophoretic ink disposed on the thermal addressing layer, and an upper conductive layer disposed on the electrophoretic ink. Activation of the electrophoretic ink is based on thermal absorption of thermal radiation in a portion of the thermal addressing layer and a bias voltage applied between the upper conductive layer and the lower conductive layer.

Abstract translation: 用于电泳显示器的电子涂料包括下导电层，设置在下导电层上的热寻址层，设置在热寻址层上的电泳墨层，以及设置在电泳墨上的上导电层。 电泳墨的激活是基于热寻址层的一部分中的热辐射的热吸收和施加在上导电层和下导电层之间的偏置电压。

公开(公告)号：WO2006033054A1

公开(公告)日：2006-03-30

申请号：PCT/IB2005/053015

申请日：2005-09-14

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  CORTENRAAD, Hubertus, M., R. ,  FEENSTRA, Bokke, J. ,  SCHLANGEN, Lucas, J., M. ,  GILLIES, Murray, F. ,  BAESJOU, Patrick, J. ,  BERGMAN, Anthonie, H.

Inventor： CORTENRAAD, Hubertus, M., R. ,  FEENSTRA, Bokke, J. ,  SCHLANGEN, Lucas, J., M. ,  GILLIES, Murray, F. ,  BAESJOU, Patrick, J. ,  BERGMAN, Anthonie, H.

IPC: G09G3/34

CPC classification number: G09G3/00 ,  G09G2300/0439 ,  G09G2300/0452 ,  G09G2310/04 ,  G09G2320/029 ,  G09G2320/0606 ,  G09G2320/0666 ,  G09G2340/0421 ,  G09G2360/148

Abstract: Display apparatus with a display area (2) having a plurality of pixels (9), a mixing unit (3) for preparing a predetermined quantity of color material for one of the plurality of pixels (9), and a transfer unit (4) for transferring the predetermined quantity for a pixel (9) to the associated pixel position in the display area (2). The transfer of color material can be based on an electro-wetting mechanism, an electrophoresis mechanism or a pumping mechanism.

Abstract translation: 具有多个像素（9）的显示区域（2）的显示装置，用于为所述多个像素（9）中的一个准备预定量的颜色材料的混合单元（3），以及转印单元（4） 用于将像素（9）的预定量转移到显示区域（2）中的相关联的像素位置。 彩色材料的转印可以基于电润湿机构，电泳机制或泵送机构。