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公开(公告)号：WO2010036998A3
公开(公告)日：2011-03-03
申请号：PCT/US2009058553
申请日：2009-09-28
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA , HU MIN
Inventor： SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA , HU MIN
IPC: C07D487/18 , A61K31/33 , A61P25/00
CPC classification number: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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2.发明申请
公开(公告)号：WO2005113536A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/014866
申请日：2005-04-29
Applicant: ABBOTT LABORATORIES , ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D401/00
CPC classification number: C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds of formula (I) wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）化合物其中R 1或R 2是三环或双环，其各自含有至少两个杂原子，R 1，R 2，R 3，R 3a，R 3b，R 4，R 5，L，X，X'，Y， Y'，Z和Z'如本文所定义，可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：WO2010151815A3
公开(公告)日：2010-12-29
申请号：PCT/US2010/040064
申请日：2010-06-25
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , NERSESIAN, Diana L. , LEE, Chih-Hung , FAGHIH, Ramin , GFESSER, Gregory A.
Inventor： SCHRIMPF, Michael R. , NERSESIAN, Diana L. , LEE, Chih-Hung , FAGHIH, Ramin , GFESSER, Gregory A.
IPC: C07D487/10 , C07D471/02 , A61K31/438 , A61P25/28
Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
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公开(公告)号：WO2009082698A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/087729
申请日：2008-12-19
Applicant: ABBOTT LABORATORIES , RUETER, Lynne E. , FOX, Gerard B. , BROWMAN, Kaitlin E. , SULLIVAN, James P. , BRIONI, Jorge D. , COWART, Marlon D. , FAGHIH, Ramin , GFESSER, Gregory A. , MORTELL, Kathleen H. , GOPALAKRISHNAN, Murali
Inventor： RUETER, Lynne E. , FOX, Gerard B. , BROWMAN, Kaitlin E. , SULLIVAN, James P. , BRIONI, Jorge D. , COWART, Marlon D. , FAGHIH, Ramin , GFESSER, Gregory A. , MORTELL, Kathleen H. , GOPALAKRISHNAN, Murali
CPC classification number: A61K45/06 , A61K31/165 , A61K31/40 , A61K2300/00
Abstract: The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either α4ß2 subtype or α7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.
Abstract translation: 本发明涉及用于治疗认知缺陷的组合物。 这样的组合物可以具有a4β2亚型或a7烟碱型乙酰胆碱亚型的烟碱型乙酰胆碱受体配体，组胺3受体配体，使用该配体的方法和相关制品。 也考虑了这些活性剂与精神兴奋剂或单胺再摄取抑制剂的组合。
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5.发明申请BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS 审中-公开具有循环取代的单环取代基的双环取代的氨基
公开(公告)号：WO2005113551A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/014863
申请日：2005-04-29
Applicant: ABBOTT LABORATORIES , ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
Inventor： ALTENBACH, Robert, J. , BLACK, Lawrence, A. , CHANG, Sou-jen , COWART, Marlon, D. , FAGHIH, Ramin , GFESSER, Gregory, A. , KU, Yi-yin , LIU, Huaqing , LUKIN, Kirill, A. , NERSESIAN, Diana, L. , PU, Yu-ming , CURTIS, Michael, P.
IPC: C07D417/14
CPC classification number: C07D215/12 , C07D401/04 , C07D401/08 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of formula (I) wherein R 1 or R 2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L 2 and L 3 , to a heteroaromatic core, and X, X', Y, Y', Z, Z', R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, L 2 , and L 3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）的化合物，其中R 1或R 2是通过由L 2和L 3表示的连接基直接连接或连接到杂芳族核心上的芳族或非芳族环，X，X'，Y，Y'，Z ，Z'，R1，R2，R3，R3a，R3b，R4，R5，L，L2和L3如本文所定义，可用于治疗组胺3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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Patent Agency Ranking
公开(公告)号：WO2011008312A3
公开(公告)日：2011-03-17
申请号：PCT/US2010027931
申请日：2010-03-19
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA L , HU MIN
Inventor： SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA L , HU MIN
IPC: C07D487/18 , A61K31/33 , A61P25/00 , C07D471/18
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本发明涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法，以及鉴定此类化合物的方法。
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公开(公告)号：WO2008002956A3
公开(公告)日：2008-07-03
申请号：PCT/US2007072185
申请日：2007-06-27
Applicant: ABBOTT LAB , FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
Inventor： FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
IPC: C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.
Abstract translation: 本发明涉及选自化合物的式I化合物。 式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。
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8.发明申请
公开(公告)号：WO2005113536A3
公开(公告)日：2006-03-30
申请号：PCT/US2005014866
申请日：2005-04-29
Applicant: ABBOTT LAB , ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
IPC: C07D401/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/02 , C07D471/04 , C07D487/04 , C07D491/02 , C07D491/04 , C07D495/04 , C07D498/02 , C07D513/04 , A61K31/4709 , A61K31/4725
CPC classification number: C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds of formula (I) wherein R
Abstract translation: 式（I）的化合物，其中R 1，
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公开(公告)号：WO2011008312A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/027931
申请日：2010-03-19
Applicant: ABBOTT LABORATORIES , SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
Inventor： SCHRIMPF, Michael R. , LEE, Chih-Hung , LI, Tao , GFESSER, Gregory A. , MORTELL, Kathleen H. , FAGHIH, Ramin , NERSESIAN, Diana L. , SIPPY, Kevin B. , BUNNELLE, William H. , SCANIO, Marc , SHI, Lei , GOPALAKRISHNAN, Murali , DONNELLY-ROBERTS, Diana L. , HU, Min
IPC: C07D487/18
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a , R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物， R 1，R 2，R 3，R 4，R 5，R 5，R 5，R 4， U，V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法以及鉴定此类化合物的方法。
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10.发明申请
公开(公告)号：WO2009086163A3
公开(公告)日：2009-09-03
申请号：PCT/US2008087774
申请日：2008-12-19
Applicant: ABBOTT LAB , FAGHIH RAMIN , GFESSER GREGORY A , MORTELL KATHLEEN H , GOPALAKRISHNAN MURALI
Inventor： FAGHIH RAMIN , GFESSER GREGORY A , MORTELL KATHLEEN H , GOPALAKRISHNAN MURALI
IPC: C07D277/02 , A61P25/00 , C07D277/50
CPC classification number: C07D277/18 , C07D401/02 , C07D417/02 , C07D417/14
Abstract: The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
Abstract translation: 本发明涉及作为神经元烟碱受体的PAM的新的噻唑啉脲和酰胺衍生物，包含其的组合物，制备这些化合物的方法以及使用这些化合物和组合物的方法。
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