公开(公告)号：WO2009111278A3

公开(公告)日：2009-09-11

申请号：PCT/US2009/035380

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61P35/00 ,  A61K31/437

Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2011025938A3

公开(公告)日：2011-05-05

申请号：PCT/US2010046952

申请日：2010-08-27

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC ,  ALIAGAS IGNACIO ,  GRADL STEFAN ,  GUNZNER JANET ,  LEE WENDY ,  MATHIEU SIMON ,  RUDOLPH JOACHIM ,  WEN ZHAOYANG ,  ZHAO GUILING ,  BUCKMELTER ALEXANDRE J ,  GRINA JONAS ,  HANSEN JOSHUA D ,  LAIRD ELLEN ,  MORENO DAVID ,  REN LI ,  WENGLOWSKY STEVEN MARK

Inventor： ALIAGAS IGNACIO ,  GRADL STEFAN ,  GUNZNER JANET ,  LEE WENDY ,  MATHIEU SIMON ,  RUDOLPH JOACHIM ,  WEN ZHAOYANG ,  ZHAO GUILING ,  BUCKMELTER ALEXANDRE J ,  GRINA JONAS ,  HANSEN JOSHUA D ,  LAIRD ELLEN ,  MORENO DAVID ,  REN LI ,  WENGLOWSKY STEVEN MARK

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这些病症或相关病理学病症的方法。

公开(公告)号：WO2009111278A2

公开(公告)日：2009-09-11

申请号：PCT/US2009035380

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC ,  AHRENDT KATERI A ,  BUCKMELTER ALEXANDRE J ,  GRINA JONAS ,  HANSEN JOSHUA D ,  LAIRD ELLEN R ,  MORENO DAVID ,  NEWHOUSE BRAD ,  REN LI ,  WENGLOWSKY STEVEN MARK ,  FENG BAINIAN ,  GUNZNER JANET ,  MALESKY KIM ,  MATHIEU SIMON ,  RUDOLPH JOACHIM ,  WEN ZHAOYANG ,  YOUNG WENDY B

Inventor： AHRENDT KATERI A ,  BUCKMELTER ALEXANDRE J ,  GRINA JONAS ,  HANSEN JOSHUA D ,  LAIRD ELLEN R ,  MORENO DAVID ,  NEWHOUSE BRAD ,  REN LI ,  WENGLOWSKY STEVEN MARK ,  FENG BAINIAN ,  GUNZNER JANET ,  MALESKY KIM ,  MATHIEU SIMON ,  RUDOLPH JOACHIM ,  WEN ZHAOYANG ,  YOUNG WENDY B

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07C311/08

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2011025940A1

公开(公告)日：2011-03-03

申请号：PCT/US2010/046955

申请日：2010-08-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  MATHIEU, Simon ,  PULK, Rebecca ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

Inventor： ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  MATHIEU, Simon ,  PULK, Rebecca ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

IPC: C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/38 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2009111280A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/035383

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B. ,  MORENO, David, A.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B. ,  MORENO, David, A.

IPC: C07C311/08 ,  C07D213/75 ,  A61K31/44 ,  A61P35/00

CPC classification number: C07D213/75 ,  C07C311/48 ,  C07D213/80 ,  C07D213/82 ,  C07D213/85 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D417/04

Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO1995019358A1

公开(公告)日：1995-07-20

申请号：PCT/EP1995000086

申请日：1995-01-11

Applicant: SANDOZ LTD. ,  SANDOZ-PATENT-GMBH ,  SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH ,  BAUM, John, William ,  BAMBERG, Joe, Timothy ,  GRINA, Jonas, Antanas

Inventor： SANDOZ LTD. ,  SANDOZ-PATENT-GMBH ,  SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH

IPC: C07D401/04

CPC classification number: C07D239/28 ,  A01N43/54 ,  A01N43/78 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14

Abstract: This invention relates to novel aryl and heteroaryl pyrimidine derivatives, shown below, substituted at the 2- and 4-position of the pyrimidine ring, their use as herbicides and agricultural compositions comprising the same. In formula (I), W is a substituted phenyl or a substituted 5- or 6-membered aromatic heterocyclic ring wherein one or two atoms of said ring are selected from oxygen, nitrogen and sulfur; W being substituted by at least R; R is CO2R , CHO, CONH-O-CH2CO2R , COSR , CO2CHR OCOR or CH=NOR ; R , R , R , R , R are as defined in the application; m = 1 or 2.

Abstract translation: 本发明涉及如下所示的在嘧啶环的2-和4-位取代的新的芳基和杂芳基嘧啶衍生物，它们作为除草剂的用途和包含它们的农业组合物。 在式（I）中，W是取代的苯基或取代的5或6元芳族杂环，其中所述环的一个或两个原子选自氧，氮和硫; W至少被R取代; R是CO 2 R 4，CHO，CONH-O-CH 2 CO 2 R 4，COSR 4，CO 2 CHR 5 OCOR 6或CH = NOR 4; R 1，R 2，R 4，R 5，R 6如本申请中所定义; m = 1或2。

公开(公告)号：WO2009111279A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/035381

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2009111277A9

公开(公告)日：2009-09-11

申请号：PCT/US2009/035379

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri, A. ,  BUCKMELTER, Alexandre, J. ,  GRINA, Jonas ,  HANSEN, Joshua, D. ,  LAIRD, Ellen, R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven, M. ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy, B. ,  MORENO, David, A.

Inventor： AHRENDT, Kateri, A. ,  BUCKMELTER, Alexandre, J. ,  GRINA, Jonas ,  HANSEN, Joshua, D. ,  LAIRD, Ellen, R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven, M. ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy, B. ,  MORENO, David, A.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P35/00 ,  A61P13/12

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2006125101A2

公开(公告)日：2006-11-23

申请号：PCT/US2006019280

申请日：2006-05-18

Applicant: ARRAY BIOPHARMA INC ,  LAIRD ELLEN ,  TOPALOV GEORGE ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD

Inventor： LAIRD ELLEN ,  TOPALOV GEORGE ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD

CPC classification number: C07D487/04

Abstract: Compounds of Formula (I) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 公开了使用式（I）化合物及其立体异构体，互变异构体，溶剂合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理学病症中的这种病症的方法 。

公开(公告)号：WO2006084015A3

公开(公告)日：2006-08-10

申请号：PCT/US2006/003654

申请日：2006-02-02

Applicant: GENENTECH, INC. ,  ARRAY BIOPHARMA, INC. ,  LAIRD, Ellen ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad ,  OLIVERO, Alan ,  TOPOLAV, George

Inventor： LAIRD, Ellen ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad ,  OLIVERO, Alan ,  TOPOLAV, George

IPC: C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/415 ,  A61P35/00 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P37/00 ,  A61P25/00

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.