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    TREATMENT OF MEIBOMIAN GLANDS
    1.
    发明申请
    TREATMENT OF MEIBOMIAN GLANDS 审中-公开
    治疗墨西哥湾

    公开(公告)号：WO2008085162A1

    公开(公告)日：2008-07-17

    申请号：PCT/US2007/000525

    申请日：2007-01-09

    Applicant: KOLIS SCIENTIFIC, INC. ,  KORB, Donald, R. ,  WILLIS, Timothy, R. ,  GRENON, Stephen, M.

    Inventor： KORB, Donald, R. ,  WILLIS, Timothy, R. ,  GRENON, Stephen, M.

    IPC: A61F7/00 ,  A61B19/00

    CPC classification number: A61F7/02 ,  A61F2007/0004

    Abstract: In one embodiment consistent with the present invention a method of treating mammalian meibomian glands (10) involves clearing the glands by applying a regulated heat (104) to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands (108), wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) (112) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

    Abstract translation: 在与本发明一致的一个实施方案中，治疗哺乳动物睑板腺的方法（10）涉及通过对含有睑板腺的眼睑施加调节热（104）至足以融化睑板腺中的阻塞物的温度来清除腺体 在流体或悬浮（熔化）状态下的障碍物并将热量保持足以熔化障碍物的时间。 然后可以对腺体进行机械处理以从腺体（108）表达流体，其中治疗在时间段期间或在时间段之后进行，但是阻塞物保持在流体状态。 然后使用药物（局部或全身）（112）对腺体进行的后续药理学治疗可以用于帮助保持来自腺体的适当的脂质流动。 该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

    METHODS, SYSTEMS, AND APPARATUSES FOR HEAT TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION
    6.
    发明申请
    METHODS, SYSTEMS, AND APPARATUSES FOR HEAT TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 审中-公开
    用于治疗脑血管功能障碍的热处理方法，系统和装置

    公开(公告)号：WO2008089327A1

    公开(公告)日：2008-07-24

    申请号：PCT/US2008/051309

    申请日：2008-01-17

    Applicant: KORB, Donald, R. ,  GRENON, Stephen, M. ,  WILLIS, Timothy, R. ,  GRAVELY, Benjamin, Tyson ,  JANS, John, Martin ,  HUTCHINSON, Jordan, W. ,  GAUSMANN, Keith

    Inventor： KORB, Donald, R. ,  GRENON, Stephen, M. ,  WILLIS, Timothy, R. ,  GRAVELY, Benjamin, Tyson ,  JANS, John, Martin ,  HUTCHINSON, Jordan, W. ,  GAUSMANN, Keith

    IPC: A61M35/00

    CPC classification number: A61F7/02 ,  A61F7/007 ,  A61F9/00718 ,  A61F2007/0004 ,  A61F2007/0086

    Abstract: Apparatuses, systems, and methods of treating meibomian gland dysfunction. Heat is applied to the patient's eyelid or surrounding tissue to apply heat to the patient's meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the patient's eyelid or surrounding tissue to improve conductive heat transfer and reduce blood flow in the tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reached desired temperature levels and/or aid in reducing discomfort to the patient during treatment.

    Abstract translation: 治疗睑板腺功能障碍的装置，系统和方法。 对患者的眼睑或周围组织施加热量以对患者的睑板腺施加热量。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 也可以将力施加到患者的眼睑或周围组织以改善传导性热传递并减少导致对流热损失的组织中的血液流动。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。 达到升高的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到所需温度水平的时间量和/或有助于减轻治疗期间患者的不适。

    MELTING MEIBOMIAN GLAND OBSTRUCTIONS
    7.
    发明申请
    MELTING MEIBOMIAN GLAND OBSTRUCTIONS 审中-公开
    熔化MEIBOMIAN GLAND阻塞

    公开(公告)号：WO2008039221A1

    公开(公告)日：2008-04-03

    申请号：PCT/US2007/000508

    申请日：2007-01-09

    Applicant: KOLIS SCIENTIFIC, INC. ,  GRENON, Stephen, M. ,  FOSHEE, David ,  KORB, Donald, R. ,  WILLIS, Timothy, R. ,  BARRIER, Omer, Jack

    Inventor： GRENON, Stephen, M. ,  FOSHEE, David ,  KORB, Donald, R. ,  WILLIS, Timothy, R. ,  BARRIER, Omer, Jack

    IPC: A61F7/00

    CPC classification number: A61F7/007 ,  A61F2007/0004

    Abstract: Consistent with certain embodiments, an apparatus provides regulated heat to at least one of a patient's eyelids, using a heater unit (38) having a heating element (42) that produces heat that is transferred to the patient's eyelid when an electrical signal is applied thereto. A temperature regulator applies an electrical signal to the heating elements (42) in order to achieve heating of the heating elements (42) to a specified temperature range. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

    Abstract translation: 根据某些实施例，一种装置使用具有加热元件（42）的加热器单元（38）向患者的眼睑中的至少一个提供调节的热量，所述加热器单元产生当向其施加电信号时传递到患者眼皮的热量 。 温度调节器将电信号施加到加热元件（42），以实现加热元件（42）的加热到指定的温度范围。 该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

    MEIBOMIAN GLAND IMAGING
    8.
    发明申请
    MEIBOMIAN GLAND IMAGING 审中-公开

    公开(公告)号：WO2008039220A1

    公开(公告)日：2008-04-03

    申请号：PCT/US2007/000505

    申请日：2007-01-09

    Applicant: KOLIS SCIENTIFIC, INC. ,  GRENON, Stephen, M. ,  WILLS, Timothy, R. ,  GRAVELY, Benjamin, T. ,  KORB, Donald, R.

    Inventor： GRENON, Stephen, M. ,  WILLS, Timothy, R. ,  GRAVELY, Benjamin, T. ,  KORB, Donald, R.

    IPC: A61B3/14

    CPC classification number: A61B3/10 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/411 ,  A61B5/4261

    Abstract: A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland (20) in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland (20). This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

    Abstract translation: 一种评估人眼干眼症的方法，其中由于眼睑中睑板腺（20）的阻塞的存在，减少或停止天然存在于眼睛的分泌物的流动，包括对眼睑施加压力，模拟施加的压力 眨眼期间 并同时对腺体进行成像以诊断睑板腺的状况（20）。 该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

    METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION EMPLOYING FLUID
    9.
    发明申请
    METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION EMPLOYING FLUID 审中-公开
    用于处理使用流体的MEIBOMIAN GLAND DYSFUNCTION的方法和装置

    公开(公告)号：WO2008027069A1

    公开(公告)日：2008-03-06

    申请号：PCT/US2007/000493

    申请日：2007-01-09

    Applicant: KOLIS SCIENTIFIC, INC. ,  GRENON, Stephen, M. ,  ROE, Steven ,  KORB, Donald, R. ,  PAUL, Lyle

    Inventor： GRENON, Stephen, M. ,  ROE, Steven ,  KORB, Donald, R. ,  PAUL, Lyle

    IPC: B08B3/10

    CPC classification number: A61F9/00 ,  A61B17/3203 ,  A61B18/04 ,  A61B2018/046 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059

    Abstract: According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice (O). The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is applied to the exterior surface of the eyelid, proximate to the gland channel orifice (O), a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed.

    Abstract translation: 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物流出腺体通道孔口（O）。 本发明包括选择能够输送加热介质射流的装置。 该装置被定位成使得当喷射器施加到眼睑的外表面时，靠近腺体通道孔口（O），加热介质射流被施加到靠近腺体通道孔的眼睑外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分堵塞被去除。

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