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公开(公告)号：WO2009003074A3
公开(公告)日：2008-12-31
申请号：PCT/US2008/068264
申请日：2008-06-26
Applicant: ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
Inventor： GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
IPC: C07K14/435
Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能嵌合受体并提供了适于筛选配体的方法和组合物，所述配体例如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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公开(公告)号：WO2008002956A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/072185
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
Abstract translation: 本发明涉及一系列噻唑啉和恶唑啉衍生物，其组合物，以及使用这些化合物治疗病症和病症的方法。
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公开(公告)号：WO2008002956A3
公开(公告)日：2008-07-03
申请号：PCT/US2007072185
申请日：2007-06-27
Applicant: ABBOTT LAB , FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
Inventor： FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
IPC: C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.
Abstract translation: 本发明涉及选自化合物的式I化合物。 式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。
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4.发明申请SCREENING SYSTEM TO IDENTIFY PATTERNS ON SUBSTRATE SURFACES FOR INDUCING STEM CELL DIFFERENTIATION AND PRODUCING HOMOGENOUS POPULATION OF A DESIRED CELL TYPE 审中-公开筛选系统识别用于诱导干细胞分化和产生所需细胞类型的均质群体的基底表面上的图案
公开(公告)号：WO2011014845A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/044028
申请日：2010-07-30
Applicant: NANOINK, INC. , JAMIL, Haris , GUBBINS, Earl, J. , AMRO, Nabil, A. , DILMAC, Nejmi , SANEDRIN, Raymond
Inventor： JAMIL, Haris , GUBBINS, Earl, J. , AMRO, Nabil, A. , DILMAC, Nejmi , SANEDRIN, Raymond
CPC classification number: C12N5/0068 , C12N2535/10 , G01N33/502 , G01N33/5073 , G01N33/54393
Abstract: Described herein is a systemic approach for identifying compounds and pattern dimensions for regulating a desired cell type including stem cells. High throughput screening can be carried out with use of nanolithography and chemical libraries. Cell growth factors can be patterned and screened.
Abstract translation: 本文描述了用于鉴定用于调节包括干细胞的所需细胞类型的化合物和模式维度的系统方法。 高通量筛选可以使用纳米光刻和化学文库进行。 细胞生长因子可以进行图案化和筛选。
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Patent Agency Ranking
公开(公告)号：WO2009003074A8
公开(公告)日：2009-07-16
申请号：PCT/US2008068264
申请日：2008-06-26
Applicant: ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
Inventor： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC: C07K14/435
CPC classification number: C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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6.发明申请
公开(公告)号：WO2010085769A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/022015
申请日：2010-01-25
Applicant: NANOINK, INC. , AMRO, Nabil, A. , SANEDRIN, Raymond , GUBBINS, Earl, J.
Inventor： AMRO, Nabil, A. , SANEDRIN, Raymond , GUBBINS, Earl, J.
IPC: G03F7/00
CPC classification number: G03F7/0002 , Y10T428/24802
Abstract: An article comprising: at least one solid substrate comprising at least one surface providing a surface area of at least one square millimeter, wherein the surface comprises a homogeneous array of material deposits which covers at least 90% of the surface area. Edge-to-edge patterning and large area substrates can be achieved. Applications include growth of cells.
Abstract translation: 一种制品，包括：至少一个固体基质，其包含提供至少一平方毫米的表面积的至少一个表面，其中所述表面包括覆盖至少90％的表面积的材料沉积物的均匀阵列。 可以实现边缘到边缘的图案化和大面积的基板。 应用包括细胞生长。
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7.发明申请CHOLINERGIC/SEROTONINERGIC CHIMERIC RECEPTOR AND USES THEREOF 审中-公开CHOLINERGIC / SERONONERGIC CHIMERIC RECEPTOR及其用途
公开(公告)号：WO2009003074A9
公开(公告)日：2010-10-28
申请号：PCT/US2008068264
申请日：2008-06-26
Applicant: ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
Inventor： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC: C07K14/435
CPC classification number: C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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公开(公告)号：WO2009003074A2
公开(公告)日：2008-12-31
申请号：PCT/US2008068264
申请日：2008-06-26
Applicant: ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
Inventor： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC: C07K14/435
CPC classification number: C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
Abstract translation: 本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。
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公开(公告)号：WO2008002974A1
公开(公告)日：2008-01-03
申请号：PCT/US2007/072228
申请日：2007-06-27
Applicant: ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
Inventor： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
IPC: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , A61K31/402 , A61P25/00
CPC classification number: C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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